Amino acid dipepetide frequency for Croceivirga radicis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.278AlaAla: 5.278 ± 0.08
0.588AlaCys: 0.588 ± 0.022
3.721AlaAsp: 3.721 ± 0.084
4.216AlaGlu: 4.216 ± 0.077
3.494AlaPhe: 3.494 ± 0.064
4.687AlaGly: 4.687 ± 0.087
1.259AlaHis: 1.259 ± 0.04
5.666AlaIle: 5.666 ± 0.085
5.182AlaLys: 5.182 ± 0.089
6.98AlaLeu: 6.98 ± 0.09
1.669AlaMet: 1.669 ± 0.038
4.246AlaAsn: 4.246 ± 0.081
2.345AlaPro: 2.345 ± 0.053
2.887AlaGln: 2.887 ± 0.052
2.039AlaArg: 2.039 ± 0.041
4.201AlaSer: 4.201 ± 0.066
4.312AlaThr: 4.312 ± 0.091
4.578AlaVal: 4.578 ± 0.081
0.682AlaTrp: 0.682 ± 0.033
2.82AlaTyr: 2.82 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.473CysAla: 0.473 ± 0.021
0.089CysCys: 0.089 ± 0.01
0.384CysAsp: 0.384 ± 0.023
0.437CysGlu: 0.437 ± 0.025
0.355CysPhe: 0.355 ± 0.022
0.561CysGly: 0.561 ± 0.03
0.177CysHis: 0.177 ± 0.015
0.511CysIle: 0.511 ± 0.024
0.464CysLys: 0.464 ± 0.023
0.649CysLeu: 0.649 ± 0.026
0.162CysMet: 0.162 ± 0.012
0.394CysAsn: 0.394 ± 0.024
0.297CysPro: 0.297 ± 0.019
0.206CysGln: 0.206 ± 0.013
0.178CysArg: 0.178 ± 0.013
0.494CysSer: 0.494 ± 0.023
0.462CysThr: 0.462 ± 0.029
0.403CysVal: 0.403 ± 0.02
0.06CysTrp: 0.06 ± 0.008
0.279CysTyr: 0.279 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
4.235AspAla: 4.235 ± 0.087
0.398AspCys: 0.398 ± 0.024
2.807AspAsp: 2.807 ± 0.074
3.283AspGlu: 3.283 ± 0.06
3.578AspPhe: 3.578 ± 0.078
4.414AspGly: 4.414 ± 0.146
0.889AspHis: 0.889 ± 0.028
3.945AspIle: 3.945 ± 0.073
3.903AspLys: 3.903 ± 0.067
5.323AspLeu: 5.323 ± 0.09
1.145AspMet: 1.145 ± 0.034
3.209AspAsn: 3.209 ± 0.082
1.788AspPro: 1.788 ± 0.047
1.881AspGln: 1.881 ± 0.04
1.871AspArg: 1.871 ± 0.045
3.191AspSer: 3.191 ± 0.054
3.091AspThr: 3.091 ± 0.064
3.654AspVal: 3.654 ± 0.081
0.806AspTrp: 0.806 ± 0.026
2.782AspTyr: 2.782 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
4.755GluAla: 4.755 ± 0.073
0.283GluCys: 0.283 ± 0.016
3.691GluAsp: 3.691 ± 0.063
5.141GluGlu: 5.141 ± 0.094
2.737GluPhe: 2.737 ± 0.055
3.84GluGly: 3.84 ± 0.073
1.213GluHis: 1.213 ± 0.037
4.738GluIle: 4.738 ± 0.074
5.299GluLys: 5.299 ± 0.095
6.221GluLeu: 6.221 ± 0.088
1.475GluMet: 1.475 ± 0.041
4.354GluAsn: 4.354 ± 0.064
1.856GluPro: 1.856 ± 0.041
2.729GluGln: 2.729 ± 0.062
2.651GluArg: 2.651 ± 0.064
3.025GluSer: 3.025 ± 0.052
3.738GluThr: 3.738 ± 0.058
4.4GluVal: 4.4 ± 0.069
0.673GluTrp: 0.673 ± 0.024
2.196GluTyr: 2.196 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.118PheAla: 3.118 ± 0.055
0.394PheCys: 0.394 ± 0.017
3.078PheAsp: 3.078 ± 0.058
3.233PheGlu: 3.233 ± 0.057
2.572PhePhe: 2.572 ± 0.066
3.705PheGly: 3.705 ± 0.064
0.768PheHis: 0.768 ± 0.03
3.458PheIle: 3.458 ± 0.071
3.82PheLys: 3.82 ± 0.072
4.862PheLeu: 4.862 ± 0.077
1.134PheMet: 1.134 ± 0.033
3.249PheAsn: 3.249 ± 0.061
1.647PhePro: 1.647 ± 0.036
1.414PheGln: 1.414 ± 0.035
1.639PheArg: 1.639 ± 0.04
3.574PheSer: 3.574 ± 0.073
3.315PheThr: 3.315 ± 0.062
2.958PheVal: 2.958 ± 0.051
0.612PheTrp: 0.612 ± 0.024
2.176PheTyr: 2.176 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
4.728GlyAla: 4.728 ± 0.075
0.648GlyCys: 0.648 ± 0.043
3.658GlyAsp: 3.658 ± 0.075
3.797GlyGlu: 3.797 ± 0.065
3.87GlyPhe: 3.87 ± 0.074
4.881GlyGly: 4.881 ± 0.097
1.204GlyHis: 1.204 ± 0.036
5.359GlyIle: 5.359 ± 0.081
4.993GlyLys: 4.993 ± 0.092
6.521GlyLeu: 6.521 ± 0.085
1.631GlyMet: 1.631 ± 0.038
3.891GlyAsn: 3.891 ± 0.082
1.677GlyPro: 1.677 ± 0.069
2.143GlyGln: 2.143 ± 0.048
2.163GlyArg: 2.163 ± 0.051
4.051GlySer: 4.051 ± 0.083
4.552GlyThr: 4.552 ± 0.115
4.569GlyVal: 4.569 ± 0.07
0.887GlyTrp: 0.887 ± 0.032
2.938GlyTyr: 2.938 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.048HisAla: 1.048 ± 0.031
0.162HisCys: 0.162 ± 0.013
0.817HisAsp: 0.817 ± 0.027
0.962HisGlu: 0.962 ± 0.031
1.1HisPhe: 1.1 ± 0.036
1.066HisGly: 1.066 ± 0.037
0.467HisHis: 0.467 ± 0.024
1.256HisIle: 1.256 ± 0.038
1.328HisLys: 1.328 ± 0.039
1.886HisLeu: 1.886 ± 0.047
0.332HisMet: 0.332 ± 0.017
0.893HisAsn: 0.893 ± 0.029
0.88HisPro: 0.88 ± 0.031
0.733HisGln: 0.733 ± 0.027
0.651HisArg: 0.651 ± 0.026
0.898HisSer: 0.898 ± 0.032
1.028HisThr: 1.028 ± 0.032
0.991HisVal: 0.991 ± 0.034
0.231HisTrp: 0.231 ± 0.016
0.772HisTyr: 0.772 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.729IleAla: 5.729 ± 0.081
0.542IleCys: 0.542 ± 0.022
4.309IleAsp: 4.309 ± 0.074
4.669IleGlu: 4.669 ± 0.07
3.168IlePhe: 3.168 ± 0.063
5.011IleGly: 5.011 ± 0.076
1.128IleHis: 1.128 ± 0.03
4.64IleIle: 4.64 ± 0.077
5.046IleLys: 5.046 ± 0.079
6.566IleLeu: 6.566 ± 0.088
1.218IleMet: 1.218 ± 0.033
4.111IleAsn: 4.111 ± 0.065
3.07IlePro: 3.07 ± 0.051
2.267IleGln: 2.267 ± 0.043
2.375IleArg: 2.375 ± 0.051
4.697IleSer: 4.697 ± 0.065
4.696IleThr: 4.696 ± 0.097
4.261IleVal: 4.261 ± 0.069
0.726IleTrp: 0.726 ± 0.028
2.669IleTyr: 2.669 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.172LysAla: 5.172 ± 0.085
0.264LysCys: 0.264 ± 0.017
4.411LysAsp: 4.411 ± 0.081
6.39LysGlu: 6.39 ± 0.098
2.623LysPhe: 2.623 ± 0.057
4.673LysGly: 4.673 ± 0.08
1.266LysHis: 1.266 ± 0.041
5.116LysIle: 5.116 ± 0.087
6.253LysLys: 6.253 ± 0.109
6.359LysLeu: 6.359 ± 0.09
1.778LysMet: 1.778 ± 0.04
4.693LysAsn: 4.693 ± 0.076
2.55LysPro: 2.55 ± 0.056
2.754LysGln: 2.754 ± 0.063
2.798LysArg: 2.798 ± 0.055
3.854LysSer: 3.854 ± 0.064
4.477LysThr: 4.477 ± 0.077
4.632LysVal: 4.632 ± 0.075
0.835LysTrp: 0.835 ± 0.03
2.655LysTyr: 2.655 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
7.025LeuAla: 7.025 ± 0.096
0.672LeuCys: 0.672 ± 0.025
5.821LeuAsp: 5.821 ± 0.101
6.665LeuGlu: 6.665 ± 0.1
4.992LeuPhe: 4.992 ± 0.078
6.422LeuGly: 6.422 ± 0.084
1.577LeuHis: 1.577 ± 0.046
6.237LeuIle: 6.237 ± 0.091
7.469LeuLys: 7.469 ± 0.102
9.4LeuLeu: 9.4 ± 0.154
2.045LeuMet: 2.045 ± 0.048
5.804LeuAsn: 5.804 ± 0.082
3.879LeuPro: 3.879 ± 0.067
3.475LeuGln: 3.475 ± 0.07
3.187LeuArg: 3.187 ± 0.054
6.163LeuSer: 6.163 ± 0.08
5.422LeuThr: 5.422 ± 0.086
6.127LeuVal: 6.127 ± 0.079
0.911LeuTrp: 0.911 ± 0.034
3.25LeuTyr: 3.25 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
1.95MetAla: 1.95 ± 0.041
0.113MetCys: 0.113 ± 0.012
1.293MetAsp: 1.293 ± 0.038
1.543MetGlu: 1.543 ± 0.039
0.802MetPhe: 0.802 ± 0.034
1.594MetGly: 1.594 ± 0.043
0.401MetHis: 0.401 ± 0.02
1.182MetIle: 1.182 ± 0.035
1.702MetLys: 1.702 ± 0.04
1.89MetLeu: 1.89 ± 0.046
0.48MetMet: 0.48 ± 0.024
1.164MetAsn: 1.164 ± 0.031
0.907MetPro: 0.907 ± 0.028
0.863MetGln: 0.863 ± 0.025
0.879MetArg: 0.879 ± 0.028
1.153MetSer: 1.153 ± 0.036
0.982MetThr: 0.982 ± 0.03
1.594MetVal: 1.594 ± 0.045
0.163MetTrp: 0.163 ± 0.012
0.663MetTyr: 0.663 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
4.141AsnAla: 4.141 ± 0.074
0.458AsnCys: 0.458 ± 0.022
2.853AsnAsp: 2.853 ± 0.072
3.208AsnGlu: 3.208 ± 0.056
3.028AsnPhe: 3.028 ± 0.056
4.611AsnGly: 4.611 ± 0.093
1.053AsnHis: 1.053 ± 0.03
4.087AsnIle: 4.087 ± 0.073
3.984AsnLys: 3.984 ± 0.072
5.778AsnLeu: 5.778 ± 0.088
1.218AsnMet: 1.218 ± 0.037
3.835AsnAsn: 3.835 ± 0.076
2.973AsnPro: 2.973 ± 0.061
2.403AsnGln: 2.403 ± 0.054
2.211AsnArg: 2.211 ± 0.05
3.5AsnSer: 3.5 ± 0.066
3.986AsnThr: 3.986 ± 0.078
3.501AsnVal: 3.501 ± 0.077
0.844AsnTrp: 0.844 ± 0.033
2.834AsnTyr: 2.834 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.14ProAla: 2.14 ± 0.056
0.23ProCys: 0.23 ± 0.016
2.225ProAsp: 2.225 ± 0.056
3.029ProGlu: 3.029 ± 0.053
1.987ProPhe: 1.987 ± 0.039
2.085ProGly: 2.085 ± 0.055
0.62ProHis: 0.62 ± 0.024
2.818ProIle: 2.818 ± 0.052
2.733ProLys: 2.733 ± 0.052
3.287ProLeu: 3.287 ± 0.06
0.746ProMet: 0.746 ± 0.026
2.466ProAsn: 2.466 ± 0.058
0.898ProPro: 0.898 ± 0.036
1.175ProGln: 1.175 ± 0.04
0.976ProArg: 0.976 ± 0.027
2.064ProSer: 2.064 ± 0.045
2.177ProThr: 2.177 ± 0.05
2.444ProVal: 2.444 ± 0.049
0.412ProTrp: 0.412 ± 0.019
1.526ProTyr: 1.526 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.264GlnAla: 2.264 ± 0.045
0.177GlnCys: 0.177 ± 0.013
1.944GlnAsp: 1.944 ± 0.045
2.642GlnGlu: 2.642 ± 0.049
1.791GlnPhe: 1.791 ± 0.039
2.043GlnGly: 2.043 ± 0.051
0.676GlnHis: 0.676 ± 0.028
2.558GlnIle: 2.558 ± 0.047
2.791GlnLys: 2.791 ± 0.059
4.06GlnLeu: 4.06 ± 0.083
0.822GlnMet: 0.822 ± 0.031
2.139GlnAsn: 2.139 ± 0.045
1.18GlnPro: 1.18 ± 0.031
1.716GlnGln: 1.716 ± 0.038
1.323GlnArg: 1.323 ± 0.032
1.736GlnSer: 1.736 ± 0.042
1.98GlnThr: 1.98 ± 0.04
2.211GlnVal: 2.211 ± 0.051
0.447GlnTrp: 0.447 ± 0.02
1.315GlnTyr: 1.315 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.133ArgAla: 2.133 ± 0.047
0.178ArgCys: 0.178 ± 0.012
1.715ArgAsp: 1.715 ± 0.038
2.102ArgGlu: 2.102 ± 0.048
1.932ArgPhe: 1.932 ± 0.05
2.03ArgGly: 2.03 ± 0.048
0.568ArgHis: 0.568 ± 0.022
2.805ArgIle: 2.805 ± 0.052
2.628ArgLys: 2.628 ± 0.051
3.455ArgLeu: 3.455 ± 0.062
0.837ArgMet: 0.837 ± 0.027
2.06ArgAsn: 2.06 ± 0.039
1.208ArgPro: 1.208 ± 0.031
1.086ArgGln: 1.086 ± 0.035
1.288ArgArg: 1.288 ± 0.037
1.837ArgSer: 1.837 ± 0.051
1.93ArgThr: 1.93 ± 0.042
2.121ArgVal: 2.121 ± 0.042
0.421ArgTrp: 0.421 ± 0.02
1.646ArgTyr: 1.646 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
3.755SerAla: 3.755 ± 0.064
0.561SerCys: 0.561 ± 0.027
2.937SerAsp: 2.937 ± 0.061
3.336SerGlu: 3.336 ± 0.056
3.381SerPhe: 3.381 ± 0.061
4.463SerGly: 4.463 ± 0.081
0.968SerHis: 0.968 ± 0.03
4.509SerIle: 4.509 ± 0.06
4.345SerLys: 4.345 ± 0.065
5.798SerLeu: 5.798 ± 0.082
1.169SerMet: 1.169 ± 0.034
3.504SerAsn: 3.504 ± 0.065
2.021SerPro: 2.021 ± 0.044
1.844SerGln: 1.844 ± 0.042
1.898SerArg: 1.898 ± 0.046
3.591SerSer: 3.591 ± 0.074
3.429SerThr: 3.429 ± 0.069
3.739SerVal: 3.739 ± 0.067
0.738SerTrp: 0.738 ± 0.031
2.691SerTyr: 2.691 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.501ThrAla: 4.501 ± 0.11
0.362ThrCys: 0.362 ± 0.023
3.71ThrAsp: 3.71 ± 0.095
3.585ThrGlu: 3.585 ± 0.064
3.131ThrPhe: 3.131 ± 0.068
4.316ThrGly: 4.316 ± 0.087
1.071ThrHis: 1.071 ± 0.036
4.739ThrIle: 4.739 ± 0.092
3.835ThrLys: 3.835 ± 0.065
5.785ThrLeu: 5.785 ± 0.069
1.018ThrMet: 1.018 ± 0.031
3.57ThrAsn: 3.57 ± 0.088
2.534ThrPro: 2.534 ± 0.062
2.116ThrGln: 2.116 ± 0.045
1.622ThrArg: 1.622 ± 0.041
3.376ThrSer: 3.376 ± 0.056
4.038ThrThr: 4.038 ± 0.105
4.334ThrVal: 4.334 ± 0.098
0.597ThrTrp: 0.597 ± 0.032
2.691ThrTyr: 2.691 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.984ValAla: 4.984 ± 0.079
0.494ValCys: 0.494 ± 0.02
3.827ValAsp: 3.827 ± 0.068
3.772ValGlu: 3.772 ± 0.074
3.289ValPhe: 3.289 ± 0.062
4.144ValGly: 4.144 ± 0.065
1.113ValHis: 1.113 ± 0.037
4.209ValIle: 4.209 ± 0.069
4.19ValLys: 4.19 ± 0.063
6.55ValLeu: 6.55 ± 0.095
1.362ValMet: 1.362 ± 0.042
3.678ValAsn: 3.678 ± 0.072
2.478ValPro: 2.478 ± 0.052
1.894ValGln: 1.894 ± 0.036
2.096ValArg: 2.096 ± 0.046
4.221ValSer: 4.221 ± 0.07
4.112ValThr: 4.112 ± 0.129
4.671ValVal: 4.671 ± 0.077
0.64ValTrp: 0.64 ± 0.026
2.494ValTyr: 2.494 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.733TrpAla: 0.733 ± 0.038
0.103TrpCys: 0.103 ± 0.01
0.698TrpAsp: 0.698 ± 0.033
0.75TrpGlu: 0.75 ± 0.028
0.597TrpPhe: 0.597 ± 0.025
0.768TrpGly: 0.768 ± 0.032
0.242TrpHis: 0.242 ± 0.016
0.682TrpIle: 0.682 ± 0.025
0.742TrpLys: 0.742 ± 0.03
1.073TrpLeu: 1.073 ± 0.037
0.32TrpMet: 0.32 ± 0.019
0.74TrpAsn: 0.74 ± 0.037
0.329TrpPro: 0.329 ± 0.018
0.531TrpGln: 0.531 ± 0.022
0.429TrpArg: 0.429 ± 0.022
0.691TrpSer: 0.691 ± 0.026
0.556TrpThr: 0.556 ± 0.026
0.733TrpVal: 0.733 ± 0.027
0.187TrpTrp: 0.187 ± 0.016
0.48TrpTyr: 0.48 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.688TyrAla: 2.688 ± 0.054
0.32TyrCys: 0.32 ± 0.018
2.295TyrAsp: 2.295 ± 0.05
2.254TyrGlu: 2.254 ± 0.051
2.3TyrPhe: 2.3 ± 0.056
2.845TyrGly: 2.845 ± 0.057
0.839TyrHis: 0.839 ± 0.031
2.384TyrIle: 2.384 ± 0.045
2.846TyrLys: 2.846 ± 0.064
4.104TyrLeu: 4.104 ± 0.066
0.756TyrMet: 0.756 ± 0.03
2.505TyrAsn: 2.505 ± 0.05
1.521TyrPro: 1.521 ± 0.037
1.701TyrGln: 1.701 ± 0.042
1.701TyrArg: 1.701 ± 0.04
2.36TyrSer: 2.36 ± 0.057
2.648TyrThr: 2.648 ± 0.065
2.296TyrVal: 2.296 ± 0.048
0.512TyrTrp: 0.512 ± 0.023
1.78TyrTyr: 1.78 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3064 proteins (1106336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski