Amino acid dipepetide frequency for Tenacibaculum sp. SZ-18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.061AlaAla: 3.061 ± 0.074	0.488AlaCys: 0.488 ± 0.022	2.83AlaAsp: 2.83 ± 0.062	3.321AlaGlu: 3.321 ± 0.061	2.819AlaPhe: 2.819 ± 0.052	3.493AlaGly: 3.493 ± 0.089	0.886AlaHis: 0.886 ± 0.029	4.837AlaIle: 4.837 ± 0.072	4.435AlaLys: 4.435 ± 0.085	5.135AlaLeu: 5.135 ± 0.079	1.206AlaMet: 1.206 ± 0.037	3.267AlaAsn: 3.267 ± 0.054	1.584AlaPro: 1.584 ± 0.041	1.966AlaGln: 1.966 ± 0.041	1.763AlaArg: 1.763 ± 0.044	3.814AlaSer: 3.814 ± 0.071	3.384AlaThr: 3.384 ± 0.119	3.372AlaVal: 3.372 ± 0.055	0.486AlaTrp: 0.486 ± 0.022	2.144AlaTyr: 2.144 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.381CysAla: 0.381 ± 0.017	0.091CysCys: 0.091 ± 0.01	0.441CysAsp: 0.441 ± 0.027	0.416CysGlu: 0.416 ± 0.019	0.435CysPhe: 0.435 ± 0.021	0.553CysGly: 0.553 ± 0.024	0.168CysHis: 0.168 ± 0.012	0.575CysIle: 0.575 ± 0.024	0.575CysLys: 0.575 ± 0.022	0.601CysLeu: 0.601 ± 0.024	0.132CysMet: 0.132 ± 0.011	0.48CysAsn: 0.48 ± 0.021	0.273CysPro: 0.273 ± 0.022	0.208CysGln: 0.208 ± 0.013	0.188CysArg: 0.188 ± 0.012	0.575CysSer: 0.575 ± 0.029	0.416CysThr: 0.416 ± 0.04	0.397CysVal: 0.397 ± 0.024	0.065CysTrp: 0.065 ± 0.008	0.295CysTyr: 0.295 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.173AspAla: 3.173 ± 0.063	0.414AspCys: 0.414 ± 0.022	2.709AspAsp: 2.709 ± 0.063	3.757AspGlu: 3.757 ± 0.068	3.611AspPhe: 3.611 ± 0.061	3.432AspGly: 3.432 ± 0.079	0.794AspHis: 0.794 ± 0.025	4.577AspIle: 4.577 ± 0.068	4.44AspLys: 4.44 ± 0.074	5.292AspLeu: 5.292 ± 0.099	0.912AspMet: 0.912 ± 0.028	3.449AspAsn: 3.449 ± 0.075	1.562AspPro: 1.562 ± 0.049	1.458AspGln: 1.458 ± 0.038	1.793AspArg: 1.793 ± 0.041	3.516AspSer: 3.516 ± 0.065	2.61AspThr: 2.61 ± 0.059	3.44AspVal: 3.44 ± 0.069	0.697AspTrp: 0.697 ± 0.024	2.779AspTyr: 2.779 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	3.74GluAla: 3.74 ± 0.068	0.351GluCys: 0.351 ± 0.02	3.552GluAsp: 3.552 ± 0.059	5.252GluGlu: 5.252 ± 0.097	3.336GluPhe: 3.336 ± 0.055	3.505GluGly: 3.505 ± 0.062	1.025GluHis: 1.025 ± 0.034	6.034GluIle: 6.034 ± 0.082	6.588GluLys: 6.588 ± 0.101	6.766GluLeu: 6.766 ± 0.082	1.496GluMet: 1.496 ± 0.039	5.117GluAsn: 5.117 ± 0.081	1.392GluPro: 1.392 ± 0.042	2.186GluGln: 2.186 ± 0.048	2.532GluArg: 2.532 ± 0.052	3.591GluSer: 3.591 ± 0.06	3.511GluThr: 3.511 ± 0.06	4.335GluVal: 4.335 ± 0.061	0.605GluTrp: 0.605 ± 0.023	2.599GluTyr: 2.599 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	2.647PheAla: 2.647 ± 0.049	0.437PheCys: 0.437 ± 0.019	3.274PheAsp: 3.274 ± 0.058	3.49PheGlu: 3.49 ± 0.062	2.906PhePhe: 2.906 ± 0.064	3.586PheGly: 3.586 ± 0.065	0.852PheHis: 0.852 ± 0.032	4.324PheIle: 4.324 ± 0.08	4.325PheLys: 4.325 ± 0.069	4.998PheLeu: 4.998 ± 0.084	1.09PheMet: 1.09 ± 0.031	3.725PheAsn: 3.725 ± 0.066	1.658PhePro: 1.658 ± 0.04	1.517PheGln: 1.517 ± 0.038	1.681PheArg: 1.681 ± 0.045	4.386PheSer: 4.386 ± 0.07	3.181PheThr: 3.181 ± 0.076	3.068PheVal: 3.068 ± 0.051	0.623PheTrp: 0.623 ± 0.023	2.364PheTyr: 2.364 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	3.528GlyAla: 3.528 ± 0.072	0.579GlyCys: 0.579 ± 0.053	3.16GlyAsp: 3.16 ± 0.064	3.501GlyGlu: 3.501 ± 0.052	3.686GlyPhe: 3.686 ± 0.061	4.331GlyGly: 4.331 ± 0.112	0.959GlyHis: 0.959 ± 0.029	5.366GlyIle: 5.366 ± 0.082	5.069GlyLys: 5.069 ± 0.081	5.342GlyLeu: 5.342 ± 0.087	1.324GlyMet: 1.324 ± 0.04	3.943GlyAsn: 3.943 ± 0.076	1.132GlyPro: 1.132 ± 0.039	1.635GlyGln: 1.635 ± 0.042	1.976GlyArg: 1.976 ± 0.049	3.842GlySer: 3.842 ± 0.124	3.849GlyThr: 3.849 ± 0.119	4.12GlyVal: 4.12 ± 0.068	0.727GlyTrp: 0.727 ± 0.029	2.73GlyTyr: 2.73 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	0.811HisAla: 0.811 ± 0.025	0.15HisCys: 0.15 ± 0.012	0.767HisAsp: 0.767 ± 0.032	0.95HisGlu: 0.95 ± 0.038	1.064HisPhe: 1.064 ± 0.036	0.928HisGly: 0.928 ± 0.03	0.453HisHis: 0.453 ± 0.025	1.294HisIle: 1.294 ± 0.037	1.383HisLys: 1.383 ± 0.041	1.616HisLeu: 1.616 ± 0.041	0.297HisMet: 0.297 ± 0.015	1.001HisAsn: 1.001 ± 0.034	0.755HisPro: 0.755 ± 0.031	0.645HisGln: 0.645 ± 0.022	0.648HisArg: 0.648 ± 0.023	1.083HisSer: 1.083 ± 0.029	0.822HisThr: 0.822 ± 0.029	0.878HisVal: 0.878 ± 0.03	0.18HisTrp: 0.18 ± 0.014	0.763HisTyr: 0.763 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.009IleAla: 5.009 ± 0.069	0.623IleCys: 0.623 ± 0.024	5.225IleAsp: 5.225 ± 0.07	6.006IleGlu: 6.006 ± 0.077	3.828IlePhe: 3.828 ± 0.072	4.992IleGly: 4.992 ± 0.075	1.417IleHis: 1.417 ± 0.038	6.733IleIle: 6.733 ± 0.109	6.773IleLys: 6.773 ± 0.095	7.337IleLeu: 7.337 ± 0.109	1.308IleMet: 1.308 ± 0.039	5.491IleAsn: 5.491 ± 0.066	3.175IlePro: 3.175 ± 0.056	2.857IleGln: 2.857 ± 0.054	2.64IleArg: 2.64 ± 0.053	6.387IleSer: 6.387 ± 0.076	5.129IleThr: 5.129 ± 0.118	4.792IleVal: 4.792 ± 0.064	0.708IleTrp: 0.708 ± 0.026	3.018IleTyr: 3.018 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.665LysAla: 4.665 ± 0.095	0.366LysCys: 0.366 ± 0.018	4.712LysAsp: 4.712 ± 0.08	7.238LysGlu: 7.238 ± 0.104	3.466LysPhe: 3.466 ± 0.067	4.767LysGly: 4.767 ± 0.073	1.391LysHis: 1.391 ± 0.034	6.983LysIle: 6.983 ± 0.105	8.356LysLys: 8.356 ± 0.12	7.587LysLeu: 7.587 ± 0.117	1.981LysMet: 1.981 ± 0.052	6.247LysAsn: 6.247 ± 0.095	2.36LysPro: 2.36 ± 0.049	2.876LysGln: 2.876 ± 0.058	3.374LysArg: 3.374 ± 0.062	5.446LysSer: 5.446 ± 0.079	4.801LysThr: 4.801 ± 0.09	5.147LysVal: 5.147 ± 0.085	0.824LysTrp: 0.824 ± 0.026	3.462LysTyr: 3.462 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.131LeuAla: 5.131 ± 0.079	0.607LeuCys: 0.607 ± 0.025	4.934LeuAsp: 4.934 ± 0.079	6.143LeuGlu: 6.143 ± 0.076	5.058LeuPhe: 5.058 ± 0.088	5.458LeuGly: 5.458 ± 0.075	1.503LeuHis: 1.503 ± 0.041	7.465LeuIle: 7.465 ± 0.107	8.324LeuLys: 8.324 ± 0.11	8.557LeuLeu: 8.557 ± 0.125	1.78LeuMet: 1.78 ± 0.046	6.224LeuAsn: 6.224 ± 0.094	3.245LeuPro: 3.245 ± 0.057	3.158LeuGln: 3.158 ± 0.06	3.114LeuArg: 3.114 ± 0.056	6.908LeuSer: 6.908 ± 0.118	5.203LeuThr: 5.203 ± 0.087	5.307LeuVal: 5.307 ± 0.067	0.734LeuTrp: 0.734 ± 0.029	3.179LeuTyr: 3.179 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.22MetAla: 1.22 ± 0.035	0.137MetCys: 0.137 ± 0.011	0.937MetAsp: 0.937 ± 0.029	1.203MetGlu: 1.203 ± 0.032	0.892MetPhe: 0.892 ± 0.032	1.106MetGly: 1.106 ± 0.034	0.32MetHis: 0.32 ± 0.017	1.529MetIle: 1.529 ± 0.041	2.203MetLys: 2.203 ± 0.048	1.691MetLeu: 1.691 ± 0.045	0.503MetMet: 0.503 ± 0.028	1.399MetAsn: 1.399 ± 0.037	0.66MetPro: 0.66 ± 0.025	0.603MetGln: 0.603 ± 0.023	0.837MetArg: 0.837 ± 0.03	1.298MetSer: 1.298 ± 0.037	1.044MetThr: 1.044 ± 0.032	1.114MetVal: 1.114 ± 0.032	0.133MetTrp: 0.133 ± 0.01	0.709MetTyr: 0.709 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.506AsnAla: 3.506 ± 0.066	0.522AsnCys: 0.522 ± 0.027	3.583AsnAsp: 3.583 ± 0.063	4.341AsnGlu: 4.341 ± 0.066	3.558AsnPhe: 3.558 ± 0.064	4.405AsnGly: 4.405 ± 0.098	1.123AsnHis: 1.123 ± 0.035	5.551AsnIle: 5.551 ± 0.081	5.409AsnLys: 5.409 ± 0.082	5.888AsnLeu: 5.888 ± 0.078	1.128AsnMet: 1.128 ± 0.03	4.752AsnAsn: 4.752 ± 0.092	2.735AsnPro: 2.735 ± 0.054	2.509AsnGln: 2.509 ± 0.05	2.421AsnArg: 2.421 ± 0.057	4.823AsnSer: 4.823 ± 0.081	4.091AsnThr: 4.091 ± 0.103	3.728AsnVal: 3.728 ± 0.058	0.853AsnTrp: 0.853 ± 0.027	3.31AsnTyr: 3.31 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.477ProAla: 1.477 ± 0.042	0.209ProCys: 0.209 ± 0.015	1.73ProAsp: 1.73 ± 0.041	2.436ProGlu: 2.436 ± 0.052	1.781ProPhe: 1.781 ± 0.043	1.578ProGly: 1.578 ± 0.044	0.562ProHis: 0.562 ± 0.023	2.698ProIle: 2.698 ± 0.049	2.594ProLys: 2.594 ± 0.061	2.584ProLeu: 2.584 ± 0.045	0.625ProMet: 0.625 ± 0.025	2.315ProAsn: 2.315 ± 0.054	0.734ProPro: 0.734 ± 0.033	0.897ProGln: 0.897 ± 0.03	0.892ProArg: 0.892 ± 0.033	2.133ProSer: 2.133 ± 0.06	1.874ProThr: 1.874 ± 0.06	2.142ProVal: 2.142 ± 0.065	0.314ProTrp: 0.314 ± 0.017	1.293ProTyr: 1.293 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.61GlnAla: 1.61 ± 0.043	0.166GlnCys: 0.166 ± 0.012	1.528GlnAsp: 1.528 ± 0.046	2.423GlnGlu: 2.423 ± 0.048	1.692GlnPhe: 1.692 ± 0.04	1.673GlnGly: 1.673 ± 0.04	0.555GlnHis: 0.555 ± 0.021	2.731GlnIle: 2.731 ± 0.047	3.097GlnLys: 3.097 ± 0.064	3.211GlnLeu: 3.211 ± 0.055	0.757GlnMet: 0.757 ± 0.023	2.339GlnAsn: 2.339 ± 0.047	0.991GlnPro: 0.991 ± 0.03	1.279GlnGln: 1.279 ± 0.036	1.177GlnArg: 1.177 ± 0.038	1.782GlnSer: 1.782 ± 0.043	1.807GlnThr: 1.807 ± 0.038	1.847GlnVal: 1.847 ± 0.042	0.301GlnTrp: 0.301 ± 0.017	1.334GlnTyr: 1.334 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.884ArgAla: 1.884 ± 0.045	0.189ArgCys: 0.189 ± 0.012	1.765ArgAsp: 1.765 ± 0.054	2.239ArgGlu: 2.239 ± 0.047	1.99ArgPhe: 1.99 ± 0.044	1.868ArgGly: 1.868 ± 0.048	0.542ArgHis: 0.542 ± 0.026	3.036ArgIle: 3.036 ± 0.054	3.289ArgLys: 3.289 ± 0.067	3.181ArgLeu: 3.181 ± 0.053	0.829ArgMet: 0.829 ± 0.031	2.425ArgAsn: 2.425 ± 0.048	0.921ArgPro: 0.921 ± 0.027	0.959ArgGln: 0.959 ± 0.028	1.351ArgArg: 1.351 ± 0.039	1.926ArgSer: 1.926 ± 0.043	1.868ArgThr: 1.868 ± 0.043	2.131ArgVal: 2.131 ± 0.04	0.349ArgTrp: 0.349 ± 0.019	1.484ArgTyr: 1.484 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.156SerAla: 3.156 ± 0.054	0.671SerCys: 0.671 ± 0.04	3.693SerAsp: 3.693 ± 0.055	4.413SerGlu: 4.413 ± 0.074	4.336SerPhe: 4.336 ± 0.069	4.681SerGly: 4.681 ± 0.111	1.031SerHis: 1.031 ± 0.032	6.027SerIle: 6.027 ± 0.077	5.607SerLys: 5.607 ± 0.078	6.482SerLeu: 6.482 ± 0.095	1.233SerMet: 1.233 ± 0.03	4.449SerAsn: 4.449 ± 0.08	1.96SerPro: 1.96 ± 0.06	2.172SerGln: 2.172 ± 0.05	2.133SerArg: 2.133 ± 0.045	5.015SerSer: 5.015 ± 0.087	3.763SerThr: 3.763 ± 0.095	4.097SerVal: 4.097 ± 0.071	0.772SerTrp: 0.772 ± 0.03	2.95SerTyr: 2.95 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	3.048ThrAla: 3.048 ± 0.109	0.357ThrCys: 0.357 ± 0.026	3.236ThrAsp: 3.236 ± 0.076	3.513ThrGlu: 3.513 ± 0.062	3.123ThrPhe: 3.123 ± 0.063	3.723ThrGly: 3.723 ± 0.139	0.955ThrHis: 0.955 ± 0.032	5.115ThrIle: 5.115 ± 0.087	4.511ThrLys: 4.511 ± 0.073	5.076ThrLeu: 5.076 ± 0.064	0.88ThrMet: 0.88 ± 0.034	3.906ThrAsn: 3.906 ± 0.081	2.294ThrPro: 2.294 ± 0.065	1.781ThrGln: 1.781 ± 0.042	1.677ThrArg: 1.677 ± 0.04	4.071ThrSer: 4.071 ± 0.102	3.535ThrThr: 3.535 ± 0.105	3.715ThrVal: 3.715 ± 0.128	0.568ThrTrp: 0.568 ± 0.026	2.353ThrTyr: 2.353 ± 0.086	0.0ThrXaa: 0.0 ± 0.0
Val	3.607ValAla: 3.607 ± 0.076	0.485ValCys: 0.485 ± 0.023	3.426ValAsp: 3.426 ± 0.064	3.769ValGlu: 3.769 ± 0.059	3.377ValPhe: 3.377 ± 0.055	3.63ValGly: 3.63 ± 0.068	0.972ValHis: 0.972 ± 0.03	4.893ValIle: 4.893 ± 0.064	4.757ValLys: 4.757 ± 0.08	5.753ValLeu: 5.753 ± 0.078	1.131ValMet: 1.131 ± 0.029	3.96ValAsn: 3.96 ± 0.065	1.853ValPro: 1.853 ± 0.045	1.731ValGln: 1.731 ± 0.037	2.034ValArg: 2.034 ± 0.052	4.521ValSer: 4.521 ± 0.094	3.601ValThr: 3.601 ± 0.129	4.004ValVal: 4.004 ± 0.079	0.562ValTrp: 0.562 ± 0.023	2.433ValTyr: 2.433 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.484TrpAla: 0.484 ± 0.022	0.103TrpCys: 0.103 ± 0.009	0.566TrpAsp: 0.566 ± 0.028	0.638TrpGlu: 0.638 ± 0.026	0.578TrpPhe: 0.578 ± 0.022	0.591TrpGly: 0.591 ± 0.024	0.18TrpHis: 0.18 ± 0.014	0.813TrpIle: 0.813 ± 0.034	0.941TrpLys: 0.941 ± 0.036	0.946TrpLeu: 0.946 ± 0.031	0.268TrpMet: 0.268 ± 0.016	0.792TrpAsn: 0.792 ± 0.032	0.171TrpPro: 0.171 ± 0.015	0.324TrpGln: 0.324 ± 0.02	0.394TrpArg: 0.394 ± 0.021	0.642TrpSer: 0.642 ± 0.027	0.509TrpThr: 0.509 ± 0.023	0.575TrpVal: 0.575 ± 0.028	0.147TrpTrp: 0.147 ± 0.013	0.453TrpTyr: 0.453 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.152TyrAla: 2.152 ± 0.049	0.323TyrCys: 0.323 ± 0.018	2.348TyrAsp: 2.348 ± 0.053	2.466TyrGlu: 2.466 ± 0.06	2.595TyrPhe: 2.595 ± 0.056	2.499TyrGly: 2.499 ± 0.044	0.804TyrHis: 0.804 ± 0.028	2.867TyrIle: 2.867 ± 0.057	3.375TyrLys: 3.375 ± 0.062	3.988TyrLeu: 3.988 ± 0.075	0.655TyrMet: 0.655 ± 0.022	2.952TyrAsn: 2.952 ± 0.06	1.413TyrPro: 1.413 ± 0.04	1.537TyrGln: 1.537 ± 0.039	1.603TyrArg: 1.603 ± 0.039	2.883TyrSer: 2.883 ± 0.058	2.437TyrThr: 2.437 ± 0.093	2.288TyrVal: 2.288 ± 0.042	0.466TyrTrp: 0.466 ± 0.018	2.059TyrTyr: 2.059 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3514 proteins (1157436 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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