Amino acid dipepetide frequency for Shewanella frigidimarina (strain NCIMB 400)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.256AlaAla: 8.256 ± 0.106	0.994AlaCys: 0.994 ± 0.032	5.218AlaAsp: 5.218 ± 0.065	5.327AlaGlu: 5.327 ± 0.079	3.37AlaPhe: 3.37 ± 0.058	5.919AlaGly: 5.919 ± 0.076	1.71AlaHis: 1.71 ± 0.036	6.511AlaIle: 6.511 ± 0.076	5.306AlaLys: 5.306 ± 0.082	9.755AlaLeu: 9.755 ± 0.094	2.72AlaMet: 2.72 ± 0.05	4.187AlaAsn: 4.187 ± 0.064	2.875AlaPro: 2.875 ± 0.051	4.155AlaGln: 4.155 ± 0.071	3.44AlaArg: 3.44 ± 0.052	5.684AlaSer: 5.684 ± 0.066	4.783AlaThr: 4.783 ± 0.072	5.87AlaVal: 5.87 ± 0.073	0.906AlaTrp: 0.906 ± 0.029	2.411AlaTyr: 2.411 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.788CysAla: 0.788 ± 0.023	0.165CysCys: 0.165 ± 0.013	0.604CysAsp: 0.604 ± 0.023	0.568CysGlu: 0.568 ± 0.019	0.477CysPhe: 0.477 ± 0.021	0.857CysGly: 0.857 ± 0.029	0.452CysHis: 0.452 ± 0.028	0.645CysIle: 0.645 ± 0.025	0.429CysLys: 0.429 ± 0.016	1.012CysLeu: 1.012 ± 0.028	0.255CysMet: 0.255 ± 0.013	0.366CysAsn: 0.366 ± 0.018	0.434CysPro: 0.434 ± 0.019	0.516CysGln: 0.516 ± 0.02	0.448CysArg: 0.448 ± 0.02	0.717CysSer: 0.717 ± 0.024	0.455CysThr: 0.455 ± 0.02	0.677CysVal: 0.677 ± 0.027	0.132CysTrp: 0.132 ± 0.009	0.34CysTyr: 0.34 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.809AspAla: 4.809 ± 0.067	0.541AspCys: 0.541 ± 0.022	3.382AspAsp: 3.382 ± 0.075	3.551AspGlu: 3.551 ± 0.057	2.508AspPhe: 2.508 ± 0.059	3.713AspGly: 3.713 ± 0.095	1.082AspHis: 1.082 ± 0.033	4.425AspIle: 4.425 ± 0.062	3.459AspLys: 3.459 ± 0.056	5.189AspLeu: 5.189 ± 0.071	1.505AspMet: 1.505 ± 0.037	2.877AspAsn: 2.877 ± 0.048	2.056AspPro: 2.056 ± 0.047	1.982AspGln: 1.982 ± 0.043	2.178AspArg: 2.178 ± 0.039	3.603AspSer: 3.603 ± 0.066	3.092AspThr: 3.092 ± 0.058	4.094AspVal: 4.094 ± 0.07	0.802AspTrp: 0.802 ± 0.022	2.071AspTyr: 2.071 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	4.692GluAla: 4.692 ± 0.076	0.458GluCys: 0.458 ± 0.018	2.488GluAsp: 2.488 ± 0.048	2.53GluGlu: 2.53 ± 0.06	2.362GluPhe: 2.362 ± 0.038	3.027GluGly: 3.027 ± 0.055	1.477GluHis: 1.477 ± 0.039	3.431GluIle: 3.431 ± 0.053	2.834GluLys: 2.834 ± 0.062	6.722GluLeu: 6.722 ± 0.077	1.51GluMet: 1.51 ± 0.038	2.238GluAsn: 2.238 ± 0.05	1.837GluPro: 1.837 ± 0.039	3.981GluGln: 3.981 ± 0.066	2.844GluArg: 2.844 ± 0.06	3.248GluSer: 3.248 ± 0.053	2.791GluThr: 2.791 ± 0.053	3.838GluVal: 3.838 ± 0.055	0.604GluTrp: 0.604 ± 0.023	1.681GluTyr: 1.681 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.689PheAla: 3.689 ± 0.061	0.49PheCys: 0.49 ± 0.02	2.795PheAsp: 2.795 ± 0.048	2.418PheGlu: 2.418 ± 0.05	1.632PhePhe: 1.632 ± 0.046	3.118PheGly: 3.118 ± 0.053	0.741PheHis: 0.741 ± 0.023	2.948PheIle: 2.948 ± 0.046	1.872PheLys: 1.872 ± 0.043	3.111PheLeu: 3.111 ± 0.057	1.129PheMet: 1.129 ± 0.032	2.311PheAsn: 2.311 ± 0.047	1.365PhePro: 1.365 ± 0.034	1.108PheGln: 1.108 ± 0.025	1.34PheArg: 1.34 ± 0.029	3.473PheSer: 3.473 ± 0.051	2.537PheThr: 2.537 ± 0.058	2.69PheVal: 2.69 ± 0.049	0.503PheTrp: 0.503 ± 0.023	1.435PheTyr: 1.435 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.183GlyAla: 5.183 ± 0.073	0.879GlyCys: 0.879 ± 0.028	3.632GlyAsp: 3.632 ± 0.074	3.797GlyGlu: 3.797 ± 0.057	3.307GlyPhe: 3.307 ± 0.057	4.488GlyGly: 4.488 ± 0.07	1.626GlyHis: 1.626 ± 0.038	4.775GlyIle: 4.775 ± 0.064	3.742GlyLys: 3.742 ± 0.064	7.152GlyLeu: 7.152 ± 0.086	2.025GlyMet: 2.025 ± 0.045	2.626GlyAsn: 2.626 ± 0.048	1.634GlyPro: 1.634 ± 0.037	2.907GlyGln: 2.907 ± 0.053	2.849GlyArg: 2.849 ± 0.049	3.997GlySer: 3.997 ± 0.065	3.334GlyThr: 3.334 ± 0.062	5.033GlyVal: 5.033 ± 0.071	0.857GlyTrp: 0.857 ± 0.03	2.505GlyTyr: 2.505 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.677HisAla: 1.677 ± 0.037	0.355HisCys: 0.355 ± 0.018	1.183HisAsp: 1.183 ± 0.032	1.005HisGlu: 1.005 ± 0.033	1.157HisPhe: 1.157 ± 0.029	1.604HisGly: 1.604 ± 0.042	0.744HisHis: 0.744 ± 0.029	1.542HisIle: 1.542 ± 0.042	1.146HisLys: 1.146 ± 0.032	2.282HisLeu: 2.282 ± 0.049	0.522HisMet: 0.522 ± 0.021	1.048HisAsn: 1.048 ± 0.032	1.156HisPro: 1.156 ± 0.033	1.343HisGln: 1.343 ± 0.032	0.97HisArg: 0.97 ± 0.027	1.531HisSer: 1.531 ± 0.044	1.063HisThr: 1.063 ± 0.029	1.336HisVal: 1.336 ± 0.031	0.368HisTrp: 0.368 ± 0.017	0.937HisTyr: 0.937 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.954IleAla: 6.954 ± 0.085	0.731IleCys: 0.731 ± 0.025	4.754IleAsp: 4.754 ± 0.064	4.666IleGlu: 4.666 ± 0.062	2.294IlePhe: 2.294 ± 0.046	4.811IleGly: 4.811 ± 0.057	1.265IleHis: 1.265 ± 0.031	4.19IleIle: 4.19 ± 0.065	3.552IleLys: 3.552 ± 0.055	5.297IleLeu: 5.297 ± 0.08	1.483IleMet: 1.483 ± 0.034	3.758IleAsn: 3.758 ± 0.06	2.537IlePro: 2.537 ± 0.045	2.287IleGln: 2.287 ± 0.046	2.669IleArg: 2.669 ± 0.045	4.864IleSer: 4.864 ± 0.065	3.938IleThr: 3.938 ± 0.066	4.285IleVal: 4.285 ± 0.061	0.613IleTrp: 0.613 ± 0.023	1.757IleTyr: 1.757 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.753LysAla: 4.753 ± 0.079	0.328LysCys: 0.328 ± 0.018	2.638LysAsp: 2.638 ± 0.051	2.375LysGlu: 2.375 ± 0.053	1.594LysPhe: 1.594 ± 0.034	3.191LysGly: 3.191 ± 0.05	1.297LysHis: 1.297 ± 0.038	2.937LysIle: 2.937 ± 0.051	2.582LysLys: 2.582 ± 0.047	5.506LysLeu: 5.506 ± 0.078	1.522LysMet: 1.522 ± 0.035	2.052LysAsn: 2.052 ± 0.044	2.343LysPro: 2.343 ± 0.048	3.332LysGln: 3.332 ± 0.053	2.545LysArg: 2.545 ± 0.041	3.242LysSer: 3.242 ± 0.059	2.828LysThr: 2.828 ± 0.047	3.806LysVal: 3.806 ± 0.06	0.56LysTrp: 0.56 ± 0.023	1.316LysTyr: 1.316 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.538LeuAla: 10.538 ± 0.112	1.114LeuCys: 1.114 ± 0.03	5.714LeuAsp: 5.714 ± 0.065	5.262LeuGlu: 5.262 ± 0.07	4.211LeuPhe: 4.211 ± 0.066	6.81LeuGly: 6.81 ± 0.086	2.193LeuHis: 2.193 ± 0.049	6.594LeuIle: 6.594 ± 0.081	5.02LeuLys: 5.02 ± 0.068	11.107LeuLeu: 11.107 ± 0.129	2.816LeuMet: 2.816 ± 0.047	4.584LeuAsn: 4.584 ± 0.066	4.687LeuPro: 4.687 ± 0.076	4.109LeuGln: 4.109 ± 0.07	4.123LeuArg: 4.123 ± 0.056	8.164LeuSer: 8.164 ± 0.093	6.86LeuThr: 6.86 ± 0.092	7.113LeuVal: 7.113 ± 0.089	1.137LeuTrp: 1.137 ± 0.029	2.687LeuTyr: 2.687 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.653MetAla: 2.653 ± 0.043	0.214MetCys: 0.214 ± 0.013	1.254MetAsp: 1.254 ± 0.032	1.115MetGlu: 1.115 ± 0.029	0.944MetPhe: 0.944 ± 0.03	1.812MetGly: 1.812 ± 0.041	0.552MetHis: 0.552 ± 0.021	1.554MetIle: 1.554 ± 0.037	1.412MetLys: 1.412 ± 0.032	3.112MetLeu: 3.112 ± 0.047	0.84MetMet: 0.84 ± 0.026	1.126MetAsn: 1.126 ± 0.027	1.311MetPro: 1.311 ± 0.031	1.23MetGln: 1.23 ± 0.032	1.133MetArg: 1.133 ± 0.032	2.106MetSer: 2.106 ± 0.037	1.776MetThr: 1.776 ± 0.038	1.809MetVal: 1.809 ± 0.037	0.261MetTrp: 0.261 ± 0.012	0.553MetTyr: 0.553 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.84AsnAla: 3.84 ± 0.055	0.445AsnCys: 0.445 ± 0.019	2.756AsnAsp: 2.756 ± 0.082	2.345AsnGlu: 2.345 ± 0.048	1.498AsnPhe: 1.498 ± 0.033	3.086AsnGly: 3.086 ± 0.07	1.022AsnHis: 1.022 ± 0.027	3.228AsnIle: 3.228 ± 0.052	2.303AsnLys: 2.303 ± 0.038	4.072AsnLeu: 4.072 ± 0.054	1.123AsnMet: 1.123 ± 0.026	2.326AsnAsn: 2.326 ± 0.046	2.095AsnPro: 2.095 ± 0.039	2.432AsnGln: 2.432 ± 0.051	1.987AsnArg: 1.987 ± 0.04	2.878AsnSer: 2.878 ± 0.058	2.573AsnThr: 2.573 ± 0.049	2.972AsnVal: 2.972 ± 0.046	0.54AsnTrp: 0.54 ± 0.017	1.328AsnTyr: 1.328 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.266ProAla: 3.266 ± 0.067	0.286ProCys: 0.286 ± 0.016	2.255ProAsp: 2.255 ± 0.039	2.679ProGlu: 2.679 ± 0.05	1.672ProPhe: 1.672 ± 0.037	2.267ProGly: 2.267 ± 0.048	0.862ProHis: 0.862 ± 0.026	2.733ProIle: 2.733 ± 0.046	2.074ProLys: 2.074 ± 0.047	4.187ProLeu: 4.187 ± 0.054	1.062ProMet: 1.062 ± 0.026	1.723ProAsn: 1.723 ± 0.042	1.141ProPro: 1.141 ± 0.035	1.891ProGln: 1.891 ± 0.038	1.27ProArg: 1.27 ± 0.033	2.461ProSer: 2.461 ± 0.047	2.214ProThr: 2.214 ± 0.043	2.894ProVal: 2.894 ± 0.052	0.498ProTrp: 0.498 ± 0.02	1.122ProTyr: 1.122 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.947GlnAla: 4.947 ± 0.068	0.452GlnCys: 0.452 ± 0.022	2.207GlnAsp: 2.207 ± 0.045	1.84GlnGlu: 1.84 ± 0.041	2.021GlnPhe: 2.021 ± 0.038	3.153GlnGly: 3.153 ± 0.053	1.557GlnHis: 1.557 ± 0.039	2.805GlnIle: 2.805 ± 0.05	2.055GlnLys: 2.055 ± 0.041	6.095GlnLeu: 6.095 ± 0.089	1.176GlnMet: 1.176 ± 0.029	1.646GlnAsn: 1.646 ± 0.039	1.842GlnPro: 1.842 ± 0.034	4.414GlnGln: 4.414 ± 0.098	2.303GlnArg: 2.303 ± 0.043	2.955GlnSer: 2.955 ± 0.049	2.642GlnThr: 2.642 ± 0.046	3.393GlnVal: 3.393 ± 0.057	0.737GlnTrp: 0.737 ± 0.026	1.65GlnTyr: 1.65 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.155ArgAla: 3.155 ± 0.05	0.423ArgCys: 0.423 ± 0.017	2.381ArgAsp: 2.381 ± 0.042	2.383ArgGlu: 2.383 ± 0.049	2.103ArgPhe: 2.103 ± 0.038	2.46ArgGly: 2.46 ± 0.052	1.099ArgHis: 1.099 ± 0.032	2.971ArgIle: 2.971 ± 0.046	2.147ArgLys: 2.147 ± 0.043	4.672ArgLeu: 4.672 ± 0.062	1.106ArgMet: 1.106 ± 0.03	1.799ArgAsn: 1.799 ± 0.036	1.485ArgPro: 1.485 ± 0.035	2.272ArgGln: 2.272 ± 0.049	2.055ArgArg: 2.055 ± 0.046	2.435ArgSer: 2.435 ± 0.047	1.972ArgThr: 1.972 ± 0.04	2.915ArgVal: 2.915 ± 0.047	0.579ArgTrp: 0.579 ± 0.025	1.746ArgTyr: 1.746 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.762SerAla: 5.762 ± 0.083	0.675SerCys: 0.675 ± 0.024	3.704SerAsp: 3.704 ± 0.075	3.57SerGlu: 3.57 ± 0.045	2.823SerPhe: 2.823 ± 0.055	4.717SerGly: 4.717 ± 0.072	1.632SerHis: 1.632 ± 0.04	4.575SerIle: 4.575 ± 0.06	3.132SerLys: 3.132 ± 0.057	7.339SerLeu: 7.339 ± 0.082	1.837SerMet: 1.837 ± 0.033	2.875SerAsn: 2.875 ± 0.054	2.596SerPro: 2.596 ± 0.044	3.498SerGln: 3.498 ± 0.06	2.84SerArg: 2.84 ± 0.049	4.602SerSer: 4.602 ± 0.074	3.662SerThr: 3.662 ± 0.059	4.708SerVal: 4.708 ± 0.066	0.776SerTrp: 0.776 ± 0.025	2.07SerTyr: 2.07 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.909ThrAla: 4.909 ± 0.066	0.509ThrCys: 0.509 ± 0.019	3.299ThrAsp: 3.299 ± 0.061	3.265ThrGlu: 3.265 ± 0.044	2.002ThrPhe: 2.002 ± 0.044	3.958ThrGly: 3.958 ± 0.062	1.266ThrHis: 1.266 ± 0.036	3.487ThrIle: 3.487 ± 0.048	2.482ThrLys: 2.482 ± 0.047	6.469ThrLeu: 6.469 ± 0.076	1.23ThrMet: 1.23 ± 0.031	2.239ThrAsn: 2.239 ± 0.052	2.848ThrPro: 2.848 ± 0.071	2.934ThrGln: 2.934 ± 0.052	2.179ThrArg: 2.179 ± 0.041	3.609ThrSer: 3.609 ± 0.06	3.156ThrThr: 3.156 ± 0.057	3.846ThrVal: 3.846 ± 0.081	0.6ThrTrp: 0.6 ± 0.02	1.476ThrTyr: 1.476 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	6.375ValAla: 6.375 ± 0.095	0.741ValCys: 0.741 ± 0.026	4.428ValAsp: 4.428 ± 0.072	4.124ValGlu: 4.124 ± 0.063	2.745ValPhe: 2.745 ± 0.049	4.476ValGly: 4.476 ± 0.066	1.216ValHis: 1.216 ± 0.035	4.993ValIle: 4.993 ± 0.066	3.472ValLys: 3.472 ± 0.058	6.654ValLeu: 6.654 ± 0.084	1.996ValMet: 1.996 ± 0.037	3.488ValAsn: 3.488 ± 0.069	2.48ValPro: 2.48 ± 0.048	2.267ValGln: 2.267 ± 0.041	2.609ValArg: 2.609 ± 0.045	4.997ValSer: 4.997 ± 0.065	4.135ValThr: 4.135 ± 0.063	5.21ValVal: 5.21 ± 0.082	0.707ValTrp: 0.707 ± 0.025	1.839ValTyr: 1.839 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.841TrpAla: 0.841 ± 0.025	0.15TrpCys: 0.15 ± 0.012	0.602TrpAsp: 0.602 ± 0.021	0.405TrpGlu: 0.405 ± 0.019	0.556TrpPhe: 0.556 ± 0.027	0.743TrpGly: 0.743 ± 0.026	0.371TrpHis: 0.371 ± 0.016	0.667TrpIle: 0.667 ± 0.022	0.438TrpLys: 0.438 ± 0.017	1.657TrpLeu: 1.657 ± 0.042	0.317TrpMet: 0.317 ± 0.017	0.403TrpAsn: 0.403 ± 0.018	0.49TrpPro: 0.49 ± 0.022	1.033TrpGln: 1.033 ± 0.032	0.657TrpArg: 0.657 ± 0.019	0.72TrpSer: 0.72 ± 0.024	0.467TrpThr: 0.467 ± 0.018	0.765TrpVal: 0.765 ± 0.025	0.177TrpTrp: 0.177 ± 0.012	0.347TrpTyr: 0.347 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.309TyrAla: 2.309 ± 0.046	0.386TyrCys: 0.386 ± 0.017	1.627TyrAsp: 1.627 ± 0.038	1.368TyrGlu: 1.368 ± 0.034	1.427TyrPhe: 1.427 ± 0.031	2.138TyrGly: 2.138 ± 0.043	0.808TyrHis: 0.808 ± 0.029	1.693TyrIle: 1.693 ± 0.039	1.29TyrLys: 1.29 ± 0.033	3.453TyrLeu: 3.453 ± 0.052	0.594TyrMet: 0.594 ± 0.02	1.178TyrAsn: 1.178 ± 0.033	1.346TyrPro: 1.346 ± 0.031	2.203TyrGln: 2.203 ± 0.047	1.719TyrArg: 1.719 ± 0.038	2.103TyrSer: 2.103 ± 0.047	1.486TyrThr: 1.486 ± 0.039	1.698TyrVal: 1.698 ± 0.035	0.447TyrTrp: 0.447 ± 0.021	1.04TyrTyr: 1.04 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3990 proteins (1345936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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