Amino acid dipepetide frequency for Fervidicella metallireducens AeB

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.571AlaAla: 4.571 ± 0.11	0.652AlaCys: 0.652 ± 0.028	2.806AlaAsp: 2.806 ± 0.064	3.884AlaGlu: 3.884 ± 0.076	2.525AlaPhe: 2.525 ± 0.065	4.034AlaGly: 4.034 ± 0.09	0.778AlaHis: 0.778 ± 0.035	5.429AlaIle: 5.429 ± 0.104	4.61AlaLys: 4.61 ± 0.091	5.795AlaLeu: 5.795 ± 0.093	1.619AlaMet: 1.619 ± 0.055	2.395AlaAsn: 2.395 ± 0.06	1.436AlaPro: 1.436 ± 0.045	1.549AlaGln: 1.549 ± 0.047	2.225AlaArg: 2.225 ± 0.049	3.216AlaSer: 3.216 ± 0.065	2.504AlaThr: 2.504 ± 0.063	4.761AlaVal: 4.761 ± 0.091	0.33AlaTrp: 0.33 ± 0.022	2.175AlaTyr: 2.175 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.601CysAla: 0.601 ± 0.03	0.208CysCys: 0.208 ± 0.02	0.689CysAsp: 0.689 ± 0.033	0.784CysGlu: 0.784 ± 0.032	0.483CysPhe: 0.483 ± 0.025	1.12CysGly: 1.12 ± 0.044	0.201CysHis: 0.201 ± 0.017	1.106CysIle: 1.106 ± 0.04	0.926CysLys: 0.926 ± 0.039	0.865CysLeu: 0.865 ± 0.031	0.278CysMet: 0.278 ± 0.02	0.728CysAsn: 0.728 ± 0.033	0.577CysPro: 0.577 ± 0.032	0.315CysGln: 0.315 ± 0.034	0.541CysArg: 0.541 ± 0.026	0.827CysSer: 0.827 ± 0.032	0.518CysThr: 0.518 ± 0.026	0.679CysVal: 0.679 ± 0.032	0.079CysTrp: 0.079 ± 0.011	0.471CysTyr: 0.471 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	2.941AspAla: 2.941 ± 0.072	0.604AspCys: 0.604 ± 0.031	2.678AspAsp: 2.678 ± 0.06	4.569AspGlu: 4.569 ± 0.092	2.794AspPhe: 2.794 ± 0.071	3.412AspGly: 3.412 ± 0.07	0.5AspHis: 0.5 ± 0.027	6.462AspIle: 6.462 ± 0.11	5.126AspLys: 5.126 ± 0.079	4.438AspLeu: 4.438 ± 0.081	1.512AspMet: 1.512 ± 0.044	3.055AspAsn: 3.055 ± 0.053	1.244AspPro: 1.244 ± 0.044	0.646AspGln: 0.646 ± 0.032	2.014AspArg: 2.014 ± 0.052	2.764AspSer: 2.764 ± 0.063	2.431AspThr: 2.431 ± 0.062	4.03AspVal: 4.03 ± 0.069	0.391AspTrp: 0.391 ± 0.022	2.567AspTyr: 2.567 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.259GluAla: 4.259 ± 0.078	0.659GluCys: 0.659 ± 0.026	3.957GluAsp: 3.957 ± 0.078	6.432GluGlu: 6.432 ± 0.123	3.178GluPhe: 3.178 ± 0.067	4.224GluGly: 4.224 ± 0.077	0.898GluHis: 0.898 ± 0.032	8.139GluIle: 8.139 ± 0.117	7.71GluLys: 7.71 ± 0.112	6.64GluLeu: 6.64 ± 0.101	2.164GluMet: 2.164 ± 0.059	5.04GluAsn: 5.04 ± 0.088	1.445GluPro: 1.445 ± 0.041	1.675GluGln: 1.675 ± 0.052	3.077GluArg: 3.077 ± 0.069	3.168GluSer: 3.168 ± 0.063	3.127GluThr: 3.127 ± 0.059	4.942GluVal: 4.942 ± 0.101	0.426GluTrp: 0.426 ± 0.024	3.202GluTyr: 3.202 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.248PheAla: 2.248 ± 0.063	0.533PheCys: 0.533 ± 0.028	2.47PheAsp: 2.47 ± 0.06	2.975PheGlu: 2.975 ± 0.068	1.863PhePhe: 1.863 ± 0.055	2.816PheGly: 2.816 ± 0.076	0.572PheHis: 0.572 ± 0.027	4.564PheIle: 4.564 ± 0.103	4.003PheLys: 4.003 ± 0.07	4.017PheLeu: 4.017 ± 0.089	1.197PheMet: 1.197 ± 0.04	2.769PheAsn: 2.769 ± 0.066	1.233PhePro: 1.233 ± 0.035	1.013PheGln: 1.013 ± 0.039	1.408PheArg: 1.408 ± 0.043	3.184PheSer: 3.184 ± 0.078	2.328PheThr: 2.328 ± 0.06	2.711PheVal: 2.711 ± 0.052	0.316PheTrp: 0.316 ± 0.019	1.725PheTyr: 1.725 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	3.894GlyAla: 3.894 ± 0.094	0.953GlyCys: 0.953 ± 0.04	3.179GlyAsp: 3.179 ± 0.07	4.256GlyGlu: 4.256 ± 0.084	3.229GlyPhe: 3.229 ± 0.071	4.259GlyGly: 4.259 ± 0.096	1.026GlyHis: 1.026 ± 0.035	6.887GlyIle: 6.887 ± 0.119	5.645GlyLys: 5.645 ± 0.094	5.625GlyLeu: 5.625 ± 0.097	1.767GlyMet: 1.767 ± 0.05	3.246GlyAsn: 3.246 ± 0.069	1.322GlyPro: 1.322 ± 0.047	1.532GlyGln: 1.532 ± 0.046	2.69GlyArg: 2.69 ± 0.066	3.339GlySer: 3.339 ± 0.072	3.452GlyThr: 3.452 ± 0.075	4.614GlyVal: 4.614 ± 0.091	0.472GlyTrp: 0.472 ± 0.025	3.168GlyTyr: 3.168 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	0.721HisAla: 0.721 ± 0.031	0.216HisCys: 0.216 ± 0.017	0.709HisAsp: 0.709 ± 0.032	0.884HisGlu: 0.884 ± 0.034	0.577HisPhe: 0.577 ± 0.028	1.041HisGly: 1.041 ± 0.04	0.309HisHis: 0.309 ± 0.021	1.336HisIle: 1.336 ± 0.043	1.065HisLys: 1.065 ± 0.037	1.27HisLeu: 1.27 ± 0.045	0.336HisMet: 0.336 ± 0.021	0.781HisAsn: 0.781 ± 0.032	0.628HisPro: 0.628 ± 0.028	0.364HisGln: 0.364 ± 0.022	0.606HisArg: 0.606 ± 0.026	0.818HisSer: 0.818 ± 0.037	0.678HisThr: 0.678 ± 0.026	0.81HisVal: 0.81 ± 0.028	0.105HisTrp: 0.105 ± 0.011	0.583HisTyr: 0.583 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.805IleAla: 5.805 ± 0.085	1.267IleCys: 1.267 ± 0.035	6.066IleAsp: 6.066 ± 0.092	7.395IleGlu: 7.395 ± 0.103	4.193IlePhe: 4.193 ± 0.096	5.938IleGly: 5.938 ± 0.108	1.211IleHis: 1.211 ± 0.036	9.253IleIle: 9.253 ± 0.141	9.491IleLys: 9.491 ± 0.111	9.061IleLeu: 9.061 ± 0.139	2.399IleMet: 2.399 ± 0.055	6.16IleAsn: 6.16 ± 0.099	3.566IlePro: 3.566 ± 0.077	2.306IleGln: 2.306 ± 0.061	3.415IleArg: 3.415 ± 0.07	6.837IleSer: 6.837 ± 0.111	5.1IleThr: 5.1 ± 0.093	6.095IleVal: 6.095 ± 0.095	0.546IleTrp: 0.546 ± 0.028	3.825IleTyr: 3.825 ± 0.08	0.0IleXaa: 0.0 ± 0.0
Lys	4.898LysAla: 4.898 ± 0.087	0.858LysCys: 0.858 ± 0.037	5.42LysAsp: 5.42 ± 0.093	8.056LysGlu: 8.056 ± 0.126	3.175LysPhe: 3.175 ± 0.062	5.295LysGly: 5.295 ± 0.09	1.244LysHis: 1.244 ± 0.042	8.865LysIle: 8.865 ± 0.103	8.006LysLys: 8.006 ± 0.114	7.724LysLeu: 7.724 ± 0.11	2.567LysMet: 2.567 ± 0.06	6.325LysAsn: 6.325 ± 0.083	2.21LysPro: 2.21 ± 0.061	2.224LysGln: 2.224 ± 0.059	3.553LysArg: 3.553 ± 0.072	4.769LysSer: 4.769 ± 0.062	4.401LysThr: 4.401 ± 0.075	5.681LysVal: 5.681 ± 0.088	0.643LysTrp: 0.643 ± 0.035	4.109LysTyr: 4.109 ± 0.082	0.0LysXaa: 0.0 ± 0.0
Leu	5.098LeuAla: 5.098 ± 0.085	1.074LeuCys: 1.074 ± 0.038	4.765LeuAsp: 4.765 ± 0.093	6.066LeuGlu: 6.066 ± 0.103	3.729LeuPhe: 3.729 ± 0.088	5.878LeuGly: 5.878 ± 0.094	1.187LeuHis: 1.187 ± 0.038	8.304LeuIle: 8.304 ± 0.125	8.882LeuLys: 8.882 ± 0.125	7.859LeuLeu: 7.859 ± 0.142	2.392LeuMet: 2.392 ± 0.064	5.926LeuAsn: 5.926 ± 0.092	2.817LeuPro: 2.817 ± 0.064	2.206LeuGln: 2.206 ± 0.056	3.418LeuArg: 3.418 ± 0.072	6.392LeuSer: 6.392 ± 0.107	4.709LeuThr: 4.709 ± 0.096	5.27LeuVal: 5.27 ± 0.095	0.591LeuTrp: 0.591 ± 0.028	3.305LeuTyr: 3.305 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.904MetAla: 1.904 ± 0.053	0.295MetCys: 0.295 ± 0.021	1.643MetAsp: 1.643 ± 0.048	1.982MetGlu: 1.982 ± 0.057	1.074MetPhe: 1.074 ± 0.038	1.788MetGly: 1.788 ± 0.051	0.414MetHis: 0.414 ± 0.025	2.147MetIle: 2.147 ± 0.055	2.357MetLys: 2.357 ± 0.054	2.349MetLeu: 2.349 ± 0.06	0.668MetMet: 0.668 ± 0.03	1.512MetAsn: 1.512 ± 0.045	1.042MetPro: 1.042 ± 0.04	0.728MetGln: 0.728 ± 0.029	0.994MetArg: 0.994 ± 0.036	1.536MetSer: 1.536 ± 0.047	1.267MetThr: 1.267 ± 0.046	1.707MetVal: 1.707 ± 0.041	0.139MetTrp: 0.139 ± 0.011	0.861MetTyr: 0.861 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.874AsnAla: 2.874 ± 0.057	0.702AsnCys: 0.702 ± 0.032	2.733AsnAsp: 2.733 ± 0.061	3.975AsnGlu: 3.975 ± 0.086	2.544AsnPhe: 2.544 ± 0.062	3.635AsnGly: 3.635 ± 0.074	0.812AsnHis: 0.812 ± 0.035	6.543AsnIle: 6.543 ± 0.101	5.646AsnLys: 5.646 ± 0.092	5.471AsnLeu: 5.471 ± 0.089	1.524AsnMet: 1.524 ± 0.053	3.984AsnAsn: 3.984 ± 0.086	2.326AsnPro: 2.326 ± 0.062	1.441AsnGln: 1.441 ± 0.048	2.169AsnArg: 2.169 ± 0.056	3.582AsnSer: 3.582 ± 0.072	2.791AsnThr: 2.791 ± 0.062	3.415AsnVal: 3.415 ± 0.071	0.414AsnTrp: 0.414 ± 0.022	2.574AsnTyr: 2.574 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.535ProAla: 1.535 ± 0.052	0.391ProCys: 0.391 ± 0.023	1.746ProAsp: 1.746 ± 0.052	2.582ProGlu: 2.582 ± 0.061	1.437ProPhe: 1.437 ± 0.041	1.932ProGly: 1.932 ± 0.058	0.471ProHis: 0.471 ± 0.024	2.643ProIle: 2.643 ± 0.061	2.132ProLys: 2.132 ± 0.053	2.574ProLeu: 2.574 ± 0.063	0.747ProMet: 0.747 ± 0.032	1.351ProAsn: 1.351 ± 0.049	0.735ProPro: 0.735 ± 0.034	0.905ProGln: 0.905 ± 0.036	0.972ProArg: 0.972 ± 0.034	1.742ProSer: 1.742 ± 0.05	1.48ProThr: 1.48 ± 0.049	2.44ProVal: 2.44 ± 0.061	0.223ProTrp: 0.223 ± 0.019	1.409ProTyr: 1.409 ± 0.051	0.0ProXaa: 0.0 ± 0.0
Gln	1.354GlnAla: 1.354 ± 0.049	0.284GlnCys: 0.284 ± 0.021	1.219GlnAsp: 1.219 ± 0.044	1.84GlnGlu: 1.84 ± 0.047	0.898GlnPhe: 0.898 ± 0.034	1.532GlnGly: 1.532 ± 0.038	0.353GlnHis: 0.353 ± 0.019	2.407GlnIle: 2.407 ± 0.058	2.129GlnLys: 2.129 ± 0.057	2.085GlnLeu: 2.085 ± 0.047	0.719GlnMet: 0.719 ± 0.033	1.528GlnAsn: 1.528 ± 0.051	0.687GlnPro: 0.687 ± 0.027	0.813GlnGln: 0.813 ± 0.035	1.275GlnArg: 1.275 ± 0.042	1.409GlnSer: 1.409 ± 0.047	1.091GlnThr: 1.091 ± 0.039	1.366GlnVal: 1.366 ± 0.04	0.228GlnTrp: 0.228 ± 0.017	1.06GlnTyr: 1.06 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.053ArgAla: 2.053 ± 0.052	0.478ArgCys: 0.478 ± 0.025	2.128ArgAsp: 2.128 ± 0.053	3.305ArgGlu: 3.305 ± 0.066	1.6ArgPhe: 1.6 ± 0.046	2.248ArgGly: 2.248 ± 0.054	0.728ArgHis: 0.728 ± 0.032	3.811ArgIle: 3.811 ± 0.065	3.328ArgLys: 3.328 ± 0.066	3.477ArgLeu: 3.477 ± 0.07	1.095ArgMet: 1.095 ± 0.039	2.106ArgAsn: 2.106 ± 0.052	0.998ArgPro: 0.998 ± 0.037	1.146ArgGln: 1.146 ± 0.039	1.718ArgArg: 1.718 ± 0.055	1.615ArgSer: 1.615 ± 0.046	1.744ArgThr: 1.744 ± 0.047	2.656ArgVal: 2.656 ± 0.066	0.272ArgTrp: 0.272 ± 0.02	1.716ArgTyr: 1.716 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	3.124SerAla: 3.124 ± 0.065	0.753SerCys: 0.753 ± 0.035	2.948SerAsp: 2.948 ± 0.065	3.965SerGlu: 3.965 ± 0.075	2.854SerPhe: 2.854 ± 0.06	4.309SerGly: 4.309 ± 0.092	0.884SerHis: 0.884 ± 0.032	6.186SerIle: 6.186 ± 0.102	5.145SerLys: 5.145 ± 0.095	5.687SerLeu: 5.687 ± 0.091	1.514SerMet: 1.514 ± 0.05	3.152SerAsn: 3.152 ± 0.076	1.738SerPro: 1.738 ± 0.044	1.61SerGln: 1.61 ± 0.052	2.275SerArg: 2.275 ± 0.057	3.858SerSer: 3.858 ± 0.08	2.851SerThr: 2.851 ± 0.067	3.591SerVal: 3.591 ± 0.067	0.396SerTrp: 0.396 ± 0.022	2.45SerTyr: 2.45 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.165ThrAla: 3.165 ± 0.082	0.538ThrCys: 0.538 ± 0.028	2.415ThrAsp: 2.415 ± 0.059	3.046ThrGlu: 3.046 ± 0.067	2.219ThrPhe: 2.219 ± 0.053	3.826ThrGly: 3.826 ± 0.078	0.747ThrHis: 0.747 ± 0.032	4.614ThrIle: 4.614 ± 0.087	3.82ThrLys: 3.82 ± 0.079	4.619ThrLeu: 4.619 ± 0.09	1.119ThrMet: 1.119 ± 0.039	2.443ThrAsn: 2.443 ± 0.061	1.851ThrPro: 1.851 ± 0.056	1.215ThrGln: 1.215 ± 0.043	1.664ThrArg: 1.664 ± 0.047	3.037ThrSer: 3.037 ± 0.063	2.577ThrThr: 2.577 ± 0.074	3.518ThrVal: 3.518 ± 0.081	0.37ThrTrp: 0.37 ± 0.019	1.842ThrTyr: 1.842 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	3.843ValAla: 3.843 ± 0.085	0.829ValCys: 0.829 ± 0.032	3.87ValAsp: 3.87 ± 0.077	4.986ValGlu: 4.986 ± 0.105	3.028ValPhe: 3.028 ± 0.073	4.013ValGly: 4.013 ± 0.086	0.813ValHis: 0.813 ± 0.033	6.543ValIle: 6.543 ± 0.091	5.887ValLys: 5.887 ± 0.098	5.868ValLeu: 5.868 ± 0.082	1.602ValMet: 1.602 ± 0.05	3.614ValAsn: 3.614 ± 0.067	2.122ValPro: 2.122 ± 0.053	1.381ValGln: 1.381 ± 0.043	2.301ValArg: 2.301 ± 0.048	4.046ValSer: 4.046 ± 0.078	3.288ValThr: 3.288 ± 0.067	4.828ValVal: 4.828 ± 0.09	0.4ValTrp: 0.4 ± 0.023	2.665ValTyr: 2.665 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.344TrpAla: 0.344 ± 0.022	0.095TrpCys: 0.095 ± 0.011	0.38TrpAsp: 0.38 ± 0.024	0.445TrpGlu: 0.445 ± 0.025	0.352TrpPhe: 0.352 ± 0.025	0.481TrpGly: 0.481 ± 0.026	0.119TrpHis: 0.119 ± 0.015	0.622TrpIle: 0.622 ± 0.027	0.453TrpLys: 0.453 ± 0.026	0.599TrpLeu: 0.599 ± 0.027	0.193TrpMet: 0.193 ± 0.018	0.449TrpAsn: 0.449 ± 0.026	0.188TrpPro: 0.188 ± 0.016	0.194TrpGln: 0.194 ± 0.016	0.27TrpArg: 0.27 ± 0.02	0.4TrpSer: 0.4 ± 0.025	0.321TrpThr: 0.321 ± 0.023	0.413TrpVal: 0.413 ± 0.022	0.07TrpTrp: 0.07 ± 0.01	0.298TrpTyr: 0.298 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.062TyrAla: 2.062 ± 0.053	0.605TyrCys: 0.605 ± 0.031	2.36TyrAsp: 2.36 ± 0.07	2.935TyrGlu: 2.935 ± 0.063	2.191TyrPhe: 2.191 ± 0.055	2.774TyrGly: 2.774 ± 0.066	0.573TyrHis: 0.573 ± 0.029	4.067TyrIle: 4.067 ± 0.074	3.663TyrLys: 3.663 ± 0.077	3.846TyrLeu: 3.846 ± 0.075	0.996TyrMet: 0.996 ± 0.031	2.59TyrAsn: 2.59 ± 0.06	1.283TyrPro: 1.283 ± 0.039	1.013TyrGln: 1.013 ± 0.036	1.64TyrArg: 1.64 ± 0.044	2.75TyrSer: 2.75 ± 0.071	1.989TyrThr: 1.989 ± 0.058	2.4TyrVal: 2.4 ± 0.057	0.272TyrTrp: 0.272 ± 0.02	1.944TyrTyr: 1.944 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2800 proteins (781929 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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