Amino acid dipepetide frequency for Korarchaeum cryptofilum (strain OPF8)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.478AlaAla: 5.478 ± 0.159
0.613AlaCys: 0.613 ± 0.043
2.996AlaAsp: 2.996 ± 0.077
4.893AlaGlu: 4.893 ± 0.107
2.819AlaPhe: 2.819 ± 0.079
4.811AlaGly: 4.811 ± 0.108
1.032AlaHis: 1.032 ± 0.05
6.135AlaIle: 6.135 ± 0.118
4.004AlaLys: 4.004 ± 0.1
8.436AlaLeu: 8.436 ± 0.154
1.922AlaMet: 1.922 ± 0.069
1.815AlaAsn: 1.815 ± 0.061
2.486AlaPro: 2.486 ± 0.081
1.213AlaGln: 1.213 ± 0.053
4.606AlaArg: 4.606 ± 0.115
5.606AlaSer: 5.606 ± 0.127
2.756AlaThr: 2.756 ± 0.084
4.865AlaVal: 4.865 ± 0.111
0.735AlaTrp: 0.735 ± 0.042
2.518AlaTyr: 2.518 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.368CysAla: 0.368 ± 0.033
0.112CysCys: 0.112 ± 0.016
0.491CysAsp: 0.491 ± 0.03
0.573CysGlu: 0.573 ± 0.039
0.255CysPhe: 0.255 ± 0.025
1.109CysGly: 1.109 ± 0.062
0.145CysHis: 0.145 ± 0.018
0.486CysIle: 0.486 ± 0.033
0.383CysLys: 0.383 ± 0.025
0.741CysLeu: 0.741 ± 0.041
0.173CysMet: 0.173 ± 0.019
0.263CysAsn: 0.263 ± 0.027
0.815CysPro: 0.815 ± 0.056
0.135CysGln: 0.135 ± 0.021
0.535CysArg: 0.535 ± 0.033
0.693CysSer: 0.693 ± 0.042
0.261CysThr: 0.261 ± 0.023
0.457CysVal: 0.457 ± 0.034
0.135CysTrp: 0.135 ± 0.016
0.322CysTyr: 0.322 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
3.131AspAla: 3.131 ± 0.098
0.44AspCys: 0.44 ± 0.03
2.177AspAsp: 2.177 ± 0.068
4.701AspGlu: 4.701 ± 0.101
2.261AspPhe: 2.261 ± 0.065
3.554AspGly: 3.554 ± 0.11
0.701AspHis: 0.701 ± 0.041
3.838AspIle: 3.838 ± 0.105
2.229AspLys: 2.229 ± 0.076
6.339AspLeu: 6.339 ± 0.131
1.147AspMet: 1.147 ± 0.052
0.989AspAsn: 0.989 ± 0.056
3.257AspPro: 3.257 ± 0.086
0.718AspGln: 0.718 ± 0.042
2.678AspArg: 2.678 ± 0.074
3.059AspSer: 3.059 ± 0.081
1.547AspThr: 1.547 ± 0.059
4.065AspVal: 4.065 ± 0.088
0.646AspTrp: 0.646 ± 0.039
1.844AspTyr: 1.844 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
6.402GluAla: 6.402 ± 0.128
0.512GluCys: 0.512 ± 0.038
4.236GluAsp: 4.236 ± 0.105
8.469GluGlu: 8.469 ± 0.178
2.893GluPhe: 2.893 ± 0.075
6.202GluGly: 6.202 ± 0.132
0.903GluHis: 0.903 ± 0.044
7.017GluIle: 7.017 ± 0.126
4.112GluLys: 4.112 ± 0.106
9.269GluLeu: 9.269 ± 0.157
2.065GluMet: 2.065 ± 0.057
2.181GluAsn: 2.181 ± 0.069
2.583GluPro: 2.583 ± 0.077
0.954GluGln: 0.954 ± 0.044
7.267GluArg: 7.267 ± 0.147
4.307GluSer: 4.307 ± 0.102
2.211GluThr: 2.211 ± 0.069
7.023GluVal: 7.023 ± 0.153
0.838GluTrp: 0.838 ± 0.041
2.128GluTyr: 2.128 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
2.021PheAla: 2.021 ± 0.07
0.349PheCys: 0.349 ± 0.029
2.008PheAsp: 2.008 ± 0.071
2.568PheGlu: 2.568 ± 0.079
1.518PhePhe: 1.518 ± 0.055
2.964PheGly: 2.964 ± 0.077
0.623PheHis: 0.623 ± 0.035
3.206PheIle: 3.206 ± 0.091
2.019PheLys: 2.019 ± 0.067
4.905PheLeu: 4.905 ± 0.127
1.053PheMet: 1.053 ± 0.041
1.244PheAsn: 1.244 ± 0.061
1.72PhePro: 1.72 ± 0.065
0.663PheGln: 0.663 ± 0.034
2.463PheArg: 2.463 ± 0.075
3.398PheSer: 3.398 ± 0.104
1.592PheThr: 1.592 ± 0.059
2.166PheVal: 2.166 ± 0.076
0.463PheTrp: 0.463 ± 0.035
1.451PheTyr: 1.451 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
5.16GlyAla: 5.16 ± 0.118
0.743GlyCys: 0.743 ± 0.047
3.754GlyAsp: 3.754 ± 0.087
5.743GlyGlu: 5.743 ± 0.104
3.381GlyPhe: 3.381 ± 0.075
5.857GlyGly: 5.857 ± 0.134
1.109GlyHis: 1.109 ± 0.053
7.198GlyIle: 7.198 ± 0.139
5.244GlyLys: 5.244 ± 0.114
7.272GlyLeu: 7.272 ± 0.131
2.385GlyMet: 2.385 ± 0.077
2.259GlyAsn: 2.259 ± 0.095
2.646GlyPro: 2.646 ± 0.08
1.044GlyGln: 1.044 ± 0.047
5.387GlyArg: 5.387 ± 0.113
5.623GlySer: 5.623 ± 0.153
3.16GlyThr: 3.16 ± 0.078
5.987GlyVal: 5.987 ± 0.113
1.059GlyTrp: 1.059 ± 0.045
2.861GlyTyr: 2.861 ± 0.085
0.0GlyXaa: 0.0 ± 0.0
His
0.903HisAla: 0.903 ± 0.042
0.162HisCys: 0.162 ± 0.018
0.6HisAsp: 0.6 ± 0.037
1.048HisGlu: 1.048 ± 0.053
0.549HisPhe: 0.549 ± 0.036
1.141HisGly: 1.141 ± 0.048
0.301HisHis: 0.301 ± 0.025
0.899HisIle: 0.899 ± 0.046
0.632HisLys: 0.632 ± 0.036
1.472HisLeu: 1.472 ± 0.061
0.4HisMet: 0.4 ± 0.032
0.326HisAsn: 0.326 ± 0.026
0.983HisPro: 0.983 ± 0.051
0.251HisGln: 0.251 ± 0.024
0.762HisArg: 0.762 ± 0.034
0.893HisSer: 0.893 ± 0.041
0.545HisThr: 0.545 ± 0.038
1.008HisVal: 1.008 ± 0.045
0.202HisTrp: 0.202 ± 0.019
0.6HisTyr: 0.6 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.625IleAla: 6.625 ± 0.126
0.621IleCys: 0.621 ± 0.036
4.086IleAsp: 4.086 ± 0.098
6.427IleGlu: 6.427 ± 0.113
3.375IlePhe: 3.375 ± 0.1
6.08IleGly: 6.08 ± 0.12
1.076IleHis: 1.076 ± 0.049
5.909IleIle: 5.909 ± 0.134
3.928IleLys: 3.928 ± 0.111
8.739IleLeu: 8.739 ± 0.172
1.949IleMet: 1.949 ± 0.056
2.149IleAsn: 2.149 ± 0.059
4.341IlePro: 4.341 ± 0.097
1.183IleGln: 1.183 ± 0.057
4.994IleArg: 4.994 ± 0.111
7.025IleSer: 7.025 ± 0.147
3.349IleThr: 3.349 ± 0.088
6.215IleVal: 6.215 ± 0.111
0.909IleTrp: 0.909 ± 0.056
3.008IleTyr: 3.008 ± 0.09
0.0IleXaa: 0.0 ± 0.0
Lys
3.874LysAla: 3.874 ± 0.098
0.564LysCys: 0.564 ± 0.039
2.604LysAsp: 2.604 ± 0.081
5.225LysGlu: 5.225 ± 0.123
1.985LysPhe: 1.985 ± 0.069
4.44LysGly: 4.44 ± 0.107
0.627LysHis: 0.627 ± 0.038
4.571LysIle: 4.571 ± 0.109
2.669LysLys: 2.669 ± 0.095
6.903LysLeu: 6.903 ± 0.13
1.413LysMet: 1.413 ± 0.057
1.314LysAsn: 1.314 ± 0.049
2.381LysPro: 2.381 ± 0.084
0.829LysGln: 0.829 ± 0.044
3.874LysArg: 3.874 ± 0.107
3.044LysSer: 3.044 ± 0.077
1.745LysThr: 1.745 ± 0.062
4.749LysVal: 4.749 ± 0.117
0.669LysTrp: 0.669 ± 0.037
2.162LysTyr: 2.162 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
7.901LeuAla: 7.901 ± 0.157
0.686LeuCys: 0.686 ± 0.041
5.554LeuAsp: 5.554 ± 0.118
8.088LeuGlu: 8.088 ± 0.152
3.341LeuPhe: 3.341 ± 0.09
8.411LeuGly: 8.411 ± 0.152
1.381LeuHis: 1.381 ± 0.049
9.394LeuIle: 9.394 ± 0.178
6.768LeuLys: 6.768 ± 0.115
11.554LeuLeu: 11.554 ± 0.23
3.059LeuMet: 3.059 ± 0.09
3.476LeuAsn: 3.476 ± 0.09
4.427LeuPro: 4.427 ± 0.101
1.503LeuGln: 1.503 ± 0.052
8.554LeuArg: 8.554 ± 0.15
9.665LeuSer: 9.665 ± 0.2
4.295LeuThr: 4.295 ± 0.095
6.514LeuVal: 6.514 ± 0.113
0.985LeuTrp: 0.985 ± 0.048
3.217LeuTyr: 3.217 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
1.686MetAla: 1.686 ± 0.06
0.131MetCys: 0.131 ± 0.019
1.425MetAsp: 1.425 ± 0.05
2.299MetGlu: 2.299 ± 0.07
0.632MetPhe: 0.632 ± 0.035
2.413MetGly: 2.413 ± 0.063
0.398MetHis: 0.398 ± 0.032
2.16MetIle: 2.16 ± 0.072
1.739MetLys: 1.739 ± 0.066
2.432MetLeu: 2.432 ± 0.083
0.846MetMet: 0.846 ± 0.046
1.008MetAsn: 1.008 ± 0.05
1.156MetPro: 1.156 ± 0.046
0.368MetGln: 0.368 ± 0.03
2.941MetArg: 2.941 ± 0.078
1.857MetSer: 1.857 ± 0.064
1.019MetThr: 1.019 ± 0.047
1.396MetVal: 1.396 ± 0.05
0.149MetTrp: 0.149 ± 0.02
0.501MetTyr: 0.501 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
1.884AsnAla: 1.884 ± 0.064
0.326AsnCys: 0.326 ± 0.03
1.109AsnAsp: 1.109 ± 0.048
2.046AsnGlu: 2.046 ± 0.069
1.343AsnPhe: 1.343 ± 0.058
1.937AsnGly: 1.937 ± 0.088
0.28AsnHis: 0.28 ± 0.027
2.168AsnIle: 2.168 ± 0.07
1.217AsnLys: 1.217 ± 0.061
3.543AsnLeu: 3.543 ± 0.095
0.773AsnMet: 0.773 ± 0.042
0.716AsnAsn: 0.716 ± 0.065
2.063AsnPro: 2.063 ± 0.073
0.398AsnGln: 0.398 ± 0.028
1.459AsnArg: 1.459 ± 0.056
1.941AsnSer: 1.941 ± 0.068
1.0AsnThr: 1.0 ± 0.06
2.356AsnVal: 2.356 ± 0.077
0.448AsnTrp: 0.448 ± 0.031
1.213AsnTyr: 1.213 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
2.345ProAla: 2.345 ± 0.077
0.335ProCys: 0.335 ± 0.026
2.356ProAsp: 2.356 ± 0.078
4.103ProGlu: 4.103 ± 0.102
1.945ProPhe: 1.945 ± 0.064
3.343ProGly: 3.343 ± 0.085
0.781ProHis: 0.781 ± 0.04
3.381ProIle: 3.381 ± 0.084
2.598ProLys: 2.598 ± 0.075
4.676ProLeu: 4.676 ± 0.122
1.042ProMet: 1.042 ± 0.053
1.396ProAsn: 1.396 ± 0.055
2.486ProPro: 2.486 ± 0.08
0.985ProGln: 0.985 ± 0.053
2.505ProArg: 2.505 ± 0.068
3.427ProSer: 3.427 ± 0.092
1.916ProThr: 1.916 ± 0.068
2.964ProVal: 2.964 ± 0.072
0.617ProTrp: 0.617 ± 0.037
1.676ProTyr: 1.676 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
1.272GlnAla: 1.272 ± 0.053
0.122GlnCys: 0.122 ± 0.016
0.728GlnAsp: 0.728 ± 0.037
1.173GlnGlu: 1.173 ± 0.061
0.552GlnPhe: 0.552 ± 0.033
1.257GlnGly: 1.257 ± 0.055
0.189GlnHis: 0.189 ± 0.023
1.297GlnIle: 1.297 ± 0.059
0.705GlnLys: 0.705 ± 0.045
1.758GlnLeu: 1.758 ± 0.066
0.463GlnMet: 0.463 ± 0.032
0.394GlnAsn: 0.394 ± 0.028
0.629GlnPro: 0.629 ± 0.038
0.326GlnGln: 0.326 ± 0.03
1.183GlnArg: 1.183 ± 0.048
0.808GlnSer: 0.808 ± 0.042
0.632GlnThr: 0.632 ± 0.045
1.253GlnVal: 1.253 ± 0.057
0.145GlnTrp: 0.145 ± 0.022
0.438GlnTyr: 0.438 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.596ArgAla: 5.596 ± 0.107
0.629ArgCys: 0.629 ± 0.04
3.6ArgAsp: 3.6 ± 0.095
7.002ArgGlu: 7.002 ± 0.145
2.215ArgPhe: 2.215 ± 0.084
6.293ArgGly: 6.293 ± 0.126
0.669ArgHis: 0.669 ± 0.045
6.029ArgIle: 6.029 ± 0.125
4.579ArgLys: 4.579 ± 0.113
5.337ArgLeu: 5.337 ± 0.113
2.004ArgMet: 2.004 ± 0.066
1.964ArgAsn: 1.964 ± 0.065
2.411ArgPro: 2.411 ± 0.071
0.756ArgGln: 0.756 ± 0.04
5.878ArgArg: 5.878 ± 0.119
4.128ArgSer: 4.128 ± 0.1
2.126ArgThr: 2.126 ± 0.054
5.773ArgVal: 5.773 ± 0.116
0.709ArgTrp: 0.709 ± 0.037
2.238ArgTyr: 2.238 ± 0.072
0.0ArgXaa: 0.0 ± 0.0
Ser
3.893SerAla: 3.893 ± 0.092
0.771SerCys: 0.771 ± 0.044
3.425SerAsp: 3.425 ± 0.096
5.318SerGlu: 5.318 ± 0.118
3.438SerPhe: 3.438 ± 0.098
6.004SerGly: 6.004 ± 0.123
1.093SerHis: 1.093 ± 0.049
6.12SerIle: 6.12 ± 0.114
4.011SerLys: 4.011 ± 0.104
9.133SerLeu: 9.133 ± 0.189
2.048SerMet: 2.048 ± 0.079
1.891SerAsn: 1.891 ± 0.079
3.162SerPro: 3.162 ± 0.078
1.297SerGln: 1.297 ± 0.055
4.166SerArg: 4.166 ± 0.096
6.461SerSer: 6.461 ± 0.143
2.549SerThr: 2.549 ± 0.101
4.731SerVal: 4.731 ± 0.095
0.872SerTrp: 0.872 ± 0.042
2.895SerTyr: 2.895 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
2.621ThrAla: 2.621 ± 0.083
0.309ThrCys: 0.309 ± 0.025
1.522ThrAsp: 1.522 ± 0.061
2.291ThrGlu: 2.291 ± 0.069
1.678ThrPhe: 1.678 ± 0.061
3.436ThrGly: 3.436 ± 0.09
0.672ThrHis: 0.672 ± 0.038
2.945ThrIle: 2.945 ± 0.094
1.821ThrLys: 1.821 ± 0.066
4.404ThrLeu: 4.404 ± 0.1
0.872ThrMet: 0.872 ± 0.044
1.074ThrAsn: 1.074 ± 0.057
2.059ThrPro: 2.059 ± 0.07
0.783ThrGln: 0.783 ± 0.048
1.893ThrArg: 1.893 ± 0.053
2.688ThrSer: 2.688 ± 0.08
1.72ThrThr: 1.72 ± 0.088
2.8ThrVal: 2.8 ± 0.101
0.425ThrTrp: 0.425 ± 0.032
1.404ThrTyr: 1.404 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
5.394ValAla: 5.394 ± 0.112
0.583ValCys: 0.583 ± 0.038
4.147ValAsp: 4.147 ± 0.092
6.109ValGlu: 6.109 ± 0.137
2.265ValPhe: 2.265 ± 0.072
4.922ValGly: 4.922 ± 0.111
1.0ValHis: 1.0 ± 0.045
6.027ValIle: 6.027 ± 0.124
4.701ValLys: 4.701 ± 0.109
6.693ValLeu: 6.693 ± 0.131
1.836ValMet: 1.836 ± 0.069
2.381ValAsn: 2.381 ± 0.091
3.168ValPro: 3.168 ± 0.075
1.135ValGln: 1.135 ± 0.048
5.819ValArg: 5.819 ± 0.119
5.267ValSer: 5.267 ± 0.105
3.238ValThr: 3.238 ± 0.095
5.219ValVal: 5.219 ± 0.126
0.674ValTrp: 0.674 ± 0.042
2.362ValTyr: 2.362 ± 0.069
0.0ValXaa: 0.0 ± 0.0
Trp
0.714TrpAla: 0.714 ± 0.042
0.067TrpCys: 0.067 ± 0.011
0.619TrpAsp: 0.619 ± 0.039
0.846TrpGlu: 0.846 ± 0.046
0.499TrpPhe: 0.499 ± 0.033
0.903TrpGly: 0.903 ± 0.043
0.181TrpHis: 0.181 ± 0.017
0.956TrpIle: 0.956 ± 0.051
0.709TrpLys: 0.709 ± 0.035
1.112TrpLeu: 1.112 ± 0.05
0.301TrpMet: 0.301 ± 0.024
0.387TrpAsn: 0.387 ± 0.03
0.417TrpPro: 0.417 ± 0.03
0.194TrpGln: 0.194 ± 0.024
0.933TrpArg: 0.933 ± 0.047
0.731TrpSer: 0.731 ± 0.043
0.379TrpThr: 0.379 ± 0.029
0.781TrpVal: 0.781 ± 0.045
0.189TrpTrp: 0.189 ± 0.02
0.442TrpTyr: 0.442 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.469TyrAla: 2.469 ± 0.077
0.375TyrCys: 0.375 ± 0.029
1.884TyrAsp: 1.884 ± 0.069
2.648TyrGlu: 2.648 ± 0.077
1.453TyrPhe: 1.453 ± 0.054
2.798TyrGly: 2.798 ± 0.075
0.516TyrHis: 0.516 ± 0.029
2.255TyrIle: 2.255 ± 0.083
1.575TyrLys: 1.575 ± 0.062
4.057TyrLeu: 4.057 ± 0.093
0.802TyrMet: 0.802 ± 0.05
0.994TyrAsn: 0.994 ± 0.05
1.686TyrPro: 1.686 ± 0.058
0.589TyrGln: 0.589 ± 0.038
2.042TyrArg: 2.042 ± 0.057
2.653TyrSer: 2.653 ± 0.087
1.377TyrThr: 1.377 ± 0.06
2.619TyrVal: 2.619 ± 0.081
0.488TyrTrp: 0.488 ± 0.031
1.373TyrTyr: 1.373 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1602 proteins (475001 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski