Amino acid dipepetide frequency for Caldibacillus debilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.696AlaAla: 7.696 ± 0.136	0.726AlaCys: 0.726 ± 0.027	3.877AlaAsp: 3.877 ± 0.063	5.947AlaGlu: 5.947 ± 0.085	3.83AlaPhe: 3.83 ± 0.073	7.104AlaGly: 7.104 ± 0.114	1.128AlaHis: 1.128 ± 0.034	4.947AlaIle: 4.947 ± 0.074	5.49AlaLys: 5.49 ± 0.077	7.521AlaLeu: 7.521 ± 0.106	1.976AlaMet: 1.976 ± 0.049	2.406AlaAsn: 2.406 ± 0.051	2.403AlaPro: 2.403 ± 0.05	1.841AlaGln: 1.841 ± 0.051	3.767AlaArg: 3.767 ± 0.066	3.701AlaSer: 3.701 ± 0.071	2.602AlaThr: 2.602 ± 0.055	6.474AlaVal: 6.474 ± 0.1	0.649AlaTrp: 0.649 ± 0.028	2.279AlaTyr: 2.279 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.571CysAla: 0.571 ± 0.023	0.108CysCys: 0.108 ± 0.013	0.345CysAsp: 0.345 ± 0.018	0.473CysGlu: 0.473 ± 0.022	0.431CysPhe: 0.431 ± 0.022	0.908CysGly: 0.908 ± 0.032	0.213CysHis: 0.213 ± 0.016	0.494CysIle: 0.494 ± 0.022	0.408CysLys: 0.408 ± 0.021	0.868CysLeu: 0.868 ± 0.034	0.213CysMet: 0.213 ± 0.017	0.216CysAsn: 0.216 ± 0.015	0.569CysPro: 0.569 ± 0.025	0.302CysGln: 0.302 ± 0.019	0.722CysArg: 0.722 ± 0.033	0.501CysSer: 0.501 ± 0.023	0.363CysThr: 0.363 ± 0.02	0.448CysVal: 0.448 ± 0.024	0.072CysTrp: 0.072 ± 0.01	0.265CysTyr: 0.265 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.318AspAla: 3.318 ± 0.059	0.399AspCys: 0.399 ± 0.021	2.096AspAsp: 2.096 ± 0.051	4.201AspGlu: 4.201 ± 0.069	2.527AspPhe: 2.527 ± 0.047	3.942AspGly: 3.942 ± 0.071	1.057AspHis: 1.057 ± 0.029	3.278AspIle: 3.278 ± 0.068	2.522AspLys: 2.522 ± 0.056	4.776AspLeu: 4.776 ± 0.08	1.129AspMet: 1.129 ± 0.037	1.198AspAsn: 1.198 ± 0.039	2.744AspPro: 2.744 ± 0.06	1.529AspGln: 1.529 ± 0.044	3.174AspArg: 3.174 ± 0.065	2.037AspSer: 2.037 ± 0.046	1.749AspThr: 1.749 ± 0.042	3.218AspVal: 3.218 ± 0.058	0.644AspTrp: 0.644 ± 0.028	1.832AspTyr: 1.832 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.686GluAla: 5.686 ± 0.091	0.382GluCys: 0.382 ± 0.024	3.327GluAsp: 3.327 ± 0.063	7.39GluGlu: 7.39 ± 0.122	2.346GluPhe: 2.346 ± 0.06	4.974GluGly: 4.974 ± 0.077	1.271GluHis: 1.271 ± 0.034	5.889GluIle: 5.889 ± 0.082	8.501GluLys: 8.501 ± 0.115	6.166GluLeu: 6.166 ± 0.092	2.329GluMet: 2.329 ± 0.054	3.743GluAsn: 3.743 ± 0.074	2.321GluPro: 2.321 ± 0.049	2.597GluGln: 2.597 ± 0.062	5.308GluArg: 5.308 ± 0.092	3.002GluSer: 3.002 ± 0.056	3.888GluThr: 3.888 ± 0.073	4.11GluVal: 4.11 ± 0.069	0.939GluTrp: 0.939 ± 0.034	2.135GluTyr: 2.135 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.742PheAla: 3.742 ± 0.073	0.573PheCys: 0.573 ± 0.024	2.143PheAsp: 2.143 ± 0.05	2.553PheGlu: 2.553 ± 0.052	3.528PhePhe: 3.528 ± 0.085	3.462PheGly: 3.462 ± 0.056	1.304PheHis: 1.304 ± 0.043	3.43PheIle: 3.43 ± 0.07	2.095PheLys: 2.095 ± 0.051	5.881PheLeu: 5.881 ± 0.114	1.203PheMet: 1.203 ± 0.037	1.35PheAsn: 1.35 ± 0.047	2.799PhePro: 2.799 ± 0.065	1.794PheGln: 1.794 ± 0.049	3.136PheArg: 3.136 ± 0.068	3.921PheSer: 3.921 ± 0.074	2.292PheThr: 2.292 ± 0.049	3.169PheVal: 3.169 ± 0.054	0.526PheTrp: 0.526 ± 0.023	1.806PheTyr: 1.806 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.081GlyAla: 5.081 ± 0.088	0.816GlyCys: 0.816 ± 0.033	3.327GlyAsp: 3.327 ± 0.067	5.547GlyGlu: 5.547 ± 0.085	3.765GlyPhe: 3.765 ± 0.073	5.975GlyGly: 5.975 ± 0.107	1.484GlyHis: 1.484 ± 0.051	5.921GlyIle: 5.921 ± 0.085	6.902GlyLys: 6.902 ± 0.089	6.52GlyLeu: 6.52 ± 0.104	2.415GlyMet: 2.415 ± 0.053	2.914GlyAsn: 2.914 ± 0.065	2.456GlyPro: 2.456 ± 0.056	2.224GlyGln: 2.224 ± 0.049	4.814GlyArg: 4.814 ± 0.08	4.063GlySer: 4.063 ± 0.075	4.093GlyThr: 4.093 ± 0.064	4.436GlyVal: 4.436 ± 0.074	0.939GlyTrp: 0.939 ± 0.034	2.575GlyTyr: 2.575 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.377HisAla: 1.377 ± 0.042	0.218HisCys: 0.218 ± 0.016	0.85HisAsp: 0.85 ± 0.031	1.212HisGlu: 1.212 ± 0.038	1.21HisPhe: 1.21 ± 0.035	1.435HisGly: 1.435 ± 0.049	0.57HisHis: 0.57 ± 0.03	1.37HisIle: 1.37 ± 0.038	0.838HisLys: 0.838 ± 0.029	2.157HisLeu: 2.157 ± 0.053	0.479HisMet: 0.479 ± 0.023	0.485HisAsn: 0.485 ± 0.023	1.561HisPro: 1.561 ± 0.043	0.682HisGln: 0.682 ± 0.031	1.233HisArg: 1.233 ± 0.034	1.062HisSer: 1.062 ± 0.037	0.837HisThr: 0.837 ± 0.034	1.237HisVal: 1.237 ± 0.041	0.229HisTrp: 0.229 ± 0.015	0.763HisTyr: 0.763 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.664IleAla: 5.664 ± 0.091	0.651IleCys: 0.651 ± 0.024	3.635IleAsp: 3.635 ± 0.071	4.517IleGlu: 4.517 ± 0.078	3.698IlePhe: 3.698 ± 0.081	5.739IleGly: 5.739 ± 0.086	1.634IleHis: 1.634 ± 0.04	4.671IleIle: 4.671 ± 0.093	3.646IleLys: 3.646 ± 0.064	7.045IleLeu: 7.045 ± 0.108	1.471IleMet: 1.471 ± 0.037	2.268IleAsn: 2.268 ± 0.058	3.557IlePro: 3.557 ± 0.072	2.243IleGln: 2.243 ± 0.051	4.842IleArg: 4.842 ± 0.08	4.004IleSer: 4.004 ± 0.064	3.249IleThr: 3.249 ± 0.065	4.811IleVal: 4.811 ± 0.076	0.625IleTrp: 0.625 ± 0.029	2.223IleTyr: 2.223 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.953LysAla: 4.953 ± 0.069	0.357LysCys: 0.357 ± 0.019	3.558LysAsp: 3.558 ± 0.062	7.131LysGlu: 7.131 ± 0.1	2.126LysPhe: 2.126 ± 0.05	5.367LysGly: 5.367 ± 0.079	1.12LysHis: 1.12 ± 0.033	5.426LysIle: 5.426 ± 0.07	6.722LysLys: 6.722 ± 0.084	5.165LysLeu: 5.165 ± 0.07	2.274LysMet: 2.274 ± 0.053	3.614LysAsn: 3.614 ± 0.069	2.699LysPro: 2.699 ± 0.054	2.213LysGln: 2.213 ± 0.054	4.785LysArg: 4.785 ± 0.063	3.12LysSer: 3.12 ± 0.058	3.876LysThr: 3.876 ± 0.068	3.91LysVal: 3.91 ± 0.078	0.796LysTrp: 0.796 ± 0.028	2.213LysTyr: 2.213 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	8.16LeuAla: 8.16 ± 0.112	0.832LeuCys: 0.832 ± 0.032	4.544LeuAsp: 4.544 ± 0.086	6.684LeuGlu: 6.684 ± 0.123	5.657LeuPhe: 5.657 ± 0.104	5.886LeuGly: 5.886 ± 0.093	1.885LeuHis: 1.885 ± 0.045	6.341LeuIle: 6.341 ± 0.111	6.765LeuLys: 6.765 ± 0.088	10.389LeuLeu: 10.389 ± 0.158	2.287LeuMet: 2.287 ± 0.048	3.507LeuAsn: 3.507 ± 0.066	4.987LeuPro: 4.987 ± 0.074	3.191LeuGln: 3.191 ± 0.059	4.915LeuArg: 4.915 ± 0.086	6.514LeuSer: 6.514 ± 0.086	4.799LeuThr: 4.799 ± 0.079	5.483LeuVal: 5.483 ± 0.076	0.926LeuTrp: 0.926 ± 0.028	3.001LeuTyr: 3.001 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	2.306MetAla: 2.306 ± 0.046	0.114MetCys: 0.114 ± 0.01	1.394MetAsp: 1.394 ± 0.039	2.385MetGlu: 2.385 ± 0.055	1.065MetPhe: 1.065 ± 0.036	1.781MetGly: 1.781 ± 0.047	0.386MetHis: 0.386 ± 0.021	2.03MetIle: 2.03 ± 0.045	2.465MetLys: 2.465 ± 0.051	2.211MetLeu: 2.211 ± 0.057	0.767MetMet: 0.767 ± 0.031	1.259MetAsn: 1.259 ± 0.033	1.17MetPro: 1.17 ± 0.036	0.714MetGln: 0.714 ± 0.027	1.447MetArg: 1.447 ± 0.042	1.268MetSer: 1.268 ± 0.039	1.35MetThr: 1.35 ± 0.04	1.552MetVal: 1.552 ± 0.039	0.142MetTrp: 0.142 ± 0.013	0.641MetTyr: 0.641 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.436AsnAla: 2.436 ± 0.055	0.284AsnCys: 0.284 ± 0.017	1.663AsnAsp: 1.663 ± 0.046	2.713AsnGlu: 2.713 ± 0.055	1.67AsnPhe: 1.67 ± 0.044	3.444AsnGly: 3.444 ± 0.065	0.836AsnHis: 0.836 ± 0.028	2.732AsnIle: 2.732 ± 0.067	2.051AsnLys: 2.051 ± 0.052	3.305AsnLeu: 3.305 ± 0.061	0.999AsnMet: 0.999 ± 0.032	1.158AsnAsn: 1.158 ± 0.045	2.257AsnPro: 2.257 ± 0.052	1.223AsnGln: 1.223 ± 0.041	2.655AsnArg: 2.655 ± 0.056	1.559AsnSer: 1.559 ± 0.045	1.413AsnThr: 1.413 ± 0.047	2.3AsnVal: 2.3 ± 0.047	0.422AsnTrp: 0.422 ± 0.021	1.147AsnTyr: 1.147 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.809ProAla: 3.809 ± 0.074	0.416ProCys: 0.416 ± 0.022	2.689ProAsp: 2.689 ± 0.051	4.067ProGlu: 4.067 ± 0.069	2.92ProPhe: 2.92 ± 0.056	3.708ProGly: 3.708 ± 0.077	0.896ProHis: 0.896 ± 0.035	2.453ProIle: 2.453 ± 0.053	2.564ProLys: 2.564 ± 0.051	4.303ProLeu: 4.303 ± 0.072	0.964ProMet: 0.964 ± 0.029	1.517ProAsn: 1.517 ± 0.042	1.932ProPro: 1.932 ± 0.05	1.134ProGln: 1.134 ± 0.038	1.92ProArg: 1.92 ± 0.052	2.631ProSer: 2.631 ± 0.058	1.539ProThr: 1.539 ± 0.043	3.811ProVal: 3.811 ± 0.07	0.485ProTrp: 0.485 ± 0.021	1.539ProTyr: 1.539 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.437GlnAla: 2.437 ± 0.061	0.182GlnCys: 0.182 ± 0.014	1.225GlnAsp: 1.225 ± 0.036	2.352GlnGlu: 2.352 ± 0.054	1.332GlnPhe: 1.332 ± 0.038	1.959GlnGly: 1.959 ± 0.042	0.554GlnHis: 0.554 ± 0.027	2.333GlnIle: 2.333 ± 0.051	2.585GlnLys: 2.585 ± 0.05	3.143GlnLeu: 3.143 ± 0.07	1.023GlnMet: 1.023 ± 0.035	1.254GlnAsn: 1.254 ± 0.036	1.171GlnPro: 1.171 ± 0.04	1.02GlnGln: 1.02 ± 0.035	1.757GlnArg: 1.757 ± 0.046	1.562GlnSer: 1.562 ± 0.04	1.677GlnThr: 1.677 ± 0.048	1.84GlnVal: 1.84 ± 0.049	0.388GlnTrp: 0.388 ± 0.021	1.088GlnTyr: 1.088 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.723ArgAla: 3.723 ± 0.061	0.495ArgCys: 0.495 ± 0.025	2.649ArgAsp: 2.649 ± 0.064	5.122ArgGlu: 5.122 ± 0.087	3.11ArgPhe: 3.11 ± 0.056	3.714ArgGly: 3.714 ± 0.064	1.24ArgHis: 1.24 ± 0.04	4.313ArgIle: 4.313 ± 0.078	5.194ArgLys: 5.194 ± 0.084	6.085ArgLeu: 6.085 ± 0.096	1.957ArgMet: 1.957 ± 0.051	2.287ArgAsn: 2.287 ± 0.054	2.794ArgPro: 2.794 ± 0.066	2.135ArgGln: 2.135 ± 0.051	4.2ArgArg: 4.2 ± 0.078	3.135ArgSer: 3.135 ± 0.063	2.747ArgThr: 2.747 ± 0.057	3.008ArgVal: 3.008 ± 0.062	0.68ArgTrp: 0.68 ± 0.03	1.873ArgTyr: 1.873 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.188SerAla: 4.188 ± 0.079	0.536SerCys: 0.536 ± 0.025	2.366SerAsp: 2.366 ± 0.054	3.295SerGlu: 3.295 ± 0.068	3.383SerPhe: 3.383 ± 0.069	5.317SerGly: 5.317 ± 0.082	1.014SerHis: 1.014 ± 0.031	3.478SerIle: 3.478 ± 0.069	2.701SerLys: 2.701 ± 0.065	5.713SerLeu: 5.713 ± 0.083	1.316SerMet: 1.316 ± 0.038	1.501SerAsn: 1.501 ± 0.05	2.624SerPro: 2.624 ± 0.056	1.48SerGln: 1.48 ± 0.044	3.237SerArg: 3.237 ± 0.068	2.961SerSer: 2.961 ± 0.066	2.06SerThr: 2.06 ± 0.054	4.044SerVal: 4.044 ± 0.077	0.571SerTrp: 0.571 ± 0.023	1.632SerTyr: 1.632 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.945ThrAla: 3.945 ± 0.064	0.34ThrCys: 0.34 ± 0.023	2.428ThrAsp: 2.428 ± 0.054	3.193ThrGlu: 3.193 ± 0.073	2.283ThrPhe: 2.283 ± 0.044	4.54ThrGly: 4.54 ± 0.076	0.823ThrHis: 0.823 ± 0.029	3.344ThrIle: 3.344 ± 0.062	2.7ThrLys: 2.7 ± 0.058	4.173ThrLeu: 4.173 ± 0.076	1.108ThrMet: 1.108 ± 0.034	1.61ThrAsn: 1.61 ± 0.044	2.043ThrPro: 2.043 ± 0.048	0.853ThrGln: 0.853 ± 0.03	1.958ThrArg: 1.958 ± 0.045	2.207ThrSer: 2.207 ± 0.052	1.873ThrThr: 1.873 ± 0.054	4.302ThrVal: 4.302 ± 0.069	0.4ThrTrp: 0.4 ± 0.02	1.494ThrTyr: 1.494 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.393ValAla: 4.393 ± 0.077	0.658ValCys: 0.658 ± 0.027	3.107ValAsp: 3.107 ± 0.053	4.431ValGlu: 4.431 ± 0.076	3.493ValPhe: 3.493 ± 0.073	3.805ValGly: 3.805 ± 0.078	1.408ValHis: 1.408 ± 0.042	4.835ValIle: 4.835 ± 0.076	4.637ValLys: 4.637 ± 0.076	6.751ValLeu: 6.751 ± 0.09	1.531ValMet: 1.531 ± 0.042	2.42ValAsn: 2.42 ± 0.052	3.283ValPro: 3.283 ± 0.063	2.094ValGln: 2.094 ± 0.049	3.767ValArg: 3.767 ± 0.066	4.015ValSer: 4.015 ± 0.06	3.267ValThr: 3.267 ± 0.069	4.13ValVal: 4.13 ± 0.077	0.624ValTrp: 0.624 ± 0.024	2.262ValTyr: 2.262 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.696TrpAla: 0.696 ± 0.029	0.077TrpCys: 0.077 ± 0.009	0.474TrpAsp: 0.474 ± 0.022	0.794TrpGlu: 0.794 ± 0.03	0.523TrpPhe: 0.523 ± 0.026	0.662TrpGly: 0.662 ± 0.029	0.225TrpHis: 0.225 ± 0.015	0.798TrpIle: 0.798 ± 0.031	0.929TrpLys: 0.929 ± 0.031	1.148TrpLeu: 1.148 ± 0.041	0.334TrpMet: 0.334 ± 0.018	0.461TrpAsn: 0.461 ± 0.023	0.394TrpPro: 0.394 ± 0.02	0.412TrpGln: 0.412 ± 0.021	0.59TrpArg: 0.59 ± 0.025	0.496TrpSer: 0.496 ± 0.024	0.54TrpThr: 0.54 ± 0.022	0.578TrpVal: 0.578 ± 0.025	0.115TrpTrp: 0.115 ± 0.011	0.343TrpTyr: 0.343 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.184TyrAla: 2.184 ± 0.055	0.327TyrCys: 0.327 ± 0.02	1.672TyrAsp: 1.672 ± 0.044	2.298TyrGlu: 2.298 ± 0.052	1.81TyrPhe: 1.81 ± 0.048	2.546TyrGly: 2.546 ± 0.054	0.756TyrHis: 0.756 ± 0.028	2.11TyrIle: 2.11 ± 0.052	1.711TyrLys: 1.711 ± 0.047	3.432TyrLeu: 3.432 ± 0.068	0.674TyrMet: 0.674 ± 0.029	1.099TyrAsn: 1.099 ± 0.033	1.532TyrPro: 1.532 ± 0.042	1.201TyrGln: 1.201 ± 0.039	2.234TyrArg: 2.234 ± 0.057	1.657TyrSer: 1.657 ± 0.045	1.401TyrThr: 1.401 ± 0.037	2.049TyrVal: 2.049 ± 0.046	0.418TyrTrp: 0.418 ± 0.023	1.323TyrTyr: 1.323 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4240 proteins (910805 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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