Amino acid dipepetide frequency for Planctomycetales bacterium 10988

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.624AlaAla: 7.624 ± 0.089	0.95AlaCys: 0.95 ± 0.026	4.578AlaAsp: 4.578 ± 0.061	6.82AlaGlu: 6.82 ± 0.08	3.196AlaPhe: 3.196 ± 0.044	6.479AlaGly: 6.479 ± 0.093	1.461AlaHis: 1.461 ± 0.034	4.841AlaIle: 4.841 ± 0.058	4.023AlaLys: 4.023 ± 0.06	7.671AlaLeu: 7.671 ± 0.084	2.091AlaMet: 2.091 ± 0.041	2.786AlaAsn: 2.786 ± 0.058	3.47AlaPro: 3.47 ± 0.045	3.355AlaGln: 3.355 ± 0.055	4.255AlaArg: 4.255 ± 0.058	5.299AlaSer: 5.299 ± 0.068	4.57AlaThr: 4.57 ± 0.065	4.991AlaVal: 4.991 ± 0.06	1.323AlaTrp: 1.323 ± 0.032	2.313AlaTyr: 2.313 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.575CysAla: 0.575 ± 0.02	0.201CysCys: 0.201 ± 0.012	0.53CysAsp: 0.53 ± 0.019	0.665CysGlu: 0.665 ± 0.021	0.495CysPhe: 0.495 ± 0.017	0.849CysGly: 0.849 ± 0.027	0.358CysHis: 0.358 ± 0.017	0.43CysIle: 0.43 ± 0.018	0.329CysLys: 0.329 ± 0.025	1.197CysLeu: 1.197 ± 0.031	0.162CysMet: 0.162 ± 0.008	0.29CysAsn: 0.29 ± 0.015	0.518CysPro: 0.518 ± 0.019	0.493CysGln: 0.493 ± 0.019	0.627CysArg: 0.627 ± 0.025	0.629CysSer: 0.629 ± 0.021	0.446CysThr: 0.446 ± 0.017	0.579CysVal: 0.579 ± 0.021	0.193CysTrp: 0.193 ± 0.011	0.359CysTyr: 0.359 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.362AspAla: 4.362 ± 0.064	0.53AspCys: 0.53 ± 0.02	3.08AspAsp: 3.08 ± 0.122	4.002AspGlu: 4.002 ± 0.064	2.58AspPhe: 2.58 ± 0.052	4.861AspGly: 4.861 ± 0.141	1.385AspHis: 1.385 ± 0.033	2.712AspIle: 2.712 ± 0.069	1.582AspLys: 1.582 ± 0.036	6.44AspLeu: 6.44 ± 0.083	0.779AspMet: 0.779 ± 0.02	1.465AspAsn: 1.465 ± 0.041	3.734AspPro: 3.734 ± 0.061	2.732AspGln: 2.732 ± 0.036	3.817AspArg: 3.817 ± 0.051	3.466AspSer: 3.466 ± 0.057	2.403AspThr: 2.403 ± 0.057	3.012AspVal: 3.012 ± 0.056	1.101AspTrp: 1.101 ± 0.023	1.772AspTyr: 1.772 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.85GluAla: 6.85 ± 0.08	0.48GluCys: 0.48 ± 0.019	4.114GluAsp: 4.114 ± 0.063	7.456GluGlu: 7.456 ± 0.113	2.486GluPhe: 2.486 ± 0.045	4.898GluGly: 4.898 ± 0.066	1.415GluHis: 1.415 ± 0.03	4.409GluIle: 4.409 ± 0.057	3.969GluLys: 3.969 ± 0.064	7.6GluLeu: 7.6 ± 0.081	1.873GluMet: 1.873 ± 0.036	2.799GluAsn: 2.799 ± 0.038	3.364GluPro: 3.364 ± 0.058	3.562GluGln: 3.562 ± 0.064	4.227GluArg: 4.227 ± 0.068	4.499GluSer: 4.499 ± 0.06	4.294GluThr: 4.294 ± 0.058	5.423GluVal: 5.423 ± 0.058	0.954GluTrp: 0.954 ± 0.027	1.833GluTyr: 1.833 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.302PheAla: 3.302 ± 0.045	0.511PheCys: 0.511 ± 0.02	2.759PheAsp: 2.759 ± 0.049	2.942PheGlu: 2.942 ± 0.041	2.098PhePhe: 2.098 ± 0.056	3.019PheGly: 3.019 ± 0.047	0.925PheHis: 0.925 ± 0.02	1.694PheIle: 1.694 ± 0.034	1.145PheLys: 1.145 ± 0.026	4.392PheLeu: 4.392 ± 0.062	0.624PheMet: 0.624 ± 0.019	1.269PheAsn: 1.269 ± 0.029	2.037PhePro: 2.037 ± 0.038	1.977PheGln: 1.977 ± 0.036	2.383PheArg: 2.383 ± 0.04	3.042PheSer: 3.042 ± 0.056	2.341PheThr: 2.341 ± 0.063	2.527PheVal: 2.527 ± 0.048	0.629PheTrp: 0.629 ± 0.021	1.387PheTyr: 1.387 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.528GlyAla: 4.528 ± 0.089	0.881GlyCys: 0.881 ± 0.032	4.075GlyAsp: 4.075 ± 0.091	4.978GlyGlu: 4.978 ± 0.068	3.134GlyPhe: 3.134 ± 0.044	5.702GlyGly: 5.702 ± 0.127	1.465GlyHis: 1.465 ± 0.033	4.336GlyIle: 4.336 ± 0.073	3.987GlyLys: 3.987 ± 0.065	6.682GlyLeu: 6.682 ± 0.076	1.903GlyMet: 1.903 ± 0.036	2.708GlyAsn: 2.708 ± 0.085	3.186GlyPro: 3.186 ± 0.053	2.835GlyGln: 2.835 ± 0.047	3.945GlyArg: 3.945 ± 0.059	4.908GlySer: 4.908 ± 0.091	5.349GlyThr: 5.349 ± 0.176	4.689GlyVal: 4.689 ± 0.063	1.269GlyTrp: 1.269 ± 0.034	2.317GlyTyr: 2.317 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	1.587HisAla: 1.587 ± 0.034	0.286HisCys: 0.286 ± 0.013	1.117HisAsp: 1.117 ± 0.027	1.294HisGlu: 1.294 ± 0.03	1.061HisPhe: 1.061 ± 0.026	1.577HisGly: 1.577 ± 0.032	0.729HisHis: 0.729 ± 0.024	0.85HisIle: 0.85 ± 0.024	0.553HisLys: 0.553 ± 0.019	2.69HisLeu: 2.69 ± 0.044	0.286HisMet: 0.286 ± 0.014	0.556HisAsn: 0.556 ± 0.02	1.613HisPro: 1.613 ± 0.039	1.156HisGln: 1.156 ± 0.026	1.529HisArg: 1.529 ± 0.035	1.238HisSer: 1.238 ± 0.03	0.945HisThr: 0.945 ± 0.026	1.242HisVal: 1.242 ± 0.031	0.458HisTrp: 0.458 ± 0.016	0.75HisTyr: 0.75 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.642IleAla: 4.642 ± 0.061	0.617IleCys: 0.617 ± 0.022	3.498IleAsp: 3.498 ± 0.059	4.247IleGlu: 4.247 ± 0.058	1.969IlePhe: 1.969 ± 0.039	3.708IleGly: 3.708 ± 0.062	1.181IleHis: 1.181 ± 0.031	2.155IleIle: 2.155 ± 0.046	1.758IleLys: 1.758 ± 0.039	5.251IleLeu: 5.251 ± 0.064	0.733IleMet: 0.733 ± 0.023	1.719IleAsn: 1.719 ± 0.042	2.894IlePro: 2.894 ± 0.043	2.333IleGln: 2.333 ± 0.042	3.249IleArg: 3.249 ± 0.044	3.256IleSer: 3.256 ± 0.057	3.0IleThr: 3.0 ± 0.075	3.429IleVal: 3.429 ± 0.054	0.676IleTrp: 0.676 ± 0.023	1.434IleTyr: 1.434 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.587LysAla: 3.587 ± 0.058	0.268LysCys: 0.268 ± 0.015	2.337LysAsp: 2.337 ± 0.043	3.609LysGlu: 3.609 ± 0.06	1.266LysPhe: 1.266 ± 0.025	2.348LysGly: 2.348 ± 0.039	0.865LysHis: 0.865 ± 0.026	2.415LysIle: 2.415 ± 0.041	2.707LysLys: 2.707 ± 0.054	4.142LysLeu: 4.142 ± 0.064	0.997LysMet: 0.997 ± 0.028	1.552LysAsn: 1.552 ± 0.029	2.378LysPro: 2.378 ± 0.045	2.147LysGln: 2.147 ± 0.045	2.557LysArg: 2.557 ± 0.047	2.721LysSer: 2.721 ± 0.044	2.504LysThr: 2.504 ± 0.048	2.921LysVal: 2.921 ± 0.044	0.634LysTrp: 0.634 ± 0.023	1.102LysTyr: 1.102 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	9.72LeuAla: 9.72 ± 0.087	1.111LeuCys: 1.111 ± 0.033	5.819LeuAsp: 5.819 ± 0.07	7.535LeuGlu: 7.535 ± 0.084	4.376LeuPhe: 4.376 ± 0.066	7.34LeuGly: 7.34 ± 0.079	2.083LeuHis: 2.083 ± 0.042	5.14LeuIle: 5.14 ± 0.061	4.572LeuLys: 4.572 ± 0.059	10.862LeuLeu: 10.862 ± 0.119	1.993LeuMet: 1.993 ± 0.036	3.404LeuAsn: 3.404 ± 0.046	5.919LeuPro: 5.919 ± 0.07	4.808LeuGln: 4.808 ± 0.06	5.857LeuArg: 5.857 ± 0.074	6.854LeuSer: 6.854 ± 0.079	5.835LeuThr: 5.835 ± 0.082	6.44LeuVal: 6.44 ± 0.059	1.702LeuTrp: 1.702 ± 0.048	2.561LeuTyr: 2.561 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.044MetAla: 2.044 ± 0.033	0.152MetCys: 0.152 ± 0.01	0.967MetAsp: 0.967 ± 0.025	1.354MetGlu: 1.354 ± 0.035	0.65MetPhe: 0.65 ± 0.021	1.338MetGly: 1.338 ± 0.028	0.407MetHis: 0.407 ± 0.016	1.273MetIle: 1.273 ± 0.03	1.098MetLys: 1.098 ± 0.028	2.177MetLeu: 2.177 ± 0.037	0.564MetMet: 0.564 ± 0.018	0.823MetAsn: 0.823 ± 0.023	1.175MetPro: 1.175 ± 0.029	0.993MetGln: 0.993 ± 0.024	1.159MetArg: 1.159 ± 0.026	1.406MetSer: 1.406 ± 0.031	1.306MetThr: 1.306 ± 0.027	1.421MetVal: 1.421 ± 0.033	0.198MetTrp: 0.198 ± 0.01	0.383MetTyr: 0.383 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.529AsnAla: 2.529 ± 0.046	0.313AsnCys: 0.313 ± 0.015	1.887AsnAsp: 1.887 ± 0.059	2.056AsnGlu: 2.056 ± 0.034	1.516AsnPhe: 1.516 ± 0.037	3.052AsnGly: 3.052 ± 0.099	0.787AsnHis: 0.787 ± 0.022	1.501AsnIle: 1.501 ± 0.033	0.961AsnLys: 0.961 ± 0.024	3.721AsnLeu: 3.721 ± 0.055	0.554AsnMet: 0.554 ± 0.017	1.194AsnAsn: 1.194 ± 0.039	2.512AsnPro: 2.512 ± 0.042	1.751AsnGln: 1.751 ± 0.036	2.141AsnArg: 2.141 ± 0.035	1.985AsnSer: 1.985 ± 0.047	1.624AsnThr: 1.624 ± 0.049	2.047AsnVal: 2.047 ± 0.051	0.568AsnTrp: 0.568 ± 0.017	1.03AsnTyr: 1.03 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.213ProAla: 4.213 ± 0.065	0.382ProCys: 0.382 ± 0.016	3.177ProAsp: 3.177 ± 0.044	5.122ProGlu: 5.122 ± 0.072	2.252ProPhe: 2.252 ± 0.04	3.957ProGly: 3.957 ± 0.064	1.321ProHis: 1.321 ± 0.032	2.603ProIle: 2.603 ± 0.038	2.237ProLys: 2.237 ± 0.044	5.12ProLeu: 5.12 ± 0.065	1.006ProMet: 1.006 ± 0.027	1.999ProAsn: 1.999 ± 0.038	3.148ProPro: 3.148 ± 0.057	2.644ProGln: 2.644 ± 0.054	2.657ProArg: 2.657 ± 0.043	3.876ProSer: 3.876 ± 0.064	3.164ProThr: 3.164 ± 0.044	3.234ProVal: 3.234 ± 0.054	0.797ProTrp: 0.797 ± 0.025	1.424ProTyr: 1.424 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.638GlnAla: 4.638 ± 0.069	0.321GlnCys: 0.321 ± 0.014	2.043GlnAsp: 2.043 ± 0.034	3.655GlnGlu: 3.655 ± 0.056	1.585GlnPhe: 1.585 ± 0.033	3.112GlnGly: 3.112 ± 0.048	0.947GlnHis: 0.947 ± 0.026	2.385GlnIle: 2.385 ± 0.041	2.135GlnLys: 2.135 ± 0.036	5.04GlnLeu: 5.04 ± 0.064	1.11GlnMet: 1.11 ± 0.028	1.407GlnAsn: 1.407 ± 0.028	2.621GlnPro: 2.621 ± 0.046	2.795GlnGln: 2.795 ± 0.056	2.876GlnArg: 2.876 ± 0.049	2.773GlnSer: 2.773 ± 0.042	2.695GlnThr: 2.695 ± 0.047	3.124GlnVal: 3.124 ± 0.042	0.687GlnTrp: 0.687 ± 0.019	1.124GlnTyr: 1.124 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	3.935ArgAla: 3.935 ± 0.053	0.585ArgCys: 0.585 ± 0.02	2.958ArgAsp: 2.958 ± 0.045	4.416ArgGlu: 4.416 ± 0.06	2.625ArgPhe: 2.625 ± 0.047	3.505ArgGly: 3.505 ± 0.053	1.261ArgHis: 1.261 ± 0.03	3.234ArgIle: 3.234 ± 0.047	2.723ArgLys: 2.723 ± 0.044	6.452ArgLeu: 6.452 ± 0.084	1.449ArgMet: 1.449 ± 0.035	1.916ArgAsn: 1.916 ± 0.036	2.856ArgPro: 2.856 ± 0.052	2.905ArgGln: 2.905 ± 0.051	3.938ArgArg: 3.938 ± 0.074	3.616ArgSer: 3.616 ± 0.052	2.885ArgThr: 2.885 ± 0.044	3.696ArgVal: 3.696 ± 0.049	1.184ArgTrp: 1.184 ± 0.03	1.887ArgTyr: 1.887 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.914SerAla: 4.914 ± 0.067	0.562SerCys: 0.562 ± 0.02	3.769SerAsp: 3.769 ± 0.066	4.79SerGlu: 4.79 ± 0.067	2.77SerPhe: 2.77 ± 0.039	5.209SerGly: 5.209 ± 0.098	1.331SerHis: 1.331 ± 0.029	3.268SerIle: 3.268 ± 0.059	2.533SerLys: 2.533 ± 0.045	6.907SerLeu: 6.907 ± 0.075	1.424SerMet: 1.424 ± 0.032	2.141SerAsn: 2.141 ± 0.045	3.884SerPro: 3.884 ± 0.051	3.142SerGln: 3.142 ± 0.048	3.433SerArg: 3.433 ± 0.053	4.974SerSer: 4.974 ± 0.076	3.479SerThr: 3.479 ± 0.058	3.654SerVal: 3.654 ± 0.057	0.992SerTrp: 0.992 ± 0.021	1.751SerTyr: 1.751 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	4.399ThrAla: 4.399 ± 0.067	0.49ThrCys: 0.49 ± 0.02	2.89ThrAsp: 2.89 ± 0.069	3.82ThrGlu: 3.82 ± 0.05	2.519ThrPhe: 2.519 ± 0.062	4.438ThrGly: 4.438 ± 0.088	1.045ThrHis: 1.045 ± 0.024	3.352ThrIle: 3.352 ± 0.066	2.176ThrLys: 2.176 ± 0.042	6.051ThrLeu: 6.051 ± 0.089	1.099ThrMet: 1.099 ± 0.024	1.986ThrAsn: 1.986 ± 0.055	3.599ThrPro: 3.599 ± 0.058	2.173ThrGln: 2.173 ± 0.035	2.445ThrArg: 2.445 ± 0.045	3.857ThrSer: 3.857 ± 0.063	3.082ThrThr: 3.082 ± 0.083	3.727ThrVal: 3.727 ± 0.09	0.859ThrTrp: 0.859 ± 0.024	1.542ThrTyr: 1.542 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.5ValAla: 5.5 ± 0.07	0.754ValCys: 0.754 ± 0.03	3.611ValAsp: 3.611 ± 0.061	4.721ValGlu: 4.721 ± 0.06	2.517ValPhe: 2.517 ± 0.045	4.412ValGly: 4.412 ± 0.057	1.318ValHis: 1.318 ± 0.028	3.282ValIle: 3.282 ± 0.05	2.721ValLys: 2.721 ± 0.051	6.366ValLeu: 6.366 ± 0.069	1.369ValMet: 1.369 ± 0.032	2.282ValAsn: 2.282 ± 0.057	3.216ValPro: 3.216 ± 0.05	2.557ValGln: 2.557 ± 0.048	3.832ValArg: 3.832 ± 0.049	3.977ValSer: 3.977 ± 0.059	3.596ValThr: 3.596 ± 0.088	4.356ValVal: 4.356 ± 0.05	0.86ValTrp: 0.86 ± 0.024	1.717ValTyr: 1.717 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.007TrpAla: 1.007 ± 0.026	0.159TrpCys: 0.159 ± 0.01	0.784TrpAsp: 0.784 ± 0.026	1.119TrpGlu: 1.119 ± 0.028	0.569TrpPhe: 0.569 ± 0.023	0.998TrpGly: 0.998 ± 0.029	0.432TrpHis: 0.432 ± 0.016	0.889TrpIle: 0.889 ± 0.025	1.078TrpLys: 1.078 ± 0.03	1.813TrpLeu: 1.813 ± 0.041	0.482TrpMet: 0.482 ± 0.021	0.626TrpAsn: 0.626 ± 0.02	0.695TrpPro: 0.695 ± 0.024	0.992TrpGln: 0.992 ± 0.026	0.967TrpArg: 0.967 ± 0.025	0.893TrpSer: 0.893 ± 0.024	0.755TrpThr: 0.755 ± 0.022	0.925TrpVal: 0.925 ± 0.026	0.308TrpTrp: 0.308 ± 0.015	0.408TrpTyr: 0.408 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.139TyrAla: 2.139 ± 0.042	0.372TyrCys: 0.372 ± 0.014	1.822TyrAsp: 1.822 ± 0.055	1.906TyrGlu: 1.906 ± 0.038	1.341TyrPhe: 1.341 ± 0.031	2.074TyrGly: 2.074 ± 0.038	0.803TyrHis: 0.803 ± 0.022	0.982TyrIle: 0.982 ± 0.027	0.772TyrLys: 0.772 ± 0.022	3.358TyrLeu: 3.358 ± 0.046	0.387TyrMet: 0.387 ± 0.017	0.804TyrAsn: 0.804 ± 0.025	1.515TyrPro: 1.515 ± 0.037	1.723TyrGln: 1.723 ± 0.033	2.132TyrArg: 2.132 ± 0.038	1.657TyrSer: 1.657 ± 0.032	1.273TyrThr: 1.273 ± 0.045	1.528TyrVal: 1.528 ± 0.03	0.508TyrTrp: 0.508 ± 0.02	1.03TyrTyr: 1.03 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4056 proteins (1770095 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---