Amino acid dipepetide frequency for Magnetospirillum aberrantis SpK

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.514AlaAla: 18.514 ± 0.182	1.267AlaCys: 1.267 ± 0.037	7.542AlaAsp: 7.542 ± 0.098	8.696AlaGlu: 8.696 ± 0.114	4.06AlaPhe: 4.06 ± 0.067	10.599AlaGly: 10.599 ± 0.118	2.34AlaHis: 2.34 ± 0.045	5.432AlaIle: 5.432 ± 0.078	4.044AlaLys: 4.044 ± 0.078	14.028AlaLeu: 14.028 ± 0.169	3.445AlaMet: 3.445 ± 0.056	2.88AlaAsn: 2.88 ± 0.058	5.458AlaPro: 5.458 ± 0.084	4.279AlaGln: 4.279 ± 0.069	8.997AlaArg: 8.997 ± 0.128	5.758AlaSer: 5.758 ± 0.077	6.175AlaThr: 6.175 ± 0.097	10.264AlaVal: 10.264 ± 0.11	1.58AlaTrp: 1.58 ± 0.038	2.292AlaTyr: 2.292 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.093CysAla: 1.093 ± 0.036	0.125CysCys: 0.125 ± 0.011	0.612CysAsp: 0.612 ± 0.023	0.433CysGlu: 0.433 ± 0.019	0.31CysPhe: 0.31 ± 0.016	1.043CysGly: 1.043 ± 0.033	0.302CysHis: 0.302 ± 0.017	0.338CysIle: 0.338 ± 0.017	0.24CysLys: 0.24 ± 0.015	0.904CysLeu: 0.904 ± 0.026	0.168CysMet: 0.168 ± 0.011	0.213CysAsn: 0.213 ± 0.014	0.583CysPro: 0.583 ± 0.023	0.257CysGln: 0.257 ± 0.014	0.825CysArg: 0.825 ± 0.03	0.457CysSer: 0.457 ± 0.019	0.464CysThr: 0.464 ± 0.019	0.699CysVal: 0.699 ± 0.025	0.131CysTrp: 0.131 ± 0.012	0.23CysTyr: 0.23 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.613AspAla: 6.613 ± 0.074	0.54AspCys: 0.54 ± 0.022	3.615AspAsp: 3.615 ± 0.068	3.47AspGlu: 3.47 ± 0.052	2.244AspPhe: 2.244 ± 0.046	6.131AspGly: 6.131 ± 0.121	1.404AspHis: 1.404 ± 0.041	2.926AspIle: 2.926 ± 0.055	1.824AspLys: 1.824 ± 0.044	6.117AspLeu: 6.117 ± 0.077	1.465AspMet: 1.465 ± 0.036	1.419AspAsn: 1.419 ± 0.039	3.362AspPro: 3.362 ± 0.054	1.832AspGln: 1.832 ± 0.037	4.178AspArg: 4.178 ± 0.06	2.859AspSer: 2.859 ± 0.063	3.042AspThr: 3.042 ± 0.084	4.374AspVal: 4.374 ± 0.065	0.958AspTrp: 0.958 ± 0.029	1.28AspTyr: 1.28 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.434GluAla: 7.434 ± 0.107	0.424GluCys: 0.424 ± 0.017	2.961GluAsp: 2.961 ± 0.061	3.251GluGlu: 3.251 ± 0.071	1.685GluPhe: 1.685 ± 0.035	4.115GluGly: 4.115 ± 0.061	1.295GluHis: 1.295 ± 0.035	3.092GluIle: 3.092 ± 0.053	2.124GluLys: 2.124 ± 0.061	5.528GluLeu: 5.528 ± 0.077	1.758GluMet: 1.758 ± 0.038	1.467GluAsn: 1.467 ± 0.034	2.408GluPro: 2.408 ± 0.05	2.338GluGln: 2.338 ± 0.063	5.232GluArg: 5.232 ± 0.083	2.367GluSer: 2.367 ± 0.047	3.427GluThr: 3.427 ± 0.054	4.49GluVal: 4.49 ± 0.061	0.745GluTrp: 0.745 ± 0.025	0.999GluTyr: 0.999 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.264PheAla: 4.264 ± 0.068	0.385PheCys: 0.385 ± 0.017	2.409PheAsp: 2.409 ± 0.048	1.841PheGlu: 1.841 ± 0.04	1.225PhePhe: 1.225 ± 0.038	3.123PheGly: 3.123 ± 0.056	0.792PheHis: 0.792 ± 0.027	1.263PheIle: 1.263 ± 0.034	1.03PheLys: 1.03 ± 0.03	3.401PheLeu: 3.401 ± 0.056	0.72PheMet: 0.72 ± 0.022	0.965PheAsn: 0.965 ± 0.027	1.48PhePro: 1.48 ± 0.039	1.062PheGln: 1.062 ± 0.032	2.247PheArg: 2.247 ± 0.042	1.955PheSer: 1.955 ± 0.046	1.884PheThr: 1.884 ± 0.044	2.755PheVal: 2.755 ± 0.055	0.484PheTrp: 0.484 ± 0.02	0.751PheTyr: 0.751 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	8.98GlyAla: 8.98 ± 0.115	1.004GlyCys: 1.004 ± 0.031	5.027GlyAsp: 5.027 ± 0.098	4.769GlyGlu: 4.769 ± 0.074	3.074GlyPhe: 3.074 ± 0.054	7.792GlyGly: 7.792 ± 0.134	2.022GlyHis: 2.022 ± 0.039	4.239GlyIle: 4.239 ± 0.064	3.35GlyLys: 3.35 ± 0.065	9.018GlyLeu: 9.018 ± 0.123	2.45GlyMet: 2.45 ± 0.048	2.261GlyAsn: 2.261 ± 0.082	3.188GlyPro: 3.188 ± 0.052	2.943GlyGln: 2.943 ± 0.053	6.434GlyArg: 6.434 ± 0.095	4.149GlySer: 4.149 ± 0.096	4.891GlyThr: 4.891 ± 0.137	6.406GlyVal: 6.406 ± 0.065	1.477GlyTrp: 1.477 ± 0.032	2.047GlyTyr: 2.047 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.434HisAla: 2.434 ± 0.047	0.253HisCys: 0.253 ± 0.014	1.35HisAsp: 1.35 ± 0.033	1.073HisGlu: 1.073 ± 0.033	0.862HisPhe: 0.862 ± 0.028	2.054HisGly: 2.054 ± 0.044	0.673HisHis: 0.673 ± 0.028	0.814HisIle: 0.814 ± 0.026	0.536HisLys: 0.536 ± 0.02	2.346HisLeu: 2.346 ± 0.043	0.534HisMet: 0.534 ± 0.021	0.47HisAsn: 0.47 ± 0.023	1.401HisPro: 1.401 ± 0.037	0.656HisGln: 0.656 ± 0.025	1.504HisArg: 1.504 ± 0.037	0.976HisSer: 0.976 ± 0.028	0.933HisThr: 0.933 ± 0.03	1.618HisVal: 1.618 ± 0.037	0.36HisTrp: 0.36 ± 0.018	0.523HisTyr: 0.523 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.713IleAla: 5.713 ± 0.079	0.444IleCys: 0.444 ± 0.019	3.024IleAsp: 3.024 ± 0.051	2.955IleGlu: 2.955 ± 0.055	1.165IlePhe: 1.165 ± 0.032	3.984IleGly: 3.984 ± 0.064	0.9IleHis: 0.9 ± 0.029	1.569IleIle: 1.569 ± 0.039	1.518IleLys: 1.518 ± 0.042	4.034IleLeu: 4.034 ± 0.05	0.86IleMet: 0.86 ± 0.03	1.239IleAsn: 1.239 ± 0.034	2.042IlePro: 2.042 ± 0.041	1.228IleGln: 1.228 ± 0.036	3.022IleArg: 3.022 ± 0.053	2.35IleSer: 2.35 ± 0.053	2.313IleThr: 2.313 ± 0.061	3.315IleVal: 3.315 ± 0.055	0.413IleTrp: 0.413 ± 0.017	0.856IleTyr: 0.856 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.2LysAla: 4.2 ± 0.074	0.192LysCys: 0.192 ± 0.013	1.821LysAsp: 1.821 ± 0.043	1.492LysGlu: 1.492 ± 0.045	0.886LysPhe: 0.886 ± 0.028	2.84LysGly: 2.84 ± 0.061	0.591LysHis: 0.591 ± 0.029	1.397LysIle: 1.397 ± 0.04	1.314LysLys: 1.314 ± 0.043	3.241LysLeu: 3.241 ± 0.058	0.836LysMet: 0.836 ± 0.026	0.81LysAsn: 0.81 ± 0.026	1.952LysPro: 1.952 ± 0.044	0.931LysGln: 0.931 ± 0.028	2.239LysArg: 2.239 ± 0.051	1.672LysSer: 1.672 ± 0.042	1.79LysThr: 1.79 ± 0.041	2.888LysVal: 2.888 ± 0.052	0.353LysTrp: 0.353 ± 0.018	0.607LysTyr: 0.607 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.305LeuAla: 15.305 ± 0.163	0.957LeuCys: 0.957 ± 0.03	6.69LeuAsp: 6.69 ± 0.073	5.509LeuGlu: 5.509 ± 0.087	3.616LeuPhe: 3.616 ± 0.061	8.81LeuGly: 8.81 ± 0.091	1.963LeuHis: 1.963 ± 0.039	3.823LeuIle: 3.823 ± 0.067	3.576LeuLys: 3.576 ± 0.059	9.643LeuLeu: 9.643 ± 0.124	2.46LeuMet: 2.46 ± 0.051	2.547LeuAsn: 2.547 ± 0.055	5.718LeuPro: 5.718 ± 0.075	2.389LeuGln: 2.389 ± 0.047	7.364LeuArg: 7.364 ± 0.092	7.023LeuSer: 7.023 ± 0.123	5.747LeuThr: 5.747 ± 0.119	8.478LeuVal: 8.478 ± 0.1	1.287LeuTrp: 1.287 ± 0.039	1.998LeuTyr: 1.998 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.693MetAla: 3.693 ± 0.058	0.168MetCys: 0.168 ± 0.011	1.363MetAsp: 1.363 ± 0.033	1.297MetGlu: 1.297 ± 0.035	0.686MetPhe: 0.686 ± 0.027	1.975MetGly: 1.975 ± 0.045	0.403MetHis: 0.403 ± 0.017	1.054MetIle: 1.054 ± 0.031	0.864MetLys: 0.864 ± 0.028	2.54MetLeu: 2.54 ± 0.046	0.657MetMet: 0.657 ± 0.024	0.746MetAsn: 0.746 ± 0.024	1.429MetPro: 1.429 ± 0.037	0.661MetGln: 0.661 ± 0.023	1.733MetArg: 1.733 ± 0.045	1.516MetSer: 1.516 ± 0.035	1.761MetThr: 1.761 ± 0.041	2.406MetVal: 2.406 ± 0.039	0.23MetTrp: 0.23 ± 0.012	0.267MetTyr: 0.267 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.052AsnAla: 3.052 ± 0.055	0.228AsnCys: 0.228 ± 0.013	1.502AsnAsp: 1.502 ± 0.057	1.029AsnGlu: 1.029 ± 0.03	0.799AsnPhe: 0.799 ± 0.024	2.275AsnGly: 2.275 ± 0.065	0.54AsnHis: 0.54 ± 0.02	1.126AsnIle: 1.126 ± 0.034	0.66AsnLys: 0.66 ± 0.027	2.688AsnLeu: 2.688 ± 0.056	0.589AsnMet: 0.589 ± 0.022	0.621AsnAsn: 0.621 ± 0.024	1.682AsnPro: 1.682 ± 0.031	0.851AsnGln: 0.851 ± 0.027	1.773AsnArg: 1.773 ± 0.039	1.234AsnSer: 1.234 ± 0.042	1.266AsnThr: 1.266 ± 0.042	1.961AsnVal: 1.961 ± 0.045	0.346AsnTrp: 0.346 ± 0.019	0.532AsnTyr: 0.532 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.252ProAla: 6.252 ± 0.086	0.422ProCys: 0.422 ± 0.017	3.556ProAsp: 3.556 ± 0.064	3.643ProGlu: 3.643 ± 0.062	1.866ProPhe: 1.866 ± 0.037	4.26ProGly: 4.26 ± 0.066	1.112ProHis: 1.112 ± 0.03	1.785ProIle: 1.785 ± 0.038	1.545ProLys: 1.545 ± 0.04	5.1ProLeu: 5.1 ± 0.072	1.21ProMet: 1.21 ± 0.031	1.19ProAsn: 1.19 ± 0.034	3.215ProPro: 3.215 ± 0.083	1.626ProGln: 1.626 ± 0.035	2.974ProArg: 2.974 ± 0.057	2.563ProSer: 2.563 ± 0.046	2.405ProThr: 2.405 ± 0.047	4.378ProVal: 4.378 ± 0.067	0.738ProTrp: 0.738 ± 0.026	1.103ProTyr: 1.103 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.494GlnAla: 4.494 ± 0.068	0.255GlnCys: 0.255 ± 0.013	1.536GlnAsp: 1.536 ± 0.039	1.5GlnGlu: 1.5 ± 0.035	0.978GlnPhe: 0.978 ± 0.031	2.824GlnGly: 2.824 ± 0.052	0.564GlnHis: 0.564 ± 0.022	1.461GlnIle: 1.461 ± 0.067	0.897GlnLys: 0.897 ± 0.03	3.006GlnLeu: 3.006 ± 0.086	0.934GlnMet: 0.934 ± 0.034	0.746GlnAsn: 0.746 ± 0.028	1.808GlnPro: 1.808 ± 0.038	1.136GlnGln: 1.136 ± 0.036	2.219GlnArg: 2.219 ± 0.049	1.712GlnSer: 1.712 ± 0.038	1.731GlnThr: 1.731 ± 0.043	2.911GlnVal: 2.911 ± 0.055	0.456GlnTrp: 0.456 ± 0.02	0.597GlnTyr: 0.597 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.153ArgAla: 8.153 ± 0.096	0.609ArgCys: 0.609 ± 0.023	4.25ArgAsp: 4.25 ± 0.071	3.929ArgGlu: 3.929 ± 0.072	2.804ArgPhe: 2.804 ± 0.05	4.521ArgGly: 4.521 ± 0.067	2.005ArgHis: 2.005 ± 0.047	3.346ArgIle: 3.346 ± 0.06	2.255ArgLys: 2.255 ± 0.049	9.007ArgLeu: 9.007 ± 0.111	2.088ArgMet: 2.088 ± 0.043	1.715ArgAsn: 1.715 ± 0.036	3.806ArgPro: 3.806 ± 0.06	2.841ArgGln: 2.841 ± 0.052	6.252ArgArg: 6.252 ± 0.107	3.259ArgSer: 3.259 ± 0.057	3.315ArgThr: 3.315 ± 0.057	5.391ArgVal: 5.391 ± 0.075	1.061ArgTrp: 1.061 ± 0.029	1.541ArgTyr: 1.541 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.144SerAla: 6.144 ± 0.099	0.498SerCys: 0.498 ± 0.021	2.84SerAsp: 2.84 ± 0.06	2.641SerGlu: 2.641 ± 0.051	1.932SerPhe: 1.932 ± 0.04	5.412SerGly: 5.412 ± 0.112	1.14SerHis: 1.14 ± 0.031	2.135SerIle: 2.135 ± 0.055	1.425SerLys: 1.425 ± 0.041	5.553SerLeu: 5.553 ± 0.081	1.289SerMet: 1.289 ± 0.033	1.196SerAsn: 1.196 ± 0.04	2.603SerPro: 2.603 ± 0.045	1.635SerGln: 1.635 ± 0.049	3.473SerArg: 3.473 ± 0.057	2.838SerSer: 2.838 ± 0.082	2.67SerThr: 2.67 ± 0.077	4.101SerVal: 4.101 ± 0.067	0.725SerTrp: 0.725 ± 0.024	1.191SerTyr: 1.191 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.645ThrAla: 6.645 ± 0.115	0.48ThrCys: 0.48 ± 0.025	2.809ThrAsp: 2.809 ± 0.074	2.753ThrGlu: 2.753 ± 0.045	1.928ThrPhe: 1.928 ± 0.04	4.748ThrGly: 4.748 ± 0.089	0.97ThrHis: 0.97 ± 0.03	2.655ThrIle: 2.655 ± 0.065	1.399ThrLys: 1.399 ± 0.034	6.206ThrLeu: 6.206 ± 0.116	1.211ThrMet: 1.211 ± 0.032	1.265ThrAsn: 1.265 ± 0.042	3.11ThrPro: 3.11 ± 0.054	1.653ThrGln: 1.653 ± 0.125	3.244ThrArg: 3.244 ± 0.046	2.514ThrSer: 2.514 ± 0.069	2.924ThrThr: 2.924 ± 0.101	4.865ThrVal: 4.865 ± 0.098	0.654ThrTrp: 0.654 ± 0.023	1.166ThrTyr: 1.166 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	11.096ValAla: 11.096 ± 0.118	0.773ValCys: 0.773 ± 0.028	4.651ValAsp: 4.651 ± 0.076	5.303ValGlu: 5.303 ± 0.082	2.679ValPhe: 2.679 ± 0.052	6.078ValGly: 6.078 ± 0.08	1.487ValHis: 1.487 ± 0.036	3.327ValIle: 3.327 ± 0.06	2.414ValLys: 2.414 ± 0.043	8.691ValLeu: 8.691 ± 0.087	2.033ValMet: 2.033 ± 0.045	2.066ValAsn: 2.066 ± 0.043	4.05ValPro: 4.05 ± 0.065	2.191ValGln: 2.191 ± 0.046	5.43ValArg: 5.43 ± 0.07	4.451ValSer: 4.451 ± 0.076	4.816ValThr: 4.816 ± 0.086	8.008ValVal: 8.008 ± 0.108	0.943ValTrp: 0.943 ± 0.031	1.409ValTyr: 1.409 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.332TrpAla: 1.332 ± 0.036	0.168TrpCys: 0.168 ± 0.012	0.698TrpAsp: 0.698 ± 0.027	0.587TrpGlu: 0.587 ± 0.021	0.464TrpPhe: 0.464 ± 0.022	1.006TrpGly: 1.006 ± 0.029	0.37TrpHis: 0.37 ± 0.02	0.499TrpIle: 0.499 ± 0.021	0.436TrpLys: 0.436 ± 0.019	1.753TrpLeu: 1.753 ± 0.047	0.344TrpMet: 0.344 ± 0.017	0.432TrpAsn: 0.432 ± 0.019	0.703TrpPro: 0.703 ± 0.023	0.577TrpGln: 0.577 ± 0.027	1.314TrpArg: 1.314 ± 0.033	0.733TrpSer: 0.733 ± 0.025	0.653TrpThr: 0.653 ± 0.024	0.951TrpVal: 0.951 ± 0.028	0.241TrpTrp: 0.241 ± 0.016	0.27TrpTyr: 0.27 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.237TyrAla: 2.237 ± 0.043	0.238TyrCys: 0.238 ± 0.013	1.398TyrAsp: 1.398 ± 0.035	0.967TyrGlu: 0.967 ± 0.029	0.772TyrPhe: 0.772 ± 0.028	1.932TyrGly: 1.932 ± 0.049	0.496TyrHis: 0.496 ± 0.022	0.666TyrIle: 0.666 ± 0.021	0.599TyrLys: 0.599 ± 0.023	2.101TyrLeu: 2.101 ± 0.045	0.396TyrMet: 0.396 ± 0.019	0.508TyrAsn: 0.508 ± 0.021	0.943TyrPro: 0.943 ± 0.027	0.677TyrGln: 0.677 ± 0.026	1.691TyrArg: 1.691 ± 0.035	1.058TyrSer: 1.058 ± 0.036	0.994TyrThr: 0.994 ± 0.038	1.635TyrVal: 1.635 ± 0.041	0.35TyrTrp: 0.35 ± 0.015	0.523TyrTyr: 0.523 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3840 proteins (1252964 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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