Amino acid dipepetide frequency for Lactococcus phage CHPC1182

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.161AlaCys: 0.161 ± 0.19
3.705AlaAsp: 3.705 ± 0.733
5.961AlaGlu: 5.961 ± 1.029
2.094AlaPhe: 2.094 ± 0.514
2.739AlaGly: 2.739 ± 0.769
0.161AlaHis: 0.161 ± 0.144
4.35AlaIle: 4.35 ± 0.824
5.8AlaLys: 5.8 ± 0.692
7.25AlaLeu: 7.25 ± 1.347
1.45AlaMet: 1.45 ± 0.346
4.511AlaAsn: 4.511 ± 0.862
0.806AlaPro: 0.806 ± 0.339
2.578AlaGln: 2.578 ± 1.035
1.772AlaArg: 1.772 ± 0.629
3.222AlaSer: 3.222 ± 0.659
3.867AlaThr: 3.867 ± 1.021
4.028AlaVal: 4.028 ± 1.142
1.289AlaTrp: 1.289 ± 0.524
3.705AlaTyr: 3.705 ± 0.705
0.0AlaXaa: 0.0 ± 0.0
Cys
0.644CysAla: 0.644 ± 0.34
0.322CysCys: 0.322 ± 0.231
0.0CysAsp: 0.0 ± 0.0
0.483CysGlu: 0.483 ± 0.308
0.161CysPhe: 0.161 ± 0.185
0.483CysGly: 0.483 ± 0.272
0.483CysHis: 0.483 ± 0.549
0.161CysIle: 0.161 ± 0.147
0.967CysLys: 0.967 ± 0.367
1.128CysLeu: 1.128 ± 0.56
0.0CysMet: 0.0 ± 0.0
0.644CysAsn: 0.644 ± 0.452
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.322CysArg: 0.322 ± 0.194
0.322CysSer: 0.322 ± 0.226
0.644CysThr: 0.644 ± 0.301
0.322CysVal: 0.322 ± 0.209
0.161CysTrp: 0.161 ± 0.183
0.483CysTyr: 0.483 ± 0.369
0.0CysXaa: 0.0 ± 0.0
Asp
2.094AspAla: 2.094 ± 0.498
0.161AspCys: 0.161 ± 0.174
2.9AspAsp: 2.9 ± 0.703
5.478AspGlu: 5.478 ± 1.147
4.511AspPhe: 4.511 ± 0.831
4.35AspGly: 4.35 ± 1.16
0.483AspHis: 0.483 ± 0.272
3.705AspIle: 3.705 ± 0.799
5.155AspLys: 5.155 ± 0.786
5.155AspLeu: 5.155 ± 0.767
2.739AspMet: 2.739 ± 0.636
3.544AspAsn: 3.544 ± 0.702
1.611AspPro: 1.611 ± 0.501
0.967AspGln: 0.967 ± 0.277
2.256AspArg: 2.256 ± 0.446
3.705AspSer: 3.705 ± 0.823
3.061AspThr: 3.061 ± 0.566
3.061AspVal: 3.061 ± 0.663
1.289AspTrp: 1.289 ± 0.563
3.061AspTyr: 3.061 ± 0.749
0.0AspXaa: 0.0 ± 0.0
Glu
3.383GluAla: 3.383 ± 0.613
0.967GluCys: 0.967 ± 0.453
3.222GluAsp: 3.222 ± 0.679
6.928GluGlu: 6.928 ± 1.188
4.028GluPhe: 4.028 ± 0.758
2.9GluGly: 2.9 ± 0.658
1.933GluHis: 1.933 ± 0.667
4.35GluIle: 4.35 ± 0.722
4.672GluLys: 4.672 ± 1.0
7.733GluLeu: 7.733 ± 1.216
4.028GluMet: 4.028 ± 0.906
2.739GluAsn: 2.739 ± 0.587
1.45GluPro: 1.45 ± 0.532
4.511GluGln: 4.511 ± 0.932
3.383GluArg: 3.383 ± 0.679
2.578GluSer: 2.578 ± 0.615
4.994GluThr: 4.994 ± 0.755
5.155GluVal: 5.155 ± 1.027
0.644GluTrp: 0.644 ± 0.324
2.739GluTyr: 2.739 ± 0.683
0.0GluXaa: 0.0 ± 0.0
Phe
2.094PheAla: 2.094 ± 0.573
0.806PheCys: 0.806 ± 0.293
2.9PheAsp: 2.9 ± 0.52
2.578PheGlu: 2.578 ± 0.71
1.289PhePhe: 1.289 ± 0.354
3.383PheGly: 3.383 ± 0.569
0.483PheHis: 0.483 ± 0.244
4.35PheIle: 4.35 ± 1.162
4.833PheLys: 4.833 ± 0.809
2.417PheLeu: 2.417 ± 0.518
1.128PheMet: 1.128 ± 0.339
4.511PheAsn: 4.511 ± 0.724
1.45PhePro: 1.45 ± 0.494
1.289PheGln: 1.289 ± 0.356
2.094PheArg: 2.094 ± 0.57
2.9PheSer: 2.9 ± 0.613
2.417PheThr: 2.417 ± 0.629
1.128PheVal: 1.128 ± 0.363
0.644PheTrp: 0.644 ± 0.353
2.094PheTyr: 2.094 ± 0.592
0.0PheXaa: 0.0 ± 0.0
Gly
4.511GlyAla: 4.511 ± 1.369
0.161GlyCys: 0.161 ± 0.149
4.189GlyAsp: 4.189 ± 0.814
2.417GlyGlu: 2.417 ± 0.553
4.189GlyPhe: 4.189 ± 0.879
5.478GlyGly: 5.478 ± 1.115
0.967GlyHis: 0.967 ± 0.293
4.35GlyIle: 4.35 ± 0.81
4.511GlyLys: 4.511 ± 0.776
6.444GlyLeu: 6.444 ± 0.712
2.417GlyMet: 2.417 ± 0.653
3.705GlyAsn: 3.705 ± 0.538
0.483GlyPro: 0.483 ± 0.206
3.061GlyGln: 3.061 ± 0.553
3.222GlyArg: 3.222 ± 0.64
4.833GlySer: 4.833 ± 1.385
4.028GlyThr: 4.028 ± 0.865
5.317GlyVal: 5.317 ± 0.976
1.289GlyTrp: 1.289 ± 0.38
4.028GlyTyr: 4.028 ± 0.945
0.0GlyXaa: 0.0 ± 0.0
His
0.967HisAla: 0.967 ± 0.307
0.161HisCys: 0.161 ± 0.183
1.128HisAsp: 1.128 ± 0.362
0.644HisGlu: 0.644 ± 0.309
0.806HisPhe: 0.806 ± 0.352
0.483HisGly: 0.483 ± 0.236
0.161HisHis: 0.161 ± 0.183
0.967HisIle: 0.967 ± 0.458
0.806HisLys: 0.806 ± 0.354
2.094HisLeu: 2.094 ± 0.731
0.161HisMet: 0.161 ± 0.144
0.483HisAsn: 0.483 ± 0.259
0.161HisPro: 0.161 ± 0.152
0.483HisGln: 0.483 ± 0.312
0.644HisArg: 0.644 ± 0.266
1.289HisSer: 1.289 ± 0.468
0.322HisThr: 0.322 ± 0.198
1.128HisVal: 1.128 ± 0.381
0.322HisTrp: 0.322 ± 0.171
1.45HisTyr: 1.45 ± 0.389
0.0HisXaa: 0.0 ± 0.0
Ile
3.383IleAla: 3.383 ± 0.644
0.483IleCys: 0.483 ± 0.313
4.833IleAsp: 4.833 ± 0.97
5.961IleGlu: 5.961 ± 0.961
1.933IlePhe: 1.933 ± 0.451
6.122IleGly: 6.122 ± 1.038
1.128IleHis: 1.128 ± 0.423
3.705IleIle: 3.705 ± 0.959
6.283IleLys: 6.283 ± 1.086
3.705IleLeu: 3.705 ± 0.893
1.289IleMet: 1.289 ± 0.449
4.833IleAsn: 4.833 ± 1.042
2.094IlePro: 2.094 ± 0.578
2.578IleGln: 2.578 ± 0.542
1.772IleArg: 1.772 ± 0.508
3.061IleSer: 3.061 ± 0.62
3.705IleThr: 3.705 ± 0.776
3.222IleVal: 3.222 ± 0.629
0.483IleTrp: 0.483 ± 0.261
2.094IleTyr: 2.094 ± 0.547
0.0IleXaa: 0.0 ± 0.0
Lys
7.894LysAla: 7.894 ± 0.959
0.644LysCys: 0.644 ± 0.452
5.317LysAsp: 5.317 ± 1.022
7.572LysGlu: 7.572 ± 1.19
3.383LysPhe: 3.383 ± 0.657
5.8LysGly: 5.8 ± 0.865
1.128LysHis: 1.128 ± 0.418
5.639LysIle: 5.639 ± 0.818
6.283LysLys: 6.283 ± 1.316
6.122LysLeu: 6.122 ± 1.045
2.739LysMet: 2.739 ± 0.74
5.155LysAsn: 5.155 ± 0.865
2.739LysPro: 2.739 ± 0.598
4.028LysGln: 4.028 ± 0.689
2.417LysArg: 2.417 ± 0.533
3.544LysSer: 3.544 ± 0.603
4.35LysThr: 4.35 ± 0.963
6.605LysVal: 6.605 ± 1.051
1.45LysTrp: 1.45 ± 0.557
3.705LysTyr: 3.705 ± 0.873
0.0LysXaa: 0.0 ± 0.0
Leu
4.35LeuAla: 4.35 ± 0.769
1.128LeuCys: 1.128 ± 0.416
4.028LeuAsp: 4.028 ± 0.67
6.605LeuGlu: 6.605 ± 1.047
3.867LeuPhe: 3.867 ± 0.669
6.605LeuGly: 6.605 ± 1.443
1.772LeuHis: 1.772 ± 0.539
5.317LeuIle: 5.317 ± 1.06
7.089LeuLys: 7.089 ± 1.201
6.122LeuLeu: 6.122 ± 1.123
2.9LeuMet: 2.9 ± 0.877
6.283LeuAsn: 6.283 ± 0.835
2.417LeuPro: 2.417 ± 0.502
4.028LeuGln: 4.028 ± 0.563
2.094LeuArg: 2.094 ± 0.558
5.478LeuSer: 5.478 ± 1.135
6.283LeuThr: 6.283 ± 0.807
4.672LeuVal: 4.672 ± 0.797
0.161LeuTrp: 0.161 ± 0.169
2.9LeuTyr: 2.9 ± 0.789
0.0LeuXaa: 0.0 ± 0.0
Met
3.383MetAla: 3.383 ± 0.496
0.0MetCys: 0.0 ± 0.0
1.933MetAsp: 1.933 ± 0.484
1.933MetGlu: 1.933 ± 0.662
1.772MetPhe: 1.772 ± 0.541
1.128MetGly: 1.128 ± 0.414
0.0MetHis: 0.0 ± 0.0
2.094MetIle: 2.094 ± 0.701
2.578MetLys: 2.578 ± 0.654
2.9MetLeu: 2.9 ± 0.738
0.161MetMet: 0.161 ± 0.174
2.094MetAsn: 2.094 ± 0.622
0.644MetPro: 0.644 ± 0.309
0.967MetGln: 0.967 ± 0.336
0.806MetArg: 0.806 ± 0.336
1.772MetSer: 1.772 ± 0.466
1.611MetThr: 1.611 ± 0.514
1.772MetVal: 1.772 ± 0.499
0.161MetTrp: 0.161 ± 0.148
0.967MetTyr: 0.967 ± 0.466
0.0MetXaa: 0.0 ± 0.0
Asn
5.8AsnAla: 5.8 ± 0.896
0.644AsnCys: 0.644 ± 0.331
4.511AsnAsp: 4.511 ± 1.046
4.833AsnGlu: 4.833 ± 1.012
2.739AsnPhe: 2.739 ± 0.466
5.478AsnGly: 5.478 ± 0.747
0.483AsnHis: 0.483 ± 0.311
3.544AsnIle: 3.544 ± 0.698
5.961AsnLys: 5.961 ± 0.995
5.639AsnLeu: 5.639 ± 0.931
1.933AsnMet: 1.933 ± 0.592
3.705AsnAsn: 3.705 ± 0.782
3.061AsnPro: 3.061 ± 0.848
2.094AsnGln: 2.094 ± 0.488
1.933AsnArg: 1.933 ± 0.516
3.222AsnSer: 3.222 ± 0.582
4.35AsnThr: 4.35 ± 1.028
3.705AsnVal: 3.705 ± 0.598
0.806AsnTrp: 0.806 ± 0.394
3.222AsnTyr: 3.222 ± 0.422
0.0AsnXaa: 0.0 ± 0.0
Pro
0.322ProAla: 0.322 ± 0.203
0.161ProCys: 0.161 ± 0.147
1.933ProAsp: 1.933 ± 0.529
1.45ProGlu: 1.45 ± 0.468
0.806ProPhe: 0.806 ± 0.403
0.0ProGly: 0.0 ± 0.0
0.161ProHis: 0.161 ± 0.158
1.289ProIle: 1.289 ± 0.5
2.739ProLys: 2.739 ± 0.669
2.9ProLeu: 2.9 ± 0.472
0.161ProMet: 0.161 ± 0.149
1.933ProAsn: 1.933 ± 0.652
1.128ProPro: 1.128 ± 0.454
1.772ProGln: 1.772 ± 0.604
0.967ProArg: 0.967 ± 0.338
2.256ProSer: 2.256 ± 0.541
1.45ProThr: 1.45 ± 0.403
2.094ProVal: 2.094 ± 0.661
0.483ProTrp: 0.483 ± 0.309
1.772ProTyr: 1.772 ± 0.582
0.0ProXaa: 0.0 ± 0.0
Gln
3.705GlnAla: 3.705 ± 1.021
0.161GlnCys: 0.161 ± 0.185
2.094GlnAsp: 2.094 ± 0.555
1.933GlnGlu: 1.933 ± 0.526
1.611GlnPhe: 1.611 ± 0.458
2.417GlnGly: 2.417 ± 0.612
0.322GlnHis: 0.322 ± 0.228
3.383GlnIle: 3.383 ± 0.699
3.061GlnLys: 3.061 ± 0.691
2.256GlnLeu: 2.256 ± 0.515
1.772GlnMet: 1.772 ± 0.492
3.222GlnAsn: 3.222 ± 0.656
0.967GlnPro: 0.967 ± 0.361
1.611GlnGln: 1.611 ± 0.524
1.611GlnArg: 1.611 ± 0.416
2.578GlnSer: 2.578 ± 0.578
2.417GlnThr: 2.417 ± 0.596
2.256GlnVal: 2.256 ± 0.518
0.644GlnTrp: 0.644 ± 0.333
2.094GlnTyr: 2.094 ± 0.624
0.0GlnXaa: 0.0 ± 0.0
Arg
1.933ArgAla: 1.933 ± 0.59
0.161ArgCys: 0.161 ± 0.163
1.128ArgAsp: 1.128 ± 0.459
4.028ArgGlu: 4.028 ± 1.262
1.611ArgPhe: 1.611 ± 0.378
2.094ArgGly: 2.094 ± 0.576
0.806ArgHis: 0.806 ± 0.319
1.128ArgIle: 1.128 ± 0.337
3.867ArgLys: 3.867 ± 0.945
2.9ArgLeu: 2.9 ± 0.475
1.289ArgMet: 1.289 ± 0.372
1.933ArgAsn: 1.933 ± 0.57
1.128ArgPro: 1.128 ± 0.716
1.128ArgGln: 1.128 ± 0.351
1.128ArgArg: 1.128 ± 0.486
2.739ArgSer: 2.739 ± 0.7
1.611ArgThr: 1.611 ± 0.558
2.256ArgVal: 2.256 ± 0.853
0.322ArgTrp: 0.322 ± 0.23
1.611ArgTyr: 1.611 ± 0.448
0.0ArgXaa: 0.0 ± 0.0
Ser
3.867SerAla: 3.867 ± 0.944
0.0SerCys: 0.0 ± 0.0
2.9SerAsp: 2.9 ± 0.721
3.544SerGlu: 3.544 ± 0.894
2.256SerPhe: 2.256 ± 0.592
4.672SerGly: 4.672 ± 0.886
0.806SerHis: 0.806 ± 0.315
3.383SerIle: 3.383 ± 0.716
4.833SerLys: 4.833 ± 1.081
5.961SerLeu: 5.961 ± 0.843
1.128SerMet: 1.128 ± 0.31
4.189SerAsn: 4.189 ± 0.859
0.806SerPro: 0.806 ± 0.335
3.061SerGln: 3.061 ± 0.748
1.289SerArg: 1.289 ± 0.342
3.544SerSer: 3.544 ± 0.729
3.383SerThr: 3.383 ± 0.987
4.028SerVal: 4.028 ± 0.788
0.483SerTrp: 0.483 ± 0.335
3.061SerTyr: 3.061 ± 0.547
0.0SerXaa: 0.0 ± 0.0
Thr
3.867ThrAla: 3.867 ± 0.482
0.0ThrCys: 0.0 ± 0.0
3.544ThrAsp: 3.544 ± 0.688
3.544ThrGlu: 3.544 ± 0.911
2.578ThrPhe: 2.578 ± 0.666
6.605ThrGly: 6.605 ± 0.989
0.806ThrHis: 0.806 ± 0.375
4.994ThrIle: 4.994 ± 0.634
6.122ThrLys: 6.122 ± 0.914
5.155ThrLeu: 5.155 ± 0.832
0.644ThrMet: 0.644 ± 0.341
3.544ThrAsn: 3.544 ± 0.968
1.772ThrPro: 1.772 ± 0.514
2.578ThrGln: 2.578 ± 0.702
1.772ThrArg: 1.772 ± 0.442
3.383ThrSer: 3.383 ± 0.899
2.9ThrThr: 2.9 ± 0.552
4.189ThrVal: 4.189 ± 0.757
1.128ThrTrp: 1.128 ± 0.385
2.578ThrTyr: 2.578 ± 0.621
0.0ThrXaa: 0.0 ± 0.0
Val
3.061ValAla: 3.061 ± 0.534
0.483ValCys: 0.483 ± 0.251
5.317ValAsp: 5.317 ± 0.87
3.383ValGlu: 3.383 ± 0.656
1.772ValPhe: 1.772 ± 0.696
3.383ValGly: 3.383 ± 0.683
1.128ValHis: 1.128 ± 0.366
2.739ValIle: 2.739 ± 0.703
5.155ValLys: 5.155 ± 0.746
4.511ValLeu: 4.511 ± 0.883
1.772ValMet: 1.772 ± 0.489
4.994ValAsn: 4.994 ± 0.765
1.933ValPro: 1.933 ± 0.521
1.611ValGln: 1.611 ± 0.598
2.9ValArg: 2.9 ± 0.701
3.867ValSer: 3.867 ± 0.907
4.833ValThr: 4.833 ± 0.65
2.578ValVal: 2.578 ± 0.677
1.45ValTrp: 1.45 ± 0.451
3.544ValTyr: 3.544 ± 0.868
0.0ValXaa: 0.0 ± 0.0
Trp
1.289TrpAla: 1.289 ± 0.412
0.483TrpCys: 0.483 ± 0.276
0.644TrpAsp: 0.644 ± 0.289
0.806TrpGlu: 0.806 ± 0.351
0.967TrpPhe: 0.967 ± 0.41
1.772TrpGly: 1.772 ± 0.46
0.322TrpHis: 0.322 ± 0.19
0.322TrpIle: 0.322 ± 0.247
0.644TrpLys: 0.644 ± 0.289
2.256TrpLeu: 2.256 ± 0.773
0.322TrpMet: 0.322 ± 0.199
0.967TrpAsn: 0.967 ± 0.476
0.0TrpPro: 0.0 ± 0.0
0.644TrpGln: 0.644 ± 0.267
0.483TrpArg: 0.483 ± 0.283
0.322TrpSer: 0.322 ± 0.238
0.967TrpThr: 0.967 ± 0.372
0.161TrpVal: 0.161 ± 0.157
0.322TrpTrp: 0.322 ± 0.203
0.483TrpTyr: 0.483 ± 0.24
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.9TyrAla: 2.9 ± 0.622
0.644TyrCys: 0.644 ± 0.288
3.061TyrAsp: 3.061 ± 0.578
2.256TyrGlu: 2.256 ± 0.614
2.417TyrPhe: 2.417 ± 0.688
3.705TyrGly: 3.705 ± 0.736
1.128TyrHis: 1.128 ± 0.465
3.061TyrIle: 3.061 ± 0.876
5.155TyrLys: 5.155 ± 0.861
1.45TyrLeu: 1.45 ± 0.494
0.483TyrMet: 0.483 ± 0.288
4.672TyrAsn: 4.672 ± 0.694
1.128TyrPro: 1.128 ± 0.36
1.128TyrGln: 1.128 ± 0.343
1.933TyrArg: 1.933 ± 0.609
2.578TyrSer: 2.578 ± 0.565
4.511TyrThr: 4.511 ± 0.717
2.739TyrVal: 2.739 ± 0.757
0.644TyrTrp: 0.644 ± 0.291
2.739TyrTyr: 2.739 ± 0.632
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 34 proteins (6208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski