Amino acid dipepetide frequency for Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.937AlaAla: 4.937 ± 1.146
2.743AlaCys: 2.743 ± 1.206
2.194AlaAsp: 2.194 ± 0.921
4.937AlaGlu: 4.937 ± 1.4
1.92AlaPhe: 1.92 ± 0.357
4.663AlaGly: 4.663 ± 1.369
0.823AlaHis: 0.823 ± 0.325
3.84AlaIle: 3.84 ± 1.156
3.84AlaLys: 3.84 ± 0.956
5.76AlaLeu: 5.76 ± 0.899
2.194AlaMet: 2.194 ± 0.507
1.92AlaAsn: 1.92 ± 0.658
2.468AlaPro: 2.468 ± 0.928
1.92AlaGln: 1.92 ± 0.357
3.291AlaArg: 3.291 ± 0.746
4.937AlaSer: 4.937 ± 0.92
3.566AlaThr: 3.566 ± 0.91
4.114AlaVal: 4.114 ± 0.927
1.371AlaTrp: 1.371 ± 0.532
0.823AlaTyr: 0.823 ± 0.325
0.0AlaXaa: 0.0 ± 0.0
Cys
0.274CysAla: 0.274 ± 0.218
0.549CysCys: 0.549 ± 0.642
0.0CysAsp: 0.0 ± 0.0
0.274CysGlu: 0.274 ± 0.34
1.92CysPhe: 1.92 ± 1.368
1.92CysGly: 1.92 ± 0.501
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
1.371CysLys: 1.371 ± 0.689
0.274CysLeu: 0.274 ± 0.218
0.0CysMet: 0.0 ± 0.0
1.646CysAsn: 1.646 ± 0.845
0.274CysPro: 0.274 ± 0.218
1.371CysGln: 1.371 ± 0.689
1.92CysArg: 1.92 ± 0.599
1.371CysSer: 1.371 ± 0.793
3.291CysThr: 3.291 ± 0.835
1.92CysVal: 1.92 ± 0.698
0.823CysTrp: 0.823 ± 0.335
0.823CysTyr: 0.823 ± 0.783
0.0CysXaa: 0.0 ± 0.0
Asp
0.823AspAla: 0.823 ± 0.346
2.743AspCys: 2.743 ± 0.904
1.371AspAsp: 1.371 ± 0.525
1.371AspGlu: 1.371 ± 0.547
1.097AspPhe: 1.097 ± 0.748
1.371AspGly: 1.371 ± 0.535
0.0AspHis: 0.0 ± 0.0
4.937AspIle: 4.937 ± 0.908
2.468AspLys: 2.468 ± 0.826
3.566AspLeu: 3.566 ± 1.297
0.823AspMet: 0.823 ± 0.321
1.92AspAsn: 1.92 ± 0.59
2.194AspPro: 2.194 ± 0.829
1.371AspGln: 1.371 ± 0.622
4.663AspArg: 4.663 ± 1.268
3.291AspSer: 3.291 ± 1.269
2.743AspThr: 2.743 ± 0.713
1.097AspVal: 1.097 ± 0.414
0.823AspTrp: 0.823 ± 0.838
1.371AspTyr: 1.371 ± 0.371
0.0AspXaa: 0.0 ± 0.0
Glu
5.211GluAla: 5.211 ± 0.997
0.0GluCys: 0.0 ± 0.0
3.566GluAsp: 3.566 ± 1.361
6.857GluGlu: 6.857 ± 1.841
1.097GluPhe: 1.097 ± 0.49
5.76GluGly: 5.76 ± 1.573
0.549GluHis: 0.549 ± 0.374
3.291GluIle: 3.291 ± 0.938
5.211GluLys: 5.211 ± 0.895
7.131GluLeu: 7.131 ± 1.072
1.097GluMet: 1.097 ± 0.422
2.194GluAsn: 2.194 ± 0.587
6.034GluPro: 6.034 ± 2.084
3.291GluGln: 3.291 ± 1.124
4.663GluArg: 4.663 ± 1.416
2.468GluSer: 2.468 ± 0.517
4.937GluThr: 4.937 ± 1.302
3.84GluVal: 3.84 ± 0.667
1.371GluTrp: 1.371 ± 0.34
1.097GluTyr: 1.097 ± 0.743
0.0GluXaa: 0.0 ± 0.0
Phe
1.371PheAla: 1.371 ± 0.333
0.274PheCys: 0.274 ± 0.218
0.823PheAsp: 0.823 ± 0.585
0.274PheGlu: 0.274 ± 0.404
0.823PhePhe: 0.823 ± 0.427
1.097PheGly: 1.097 ± 0.643
0.823PheHis: 0.823 ± 0.783
1.92PheIle: 1.92 ± 0.768
0.823PheLys: 0.823 ± 0.52
3.291PheLeu: 3.291 ± 0.897
0.0PheMet: 0.0 ± 0.0
2.468PheAsn: 2.468 ± 1.115
1.92PhePro: 1.92 ± 1.103
0.823PheGln: 0.823 ± 0.378
3.566PheArg: 3.566 ± 0.767
1.92PheSer: 1.92 ± 0.665
1.097PheThr: 1.097 ± 0.49
0.274PheVal: 0.274 ± 0.187
0.549PheTrp: 0.549 ± 0.204
1.646PheTyr: 1.646 ± 0.502
0.0PheXaa: 0.0 ± 0.0
Gly
4.937GlyAla: 4.937 ± 0.901
1.92GlyCys: 1.92 ± 0.521
3.017GlyAsp: 3.017 ± 0.828
3.84GlyGlu: 3.84 ± 0.701
1.92GlyPhe: 1.92 ± 0.902
7.131GlyGly: 7.131 ± 1.164
3.84GlyHis: 3.84 ± 1.62
6.034GlyIle: 6.034 ± 1.532
5.211GlyLys: 5.211 ± 1.234
3.84GlyLeu: 3.84 ± 1.027
0.823GlyMet: 0.823 ± 0.378
3.017GlyAsn: 3.017 ± 1.058
5.211GlyPro: 5.211 ± 0.685
4.388GlyGln: 4.388 ± 1.206
3.017GlyArg: 3.017 ± 0.917
4.114GlySer: 4.114 ± 0.846
3.84GlyThr: 3.84 ± 1.857
3.017GlyVal: 3.017 ± 1.057
1.92GlyTrp: 1.92 ± 0.828
1.371GlyTyr: 1.371 ± 0.666
0.0GlyXaa: 0.0 ± 0.0
His
0.274HisAla: 0.274 ± 0.218
0.823HisCys: 0.823 ± 0.634
0.0HisAsp: 0.0 ± 0.0
0.549HisGlu: 0.549 ± 0.204
0.823HisPhe: 0.823 ± 1.2
1.371HisGly: 1.371 ± 0.862
0.823HisHis: 0.823 ± 0.82
1.92HisIle: 1.92 ± 0.862
1.371HisLys: 1.371 ± 0.571
2.468HisLeu: 2.468 ± 0.793
1.097HisMet: 1.097 ± 0.793
0.823HisAsn: 0.823 ± 0.346
2.194HisPro: 2.194 ± 1.03
3.017HisGln: 3.017 ± 1.225
0.549HisArg: 0.549 ± 0.34
1.097HisSer: 1.097 ± 1.199
1.646HisThr: 1.646 ± 0.797
0.549HisVal: 0.549 ± 0.461
0.0HisTrp: 0.0 ± 0.0
0.549HisTyr: 0.549 ± 0.4
0.0HisXaa: 0.0 ± 0.0
Ile
3.017IleAla: 3.017 ± 0.569
1.097IleCys: 1.097 ± 0.408
1.646IleAsp: 1.646 ± 0.726
3.84IleGlu: 3.84 ± 0.764
0.549IlePhe: 0.549 ± 0.204
4.937IleGly: 4.937 ± 1.22
1.646IleHis: 1.646 ± 0.495
4.114IleIle: 4.114 ± 0.834
4.663IleLys: 4.663 ± 1.072
5.485IleLeu: 5.485 ± 1.595
0.823IleMet: 0.823 ± 0.246
1.371IleAsn: 1.371 ± 0.333
3.291IlePro: 3.291 ± 0.828
2.468IleGln: 2.468 ± 1.059
5.76IleArg: 5.76 ± 1.759
3.291IleSer: 3.291 ± 0.922
3.291IleThr: 3.291 ± 1.29
7.954IleVal: 7.954 ± 1.864
1.646IleTrp: 1.646 ± 0.451
2.194IleTyr: 2.194 ± 0.438
0.0IleXaa: 0.0 ± 0.0
Lys
5.485LysAla: 5.485 ± 1.386
2.194LysCys: 2.194 ± 0.721
1.92LysAsp: 1.92 ± 0.802
7.68LysGlu: 7.68 ± 1.54
0.823LysPhe: 0.823 ± 0.383
4.388LysGly: 4.388 ± 1.073
1.646LysHis: 1.646 ± 0.754
5.211LysIle: 5.211 ± 1.781
7.131LysLys: 7.131 ± 2.567
5.211LysLeu: 5.211 ± 1.268
0.274LysMet: 0.274 ± 0.338
3.566LysAsn: 3.566 ± 1.048
1.646LysPro: 1.646 ± 0.731
3.566LysGln: 3.566 ± 1.232
3.017LysArg: 3.017 ± 0.871
3.291LysSer: 3.291 ± 0.62
5.211LysThr: 5.211 ± 0.788
4.663LysVal: 4.663 ± 1.307
1.646LysTrp: 1.646 ± 0.52
2.194LysTyr: 2.194 ± 0.553
0.0LysXaa: 0.0 ± 0.0
Leu
5.485LeuAla: 5.485 ± 1.473
0.823LeuCys: 0.823 ± 0.378
4.114LeuAsp: 4.114 ± 0.773
7.405LeuGlu: 7.405 ± 1.596
2.468LeuPhe: 2.468 ± 1.258
6.034LeuGly: 6.034 ± 1.596
1.92LeuHis: 1.92 ± 1.093
2.743LeuIle: 2.743 ± 0.964
6.857LeuLys: 6.857 ± 1.258
9.051LeuLeu: 9.051 ± 3.31
1.097LeuMet: 1.097 ± 0.711
4.388LeuAsn: 4.388 ± 0.996
2.194LeuPro: 2.194 ± 0.917
5.485LeuGln: 5.485 ± 0.787
4.388LeuArg: 4.388 ± 1.171
3.84LeuSer: 3.84 ± 0.618
3.566LeuThr: 3.566 ± 0.83
5.211LeuVal: 5.211 ± 1.635
2.468LeuTrp: 2.468 ± 0.754
2.743LeuTyr: 2.743 ± 0.743
0.0LeuXaa: 0.0 ± 0.0
Met
1.097MetAla: 1.097 ± 0.568
0.0MetCys: 0.0 ± 0.0
0.549MetAsp: 0.549 ± 0.374
1.92MetGlu: 1.92 ± 0.878
0.549MetPhe: 0.549 ± 0.261
1.646MetGly: 1.646 ± 0.377
0.823MetHis: 0.823 ± 0.378
1.097MetIle: 1.097 ± 0.467
0.549MetLys: 0.549 ± 0.261
2.194MetLeu: 2.194 ± 0.692
1.371MetMet: 1.371 ± 0.458
0.274MetAsn: 0.274 ± 0.187
0.0MetPro: 0.0 ± 0.0
1.097MetGln: 1.097 ± 0.522
1.92MetArg: 1.92 ± 0.429
0.823MetSer: 0.823 ± 0.335
2.743MetThr: 2.743 ± 0.656
0.823MetVal: 0.823 ± 0.246
0.549MetTrp: 0.549 ± 0.435
1.097MetTyr: 1.097 ± 0.383
0.0MetXaa: 0.0 ± 0.0
Asn
1.92AsnAla: 1.92 ± 0.498
2.743AsnCys: 2.743 ± 0.87
1.371AsnAsp: 1.371 ± 0.405
2.468AsnGlu: 2.468 ± 0.629
3.017AsnPhe: 3.017 ± 0.792
1.646AsnGly: 1.646 ± 0.872
0.0AsnHis: 0.0 ± 0.0
2.468AsnIle: 2.468 ± 0.854
3.566AsnLys: 3.566 ± 0.774
2.468AsnLeu: 2.468 ± 0.964
1.371AsnMet: 1.371 ± 0.875
3.84AsnAsn: 3.84 ± 1.466
4.114AsnPro: 4.114 ± 0.854
1.371AsnGln: 1.371 ± 0.363
1.92AsnArg: 1.92 ± 0.604
3.017AsnSer: 3.017 ± 0.448
4.388AsnThr: 4.388 ± 1.031
1.646AsnVal: 1.646 ± 1.007
2.194AsnTrp: 2.194 ± 0.663
1.097AsnTyr: 1.097 ± 0.419
0.0AsnXaa: 0.0 ± 0.0
Pro
3.017ProAla: 3.017 ± 1.335
0.549ProCys: 0.549 ± 0.435
2.468ProAsp: 2.468 ± 0.892
3.017ProGlu: 3.017 ± 0.687
1.371ProPhe: 1.371 ± 0.496
5.76ProGly: 5.76 ± 1.13
0.274ProHis: 0.274 ± 0.187
4.114ProIle: 4.114 ± 0.912
2.468ProLys: 2.468 ± 1.032
4.388ProLeu: 4.388 ± 1.197
0.823ProMet: 0.823 ± 0.468
0.549ProAsn: 0.549 ± 0.435
3.566ProPro: 3.566 ± 1.353
3.566ProGln: 3.566 ± 0.948
3.017ProArg: 3.017 ± 1.067
3.84ProSer: 3.84 ± 1.887
2.468ProThr: 2.468 ± 0.654
5.485ProVal: 5.485 ± 1.23
1.097ProTrp: 1.097 ± 0.684
1.097ProTyr: 1.097 ± 0.57
0.0ProXaa: 0.0 ± 0.0
Gln
6.857GlnAla: 6.857 ± 1.226
0.549GlnCys: 0.549 ± 0.435
2.468GlnAsp: 2.468 ± 0.915
3.84GlnGlu: 3.84 ± 0.644
0.0GlnPhe: 0.0 ± 0.0
4.937GlnGly: 4.937 ± 0.746
1.646GlnHis: 1.646 ± 0.661
4.663GlnIle: 4.663 ± 1.008
3.566GlnLys: 3.566 ± 1.084
4.663GlnLeu: 4.663 ± 1.162
3.291GlnMet: 3.291 ± 1.209
3.291GlnAsn: 3.291 ± 0.922
1.646GlnPro: 1.646 ± 0.977
2.743GlnGln: 2.743 ± 1.479
4.114GlnArg: 4.114 ± 1.342
1.92GlnSer: 1.92 ± 0.501
2.468GlnThr: 2.468 ± 0.555
4.114GlnVal: 4.114 ± 1.361
0.549GlnTrp: 0.549 ± 0.374
1.646GlnTyr: 1.646 ± 0.646
0.0GlnXaa: 0.0 ± 0.0
Arg
5.211ArgAla: 5.211 ± 1.158
0.274ArgCys: 0.274 ± 0.218
3.84ArgAsp: 3.84 ± 0.713
5.76ArgGlu: 5.76 ± 1.393
1.92ArgPhe: 1.92 ± 0.905
3.566ArgGly: 3.566 ± 0.582
1.097ArgHis: 1.097 ± 1.239
4.663ArgIle: 4.663 ± 2.337
4.663ArgLys: 4.663 ± 1.244
3.566ArgLeu: 3.566 ± 1.072
1.371ArgMet: 1.371 ± 0.513
3.017ArgAsn: 3.017 ± 1.219
3.566ArgPro: 3.566 ± 1.14
5.485ArgGln: 5.485 ± 1.281
5.76ArgArg: 5.76 ± 2.961
1.646ArgSer: 1.646 ± 1.058
1.646ArgThr: 1.646 ± 0.457
1.92ArgVal: 1.92 ± 0.698
2.468ArgTrp: 2.468 ± 0.821
1.097ArgTyr: 1.097 ± 0.504
0.0ArgXaa: 0.0 ± 0.0
Ser
2.468SerAla: 2.468 ± 0.494
0.823SerCys: 0.823 ± 0.346
2.468SerAsp: 2.468 ± 0.605
4.388SerGlu: 4.388 ± 0.652
1.646SerPhe: 1.646 ± 0.779
3.84SerGly: 3.84 ± 0.975
0.823SerHis: 0.823 ± 0.64
3.017SerIle: 3.017 ± 0.79
1.92SerLys: 1.92 ± 0.961
7.405SerLeu: 7.405 ± 1.524
0.823SerMet: 0.823 ± 0.437
1.371SerAsn: 1.371 ± 0.627
3.84SerPro: 3.84 ± 0.959
6.034SerGln: 6.034 ± 1.941
2.743SerArg: 2.743 ± 0.953
4.388SerSer: 4.388 ± 0.736
3.017SerThr: 3.017 ± 0.986
2.743SerVal: 2.743 ± 0.857
0.823SerTrp: 0.823 ± 0.378
0.823SerTyr: 0.823 ± 0.754
0.0SerXaa: 0.0 ± 0.0
Thr
2.743ThrAla: 2.743 ± 0.673
0.0ThrCys: 0.0 ± 0.0
2.468ThrAsp: 2.468 ± 0.791
5.485ThrGlu: 5.485 ± 1.125
1.097ThrPhe: 1.097 ± 0.579
3.84ThrGly: 3.84 ± 0.684
1.371ThrHis: 1.371 ± 0.63
3.566ThrIle: 3.566 ± 0.575
4.388ThrLys: 4.388 ± 1.1
6.034ThrLeu: 6.034 ± 1.27
1.097ThrMet: 1.097 ± 0.383
4.663ThrAsn: 4.663 ± 0.741
3.291ThrPro: 3.291 ± 0.81
2.194ThrGln: 2.194 ± 0.689
2.743ThrArg: 2.743 ± 1.25
3.017ThrSer: 3.017 ± 0.65
3.84ThrThr: 3.84 ± 1.02
5.211ThrVal: 5.211 ± 1.216
1.92ThrTrp: 1.92 ± 0.645
1.097ThrTyr: 1.097 ± 0.762
0.0ThrXaa: 0.0 ± 0.0
Val
3.84ValAla: 3.84 ± 0.951
0.0ValCys: 0.0 ± 0.0
3.84ValAsp: 3.84 ± 0.732
2.743ValGlu: 2.743 ± 1.172
1.371ValPhe: 1.371 ± 0.473
5.211ValGly: 5.211 ± 0.735
2.743ValHis: 2.743 ± 0.557
3.291ValIle: 3.291 ± 0.938
5.211ValLys: 5.211 ± 1.317
3.84ValLeu: 3.84 ± 0.832
0.549ValMet: 0.549 ± 0.4
2.743ValAsn: 2.743 ± 0.733
3.566ValPro: 3.566 ± 1.033
4.388ValGln: 4.388 ± 1.012
2.468ValArg: 2.468 ± 0.699
4.388ValSer: 4.388 ± 0.796
3.84ValThr: 3.84 ± 1.078
4.388ValVal: 4.388 ± 1.032
2.468ValTrp: 2.468 ± 0.67
1.097ValTyr: 1.097 ± 0.63
0.0ValXaa: 0.0 ± 0.0
Trp
1.646TrpAla: 1.646 ± 0.379
0.274TrpCys: 0.274 ± 0.474
1.097TrpAsp: 1.097 ± 0.433
1.92TrpGlu: 1.92 ± 0.496
0.274TrpPhe: 0.274 ± 0.218
1.92TrpGly: 1.92 ± 0.614
0.274TrpHis: 0.274 ± 0.34
0.823TrpIle: 0.823 ± 0.335
2.743TrpLys: 2.743 ± 0.811
0.823TrpLeu: 0.823 ± 0.777
1.646TrpMet: 1.646 ± 0.472
1.92TrpAsn: 1.92 ± 1.343
0.823TrpPro: 0.823 ± 0.335
2.468TrpGln: 2.468 ± 0.971
1.92TrpArg: 1.92 ± 0.604
1.371TrpSer: 1.371 ± 0.804
1.646TrpThr: 1.646 ± 0.947
1.646TrpVal: 1.646 ± 0.377
0.823TrpTrp: 0.823 ± 0.325
0.549TrpTyr: 0.549 ± 0.204
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.646TyrAla: 1.646 ± 0.612
1.646TyrCys: 1.646 ± 0.661
0.823TyrAsp: 0.823 ± 0.378
1.097TyrGlu: 1.097 ± 0.513
1.097TyrPhe: 1.097 ± 0.555
1.371TyrGly: 1.371 ± 0.79
0.823TyrHis: 0.823 ± 0.427
1.371TyrIle: 1.371 ± 0.642
3.017TyrLys: 3.017 ± 0.82
0.823TyrLeu: 0.823 ± 0.346
0.274TyrMet: 0.274 ± 0.187
1.646TyrAsn: 1.646 ± 0.608
1.097TyrPro: 1.097 ± 0.643
1.92TyrGln: 1.92 ± 0.856
1.097TyrArg: 1.097 ± 0.484
1.371TyrSer: 1.371 ± 0.34
0.823TyrThr: 0.823 ± 0.427
1.371TyrVal: 1.371 ± 0.641
1.097TyrTrp: 1.097 ± 0.467
1.097TyrTyr: 1.097 ± 0.386
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (3647 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski