Amino acid dipepetide frequency for Achromobacter phage vB_Ade_ART

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.546AlaAla: 8.546 ± 0.597
0.673AlaCys: 0.673 ± 0.152
5.619AlaAsp: 5.619 ± 0.46
6.729AlaGlu: 6.729 ± 0.607
3.365AlaPhe: 3.365 ± 0.339
7.941AlaGly: 7.941 ± 0.542
1.548AlaHis: 1.548 ± 0.233
5.35AlaIle: 5.35 ± 0.537
5.148AlaLys: 5.148 ± 0.497
7.402AlaLeu: 7.402 ± 0.525
2.826AlaMet: 2.826 ± 0.274
3.802AlaAsn: 3.802 ± 0.417
3.6AlaPro: 3.6 ± 0.417
3.668AlaGln: 3.668 ± 0.371
5.417AlaArg: 5.417 ± 0.45
5.249AlaSer: 5.249 ± 0.468
6.864AlaThr: 6.864 ± 0.449
6.157AlaVal: 6.157 ± 0.577
1.649AlaTrp: 1.649 ± 0.19
3.062AlaTyr: 3.062 ± 0.297
0.0AlaXaa: 0.0 ± 0.0
Cys
0.572CysAla: 0.572 ± 0.157
0.101CysCys: 0.101 ± 0.061
0.471CysAsp: 0.471 ± 0.148
0.841CysGlu: 0.841 ± 0.184
0.404CysPhe: 0.404 ± 0.097
0.572CysGly: 0.572 ± 0.158
0.101CysHis: 0.101 ± 0.062
0.336CysIle: 0.336 ± 0.11
0.505CysLys: 0.505 ± 0.136
0.505CysLeu: 0.505 ± 0.12
0.37CysMet: 0.37 ± 0.125
0.437CysAsn: 0.437 ± 0.141
0.538CysPro: 0.538 ± 0.202
0.404CysGln: 0.404 ± 0.127
0.707CysArg: 0.707 ± 0.181
0.572CysSer: 0.572 ± 0.175
0.37CysThr: 0.37 ± 0.121
0.572CysVal: 0.572 ± 0.126
0.236CysTrp: 0.236 ± 0.093
0.336CysTyr: 0.336 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
4.946AspAla: 4.946 ± 0.412
0.37AspCys: 0.37 ± 0.11
4.004AspAsp: 4.004 ± 0.415
4.61AspGlu: 4.61 ± 0.445
2.187AspPhe: 2.187 ± 0.301
5.585AspGly: 5.585 ± 0.439
0.875AspHis: 0.875 ± 0.175
2.557AspIle: 2.557 ± 0.3
2.591AspLys: 2.591 ± 0.32
5.384AspLeu: 5.384 ± 0.434
1.716AspMet: 1.716 ± 0.344
1.952AspAsn: 1.952 ± 0.243
2.759AspPro: 2.759 ± 0.292
2.12AspGln: 2.12 ± 0.335
2.692AspArg: 2.692 ± 0.311
2.759AspSer: 2.759 ± 0.309
2.322AspThr: 2.322 ± 0.295
4.038AspVal: 4.038 ± 0.47
1.077AspTrp: 1.077 ± 0.215
2.221AspTyr: 2.221 ± 0.296
0.0AspXaa: 0.0 ± 0.0
Glu
7.1GluAla: 7.1 ± 0.626
0.639GluCys: 0.639 ± 0.145
3.701GluAsp: 3.701 ± 0.397
4.341GluGlu: 4.341 ± 0.438
2.322GluPhe: 2.322 ± 0.268
4.139GluGly: 4.139 ± 0.423
0.976GluHis: 0.976 ± 0.185
3.264GluIle: 3.264 ± 0.332
3.129GluLys: 3.129 ± 0.353
6.662GluLeu: 6.662 ± 0.481
2.12GluMet: 2.12 ± 0.292
2.423GluAsn: 2.423 ± 0.275
2.961GluPro: 2.961 ± 0.365
3.129GluGln: 3.129 ± 0.334
3.735GluArg: 3.735 ± 0.371
3.365GluSer: 3.365 ± 0.378
3.365GluThr: 3.365 ± 0.38
4.441GluVal: 4.441 ± 0.414
1.312GluTrp: 1.312 ± 0.233
2.187GluTyr: 2.187 ± 0.305
0.0GluXaa: 0.0 ± 0.0
Phe
2.927PheAla: 2.927 ± 0.353
0.37PheCys: 0.37 ± 0.107
2.624PheAsp: 2.624 ± 0.304
2.389PheGlu: 2.389 ± 0.284
0.774PhePhe: 0.774 ± 0.14
3.499PheGly: 3.499 ± 0.343
0.572PheHis: 0.572 ± 0.189
1.615PheIle: 1.615 ± 0.261
2.355PheLys: 2.355 ± 0.289
2.019PheLeu: 2.019 ± 0.28
0.976PheMet: 0.976 ± 0.18
1.447PheAsn: 1.447 ± 0.214
2.086PhePro: 2.086 ± 0.273
1.178PheGln: 1.178 ± 0.189
1.952PheArg: 1.952 ± 0.298
2.624PheSer: 2.624 ± 0.259
1.817PheThr: 1.817 ± 0.303
2.456PheVal: 2.456 ± 0.323
0.774PheTrp: 0.774 ± 0.143
1.043PheTyr: 1.043 ± 0.191
0.0PheXaa: 0.0 ± 0.0
Gly
6.46GlyAla: 6.46 ± 0.58
0.572GlyCys: 0.572 ± 0.139
4.341GlyAsp: 4.341 ± 0.348
4.845GlyGlu: 4.845 ± 0.392
2.961GlyPhe: 2.961 ± 0.39
7.234GlyGly: 7.234 ± 0.551
0.976GlyHis: 0.976 ± 0.171
4.542GlyIle: 4.542 ± 0.388
4.576GlyLys: 4.576 ± 0.492
6.561GlyLeu: 6.561 ± 0.426
2.086GlyMet: 2.086 ± 0.243
3.331GlyAsn: 3.331 ± 0.394
3.062GlyPro: 3.062 ± 0.417
2.961GlyGln: 2.961 ± 0.325
4.105GlyArg: 4.105 ± 0.42
6.09GlySer: 6.09 ± 0.66
4.408GlyThr: 4.408 ± 0.44
6.326GlyVal: 6.326 ± 0.57
2.086GlyTrp: 2.086 ± 0.291
2.793GlyTyr: 2.793 ± 0.297
0.0GlyXaa: 0.0 ± 0.0
His
1.649HisAla: 1.649 ± 0.253
0.336HisCys: 0.336 ± 0.098
0.841HisAsp: 0.841 ± 0.166
0.808HisGlu: 0.808 ± 0.189
0.471HisPhe: 0.471 ± 0.107
1.346HisGly: 1.346 ± 0.23
0.437HisHis: 0.437 ± 0.118
1.009HisIle: 1.009 ± 0.18
0.808HisLys: 0.808 ± 0.158
1.144HisLeu: 1.144 ± 0.25
0.471HisMet: 0.471 ± 0.133
0.673HisAsn: 0.673 ± 0.145
0.942HisPro: 0.942 ± 0.183
0.505HisGln: 0.505 ± 0.126
1.077HisArg: 1.077 ± 0.213
0.976HisSer: 0.976 ± 0.189
0.673HisThr: 0.673 ± 0.128
1.077HisVal: 1.077 ± 0.176
0.336HisTrp: 0.336 ± 0.097
0.908HisTyr: 0.908 ± 0.232
0.0HisXaa: 0.0 ± 0.0
Ile
5.047IleAla: 5.047 ± 0.397
0.639IleCys: 0.639 ± 0.168
3.937IleAsp: 3.937 ± 0.471
3.668IleGlu: 3.668 ± 0.374
1.144IlePhe: 1.144 ± 0.19
4.139IleGly: 4.139 ± 0.381
1.211IleHis: 1.211 ± 0.215
2.355IleIle: 2.355 ± 0.272
2.524IleLys: 2.524 ± 0.281
3.533IleLeu: 3.533 ± 0.367
1.211IleMet: 1.211 ± 0.203
2.423IleAsn: 2.423 ± 0.33
3.264IlePro: 3.264 ± 0.306
1.985IleGln: 1.985 ± 0.232
3.533IleArg: 3.533 ± 0.279
3.735IleSer: 3.735 ± 0.438
3.129IleThr: 3.129 ± 0.349
3.331IleVal: 3.331 ± 0.303
0.707IleTrp: 0.707 ± 0.159
1.38IleTyr: 1.38 ± 0.208
0.0IleXaa: 0.0 ± 0.0
Lys
5.451LysAla: 5.451 ± 0.499
0.336LysCys: 0.336 ± 0.108
2.524LysAsp: 2.524 ± 0.279
4.004LysGlu: 4.004 ± 0.472
2.254LysPhe: 2.254 ± 0.322
3.836LysGly: 3.836 ± 0.372
0.841LysHis: 0.841 ± 0.186
2.826LysIle: 2.826 ± 0.258
2.995LysLys: 2.995 ± 0.434
3.903LysLeu: 3.903 ± 0.456
1.581LysMet: 1.581 ± 0.249
1.615LysAsn: 1.615 ± 0.228
2.658LysPro: 2.658 ± 0.341
2.254LysGln: 2.254 ± 0.282
2.894LysArg: 2.894 ± 0.357
2.995LysSer: 2.995 ± 0.321
3.096LysThr: 3.096 ± 0.334
4.038LysVal: 4.038 ± 0.411
0.908LysTrp: 0.908 ± 0.219
1.447LysTyr: 1.447 ± 0.218
0.0LysXaa: 0.0 ± 0.0
Leu
8.244LeuAla: 8.244 ± 0.5
0.639LeuCys: 0.639 ± 0.15
4.61LeuAsp: 4.61 ± 0.471
5.451LeuGlu: 5.451 ± 0.425
2.725LeuPhe: 2.725 ± 0.303
5.619LeuGly: 5.619 ± 0.486
1.043LeuHis: 1.043 ± 0.159
3.769LeuIle: 3.769 ± 0.313
4.744LeuLys: 4.744 ± 0.408
5.754LeuLeu: 5.754 ± 0.469
2.355LeuMet: 2.355 ± 0.297
3.466LeuAsn: 3.466 ± 0.364
5.249LeuPro: 5.249 ± 0.438
3.903LeuGln: 3.903 ± 0.326
4.879LeuArg: 4.879 ± 0.374
4.509LeuSer: 4.509 ± 0.35
5.518LeuThr: 5.518 ± 0.402
4.744LeuVal: 4.744 ± 0.366
0.976LeuTrp: 0.976 ± 0.191
2.12LeuTyr: 2.12 ± 0.3
0.0LeuXaa: 0.0 ± 0.0
Met
3.297MetAla: 3.297 ± 0.376
0.236MetCys: 0.236 ± 0.088
1.514MetAsp: 1.514 ± 0.242
1.581MetGlu: 1.581 ± 0.228
1.11MetPhe: 1.11 ± 0.179
1.716MetGly: 1.716 ± 0.194
0.606MetHis: 0.606 ± 0.157
1.615MetIle: 1.615 ± 0.241
1.312MetLys: 1.312 ± 0.227
2.725MetLeu: 2.725 ± 0.321
0.74MetMet: 0.74 ± 0.134
1.178MetAsn: 1.178 ± 0.23
1.48MetPro: 1.48 ± 0.169
0.942MetGln: 0.942 ± 0.178
1.682MetArg: 1.682 ± 0.217
1.985MetSer: 1.985 ± 0.301
1.682MetThr: 1.682 ± 0.276
1.952MetVal: 1.952 ± 0.261
0.135MetTrp: 0.135 ± 0.077
0.774MetTyr: 0.774 ± 0.123
0.0MetXaa: 0.0 ± 0.0
Asn
4.105AsnAla: 4.105 ± 0.328
0.707AsnCys: 0.707 ± 0.144
1.884AsnAsp: 1.884 ± 0.225
2.052AsnGlu: 2.052 ± 0.235
1.514AsnPhe: 1.514 ± 0.229
4.172AsnGly: 4.172 ± 0.407
0.505AsnHis: 0.505 ± 0.113
2.052AsnIle: 2.052 ± 0.272
1.682AsnLys: 1.682 ± 0.248
3.499AsnLeu: 3.499 ± 0.276
1.279AsnMet: 1.279 ± 0.205
1.514AsnAsn: 1.514 ± 0.308
2.759AsnPro: 2.759 ± 0.289
1.581AsnGln: 1.581 ± 0.289
2.187AsnArg: 2.187 ± 0.25
2.524AsnSer: 2.524 ± 0.3
1.817AsnThr: 1.817 ± 0.27
2.624AsnVal: 2.624 ± 0.344
1.11AsnTrp: 1.11 ± 0.192
1.514AsnTyr: 1.514 ± 0.257
0.0AsnXaa: 0.0 ± 0.0
Pro
4.778ProAla: 4.778 ± 0.415
0.269ProCys: 0.269 ± 0.1
3.297ProAsp: 3.297 ± 0.335
3.668ProGlu: 3.668 ± 0.368
1.75ProPhe: 1.75 ± 0.271
4.542ProGly: 4.542 ± 0.511
0.942ProHis: 0.942 ± 0.192
2.961ProIle: 2.961 ± 0.317
2.995ProLys: 2.995 ± 0.311
3.297ProLeu: 3.297 ± 0.324
1.043ProMet: 1.043 ± 0.202
2.187ProAsn: 2.187 ± 0.308
2.624ProPro: 2.624 ± 0.408
2.052ProGln: 2.052 ± 0.276
2.12ProArg: 2.12 ± 0.307
2.86ProSer: 2.86 ± 0.295
3.163ProThr: 3.163 ± 0.345
4.004ProVal: 4.004 ± 0.441
0.774ProTrp: 0.774 ± 0.136
1.312ProTyr: 1.312 ± 0.181
0.0ProXaa: 0.0 ± 0.0
Gln
4.643GlnAla: 4.643 ± 0.476
0.404GlnCys: 0.404 ± 0.137
1.918GlnAsp: 1.918 ± 0.284
2.826GlnGlu: 2.826 ± 0.302
1.783GlnPhe: 1.783 ± 0.287
2.86GlnGly: 2.86 ± 0.314
0.538GlnHis: 0.538 ± 0.146
2.187GlnIle: 2.187 ± 0.261
1.682GlnLys: 1.682 ± 0.286
3.297GlnLeu: 3.297 ± 0.334
1.48GlnMet: 1.48 ± 0.244
1.447GlnAsn: 1.447 ± 0.259
1.682GlnPro: 1.682 ± 0.231
1.447GlnGln: 1.447 ± 0.253
2.524GlnArg: 2.524 ± 0.271
2.557GlnSer: 2.557 ± 0.264
1.918GlnThr: 1.918 ± 0.238
3.197GlnVal: 3.197 ± 0.346
0.808GlnTrp: 0.808 ± 0.155
1.581GlnTyr: 1.581 ± 0.254
0.0GlnXaa: 0.0 ± 0.0
Arg
5.686ArgAla: 5.686 ± 0.382
0.37ArgCys: 0.37 ± 0.109
2.793ArgAsp: 2.793 ± 0.392
3.432ArgGlu: 3.432 ± 0.392
2.086ArgPhe: 2.086 ± 0.327
4.273ArgGly: 4.273 ± 0.381
0.908ArgHis: 0.908 ± 0.162
2.692ArgIle: 2.692 ± 0.314
3.331ArgLys: 3.331 ± 0.359
4.812ArgLeu: 4.812 ± 0.406
2.221ArgMet: 2.221 ± 0.278
2.725ArgAsn: 2.725 ± 0.332
3.129ArgPro: 3.129 ± 0.341
2.423ArgGln: 2.423 ± 0.32
4.105ArgArg: 4.105 ± 0.299
2.793ArgSer: 2.793 ± 0.346
3.028ArgThr: 3.028 ± 0.288
4.004ArgVal: 4.004 ± 0.277
1.11ArgTrp: 1.11 ± 0.207
1.817ArgTyr: 1.817 ± 0.239
0.0ArgXaa: 0.0 ± 0.0
Ser
5.417SerAla: 5.417 ± 0.53
0.538SerCys: 0.538 ± 0.12
3.432SerAsp: 3.432 ± 0.33
3.297SerGlu: 3.297 ± 0.351
2.187SerPhe: 2.187 ± 0.226
5.754SerGly: 5.754 ± 0.504
1.077SerHis: 1.077 ± 0.225
3.062SerIle: 3.062 ± 0.363
2.557SerLys: 2.557 ± 0.296
4.61SerLeu: 4.61 ± 0.394
1.615SerMet: 1.615 ± 0.224
2.591SerAsn: 2.591 ± 0.361
2.187SerPro: 2.187 ± 0.316
2.456SerGln: 2.456 ± 0.318
3.365SerArg: 3.365 ± 0.244
2.894SerSer: 2.894 ± 0.373
3.869SerThr: 3.869 ± 0.411
4.307SerVal: 4.307 ± 0.431
0.908SerTrp: 0.908 ± 0.15
1.851SerTyr: 1.851 ± 0.245
0.0SerXaa: 0.0 ± 0.0
Thr
5.013ThrAla: 5.013 ± 0.492
0.538ThrCys: 0.538 ± 0.148
2.355ThrAsp: 2.355 ± 0.266
3.365ThrGlu: 3.365 ± 0.347
1.952ThrPhe: 1.952 ± 0.254
4.643ThrGly: 4.643 ± 0.423
0.875ThrHis: 0.875 ± 0.17
3.466ThrIle: 3.466 ± 0.279
3.365ThrLys: 3.365 ± 0.444
5.821ThrLeu: 5.821 ± 0.534
1.447ThrMet: 1.447 ± 0.229
2.389ThrAsn: 2.389 ± 0.333
3.668ThrPro: 3.668 ± 0.357
2.423ThrGln: 2.423 ± 0.286
2.759ThrArg: 2.759 ± 0.298
3.062ThrSer: 3.062 ± 0.359
3.869ThrThr: 3.869 ± 0.33
3.769ThrVal: 3.769 ± 0.269
1.548ThrTrp: 1.548 ± 0.196
2.12ThrTyr: 2.12 ± 0.254
0.0ThrXaa: 0.0 ± 0.0
Val
6.157ValAla: 6.157 ± 0.428
0.538ValCys: 0.538 ± 0.171
3.836ValAsp: 3.836 ± 0.346
4.408ValGlu: 4.408 ± 0.468
2.658ValPhe: 2.658 ± 0.265
4.576ValGly: 4.576 ± 0.36
1.48ValHis: 1.48 ± 0.182
3.97ValIle: 3.97 ± 0.393
3.533ValLys: 3.533 ± 0.425
5.888ValLeu: 5.888 ± 0.483
1.245ValMet: 1.245 ± 0.163
3.365ValAsn: 3.365 ± 0.402
3.701ValPro: 3.701 ± 0.378
3.096ValGln: 3.096 ± 0.245
4.139ValArg: 4.139 ± 0.421
3.432ValSer: 3.432 ± 0.283
4.913ValThr: 4.913 ± 0.414
4.98ValVal: 4.98 ± 0.447
1.279ValTrp: 1.279 ± 0.196
2.456ValTyr: 2.456 ± 0.311
0.0ValXaa: 0.0 ± 0.0
Trp
1.716TrpAla: 1.716 ± 0.255
0.269TrpCys: 0.269 ± 0.088
1.144TrpAsp: 1.144 ± 0.196
1.144TrpGlu: 1.144 ± 0.184
0.875TrpPhe: 0.875 ± 0.151
1.279TrpGly: 1.279 ± 0.211
0.236TrpHis: 0.236 ± 0.091
1.077TrpIle: 1.077 ± 0.168
0.673TrpLys: 0.673 ± 0.169
1.11TrpLeu: 1.11 ± 0.233
0.471TrpMet: 0.471 ± 0.121
0.606TrpAsn: 0.606 ± 0.124
0.942TrpPro: 0.942 ± 0.154
0.538TrpGln: 0.538 ± 0.142
1.581TrpArg: 1.581 ± 0.252
1.279TrpSer: 1.279 ± 0.189
0.875TrpThr: 0.875 ± 0.195
1.447TrpVal: 1.447 ± 0.243
0.303TrpTrp: 0.303 ± 0.093
1.144TrpTyr: 1.144 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.86TyrAla: 2.86 ± 0.322
0.404TyrCys: 0.404 ± 0.122
1.918TyrAsp: 1.918 ± 0.237
1.851TyrGlu: 1.851 ± 0.269
1.009TyrPhe: 1.009 ± 0.179
2.591TyrGly: 2.591 ± 0.318
0.74TyrHis: 0.74 ± 0.14
2.187TyrIle: 2.187 ± 0.335
1.952TyrLys: 1.952 ± 0.292
2.389TyrLeu: 2.389 ± 0.305
0.976TyrMet: 0.976 ± 0.195
1.514TyrAsn: 1.514 ± 0.216
1.346TyrPro: 1.346 ± 0.238
1.716TyrGln: 1.716 ± 0.259
2.288TyrArg: 2.288 ± 0.259
1.716TyrSer: 1.716 ± 0.228
1.75TyrThr: 1.75 ± 0.23
2.187TyrVal: 2.187 ± 0.319
0.673TyrTrp: 0.673 ± 0.141
1.043TyrTyr: 1.043 ± 0.188
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 127 proteins (29721 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski