Amino acid dipepetide frequency for Streptococcus satellite phage Javan747

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.708AlaAla: 0.708 ± 0.618
0.0AlaCys: 0.0 ± 0.0
3.188AlaAsp: 3.188 ± 0.948
4.605AlaGlu: 4.605 ± 1.264
2.48AlaPhe: 2.48 ± 1.139
1.771AlaGly: 1.771 ± 0.873
0.354AlaHis: 0.354 ± 0.409
3.897AlaIle: 3.897 ± 1.002
4.251AlaLys: 4.251 ± 1.155
7.793AlaLeu: 7.793 ± 1.375
1.063AlaMet: 1.063 ± 0.664
1.417AlaAsn: 1.417 ± 0.555
0.354AlaPro: 0.354 ± 0.3
1.417AlaGln: 1.417 ± 0.742
5.668AlaArg: 5.668 ± 1.2
2.125AlaSer: 2.125 ± 0.916
2.834AlaThr: 2.834 ± 1.131
4.605AlaVal: 4.605 ± 0.843
0.354AlaTrp: 0.354 ± 0.409
0.354AlaTyr: 0.354 ± 0.3
0.0AlaXaa: 0.0 ± 0.0
Cys
0.354CysAla: 0.354 ± 0.306
0.0CysCys: 0.0 ± 0.0
0.708CysAsp: 0.708 ± 0.503
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.063CysGly: 1.063 ± 0.742
0.708CysHis: 0.708 ± 0.349
0.708CysIle: 0.708 ± 0.611
0.354CysLys: 0.354 ± 0.334
1.417CysLeu: 1.417 ± 0.568
0.354CysMet: 0.354 ± 0.372
0.354CysAsn: 0.354 ± 0.306
0.708CysPro: 0.708 ± 0.452
0.708CysGln: 0.708 ± 0.541
0.708CysArg: 0.708 ± 0.458
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.354CysVal: 0.354 ± 0.409
0.0CysTrp: 0.0 ± 0.0
0.708CysTyr: 0.708 ± 0.563
0.0CysXaa: 0.0 ± 0.0
Asp
0.354AspAla: 0.354 ± 0.308
1.063AspCys: 1.063 ± 0.689
3.542AspAsp: 3.542 ± 0.923
4.251AspGlu: 4.251 ± 1.19
4.959AspPhe: 4.959 ± 1.38
5.313AspGly: 5.313 ± 1.366
0.0AspHis: 0.0 ± 0.0
6.73AspIle: 6.73 ± 1.122
6.73AspLys: 6.73 ± 1.35
8.147AspLeu: 8.147 ± 2.228
2.125AspMet: 2.125 ± 0.893
2.48AspAsn: 2.48 ± 1.052
1.771AspPro: 1.771 ± 0.825
1.417AspGln: 1.417 ± 0.658
3.542AspArg: 3.542 ± 1.118
3.188AspSer: 3.188 ± 0.936
2.48AspThr: 2.48 ± 0.872
2.834AspVal: 2.834 ± 1.301
0.0AspTrp: 0.0 ± 0.0
2.834AspTyr: 2.834 ± 1.285
0.0AspXaa: 0.0 ± 0.0
Glu
5.313GluAla: 5.313 ± 1.36
0.708GluCys: 0.708 ± 0.47
3.897GluAsp: 3.897 ± 1.361
6.022GluGlu: 6.022 ± 1.39
2.834GluPhe: 2.834 ± 1.14
3.897GluGly: 3.897 ± 0.978
1.417GluHis: 1.417 ± 0.616
7.439GluIle: 7.439 ± 1.539
5.313GluLys: 5.313 ± 1.515
9.919GluLeu: 9.919 ± 1.135
1.771GluMet: 1.771 ± 0.972
4.959GluAsn: 4.959 ± 1.558
2.48GluPro: 2.48 ± 1.183
4.251GluGln: 4.251 ± 1.423
6.376GluArg: 6.376 ± 1.293
4.251GluSer: 4.251 ± 1.651
4.605GluThr: 4.605 ± 0.947
4.605GluVal: 4.605 ± 1.408
0.708GluTrp: 0.708 ± 0.349
3.542GluTyr: 3.542 ± 1.036
0.0GluXaa: 0.0 ± 0.0
Phe
1.417PheAla: 1.417 ± 0.87
0.0PheCys: 0.0 ± 0.0
4.605PheAsp: 4.605 ± 1.016
1.417PheGlu: 1.417 ± 0.936
1.063PhePhe: 1.063 ± 0.472
2.125PheGly: 2.125 ± 0.727
0.708PheHis: 0.708 ± 0.349
4.605PheIle: 4.605 ± 1.368
2.834PheLys: 2.834 ± 1.18
4.959PheLeu: 4.959 ± 1.143
0.708PheMet: 0.708 ± 0.75
2.834PheAsn: 2.834 ± 0.836
0.354PhePro: 0.354 ± 0.325
2.48PheGln: 2.48 ± 0.797
2.48PheArg: 2.48 ± 0.936
3.542PheSer: 3.542 ± 0.803
2.125PheThr: 2.125 ± 0.612
1.063PheVal: 1.063 ± 0.528
0.354PheTrp: 0.354 ± 0.325
3.188PheTyr: 3.188 ± 1.063
0.0PheXaa: 0.0 ± 0.0
Gly
1.771GlyAla: 1.771 ± 0.909
0.708GlyCys: 0.708 ± 0.492
3.897GlyAsp: 3.897 ± 1.256
3.188GlyGlu: 3.188 ± 1.13
3.188GlyPhe: 3.188 ± 0.87
3.188GlyGly: 3.188 ± 1.317
1.063GlyHis: 1.063 ± 0.438
1.771GlyIle: 1.771 ± 0.935
4.251GlyLys: 4.251 ± 1.302
5.668GlyLeu: 5.668 ± 1.37
2.125GlyMet: 2.125 ± 0.699
2.125GlyAsn: 2.125 ± 0.687
0.354GlyPro: 0.354 ± 0.308
2.48GlyGln: 2.48 ± 0.717
3.897GlyArg: 3.897 ± 1.117
2.125GlySer: 2.125 ± 0.839
5.313GlyThr: 5.313 ± 1.233
3.897GlyVal: 3.897 ± 1.389
1.417GlyTrp: 1.417 ± 0.96
2.48GlyTyr: 2.48 ± 1.055
0.0GlyXaa: 0.0 ± 0.0
His
1.063HisAla: 1.063 ± 0.924
0.0HisCys: 0.0 ± 0.0
1.417HisAsp: 1.417 ± 0.768
1.063HisGlu: 1.063 ± 0.644
0.354HisPhe: 0.354 ± 0.306
1.063HisGly: 1.063 ± 0.509
0.0HisHis: 0.0 ± 0.0
0.354HisIle: 0.354 ± 0.308
1.063HisLys: 1.063 ± 0.706
1.417HisLeu: 1.417 ± 0.698
0.0HisMet: 0.0 ± 0.0
0.708HisAsn: 0.708 ± 0.556
0.354HisPro: 0.354 ± 0.359
1.063HisGln: 1.063 ± 0.668
1.771HisArg: 1.771 ± 0.927
0.708HisSer: 0.708 ± 0.427
0.708HisThr: 0.708 ± 0.616
0.354HisVal: 0.354 ± 0.306
0.0HisTrp: 0.0 ± 0.0
1.771HisTyr: 1.771 ± 0.706
0.0HisXaa: 0.0 ± 0.0
Ile
4.605IleAla: 4.605 ± 1.29
1.417IleCys: 1.417 ± 0.673
6.73IleAsp: 6.73 ± 2.857
6.022IleGlu: 6.022 ± 1.713
2.48IlePhe: 2.48 ± 0.796
3.188IleGly: 3.188 ± 1.001
1.417IleHis: 1.417 ± 0.787
3.542IleIle: 3.542 ± 0.904
4.605IleLys: 4.605 ± 1.091
3.542IleLeu: 3.542 ± 0.93
0.354IleMet: 0.354 ± 0.352
2.834IleAsn: 2.834 ± 1.242
3.542IlePro: 3.542 ± 1.21
2.48IleGln: 2.48 ± 0.733
2.834IleArg: 2.834 ± 1.155
7.439IleSer: 7.439 ± 2.015
3.897IleThr: 3.897 ± 0.877
3.542IleVal: 3.542 ± 0.781
0.354IleTrp: 0.354 ± 0.306
1.771IleTyr: 1.771 ± 0.927
0.0IleXaa: 0.0 ± 0.0
Lys
7.439LysAla: 7.439 ± 1.925
0.0LysCys: 0.0 ± 0.0
2.48LysAsp: 2.48 ± 1.175
8.147LysGlu: 8.147 ± 1.286
3.188LysPhe: 3.188 ± 0.853
4.605LysGly: 4.605 ± 1.388
3.188LysHis: 3.188 ± 1.133
3.897LysIle: 3.897 ± 1.25
7.793LysLys: 7.793 ± 1.655
9.21LysLeu: 9.21 ± 1.511
3.188LysMet: 3.188 ± 1.279
4.959LysAsn: 4.959 ± 1.198
3.188LysPro: 3.188 ± 1.354
3.897LysGln: 3.897 ± 0.976
6.376LysArg: 6.376 ± 1.852
4.251LysSer: 4.251 ± 0.996
5.313LysThr: 5.313 ± 1.761
4.959LysVal: 4.959 ± 0.885
0.708LysTrp: 0.708 ± 0.412
4.251LysTyr: 4.251 ± 1.347
0.0LysXaa: 0.0 ± 0.0
Leu
5.313LeuAla: 5.313 ± 1.322
1.417LeuCys: 1.417 ± 0.724
12.398LeuAsp: 12.398 ± 1.643
12.752LeuGlu: 12.752 ± 2.019
2.48LeuPhe: 2.48 ± 1.001
3.897LeuGly: 3.897 ± 1.41
1.063LeuHis: 1.063 ± 0.611
5.313LeuIle: 5.313 ± 2.042
9.21LeuLys: 9.21 ± 1.771
9.564LeuLeu: 9.564 ± 1.438
3.188LeuMet: 3.188 ± 0.855
6.022LeuAsn: 6.022 ± 1.536
3.542LeuPro: 3.542 ± 1.153
3.188LeuGln: 3.188 ± 0.856
3.897LeuArg: 3.897 ± 1.549
4.605LeuSer: 4.605 ± 0.872
5.668LeuThr: 5.668 ± 1.421
3.188LeuVal: 3.188 ± 1.063
1.063LeuTrp: 1.063 ± 0.613
4.959LeuTyr: 4.959 ± 0.889
0.0LeuXaa: 0.0 ± 0.0
Met
1.771MetAla: 1.771 ± 0.936
0.0MetCys: 0.0 ± 0.0
1.063MetAsp: 1.063 ± 0.709
3.542MetGlu: 3.542 ± 1.296
1.063MetPhe: 1.063 ± 0.559
3.188MetGly: 3.188 ± 0.937
0.0MetHis: 0.0 ± 0.0
1.771MetIle: 1.771 ± 0.868
2.48MetLys: 2.48 ± 1.082
1.771MetLeu: 1.771 ± 0.665
1.063MetMet: 1.063 ± 0.608
2.48MetAsn: 2.48 ± 1.023
0.708MetPro: 0.708 ± 0.388
0.0MetGln: 0.0 ± 0.0
1.063MetArg: 1.063 ± 0.564
1.063MetSer: 1.063 ± 0.547
4.251MetThr: 4.251 ± 1.73
1.063MetVal: 1.063 ± 0.682
0.354MetTrp: 0.354 ± 0.306
0.354MetTyr: 0.354 ± 0.357
0.0MetXaa: 0.0 ± 0.0
Asn
2.48AsnAla: 2.48 ± 1.041
0.0AsnCys: 0.0 ± 0.0
4.251AsnAsp: 4.251 ± 1.679
3.188AsnGlu: 3.188 ± 0.947
2.125AsnPhe: 2.125 ± 0.583
4.251AsnGly: 4.251 ± 1.291
1.063AsnHis: 1.063 ± 0.664
2.834AsnIle: 2.834 ± 0.965
6.022AsnLys: 6.022 ± 1.731
4.251AsnLeu: 4.251 ± 0.947
1.417AsnMet: 1.417 ± 0.728
2.125AsnAsn: 2.125 ± 0.725
1.771AsnPro: 1.771 ± 0.723
2.125AsnGln: 2.125 ± 1.034
2.125AsnArg: 2.125 ± 0.882
2.834AsnSer: 2.834 ± 0.936
2.48AsnThr: 2.48 ± 0.928
1.771AsnVal: 1.771 ± 0.834
0.354AsnTrp: 0.354 ± 0.308
2.48AsnTyr: 2.48 ± 0.866
0.0AsnXaa: 0.0 ± 0.0
Pro
1.771ProAla: 1.771 ± 0.774
0.354ProCys: 0.354 ± 0.306
2.125ProAsp: 2.125 ± 0.855
3.188ProGlu: 3.188 ± 1.034
1.771ProPhe: 1.771 ± 0.908
1.063ProGly: 1.063 ± 0.704
0.0ProHis: 0.0 ± 0.0
2.125ProIle: 2.125 ± 0.632
2.125ProLys: 2.125 ± 0.646
1.417ProLeu: 1.417 ± 0.641
1.063ProMet: 1.063 ± 0.514
1.771ProAsn: 1.771 ± 0.896
1.771ProPro: 1.771 ± 0.89
0.354ProGln: 0.354 ± 0.306
3.897ProArg: 3.897 ± 1.067
1.063ProSer: 1.063 ± 0.606
0.708ProThr: 0.708 ± 0.523
1.771ProVal: 1.771 ± 1.001
0.0ProTrp: 0.0 ± 0.0
1.771ProTyr: 1.771 ± 0.597
0.0ProXaa: 0.0 ± 0.0
Gln
2.834GlnAla: 2.834 ± 1.097
0.0GlnCys: 0.0 ± 0.0
1.063GlnAsp: 1.063 ± 0.711
3.188GlnGlu: 3.188 ± 0.944
1.417GlnPhe: 1.417 ± 0.741
2.834GlnGly: 2.834 ± 0.983
0.0GlnHis: 0.0 ± 0.0
1.771GlnIle: 1.771 ± 0.885
4.251GlnLys: 4.251 ± 0.992
3.542GlnLeu: 3.542 ± 1.232
0.354GlnMet: 0.354 ± 0.398
1.063GlnAsn: 1.063 ± 0.77
1.417GlnPro: 1.417 ± 0.754
0.708GlnGln: 0.708 ± 0.566
1.771GlnArg: 1.771 ± 0.795
1.771GlnSer: 1.771 ± 0.52
1.417GlnThr: 1.417 ± 0.529
3.188GlnVal: 3.188 ± 0.672
1.063GlnTrp: 1.063 ± 0.442
1.063GlnTyr: 1.063 ± 0.535
0.0GlnXaa: 0.0 ± 0.0
Arg
3.542ArgAla: 3.542 ± 1.094
0.708ArgCys: 0.708 ± 0.492
2.125ArgAsp: 2.125 ± 0.751
5.313ArgGlu: 5.313 ± 1.528
4.251ArgPhe: 4.251 ± 0.962
3.542ArgGly: 3.542 ± 1.237
0.708ArgHis: 0.708 ± 0.349
4.959ArgIle: 4.959 ± 0.847
4.959ArgLys: 4.959 ± 1.437
7.085ArgLeu: 7.085 ± 1.47
2.125ArgMet: 2.125 ± 1.018
2.834ArgAsn: 2.834 ± 0.995
1.063ArgPro: 1.063 ± 0.541
0.708ArgGln: 0.708 ± 0.432
2.48ArgArg: 2.48 ± 1.063
1.771ArgSer: 1.771 ± 0.553
3.188ArgThr: 3.188 ± 0.862
2.834ArgVal: 2.834 ± 1.118
0.708ArgTrp: 0.708 ± 0.444
4.251ArgTyr: 4.251 ± 1.431
0.0ArgXaa: 0.0 ± 0.0
Ser
1.771SerAla: 1.771 ± 0.875
0.708SerCys: 0.708 ± 0.458
2.834SerAsp: 2.834 ± 0.969
4.605SerGlu: 4.605 ± 2.048
2.48SerPhe: 2.48 ± 0.921
3.542SerGly: 3.542 ± 0.775
0.354SerHis: 0.354 ± 0.308
3.897SerIle: 3.897 ± 1.549
3.542SerLys: 3.542 ± 1.257
5.668SerLeu: 5.668 ± 1.358
1.771SerMet: 1.771 ± 0.829
4.251SerAsn: 4.251 ± 1.601
1.417SerPro: 1.417 ± 0.757
2.48SerGln: 2.48 ± 0.939
2.125SerArg: 2.125 ± 0.842
2.834SerSer: 2.834 ± 0.961
2.834SerThr: 2.834 ± 0.831
2.48SerVal: 2.48 ± 0.668
0.354SerTrp: 0.354 ± 0.332
2.48SerTyr: 2.48 ± 0.778
0.0SerXaa: 0.0 ± 0.0
Thr
1.771ThrAla: 1.771 ± 0.893
0.708ThrCys: 0.708 ± 0.497
2.834ThrAsp: 2.834 ± 1.099
2.834ThrGlu: 2.834 ± 0.861
2.834ThrPhe: 2.834 ± 0.865
2.125ThrGly: 2.125 ± 0.986
1.417ThrHis: 1.417 ± 0.508
2.834ThrIle: 2.834 ± 1.076
7.439ThrLys: 7.439 ± 1.816
5.668ThrLeu: 5.668 ± 1.704
2.48ThrMet: 2.48 ± 0.889
1.063ThrAsn: 1.063 ± 0.569
1.417ThrPro: 1.417 ± 0.628
1.771ThrGln: 1.771 ± 0.853
1.771ThrArg: 1.771 ± 0.478
3.188ThrSer: 3.188 ± 0.977
2.48ThrThr: 2.48 ± 1.01
4.251ThrVal: 4.251 ± 1.511
0.354ThrTrp: 0.354 ± 0.3
5.313ThrTyr: 5.313 ± 1.962
0.0ThrXaa: 0.0 ± 0.0
Val
2.834ValAla: 2.834 ± 1.151
0.354ValCys: 0.354 ± 0.306
2.125ValAsp: 2.125 ± 0.802
6.376ValGlu: 6.376 ± 1.253
1.417ValPhe: 1.417 ± 0.842
2.48ValGly: 2.48 ± 1.257
0.0ValHis: 0.0 ± 0.0
4.251ValIle: 4.251 ± 1.485
4.605ValLys: 4.605 ± 1.442
5.668ValLeu: 5.668 ± 1.238
2.125ValMet: 2.125 ± 0.993
3.188ValAsn: 3.188 ± 0.934
2.125ValPro: 2.125 ± 0.715
1.063ValGln: 1.063 ± 0.621
2.125ValArg: 2.125 ± 0.874
2.48ValSer: 2.48 ± 0.875
2.48ValThr: 2.48 ± 0.98
3.188ValVal: 3.188 ± 1.003
1.417ValTrp: 1.417 ± 0.716
2.48ValTyr: 2.48 ± 0.634
0.0ValXaa: 0.0 ± 0.0
Trp
0.354TrpAla: 0.354 ± 0.308
0.0TrpCys: 0.0 ± 0.0
0.708TrpAsp: 0.708 ± 0.681
1.771TrpGlu: 1.771 ± 0.791
0.708TrpPhe: 0.708 ± 0.452
1.063TrpGly: 1.063 ± 0.569
0.354TrpHis: 0.354 ± 0.306
0.0TrpIle: 0.0 ± 0.0
0.354TrpLys: 0.354 ± 0.409
1.063TrpLeu: 1.063 ± 0.472
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.708TrpGln: 0.708 ± 0.454
0.354TrpArg: 0.354 ± 0.306
1.063TrpSer: 1.063 ± 0.522
0.354TrpThr: 0.354 ± 0.332
1.063TrpVal: 1.063 ± 0.63
0.0TrpTrp: 0.0 ± 0.0
0.354TrpTyr: 0.354 ± 0.306
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.771TyrAla: 1.771 ± 0.76
1.063TyrCys: 1.063 ± 0.529
1.771TyrAsp: 1.771 ± 0.672
2.834TyrGlu: 2.834 ± 1.356
2.125TyrPhe: 2.125 ± 1.123
0.708TyrGly: 0.708 ± 0.68
1.417TyrHis: 1.417 ± 0.6
3.897TyrIle: 3.897 ± 1.445
8.856TyrLys: 8.856 ± 2.21
4.959TyrLeu: 4.959 ± 1.27
1.417TyrMet: 1.417 ± 0.734
2.48TyrAsn: 2.48 ± 0.755
1.771TyrPro: 1.771 ± 0.971
1.417TyrGln: 1.417 ± 0.708
3.897TyrArg: 3.897 ± 0.813
2.125TyrSer: 2.125 ± 0.615
1.417TyrThr: 1.417 ± 0.712
1.771TyrVal: 1.771 ± 0.705
0.708TyrTrp: 0.708 ± 0.464
0.708TyrTyr: 0.708 ± 0.464
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 22 proteins (2824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski