Amino acid dipepetide frequency for Tepidamorphus gemmatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.376AlaAla: 21.376 ± 0.216
1.2AlaCys: 1.2 ± 0.034
7.647AlaAsp: 7.647 ± 0.095
8.693AlaGlu: 8.693 ± 0.105
4.585AlaPhe: 4.585 ± 0.065
12.395AlaGly: 12.395 ± 0.115
2.243AlaHis: 2.243 ± 0.046
6.959AlaIle: 6.959 ± 0.085
2.667AlaLys: 2.667 ± 0.056
13.705AlaLeu: 13.705 ± 0.123
3.677AlaMet: 3.677 ± 0.055
2.508AlaAsn: 2.508 ± 0.048
5.873AlaPro: 5.873 ± 0.089
3.406AlaGln: 3.406 ± 0.061
11.415AlaArg: 11.415 ± 0.118
5.767AlaSer: 5.767 ± 0.073
6.459AlaThr: 6.459 ± 0.082
10.17AlaVal: 10.17 ± 0.11
1.736AlaTrp: 1.736 ± 0.038
2.575AlaTyr: 2.575 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.057CysAla: 1.057 ± 0.03
0.094CysCys: 0.094 ± 0.01
0.578CysAsp: 0.578 ± 0.025
0.461CysGlu: 0.461 ± 0.02
0.314CysPhe: 0.314 ± 0.016
1.008CysGly: 1.008 ± 0.034
0.218CysHis: 0.218 ± 0.013
0.376CysIle: 0.376 ± 0.017
0.127CysLys: 0.127 ± 0.01
0.816CysLeu: 0.816 ± 0.027
0.172CysMet: 0.172 ± 0.011
0.183CysAsn: 0.183 ± 0.013
0.493CysPro: 0.493 ± 0.023
0.162CysGln: 0.162 ± 0.014
0.786CysArg: 0.786 ± 0.028
0.395CysSer: 0.395 ± 0.021
0.43CysThr: 0.43 ± 0.017
0.621CysVal: 0.621 ± 0.022
0.11CysTrp: 0.11 ± 0.01
0.199CysTyr: 0.199 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.816AspAla: 6.816 ± 0.085
0.499AspCys: 0.499 ± 0.024
2.871AspAsp: 2.871 ± 0.062
3.42AspGlu: 3.42 ± 0.064
2.073AspPhe: 2.073 ± 0.045
5.484AspGly: 5.484 ± 0.078
1.174AspHis: 1.174 ± 0.029
3.147AspIle: 3.147 ± 0.051
1.14AspLys: 1.14 ± 0.035
5.95AspLeu: 5.95 ± 0.074
1.296AspMet: 1.296 ± 0.034
1.039AspAsn: 1.039 ± 0.032
3.981AspPro: 3.981 ± 0.068
1.457AspGln: 1.457 ± 0.036
5.246AspArg: 5.246 ± 0.083
2.128AspSer: 2.128 ± 0.046
2.561AspThr: 2.561 ± 0.047
4.138AspVal: 4.138 ± 0.066
1.017AspTrp: 1.017 ± 0.035
1.374AspTyr: 1.374 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
8.825GluAla: 8.825 ± 0.105
0.33GluCys: 0.33 ± 0.018
2.672GluAsp: 2.672 ± 0.053
3.266GluGlu: 3.266 ± 0.06
1.719GluPhe: 1.719 ± 0.039
4.194GluGly: 4.194 ± 0.059
1.111GluHis: 1.111 ± 0.031
3.886GluIle: 3.886 ± 0.062
1.617GluLys: 1.617 ± 0.043
5.473GluLeu: 5.473 ± 0.072
1.542GluMet: 1.542 ± 0.037
1.139GluAsn: 1.139 ± 0.033
3.01GluPro: 3.01 ± 0.054
1.795GluGln: 1.795 ± 0.04
5.68GluArg: 5.68 ± 0.075
2.234GluSer: 2.234 ± 0.04
3.637GluThr: 3.637 ± 0.054
4.247GluVal: 4.247 ± 0.073
0.646GluTrp: 0.646 ± 0.026
0.873GluTyr: 0.873 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.766PheAla: 4.766 ± 0.076
0.383PheCys: 0.383 ± 0.018
2.567PheAsp: 2.567 ± 0.051
2.19PheGlu: 2.19 ± 0.051
1.239PhePhe: 1.239 ± 0.04
3.619PheGly: 3.619 ± 0.064
0.747PheHis: 0.747 ± 0.028
1.516PheIle: 1.516 ± 0.043
0.667PheLys: 0.667 ± 0.025
3.317PheLeu: 3.317 ± 0.062
0.741PheMet: 0.741 ± 0.025
0.889PheAsn: 0.889 ± 0.029
1.634PhePro: 1.634 ± 0.036
0.815PheGln: 0.815 ± 0.026
2.638PheArg: 2.638 ± 0.051
1.715PheSer: 1.715 ± 0.042
1.77PheThr: 1.77 ± 0.04
2.937PheVal: 2.937 ± 0.052
0.502PheTrp: 0.502 ± 0.024
0.794PheTyr: 0.794 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.744GlyAla: 9.744 ± 0.088
0.897GlyCys: 0.897 ± 0.026
4.432GlyAsp: 4.432 ± 0.06
5.17GlyGlu: 5.17 ± 0.074
3.534GlyPhe: 3.534 ± 0.055
7.706GlyGly: 7.706 ± 0.092
1.915GlyHis: 1.915 ± 0.038
5.08GlyIle: 5.08 ± 0.072
2.355GlyLys: 2.355 ± 0.055
9.586GlyLeu: 9.586 ± 0.102
2.376GlyMet: 2.376 ± 0.046
1.877GlyAsn: 1.877 ± 0.043
4.123GlyPro: 4.123 ± 0.055
2.554GlyGln: 2.554 ± 0.057
7.936GlyArg: 7.936 ± 0.088
4.496GlySer: 4.496 ± 0.067
4.642GlyThr: 4.642 ± 0.07
6.09GlyVal: 6.09 ± 0.076
1.432GlyTrp: 1.432 ± 0.038
2.398GlyTyr: 2.398 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.366HisAla: 2.366 ± 0.046
0.237HisCys: 0.237 ± 0.016
1.151HisAsp: 1.151 ± 0.039
0.991HisGlu: 0.991 ± 0.026
0.781HisPhe: 0.781 ± 0.023
2.008HisGly: 2.008 ± 0.042
0.526HisHis: 0.526 ± 0.024
0.854HisIle: 0.854 ± 0.025
0.365HisLys: 0.365 ± 0.019
2.006HisLeu: 2.006 ± 0.038
0.453HisMet: 0.453 ± 0.021
0.399HisAsn: 0.399 ± 0.021
1.418HisPro: 1.418 ± 0.035
0.449HisGln: 0.449 ± 0.019
1.625HisArg: 1.625 ± 0.041
0.815HisSer: 0.815 ± 0.03
0.752HisThr: 0.752 ± 0.03
1.623HisVal: 1.623 ± 0.033
0.309HisTrp: 0.309 ± 0.017
0.533HisTyr: 0.533 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
8.208IleAla: 8.208 ± 0.094
0.515IleCys: 0.515 ± 0.02
3.719IleAsp: 3.719 ± 0.057
3.767IleGlu: 3.767 ± 0.062
1.512IlePhe: 1.512 ± 0.039
5.425IleGly: 5.425 ± 0.074
0.93IleHis: 0.93 ± 0.029
2.097IleIle: 2.097 ± 0.057
1.008IleLys: 1.008 ± 0.031
4.599IleLeu: 4.599 ± 0.072
0.902IleMet: 0.902 ± 0.029
1.204IleAsn: 1.204 ± 0.036
2.413IlePro: 2.413 ± 0.047
1.0IleGln: 1.0 ± 0.031
3.949IleArg: 3.949 ± 0.064
2.432IleSer: 2.432 ± 0.048
2.447IleThr: 2.447 ± 0.049
4.808IleVal: 4.808 ± 0.074
0.618IleTrp: 0.618 ± 0.024
1.148IleTyr: 1.148 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.194LysAla: 3.194 ± 0.072
0.12LysCys: 0.12 ± 0.011
1.175LysAsp: 1.175 ± 0.036
1.119LysGlu: 1.119 ± 0.04
0.603LysPhe: 0.603 ± 0.021
1.97LysGly: 1.97 ± 0.045
0.412LysHis: 0.412 ± 0.019
1.207LysIle: 1.207 ± 0.035
0.651LysLys: 0.651 ± 0.031
2.296LysLeu: 2.296 ± 0.05
0.507LysMet: 0.507 ± 0.02
0.478LysAsn: 0.478 ± 0.021
1.511LysPro: 1.511 ± 0.041
0.649LysGln: 0.649 ± 0.025
1.976LysArg: 1.976 ± 0.047
1.192LysSer: 1.192 ± 0.035
1.296LysThr: 1.296 ± 0.037
1.98LysVal: 1.98 ± 0.048
0.268LysTrp: 0.268 ± 0.017
0.468LysTyr: 0.468 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.457LeuAla: 15.457 ± 0.127
0.868LeuCys: 0.868 ± 0.029
6.31LeuAsp: 6.31 ± 0.078
5.498LeuGlu: 5.498 ± 0.074
3.469LeuPhe: 3.469 ± 0.064
8.359LeuGly: 8.359 ± 0.105
1.764LeuHis: 1.764 ± 0.047
5.006LeuIle: 5.006 ± 0.079
2.931LeuLys: 2.931 ± 0.058
9.034LeuLeu: 9.034 ± 0.133
2.375LeuMet: 2.375 ± 0.045
2.081LeuAsn: 2.081 ± 0.047
5.695LeuPro: 5.695 ± 0.081
2.266LeuGln: 2.266 ± 0.047
7.295LeuArg: 7.295 ± 0.091
5.537LeuSer: 5.537 ± 0.06
5.265LeuThr: 5.265 ± 0.063
8.419LeuVal: 8.419 ± 0.102
1.191LeuTrp: 1.191 ± 0.032
1.931LeuTyr: 1.931 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
3.27MetAla: 3.27 ± 0.061
0.159MetCys: 0.159 ± 0.011
1.001MetAsp: 1.001 ± 0.03
0.972MetGlu: 0.972 ± 0.03
0.728MetPhe: 0.728 ± 0.026
1.669MetGly: 1.669 ± 0.036
0.416MetHis: 0.416 ± 0.019
1.416MetIle: 1.416 ± 0.039
0.732MetLys: 0.732 ± 0.025
2.55MetLeu: 2.55 ± 0.042
0.639MetMet: 0.639 ± 0.028
0.647MetAsn: 0.647 ± 0.023
1.585MetPro: 1.585 ± 0.034
0.716MetGln: 0.716 ± 0.023
2.061MetArg: 2.061 ± 0.041
1.588MetSer: 1.588 ± 0.036
1.822MetThr: 1.822 ± 0.041
1.791MetVal: 1.791 ± 0.037
0.228MetTrp: 0.228 ± 0.014
0.301MetTyr: 0.301 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.605AsnAla: 2.605 ± 0.053
0.233AsnCys: 0.233 ± 0.016
1.096AsnAsp: 1.096 ± 0.03
1.023AsnGlu: 1.023 ± 0.034
0.73AsnPhe: 0.73 ± 0.025
1.938AsnGly: 1.938 ± 0.048
0.41AsnHis: 0.41 ± 0.02
1.119AsnIle: 1.119 ± 0.031
0.43AsnLys: 0.43 ± 0.019
2.176AsnLeu: 2.176 ± 0.042
0.497AsnMet: 0.497 ± 0.022
0.49AsnAsn: 0.49 ± 0.02
1.585AsnPro: 1.585 ± 0.037
0.543AsnGln: 0.543 ± 0.025
1.856AsnArg: 1.856 ± 0.04
0.844AsnSer: 0.844 ± 0.027
0.985AsnThr: 0.985 ± 0.033
1.776AsnVal: 1.776 ± 0.048
0.34AsnTrp: 0.34 ± 0.017
0.563AsnTyr: 0.563 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.251ProAla: 7.251 ± 0.08
0.374ProCys: 0.374 ± 0.019
4.186ProAsp: 4.186 ± 0.065
3.611ProGlu: 3.611 ± 0.055
2.035ProPhe: 2.035 ± 0.04
5.284ProGly: 5.284 ± 0.071
1.105ProHis: 1.105 ± 0.031
2.469ProIle: 2.469 ± 0.046
1.255ProLys: 1.255 ± 0.038
4.847ProLeu: 4.847 ± 0.062
1.204ProMet: 1.204 ± 0.034
1.14ProAsn: 1.14 ± 0.031
3.077ProPro: 3.077 ± 0.062
1.566ProGln: 1.566 ± 0.038
3.63ProArg: 3.63 ± 0.056
2.481ProSer: 2.481 ± 0.051
2.44ProThr: 2.44 ± 0.049
4.907ProVal: 4.907 ± 0.065
0.708ProTrp: 0.708 ± 0.024
1.185ProTyr: 1.185 ± 0.033
0.001ProXaa: 0.001 ± 0.001
Gln
3.529GlnAla: 3.529 ± 0.059
0.165GlnCys: 0.165 ± 0.012
1.189GlnAsp: 1.189 ± 0.032
1.269GlnGlu: 1.269 ± 0.034
0.892GlnPhe: 0.892 ± 0.029
1.946GlnGly: 1.946 ± 0.041
0.532GlnHis: 0.532 ± 0.021
1.637GlnIle: 1.637 ± 0.034
0.735GlnLys: 0.735 ± 0.03
2.335GlnLeu: 2.335 ± 0.047
0.769GlnMet: 0.769 ± 0.026
0.574GlnAsn: 0.574 ± 0.024
1.605GlnPro: 1.605 ± 0.046
0.918GlnGln: 0.918 ± 0.032
2.358GlnArg: 2.358 ± 0.051
1.393GlnSer: 1.393 ± 0.041
1.568GlnThr: 1.568 ± 0.039
2.043GlnVal: 2.043 ± 0.047
0.317GlnTrp: 0.317 ± 0.016
0.506GlnTyr: 0.506 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
9.77ArgAla: 9.77 ± 0.1
0.59ArgCys: 0.59 ± 0.023
4.624ArgAsp: 4.624 ± 0.065
4.748ArgGlu: 4.748 ± 0.081
3.219ArgPhe: 3.219 ± 0.051
5.633ArgGly: 5.633 ± 0.081
2.063ArgHis: 2.063 ± 0.045
4.988ArgIle: 4.988 ± 0.07
1.932ArgLys: 1.932 ± 0.046
9.938ArgLeu: 9.938 ± 0.103
2.184ArgMet: 2.184 ± 0.042
1.856ArgAsn: 1.856 ± 0.038
4.702ArgPro: 4.702 ± 0.071
2.683ArgGln: 2.683 ± 0.055
8.097ArgArg: 8.097 ± 0.106
3.922ArgSer: 3.922 ± 0.07
3.935ArgThr: 3.935 ± 0.069
5.42ArgVal: 5.42 ± 0.078
1.085ArgTrp: 1.085 ± 0.033
1.785ArgTyr: 1.785 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.78SerAla: 5.78 ± 0.079
0.391SerCys: 0.391 ± 0.021
2.628SerAsp: 2.628 ± 0.054
2.536SerGlu: 2.536 ± 0.051
1.877SerPhe: 1.877 ± 0.046
5.286SerGly: 5.286 ± 0.077
0.887SerHis: 0.887 ± 0.031
2.503SerIle: 2.503 ± 0.052
0.988SerLys: 0.988 ± 0.03
4.829SerLeu: 4.829 ± 0.069
1.157SerMet: 1.157 ± 0.03
1.028SerAsn: 1.028 ± 0.032
2.668SerPro: 2.668 ± 0.055
1.283SerGln: 1.283 ± 0.035
3.746SerArg: 3.746 ± 0.066
2.248SerSer: 2.248 ± 0.057
2.206SerThr: 2.206 ± 0.049
3.648SerVal: 3.648 ± 0.058
0.637SerTrp: 0.637 ± 0.022
1.069SerTyr: 1.069 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
6.648ThrAla: 6.648 ± 0.092
0.458ThrCys: 0.458 ± 0.023
2.648ThrAsp: 2.648 ± 0.051
2.494ThrGlu: 2.494 ± 0.055
1.873ThrPhe: 1.873 ± 0.041
5.354ThrGly: 5.354 ± 0.068
0.874ThrHis: 0.874 ± 0.027
2.831ThrIle: 2.831 ± 0.049
0.915ThrLys: 0.915 ± 0.032
5.369ThrLeu: 5.369 ± 0.071
1.147ThrMet: 1.147 ± 0.031
1.043ThrAsn: 1.043 ± 0.031
3.233ThrPro: 3.233 ± 0.059
1.084ThrGln: 1.084 ± 0.035
3.661ThrArg: 3.661 ± 0.053
2.412ThrSer: 2.412 ± 0.052
2.66ThrThr: 2.66 ± 0.056
4.611ThrVal: 4.611 ± 0.074
0.666ThrTrp: 0.666 ± 0.022
1.11ThrTyr: 1.11 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
10.686ValAla: 10.686 ± 0.108
0.709ValCys: 0.709 ± 0.024
4.335ValAsp: 4.335 ± 0.064
4.931ValGlu: 4.931 ± 0.071
2.96ValPhe: 2.96 ± 0.05
6.064ValGly: 6.064 ± 0.086
1.49ValHis: 1.49 ± 0.04
4.051ValIle: 4.051 ± 0.076
1.759ValLys: 1.759 ± 0.043
7.936ValLeu: 7.936 ± 0.107
1.869ValMet: 1.869 ± 0.05
1.813ValAsn: 1.813 ± 0.045
4.265ValPro: 4.265 ± 0.062
1.792ValGln: 1.792 ± 0.038
5.94ValArg: 5.94 ± 0.076
4.064ValSer: 4.064 ± 0.063
4.41ValThr: 4.41 ± 0.056
6.954ValVal: 6.954 ± 0.098
1.026ValTrp: 1.026 ± 0.035
1.649ValTyr: 1.649 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.242TrpAla: 1.242 ± 0.034
0.138TrpCys: 0.138 ± 0.011
0.633TrpAsp: 0.633 ± 0.023
0.534TrpGlu: 0.534 ± 0.022
0.515TrpPhe: 0.515 ± 0.022
0.886TrpGly: 0.886 ± 0.028
0.332TrpHis: 0.332 ± 0.017
0.71TrpIle: 0.71 ± 0.022
0.37TrpLys: 0.37 ± 0.017
1.72TrpLeu: 1.72 ± 0.045
0.36TrpMet: 0.36 ± 0.017
0.364TrpAsn: 0.364 ± 0.019
0.755TrpPro: 0.755 ± 0.029
0.547TrpGln: 0.547 ± 0.023
1.318TrpArg: 1.318 ± 0.037
0.794TrpSer: 0.794 ± 0.026
0.788TrpThr: 0.788 ± 0.029
0.838TrpVal: 0.838 ± 0.028
0.232TrpTrp: 0.232 ± 0.014
0.333TrpTyr: 0.333 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.467TyrAla: 2.467 ± 0.05
0.239TyrCys: 0.239 ± 0.013
1.349TyrAsp: 1.349 ± 0.036
1.204TyrGlu: 1.204 ± 0.034
0.79TyrPhe: 0.79 ± 0.025
2.117TyrGly: 2.117 ± 0.043
0.513TyrHis: 0.513 ± 0.021
0.848TyrIle: 0.848 ± 0.028
0.428TyrLys: 0.428 ± 0.02
2.268TyrLeu: 2.268 ± 0.055
0.426TyrMet: 0.426 ± 0.019
0.484TyrAsn: 0.484 ± 0.021
1.13TyrPro: 1.13 ± 0.034
0.595TyrGln: 0.595 ± 0.024
1.961TyrArg: 1.961 ± 0.045
0.937TyrSer: 0.937 ± 0.032
1.018TyrThr: 1.018 ± 0.031
1.681TyrVal: 1.681 ± 0.04
0.343TyrTrp: 0.343 ± 0.019
0.529TyrTyr: 0.529 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.002XaaXaa: 0.002 ± 0.002
Statistics based on 3554 proteins (1129158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski