Amino acid dipepetide frequency for Gordonia terrae phage McKinley

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.012AlaAla: 17.012 ± 1.275
0.587AlaCys: 0.587 ± 0.188
8.052AlaAsp: 8.052 ± 0.795
9.706AlaGlu: 9.706 ± 1.073
2.986AlaPhe: 2.986 ± 0.586
10.826AlaGly: 10.826 ± 0.964
1.973AlaHis: 1.973 ± 0.291
6.506AlaIle: 6.506 ± 1.029
3.573AlaLys: 3.573 ± 0.477
9.012AlaLeu: 9.012 ± 0.919
2.613AlaMet: 2.613 ± 0.406
2.72AlaAsn: 2.72 ± 0.482
6.826AlaPro: 6.826 ± 0.678
4.213AlaGln: 4.213 ± 0.498
8.746AlaArg: 8.746 ± 0.829
5.546AlaSer: 5.546 ± 0.614
7.413AlaThr: 7.413 ± 0.691
8.746AlaVal: 8.746 ± 0.649
2.88AlaTrp: 2.88 ± 0.367
2.186AlaTyr: 2.186 ± 0.337
0.0AlaXaa: 0.0 ± 0.0
Cys
1.227CysAla: 1.227 ± 0.296
0.0CysCys: 0.0 ± 0.0
0.64CysAsp: 0.64 ± 0.199
0.427CysGlu: 0.427 ± 0.134
0.107CysPhe: 0.107 ± 0.077
1.173CysGly: 1.173 ± 0.323
0.373CysHis: 0.373 ± 0.118
0.107CysIle: 0.107 ± 0.071
0.16CysLys: 0.16 ± 0.089
0.16CysLeu: 0.16 ± 0.096
0.053CysMet: 0.053 ± 0.052
0.107CysAsn: 0.107 ± 0.071
0.8CysPro: 0.8 ± 0.2
0.32CysGln: 0.32 ± 0.13
0.587CysArg: 0.587 ± 0.192
0.427CysSer: 0.427 ± 0.155
0.48CysThr: 0.48 ± 0.187
0.693CysVal: 0.693 ± 0.206
0.053CysTrp: 0.053 ± 0.055
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.212AspAla: 8.212 ± 0.722
0.48AspCys: 0.48 ± 0.192
7.306AspAsp: 7.306 ± 0.947
6.293AspGlu: 6.293 ± 0.891
1.173AspPhe: 1.173 ± 0.291
6.506AspGly: 6.506 ± 0.701
1.653AspHis: 1.653 ± 0.322
1.973AspIle: 1.973 ± 0.347
1.44AspLys: 1.44 ± 0.29
5.226AspLeu: 5.226 ± 0.507
1.653AspMet: 1.653 ± 0.241
1.92AspAsn: 1.92 ± 0.351
7.146AspPro: 7.146 ± 0.886
2.08AspGln: 2.08 ± 0.451
5.066AspArg: 5.066 ± 0.636
2.72AspSer: 2.72 ± 0.405
3.893AspThr: 3.893 ± 0.487
6.559AspVal: 6.559 ± 0.749
1.706AspTrp: 1.706 ± 0.358
1.76AspTyr: 1.76 ± 0.346
0.0AspXaa: 0.0 ± 0.0
Glu
5.493GluAla: 5.493 ± 0.568
0.693GluCys: 0.693 ± 0.22
3.093GluAsp: 3.093 ± 0.57
1.493GluGlu: 1.493 ± 0.235
1.973GluPhe: 1.973 ± 0.347
3.733GluGly: 3.733 ± 0.489
2.346GluHis: 2.346 ± 0.344
2.506GluIle: 2.506 ± 0.324
1.333GluLys: 1.333 ± 0.371
5.066GluLeu: 5.066 ± 0.661
1.12GluMet: 1.12 ± 0.23
1.706GluAsn: 1.706 ± 0.226
3.146GluPro: 3.146 ± 0.588
3.893GluGln: 3.893 ± 0.518
4.32GluArg: 4.32 ± 0.641
2.773GluSer: 2.773 ± 0.496
3.146GluThr: 3.146 ± 0.504
4.373GluVal: 4.373 ± 0.549
1.813GluTrp: 1.813 ± 0.341
1.44GluTyr: 1.44 ± 0.311
0.0GluXaa: 0.0 ± 0.0
Phe
3.306PheAla: 3.306 ± 0.433
0.267PheCys: 0.267 ± 0.134
2.88PheAsp: 2.88 ± 0.59
1.653PheGlu: 1.653 ± 0.322
0.693PhePhe: 0.693 ± 0.241
2.88PheGly: 2.88 ± 0.375
0.533PheHis: 0.533 ± 0.138
1.173PheIle: 1.173 ± 0.26
0.8PheLys: 0.8 ± 0.188
1.387PheLeu: 1.387 ± 0.281
0.64PheMet: 0.64 ± 0.15
1.013PheAsn: 1.013 ± 0.263
1.067PhePro: 1.067 ± 0.241
0.587PheGln: 0.587 ± 0.152
0.907PheArg: 0.907 ± 0.246
0.96PheSer: 0.96 ± 0.257
1.813PheThr: 1.813 ± 0.321
2.08PheVal: 2.08 ± 0.243
0.32PheTrp: 0.32 ± 0.131
0.213PheTyr: 0.213 ± 0.095
0.0PheXaa: 0.0 ± 0.0
Gly
8.639GlyAla: 8.639 ± 0.904
0.533GlyCys: 0.533 ± 0.207
6.506GlyAsp: 6.506 ± 0.654
4.32GlyGlu: 4.32 ± 0.533
2.4GlyPhe: 2.4 ± 0.37
8.266GlyGly: 8.266 ± 1.145
2.293GlyHis: 2.293 ± 0.418
4.266GlyIle: 4.266 ± 0.437
3.52GlyLys: 3.52 ± 0.483
6.186GlyLeu: 6.186 ± 0.847
1.813GlyMet: 1.813 ± 0.258
2.56GlyAsn: 2.56 ± 0.479
3.893GlyPro: 3.893 ± 0.514
3.306GlyGln: 3.306 ± 0.491
6.079GlyArg: 6.079 ± 0.539
5.173GlySer: 5.173 ± 0.604
5.226GlyThr: 5.226 ± 0.75
7.679GlyVal: 7.679 ± 0.61
1.493GlyTrp: 1.493 ± 0.273
1.813GlyTyr: 1.813 ± 0.345
0.0GlyXaa: 0.0 ± 0.0
His
2.346HisAla: 2.346 ± 0.416
0.16HisCys: 0.16 ± 0.096
2.026HisAsp: 2.026 ± 0.337
1.333HisGlu: 1.333 ± 0.311
0.48HisPhe: 0.48 ± 0.156
1.44HisGly: 1.44 ± 0.261
0.32HisHis: 0.32 ± 0.126
0.96HisIle: 0.96 ± 0.227
0.427HisLys: 0.427 ± 0.132
1.813HisLeu: 1.813 ± 0.282
0.533HisMet: 0.533 ± 0.182
0.48HisAsn: 0.48 ± 0.151
1.173HisPro: 1.173 ± 0.243
0.853HisGln: 0.853 ± 0.188
1.706HisArg: 1.706 ± 0.258
0.907HisSer: 0.907 ± 0.244
1.653HisThr: 1.653 ± 0.326
1.76HisVal: 1.76 ± 0.322
0.373HisTrp: 0.373 ± 0.145
0.587HisTyr: 0.587 ± 0.159
0.0HisXaa: 0.0 ± 0.0
Ile
6.026IleAla: 6.026 ± 0.519
0.267IleCys: 0.267 ± 0.124
3.84IleAsp: 3.84 ± 0.48
3.626IleGlu: 3.626 ± 0.468
0.48IlePhe: 0.48 ± 0.211
5.333IleGly: 5.333 ± 1.015
0.747IleHis: 0.747 ± 0.193
2.24IleIle: 2.24 ± 0.504
0.96IleLys: 0.96 ± 0.365
2.4IleLeu: 2.4 ± 0.346
0.64IleMet: 0.64 ± 0.221
0.8IleAsn: 0.8 ± 0.279
2.666IlePro: 2.666 ± 0.332
1.547IleGln: 1.547 ± 0.355
2.986IleArg: 2.986 ± 0.422
2.186IleSer: 2.186 ± 0.391
3.36IleThr: 3.36 ± 0.425
3.253IleVal: 3.253 ± 0.362
0.693IleTrp: 0.693 ± 0.194
0.96IleTyr: 0.96 ± 0.219
0.0IleXaa: 0.0 ± 0.0
Lys
2.666LysAla: 2.666 ± 0.447
0.107LysCys: 0.107 ± 0.072
0.96LysAsp: 0.96 ± 0.225
0.587LysGlu: 0.587 ± 0.161
1.067LysPhe: 1.067 ± 0.278
1.6LysGly: 1.6 ± 0.32
0.587LysHis: 0.587 ± 0.156
1.44LysIle: 1.44 ± 0.265
0.533LysLys: 0.533 ± 0.157
2.453LysLeu: 2.453 ± 0.354
0.48LysMet: 0.48 ± 0.154
0.8LysAsn: 0.8 ± 0.254
2.026LysPro: 2.026 ± 0.398
0.907LysGln: 0.907 ± 0.212
2.24LysArg: 2.24 ± 0.402
1.866LysSer: 1.866 ± 0.375
2.026LysThr: 2.026 ± 0.279
2.133LysVal: 2.133 ± 0.345
0.427LysTrp: 0.427 ± 0.159
0.907LysTyr: 0.907 ± 0.253
0.0LysXaa: 0.0 ± 0.0
Leu
9.546LeuAla: 9.546 ± 0.916
0.533LeuCys: 0.533 ± 0.161
5.599LeuAsp: 5.599 ± 0.72
2.4LeuGlu: 2.4 ± 0.387
2.133LeuPhe: 2.133 ± 0.343
7.093LeuGly: 7.093 ± 1.098
1.76LeuHis: 1.76 ± 0.352
3.04LeuIle: 3.04 ± 0.407
1.227LeuLys: 1.227 ± 0.253
6.133LeuLeu: 6.133 ± 0.665
1.493LeuMet: 1.493 ± 0.279
2.026LeuAsn: 2.026 ± 0.281
5.386LeuPro: 5.386 ± 0.667
3.2LeuGln: 3.2 ± 0.378
6.026LeuArg: 6.026 ± 0.489
3.68LeuSer: 3.68 ± 0.433
5.706LeuThr: 5.706 ± 0.542
5.813LeuVal: 5.813 ± 0.553
1.866LeuTrp: 1.866 ± 0.338
1.44LeuTyr: 1.44 ± 0.285
0.0LeuXaa: 0.0 ± 0.0
Met
1.92MetAla: 1.92 ± 0.346
0.213MetCys: 0.213 ± 0.105
1.067MetAsp: 1.067 ± 0.217
0.587MetGlu: 0.587 ± 0.226
0.427MetPhe: 0.427 ± 0.16
1.013MetGly: 1.013 ± 0.233
0.267MetHis: 0.267 ± 0.121
0.747MetIle: 0.747 ± 0.154
0.693MetLys: 0.693 ± 0.19
2.08MetLeu: 2.08 ± 0.315
0.587MetMet: 0.587 ± 0.186
0.533MetAsn: 0.533 ± 0.204
2.24MetPro: 2.24 ± 0.302
0.853MetGln: 0.853 ± 0.325
1.653MetArg: 1.653 ± 0.31
1.44MetSer: 1.44 ± 0.256
3.466MetThr: 3.466 ± 0.417
1.28MetVal: 1.28 ± 0.261
0.427MetTrp: 0.427 ± 0.127
0.16MetTyr: 0.16 ± 0.091
0.0MetXaa: 0.0 ± 0.0
Asn
3.84AsnAla: 3.84 ± 0.566
0.32AsnCys: 0.32 ± 0.124
1.973AsnAsp: 1.973 ± 0.339
1.493AsnGlu: 1.493 ± 0.311
0.693AsnPhe: 0.693 ± 0.205
2.773AsnGly: 2.773 ± 0.381
0.427AsnHis: 0.427 ± 0.123
0.8AsnIle: 0.8 ± 0.221
0.373AsnLys: 0.373 ± 0.157
2.186AsnLeu: 2.186 ± 0.449
0.64AsnMet: 0.64 ± 0.204
0.747AsnAsn: 0.747 ± 0.195
2.346AsnPro: 2.346 ± 0.388
0.96AsnGln: 0.96 ± 0.236
1.653AsnArg: 1.653 ± 0.278
1.067AsnSer: 1.067 ± 0.274
1.493AsnThr: 1.493 ± 0.268
1.493AsnVal: 1.493 ± 0.256
0.907AsnTrp: 0.907 ± 0.242
0.64AsnTyr: 0.64 ± 0.173
0.0AsnXaa: 0.0 ± 0.0
Pro
8.852ProAla: 8.852 ± 0.897
0.213ProCys: 0.213 ± 0.132
5.599ProAsp: 5.599 ± 0.776
3.093ProGlu: 3.093 ± 0.513
1.706ProPhe: 1.706 ± 0.299
4.853ProGly: 4.853 ± 0.44
0.853ProHis: 0.853 ± 0.239
3.413ProIle: 3.413 ± 0.422
1.706ProLys: 1.706 ± 0.329
4.266ProLeu: 4.266 ± 0.455
1.333ProMet: 1.333 ± 0.227
2.293ProAsn: 2.293 ± 0.404
4.533ProPro: 4.533 ± 0.699
2.4ProGln: 2.4 ± 0.383
3.413ProArg: 3.413 ± 0.465
3.733ProSer: 3.733 ± 0.425
4.266ProThr: 4.266 ± 0.623
4.959ProVal: 4.959 ± 0.617
1.013ProTrp: 1.013 ± 0.245
1.28ProTyr: 1.28 ± 0.201
0.0ProXaa: 0.0 ± 0.0
Gln
5.173GlnAla: 5.173 ± 0.556
0.213GlnCys: 0.213 ± 0.111
1.28GlnAsp: 1.28 ± 0.329
0.853GlnGlu: 0.853 ± 0.249
1.28GlnPhe: 1.28 ± 0.218
1.92GlnGly: 1.92 ± 0.308
0.96GlnHis: 0.96 ± 0.213
1.76GlnIle: 1.76 ± 0.421
0.96GlnLys: 0.96 ± 0.197
3.626GlnLeu: 3.626 ± 0.409
0.907GlnMet: 0.907 ± 0.249
0.8GlnAsn: 0.8 ± 0.218
2.72GlnPro: 2.72 ± 0.338
2.613GlnGln: 2.613 ± 0.414
3.68GlnArg: 3.68 ± 0.539
1.547GlnSer: 1.547 ± 0.281
2.026GlnThr: 2.026 ± 0.269
2.986GlnVal: 2.986 ± 0.413
0.96GlnTrp: 0.96 ± 0.196
0.907GlnTyr: 0.907 ± 0.196
0.0GlnXaa: 0.0 ± 0.0
Arg
9.226ArgAla: 9.226 ± 0.71
0.427ArgCys: 0.427 ± 0.154
4.799ArgAsp: 4.799 ± 0.489
3.893ArgGlu: 3.893 ± 0.544
1.973ArgPhe: 1.973 ± 0.363
4.853ArgGly: 4.853 ± 0.591
1.6ArgHis: 1.6 ± 0.366
3.786ArgIle: 3.786 ± 0.454
2.026ArgLys: 2.026 ± 0.361
5.066ArgLeu: 5.066 ± 0.541
2.24ArgMet: 2.24 ± 0.287
2.08ArgAsn: 2.08 ± 0.315
3.84ArgPro: 3.84 ± 0.486
2.346ArgGln: 2.346 ± 0.361
8.426ArgArg: 8.426 ± 1.099
3.2ArgSer: 3.2 ± 0.363
4.106ArgThr: 4.106 ± 0.529
5.759ArgVal: 5.759 ± 0.805
1.866ArgTrp: 1.866 ± 0.313
1.92ArgTyr: 1.92 ± 0.405
0.0ArgXaa: 0.0 ± 0.0
Ser
5.493SerAla: 5.493 ± 0.566
0.587SerCys: 0.587 ± 0.201
3.68SerAsp: 3.68 ± 0.416
2.453SerGlu: 2.453 ± 0.451
0.96SerPhe: 0.96 ± 0.243
5.759SerGly: 5.759 ± 0.757
0.853SerHis: 0.853 ± 0.217
2.24SerIle: 2.24 ± 0.442
1.173SerLys: 1.173 ± 0.27
3.52SerLeu: 3.52 ± 0.42
0.96SerMet: 0.96 ± 0.243
1.067SerAsn: 1.067 ± 0.251
2.933SerPro: 2.933 ± 0.395
0.96SerGln: 0.96 ± 0.262
3.733SerArg: 3.733 ± 0.518
2.773SerSer: 2.773 ± 0.491
4.213SerThr: 4.213 ± 0.545
3.466SerVal: 3.466 ± 0.37
1.12SerTrp: 1.12 ± 0.245
1.28SerTyr: 1.28 ± 0.31
0.0SerXaa: 0.0 ± 0.0
Thr
9.652ThrAla: 9.652 ± 0.872
0.907ThrCys: 0.907 ± 0.264
5.546ThrAsp: 5.546 ± 0.549
3.04ThrGlu: 3.04 ± 0.465
1.227ThrPhe: 1.227 ± 0.258
6.133ThrGly: 6.133 ± 0.75
1.227ThrHis: 1.227 ± 0.285
2.88ThrIle: 2.88 ± 0.405
1.813ThrLys: 1.813 ± 0.317
5.439ThrLeu: 5.439 ± 0.58
1.173ThrMet: 1.173 ± 0.248
1.76ThrAsn: 1.76 ± 0.308
5.066ThrPro: 5.066 ± 0.486
1.227ThrGln: 1.227 ± 0.263
3.626ThrArg: 3.626 ± 0.431
3.68ThrSer: 3.68 ± 0.387
4.213ThrThr: 4.213 ± 0.595
5.013ThrVal: 5.013 ± 0.643
1.227ThrTrp: 1.227 ± 0.262
1.6ThrTyr: 1.6 ± 0.264
0.0ThrXaa: 0.0 ± 0.0
Val
8.479ValAla: 8.479 ± 0.775
0.853ValCys: 0.853 ± 0.219
7.306ValAsp: 7.306 ± 0.63
5.279ValGlu: 5.279 ± 0.577
1.92ValPhe: 1.92 ± 0.284
6.773ValGly: 6.773 ± 0.63
1.547ValHis: 1.547 ± 0.27
3.573ValIle: 3.573 ± 0.413
1.6ValLys: 1.6 ± 0.256
5.973ValLeu: 5.973 ± 0.61
1.227ValMet: 1.227 ± 0.227
2.56ValAsn: 2.56 ± 0.405
3.786ValPro: 3.786 ± 0.506
3.253ValGln: 3.253 ± 0.384
4.533ValArg: 4.533 ± 0.502
3.52ValSer: 3.52 ± 0.445
5.599ValThr: 5.599 ± 0.689
6.026ValVal: 6.026 ± 0.609
1.866ValTrp: 1.866 ± 0.214
2.293ValTyr: 2.293 ± 0.407
0.0ValXaa: 0.0 ± 0.0
Trp
2.186TrpAla: 2.186 ± 0.388
0.267TrpCys: 0.267 ± 0.103
1.067TrpAsp: 1.067 ± 0.179
1.12TrpGlu: 1.12 ± 0.243
0.747TrpPhe: 0.747 ± 0.175
1.333TrpGly: 1.333 ± 0.274
0.373TrpHis: 0.373 ± 0.139
0.853TrpIle: 0.853 ± 0.272
0.96TrpLys: 0.96 ± 0.231
2.453TrpLeu: 2.453 ± 0.379
0.96TrpMet: 0.96 ± 0.249
0.693TrpAsn: 0.693 ± 0.212
1.12TrpPro: 1.12 ± 0.203
1.013TrpGln: 1.013 ± 0.205
1.866TrpArg: 1.866 ± 0.33
1.067TrpSer: 1.067 ± 0.241
1.067TrpThr: 1.067 ± 0.299
1.866TrpVal: 1.866 ± 0.307
0.373TrpTrp: 0.373 ± 0.165
0.427TrpTyr: 0.427 ± 0.15
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.826TyrAla: 2.826 ± 0.45
0.267TyrCys: 0.267 ± 0.129
1.547TyrAsp: 1.547 ± 0.301
1.813TyrGlu: 1.813 ± 0.343
0.747TyrPhe: 0.747 ± 0.191
1.706TyrGly: 1.706 ± 0.248
0.64TyrHis: 0.64 ± 0.217
0.747TyrIle: 0.747 ± 0.176
0.533TyrLys: 0.533 ± 0.157
1.653TyrLeu: 1.653 ± 0.309
0.533TyrMet: 0.533 ± 0.129
0.213TyrAsn: 0.213 ± 0.111
1.067TyrPro: 1.067 ± 0.298
0.64TyrGln: 0.64 ± 0.186
2.186TyrArg: 2.186 ± 0.38
0.96TyrSer: 0.96 ± 0.215
1.28TyrThr: 1.28 ± 0.324
2.026TyrVal: 2.026 ± 0.376
0.427TyrTrp: 0.427 ± 0.136
0.267TyrTyr: 0.267 ± 0.117
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 88 proteins (18753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski