Amino acid dipepetide frequency for Helicobacter canis NCTC 12740

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.845AlaAla: 4.845 ± 0.114
1.485AlaCys: 1.485 ± 0.05
3.424AlaAsp: 3.424 ± 0.083
3.347AlaGlu: 3.347 ± 0.084
3.912AlaPhe: 3.912 ± 0.091
4.594AlaGly: 4.594 ± 0.096
2.408AlaHis: 2.408 ± 0.068
6.515AlaIle: 6.515 ± 0.12
7.18AlaLys: 7.18 ± 0.127
12.017AlaLeu: 12.017 ± 0.185
2.33AlaMet: 2.33 ± 0.072
3.759AlaAsn: 3.759 ± 0.088
3.29AlaPro: 3.29 ± 0.077
5.536AlaGln: 5.536 ± 0.116
5.048AlaArg: 5.048 ± 0.112
6.008AlaSer: 6.008 ± 0.125
4.138AlaThr: 4.138 ± 0.091
3.753AlaVal: 3.753 ± 0.088
0.642AlaTrp: 0.642 ± 0.034
3.308AlaTyr: 3.308 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.753CysAla: 1.753 ± 0.06
0.154CysCys: 0.154 ± 0.017
0.823CysAsp: 0.823 ± 0.036
1.084CysGlu: 1.084 ± 0.041
0.699CysPhe: 0.699 ± 0.036
1.202CysGly: 1.202 ± 0.047
0.401CysHis: 0.401 ± 0.029
0.903CysIle: 0.903 ± 0.038
0.84CysLys: 0.84 ± 0.04
1.155CysLeu: 1.155 ± 0.051
0.283CysMet: 0.283 ± 0.022
0.427CysAsn: 0.427 ± 0.028
0.392CysPro: 0.392 ± 0.025
0.392CysGln: 0.392 ± 0.027
0.357CysArg: 0.357 ± 0.023
0.766CysSer: 0.766 ± 0.041
0.476CysThr: 0.476 ± 0.028
1.156CysVal: 1.156 ± 0.046
0.099CysTrp: 0.099 ± 0.015
0.449CysTyr: 0.449 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
2.487AspAla: 2.487 ± 0.064
0.766AspCys: 0.766 ± 0.039
2.383AspAsp: 2.383 ± 0.07
3.789AspGlu: 3.789 ± 0.083
3.406AspPhe: 3.406 ± 0.082
3.027AspGly: 3.027 ± 0.084
0.644AspHis: 0.644 ± 0.03
3.997AspIle: 3.997 ± 0.085
3.8AspLys: 3.8 ± 0.093
4.651AspLeu: 4.651 ± 0.086
1.391AspMet: 1.391 ± 0.054
1.859AspAsn: 1.859 ± 0.056
1.58AspPro: 1.58 ± 0.052
0.885AspGln: 0.885 ± 0.041
2.145AspArg: 2.145 ± 0.059
6.469AspSer: 6.469 ± 0.12
2.683AspThr: 2.683 ± 0.066
2.702AspVal: 2.702 ± 0.076
0.313AspTrp: 0.313 ± 0.022
1.944AspTyr: 1.944 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
4.225GluAla: 4.225 ± 0.105
0.851GluCys: 0.851 ± 0.041
1.929GluAsp: 1.929 ± 0.067
3.347GluGlu: 3.347 ± 0.096
2.821GluPhe: 2.821 ± 0.07
2.207GluGly: 2.207 ± 0.071
1.317GluHis: 1.317 ± 0.049
5.124GluIle: 5.124 ± 0.118
3.982GluLys: 3.982 ± 0.102
6.922GluLeu: 6.922 ± 0.122
1.348GluMet: 1.348 ± 0.054
2.717GluAsn: 2.717 ± 0.078
1.813GluPro: 1.813 ± 0.067
3.198GluGln: 3.198 ± 0.087
2.873GluArg: 2.873 ± 0.076
7.224GluSer: 7.224 ± 0.128
1.725GluThr: 1.725 ± 0.059
3.613GluVal: 3.613 ± 0.085
0.669GluTrp: 0.669 ± 0.04
2.008GluTyr: 2.008 ± 0.069
0.0GluXaa: 0.0 ± 0.0
Phe
4.497PheAla: 4.497 ± 0.09
0.91PheCys: 0.91 ± 0.045
2.881PheAsp: 2.881 ± 0.069
2.405PheGlu: 2.405 ± 0.063
2.462PhePhe: 2.462 ± 0.081
3.823PheGly: 3.823 ± 0.104
0.81PheHis: 0.81 ± 0.037
3.598PheIle: 3.598 ± 0.084
2.098PheLys: 2.098 ± 0.066
4.696PheLeu: 4.696 ± 0.109
1.166PheMet: 1.166 ± 0.047
1.663PheAsn: 1.663 ± 0.06
1.208PhePro: 1.208 ± 0.047
0.888PheGln: 0.888 ± 0.042
1.463PheArg: 1.463 ± 0.051
4.492PheSer: 4.492 ± 0.098
2.278PheThr: 2.278 ± 0.069
3.424PheVal: 3.424 ± 0.084
0.508PheTrp: 0.508 ± 0.03
2.169PheTyr: 2.169 ± 0.063
0.0PheXaa: 0.0 ± 0.0
Gly
5.534GlyAla: 5.534 ± 0.121
0.721GlyCys: 0.721 ± 0.042
3.303GlyAsp: 3.303 ± 0.07
3.992GlyGlu: 3.992 ± 0.095
3.999GlyPhe: 3.999 ± 0.09
5.006GlyGly: 5.006 ± 0.132
0.98GlyHis: 0.98 ± 0.045
4.973GlyIle: 4.973 ± 0.096
3.929GlyLys: 3.929 ± 0.117
6.106GlyLeu: 6.106 ± 0.124
1.202GlyMet: 1.202 ± 0.048
2.063GlyAsn: 2.063 ± 0.071
0.649GlyPro: 0.649 ± 0.036
1.813GlyGln: 1.813 ± 0.059
2.429GlyArg: 2.429 ± 0.074
4.368GlySer: 4.368 ± 0.1
2.266GlyThr: 2.266 ± 0.077
5.43GlyVal: 5.43 ± 0.116
0.494GlyTrp: 0.494 ± 0.029
2.656GlyTyr: 2.656 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.57HisAla: 1.57 ± 0.053
0.36HisCys: 0.36 ± 0.026
0.736HisAsp: 0.736 ± 0.036
0.578HisGlu: 0.578 ± 0.028
1.416HisPhe: 1.416 ± 0.054
0.778HisGly: 0.778 ± 0.039
0.541HisHis: 0.541 ± 0.035
2.594HisIle: 2.594 ± 0.074
1.882HisLys: 1.882 ± 0.056
2.127HisLeu: 2.127 ± 0.063
0.245HisMet: 0.245 ± 0.018
1.247HisAsn: 1.247 ± 0.047
0.845HisPro: 0.845 ± 0.039
0.68HisGln: 0.68 ± 0.034
0.912HisArg: 0.912 ± 0.041
1.87HisSer: 1.87 ± 0.06
1.736HisThr: 1.736 ± 0.058
0.169HisVal: 0.169 ± 0.015
0.146HisTrp: 0.146 ± 0.016
1.031HisTyr: 1.031 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
8.052IleAla: 8.052 ± 0.127
1.089IleCys: 1.089 ± 0.046
4.599IleAsp: 4.599 ± 0.089
4.549IleGlu: 4.549 ± 0.097
3.245IlePhe: 3.245 ± 0.075
4.723IleGly: 4.723 ± 0.107
1.53IleHis: 1.53 ± 0.057
5.527IleIle: 5.527 ± 0.108
4.505IleLys: 4.505 ± 0.096
7.212IleLeu: 7.212 ± 0.123
1.374IleMet: 1.374 ± 0.049
2.977IleAsn: 2.977 ± 0.08
2.811IlePro: 2.811 ± 0.079
2.462IleGln: 2.462 ± 0.078
2.341IleArg: 2.341 ± 0.066
4.869IleSer: 4.869 ± 0.092
4.659IleThr: 4.659 ± 0.103
4.458IleVal: 4.458 ± 0.099
0.489IleTrp: 0.489 ± 0.026
2.913IleTyr: 2.913 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
6.079LysAla: 6.079 ± 0.105
0.563LysCys: 0.563 ± 0.034
4.433LysAsp: 4.433 ± 0.1
5.214LysGlu: 5.214 ± 0.134
1.775LysPhe: 1.775 ± 0.059
3.726LysGly: 3.726 ± 0.099
1.611LysHis: 1.611 ± 0.056
4.698LysIle: 4.698 ± 0.102
4.208LysLys: 4.208 ± 0.113
6.377LysLeu: 6.377 ± 0.118
1.408LysMet: 1.408 ± 0.047
3.104LysAsn: 3.104 ± 0.078
3.002LysPro: 3.002 ± 0.086
3.422LysGln: 3.422 ± 0.08
3.127LysArg: 3.127 ± 0.07
5.021LysSer: 5.021 ± 0.096
2.948LysThr: 2.948 ± 0.082
3.409LysVal: 3.409 ± 0.075
0.486LysTrp: 0.486 ± 0.031
1.797LysTyr: 1.797 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
10.386LeuAla: 10.386 ± 0.17
2.058LeuCys: 2.058 ± 0.066
6.315LeuAsp: 6.315 ± 0.109
8.717LeuGlu: 8.717 ± 0.154
4.478LeuPhe: 4.478 ± 0.111
7.574LeuGly: 7.574 ± 0.133
2.568LeuHis: 2.568 ± 0.066
5.941LeuIle: 5.941 ± 0.109
5.967LeuLys: 5.967 ± 0.12
11.399LeuLeu: 11.399 ± 0.206
1.917LeuMet: 1.917 ± 0.054
3.727LeuAsn: 3.727 ± 0.087
4.332LeuPro: 4.332 ± 0.1
5.204LeuGln: 5.204 ± 0.101
4.813LeuArg: 4.813 ± 0.086
8.251LeuSer: 8.251 ± 0.125
4.006LeuThr: 4.006 ± 0.094
5.41LeuVal: 5.41 ± 0.1
1.011LeuTrp: 1.011 ± 0.05
3.737LeuTyr: 3.737 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
1.53MetAla: 1.53 ± 0.062
0.278MetCys: 0.278 ± 0.026
1.071MetAsp: 1.071 ± 0.047
1.031MetGlu: 1.031 ± 0.045
0.779MetPhe: 0.779 ± 0.035
1.51MetGly: 1.51 ± 0.05
0.416MetHis: 0.416 ± 0.026
1.502MetIle: 1.502 ± 0.055
1.229MetLys: 1.229 ± 0.046
2.755MetLeu: 2.755 ± 0.082
0.463MetMet: 0.463 ± 0.029
0.635MetAsn: 0.635 ± 0.034
1.177MetPro: 1.177 ± 0.053
1.396MetGln: 1.396 ± 0.047
1.416MetArg: 1.416 ± 0.049
1.398MetSer: 1.398 ± 0.052
0.714MetThr: 0.714 ± 0.032
1.16MetVal: 1.16 ± 0.048
0.183MetTrp: 0.183 ± 0.016
0.469MetTyr: 0.469 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
5.038AsnAla: 5.038 ± 0.111
0.318AsnCys: 0.318 ± 0.025
2.236AsnAsp: 2.236 ± 0.061
2.142AsnGlu: 2.142 ± 0.068
1.782AsnPhe: 1.782 ± 0.066
2.77AsnGly: 2.77 ± 0.085
0.779AsnHis: 0.779 ± 0.04
3.079AsnIle: 3.079 ± 0.077
2.182AsnLys: 2.182 ± 0.079
4.564AsnLeu: 4.564 ± 0.087
0.756AsnMet: 0.756 ± 0.04
1.688AsnAsn: 1.688 ± 0.065
2.237AsnPro: 2.237 ± 0.057
1.262AsnGln: 1.262 ± 0.048
1.508AsnArg: 1.508 ± 0.047
2.085AsnSer: 2.085 ± 0.069
2.444AsnThr: 2.444 ± 0.073
2.072AsnVal: 2.072 ± 0.065
0.24AsnTrp: 0.24 ± 0.024
1.292AsnTyr: 1.292 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.397ProAla: 2.397 ± 0.066
0.417ProCys: 0.417 ± 0.026
1.361ProAsp: 1.361 ± 0.056
1.79ProGlu: 1.79 ± 0.052
1.795ProPhe: 1.795 ± 0.06
0.979ProGly: 0.979 ± 0.046
1.007ProHis: 1.007 ± 0.039
2.894ProIle: 2.894 ± 0.072
3.461ProLys: 3.461 ± 0.082
4.128ProLeu: 4.128 ± 0.082
0.749ProMet: 0.749 ± 0.036
1.954ProAsn: 1.954 ± 0.059
1.317ProPro: 1.317 ± 0.048
1.837ProGln: 1.837 ± 0.063
1.478ProArg: 1.478 ± 0.049
3.225ProSer: 3.225 ± 0.083
2.284ProThr: 2.284 ± 0.067
1.525ProVal: 1.525 ± 0.056
0.199ProTrp: 0.199 ± 0.02
1.656ProTyr: 1.656 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
5.502GlnAla: 5.502 ± 0.114
0.412GlnCys: 0.412 ± 0.029
2.558GlnAsp: 2.558 ± 0.08
3.856GlnGlu: 3.856 ± 0.102
1.017GlnPhe: 1.017 ± 0.039
2.987GlnGly: 2.987 ± 0.068
0.664GlnHis: 0.664 ± 0.036
3.148GlnIle: 3.148 ± 0.07
3.55GlnLys: 3.55 ± 0.094
2.469GlnLeu: 2.469 ± 0.063
0.897GlnMet: 0.897 ± 0.037
2.415GlnAsn: 2.415 ± 0.07
0.98GlnPro: 0.98 ± 0.047
1.388GlnGln: 1.388 ± 0.051
1.562GlnArg: 1.562 ± 0.05
3.406GlnSer: 3.406 ± 0.094
1.958GlnThr: 1.958 ± 0.063
2.363GlnVal: 2.363 ± 0.069
0.31GlnTrp: 0.31 ± 0.023
1.031GlnTyr: 1.031 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
4.508ArgAla: 4.508 ± 0.097
0.359ArgCys: 0.359 ± 0.027
2.578ArgAsp: 2.578 ± 0.066
3.144ArgGlu: 3.144 ± 0.08
2.615ArgPhe: 2.615 ± 0.066
2.222ArgGly: 2.222 ± 0.059
0.753ArgHis: 0.753 ± 0.036
3.62ArgIle: 3.62 ± 0.081
2.613ArgLys: 2.613 ± 0.064
4.394ArgLeu: 4.394 ± 0.096
0.756ArgMet: 0.756 ± 0.039
1.842ArgAsn: 1.842 ± 0.065
1.093ArgPro: 1.093 ± 0.04
1.627ArgGln: 1.627 ± 0.048
1.507ArgArg: 1.507 ± 0.055
2.326ArgSer: 2.326 ± 0.058
1.671ArgThr: 1.671 ± 0.062
3.032ArgVal: 3.032 ± 0.064
0.315ArgTrp: 0.315 ± 0.024
1.954ArgTyr: 1.954 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
6.914SerAla: 6.914 ± 0.123
0.789SerCys: 0.789 ± 0.038
3.144SerAsp: 3.144 ± 0.075
3.052SerGlu: 3.052 ± 0.078
3.89SerPhe: 3.89 ± 0.08
5.261SerGly: 5.261 ± 0.107
1.699SerHis: 1.699 ± 0.054
5.534SerIle: 5.534 ± 0.103
5.729SerLys: 5.729 ± 0.106
8.819SerLeu: 8.819 ± 0.133
1.731SerMet: 1.731 ± 0.059
2.898SerAsn: 2.898 ± 0.078
3.238SerPro: 3.238 ± 0.085
3.064SerGln: 3.064 ± 0.071
3.029SerArg: 3.029 ± 0.087
7.25SerSer: 7.25 ± 0.134
4.274SerThr: 4.274 ± 0.115
4.599SerVal: 4.599 ± 0.105
0.546SerTrp: 0.546 ± 0.03
2.99SerTyr: 2.99 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.169ThrAla: 3.169 ± 0.075
0.484ThrCys: 0.484 ± 0.033
1.835ThrAsp: 1.835 ± 0.062
1.559ThrGlu: 1.559 ± 0.061
1.73ThrPhe: 1.73 ± 0.057
2.07ThrGly: 2.07 ± 0.065
1.461ThrHis: 1.461 ± 0.047
3.927ThrIle: 3.927 ± 0.087
3.513ThrLys: 3.513 ± 0.08
6.553ThrLeu: 6.553 ± 0.129
1.054ThrMet: 1.054 ± 0.046
2.075ThrAsn: 2.075 ± 0.064
3.23ThrPro: 3.23 ± 0.087
3.34ThrGln: 3.34 ± 0.084
2.078ThrArg: 2.078 ± 0.06
3.344ThrSer: 3.344 ± 0.086
2.71ThrThr: 2.71 ± 0.079
0.414ThrVal: 0.414 ± 0.036
0.246ThrTrp: 0.246 ± 0.021
1.748ThrTyr: 1.748 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
4.82ValAla: 4.82 ± 0.102
1.168ValCys: 1.168 ± 0.049
2.911ValAsp: 2.911 ± 0.07
3.295ValGlu: 3.295 ± 0.073
3.437ValPhe: 3.437 ± 0.08
4.192ValGly: 4.192 ± 0.105
0.746ValHis: 0.746 ± 0.036
3.768ValIle: 3.768 ± 0.094
2.821ValLys: 2.821 ± 0.092
6.821ValLeu: 6.821 ± 0.135
1.173ValMet: 1.173 ± 0.045
1.594ValAsn: 1.594 ± 0.052
1.738ValPro: 1.738 ± 0.07
2.211ValGln: 2.211 ± 0.057
2.821ValArg: 2.821 ± 0.069
3.692ValSer: 3.692 ± 0.083
1.398ValThr: 1.398 ± 0.053
4.309ValVal: 4.309 ± 0.104
0.573ValTrp: 0.573 ± 0.034
1.884ValTyr: 1.884 ± 0.065
0.0ValXaa: 0.0 ± 0.0
Trp
0.62TrpAla: 0.62 ± 0.042
0.122TrpCys: 0.122 ± 0.015
0.426TrpAsp: 0.426 ± 0.025
0.538TrpGlu: 0.538 ± 0.029
0.345TrpPhe: 0.345 ± 0.025
0.63TrpGly: 0.63 ± 0.039
0.251TrpHis: 0.251 ± 0.022
0.57TrpIle: 0.57 ± 0.034
0.32TrpLys: 0.32 ± 0.024
1.135TrpLeu: 1.135 ± 0.053
0.112TrpMet: 0.112 ± 0.014
0.29TrpAsn: 0.29 ± 0.022
0.06TrpPro: 0.06 ± 0.01
0.478TrpGln: 0.478 ± 0.03
0.451TrpArg: 0.451 ± 0.03
0.424TrpSer: 0.424 ± 0.027
0.204TrpThr: 0.204 ± 0.02
0.504TrpVal: 0.504 ± 0.031
0.131TrpTrp: 0.131 ± 0.015
0.275TrpTyr: 0.275 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.612TyrAla: 3.612 ± 0.084
0.504TyrCys: 0.504 ± 0.033
1.976TyrAsp: 1.976 ± 0.056
2.482TyrGlu: 2.482 ± 0.059
1.837TyrPhe: 1.837 ± 0.057
2.633TyrGly: 2.633 ± 0.068
0.878TyrHis: 0.878 ± 0.039
2.472TyrIle: 2.472 ± 0.074
2.601TyrLys: 2.601 ± 0.065
3.513TyrLeu: 3.513 ± 0.089
0.756TyrMet: 0.756 ± 0.037
1.54TyrAsn: 1.54 ± 0.056
1.461TyrPro: 1.461 ± 0.05
1.388TyrGln: 1.388 ± 0.048
1.57TyrArg: 1.57 ± 0.054
1.963TyrSer: 1.963 ± 0.053
1.969TyrThr: 1.969 ± 0.067
1.869TyrVal: 1.869 ± 0.059
0.287TyrTrp: 0.287 ± 0.021
1.389TyrTyr: 1.389 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1800 proteins (596658 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski