Amino acid dipepetide frequency for Penicillium nordicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.048AlaAla: 8.048 ± 0.056	1.076AlaCys: 1.076 ± 0.016	4.118AlaAsp: 4.118 ± 0.033	4.865AlaGlu: 4.865 ± 0.042	3.095AlaPhe: 3.095 ± 0.029	5.504AlaGly: 5.504 ± 0.038	1.763AlaHis: 1.763 ± 0.017	4.319AlaIle: 4.319 ± 0.029	3.747AlaLys: 3.747 ± 0.031	7.499AlaLeu: 7.499 ± 0.052	1.973AlaMet: 1.973 ± 0.019	2.923AlaAsn: 2.923 ± 0.025	4.681AlaPro: 4.681 ± 0.047	3.268AlaGln: 3.268 ± 0.028	4.641AlaArg: 4.641 ± 0.034	6.914AlaSer: 6.914 ± 0.042	5.076AlaThr: 5.076 ± 0.036	5.182AlaVal: 5.182 ± 0.038	1.115AlaTrp: 1.115 ± 0.015	2.08AlaTyr: 2.08 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.949CysAla: 0.949 ± 0.016	0.267CysCys: 0.267 ± 0.008	0.681CysAsp: 0.681 ± 0.012	0.603CysGlu: 0.603 ± 0.012	0.598CysPhe: 0.598 ± 0.012	0.954CysGly: 0.954 ± 0.017	0.379CysHis: 0.379 ± 0.009	0.75CysIle: 0.75 ± 0.013	0.494CysLys: 0.494 ± 0.009	1.38CysLeu: 1.38 ± 0.019	0.302CysMet: 0.302 ± 0.008	0.441CysAsn: 0.441 ± 0.009	0.67CysPro: 0.67 ± 0.014	0.487CysGln: 0.487 ± 0.01	0.774CysArg: 0.774 ± 0.014	0.96CysSer: 0.96 ± 0.014	0.702CysThr: 0.702 ± 0.014	0.847CysVal: 0.847 ± 0.013	0.214CysTrp: 0.214 ± 0.006	0.377CysTyr: 0.377 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.332AspAla: 4.332 ± 0.033	0.619AspCys: 0.619 ± 0.011	3.842AspAsp: 3.842 ± 0.036	4.173AspGlu: 4.173 ± 0.039	2.137AspPhe: 2.137 ± 0.022	3.779AspGly: 3.779 ± 0.03	1.355AspHis: 1.355 ± 0.018	3.216AspIle: 3.216 ± 0.023	2.25AspLys: 2.25 ± 0.02	5.186AspLeu: 5.186 ± 0.028	1.305AspMet: 1.305 ± 0.016	1.929AspAsn: 1.929 ± 0.019	3.345AspPro: 3.345 ± 0.025	2.034AspGln: 2.034 ± 0.022	3.07AspArg: 3.07 ± 0.033	4.32AspSer: 4.32 ± 0.036	3.054AspThr: 3.054 ± 0.023	3.551AspVal: 3.551 ± 0.029	0.89AspTrp: 0.89 ± 0.013	1.574AspTyr: 1.574 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	4.95GluAla: 4.95 ± 0.037	0.627GluCys: 0.627 ± 0.011	4.048GluAsp: 4.048 ± 0.033	5.102GluGlu: 5.102 ± 0.059	1.97GluPhe: 1.97 ± 0.022	3.545GluGly: 3.545 ± 0.03	1.4GluHis: 1.4 ± 0.018	3.174GluIle: 3.174 ± 0.028	3.465GluLys: 3.465 ± 0.03	5.055GluLeu: 5.055 ± 0.034	1.487GluMet: 1.487 ± 0.019	2.374GluAsn: 2.374 ± 0.024	2.846GluPro: 2.846 ± 0.049	2.417GluGln: 2.417 ± 0.029	3.703GluArg: 3.703 ± 0.032	4.468GluSer: 4.468 ± 0.037	3.615GluThr: 3.615 ± 0.03	3.449GluVal: 3.449 ± 0.028	0.859GluTrp: 0.859 ± 0.012	1.682GluTyr: 1.682 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.041PheAla: 3.041 ± 0.025	0.618PheCys: 0.618 ± 0.011	2.305PheAsp: 2.305 ± 0.024	2.143PheGlu: 2.143 ± 0.021	1.927PhePhe: 1.927 ± 0.027	2.895PheGly: 2.895 ± 0.031	0.98PheHis: 0.98 ± 0.015	2.001PheIle: 2.001 ± 0.026	1.483PheLys: 1.483 ± 0.016	3.686PheLeu: 3.686 ± 0.034	0.864PheMet: 0.864 ± 0.012	1.533PheAsn: 1.533 ± 0.018	2.063PhePro: 2.063 ± 0.021	1.481PheGln: 1.481 ± 0.016	2.028PheArg: 2.028 ± 0.023	3.155PheSer: 3.155 ± 0.026	2.223PheThr: 2.223 ± 0.02	2.45PheVal: 2.45 ± 0.023	0.666PheTrp: 0.666 ± 0.01	1.178PheTyr: 1.178 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.084GlyAla: 5.084 ± 0.038	0.904GlyCys: 0.904 ± 0.016	3.52GlyAsp: 3.52 ± 0.028	3.488GlyGlu: 3.488 ± 0.029	2.867GlyPhe: 2.867 ± 0.026	5.309GlyGly: 5.309 ± 0.057	1.698GlyHis: 1.698 ± 0.022	3.655GlyIle: 3.655 ± 0.03	3.251GlyLys: 3.251 ± 0.028	6.153GlyLeu: 6.153 ± 0.044	1.619GlyMet: 1.619 ± 0.021	2.537GlyAsn: 2.537 ± 0.022	3.333GlyPro: 3.333 ± 0.03	2.555GlyGln: 2.555 ± 0.027	3.917GlyArg: 3.917 ± 0.031	5.676GlySer: 5.676 ± 0.036	3.905GlyThr: 3.905 ± 0.027	4.372GlyVal: 4.372 ± 0.035	1.148GlyTrp: 1.148 ± 0.017	2.141GlyTyr: 2.141 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.815HisAla: 1.815 ± 0.019	0.352HisCys: 0.352 ± 0.009	1.336HisAsp: 1.336 ± 0.017	1.346HisGlu: 1.346 ± 0.016	0.989HisPhe: 0.989 ± 0.015	1.742HisGly: 1.742 ± 0.021	0.839HisHis: 0.839 ± 0.016	1.325HisIle: 1.325 ± 0.017	0.895HisLys: 0.895 ± 0.013	2.343HisLeu: 2.343 ± 0.025	0.544HisMet: 0.544 ± 0.01	0.929HisAsn: 0.929 ± 0.014	1.759HisPro: 1.759 ± 0.019	0.997HisGln: 0.997 ± 0.013	1.61HisArg: 1.61 ± 0.019	1.969HisSer: 1.969 ± 0.022	1.379HisThr: 1.379 ± 0.017	1.491HisVal: 1.491 ± 0.017	0.36HisTrp: 0.36 ± 0.009	0.709HisTyr: 0.709 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.261IleAla: 4.261 ± 0.031	0.848IleCys: 0.848 ± 0.015	2.949IleAsp: 2.949 ± 0.027	2.939IleGlu: 2.939 ± 0.025	2.204IlePhe: 2.204 ± 0.026	3.358IleGly: 3.358 ± 0.03	1.328IleHis: 1.328 ± 0.016	2.743IleIle: 2.743 ± 0.025	2.174IleLys: 2.174 ± 0.024	4.796IleLeu: 4.796 ± 0.036	1.142IleMet: 1.142 ± 0.014	1.872IleAsn: 1.872 ± 0.019	3.303IlePro: 3.303 ± 0.028	2.13IleGln: 2.13 ± 0.024	2.836IleArg: 2.836 ± 0.022	4.244IleSer: 4.244 ± 0.029	2.959IleThr: 2.959 ± 0.028	3.256IleVal: 3.256 ± 0.029	0.773IleTrp: 0.773 ± 0.015	1.566IleTyr: 1.566 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.88LysAla: 3.88 ± 0.035	0.512LysCys: 0.512 ± 0.01	2.64LysAsp: 2.64 ± 0.024	3.137LysGlu: 3.137 ± 0.033	1.468LysPhe: 1.468 ± 0.017	2.808LysGly: 2.808 ± 0.026	1.078LysHis: 1.078 ± 0.014	2.255LysIle: 2.255 ± 0.023	3.242LysLys: 3.242 ± 0.044	3.888LysLeu: 3.888 ± 0.032	1.039LysMet: 1.039 ± 0.015	1.753LysAsn: 1.753 ± 0.019	2.674LysPro: 2.674 ± 0.027	1.84LysGln: 1.84 ± 0.023	3.202LysArg: 3.202 ± 0.027	3.539LysSer: 3.539 ± 0.029	2.782LysThr: 2.782 ± 0.023	2.722LysVal: 2.722 ± 0.026	0.676LysTrp: 0.676 ± 0.012	1.357LysTyr: 1.357 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	7.643LeuAla: 7.643 ± 0.044	1.297LeuCys: 1.297 ± 0.017	5.196LeuAsp: 5.196 ± 0.039	5.423LeuGlu: 5.423 ± 0.04	3.57LeuPhe: 3.57 ± 0.034	6.028LeuGly: 6.028 ± 0.04	2.306LeuHis: 2.306 ± 0.025	4.205LeuIle: 4.205 ± 0.039	4.031LeuLys: 4.031 ± 0.03	8.599LeuLeu: 8.599 ± 0.062	1.901LeuMet: 1.901 ± 0.02	3.358LeuAsn: 3.358 ± 0.025	5.504LeuPro: 5.504 ± 0.035	3.932LeuGln: 3.932 ± 0.029	5.657LeuArg: 5.657 ± 0.034	7.667LeuSer: 7.667 ± 0.048	4.871LeuThr: 4.871 ± 0.033	5.533LeuVal: 5.533 ± 0.038	1.212LeuTrp: 1.212 ± 0.018	2.437LeuTyr: 2.437 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.185MetAla: 2.185 ± 0.021	0.276MetCys: 0.276 ± 0.008	1.322MetAsp: 1.322 ± 0.015	1.329MetGlu: 1.329 ± 0.019	0.816MetPhe: 0.816 ± 0.013	1.579MetGly: 1.579 ± 0.022	0.526MetHis: 0.526 ± 0.01	1.114MetIle: 1.114 ± 0.016	1.029MetLys: 1.029 ± 0.014	1.925MetLeu: 1.925 ± 0.02	0.615MetMet: 0.615 ± 0.012	0.873MetAsn: 0.873 ± 0.013	1.288MetPro: 1.288 ± 0.018	0.919MetGln: 0.919 ± 0.014	1.295MetArg: 1.295 ± 0.017	1.991MetSer: 1.991 ± 0.019	1.377MetThr: 1.377 ± 0.016	1.423MetVal: 1.423 ± 0.016	0.281MetTrp: 0.281 ± 0.007	0.553MetTyr: 0.553 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.077AsnAla: 3.077 ± 0.026	0.485AsnCys: 0.485 ± 0.01	1.977AsnAsp: 1.977 ± 0.02	2.095AsnGlu: 2.095 ± 0.025	1.426AsnPhe: 1.426 ± 0.015	2.843AsnGly: 2.843 ± 0.027	0.905AsnHis: 0.905 ± 0.014	2.168AsnIle: 2.168 ± 0.017	1.568AsnLys: 1.568 ± 0.02	3.346AsnLeu: 3.346 ± 0.027	0.935AsnMet: 0.935 ± 0.014	1.506AsnAsn: 1.506 ± 0.023	2.636AsnPro: 2.636 ± 0.024	1.442AsnGln: 1.442 ± 0.019	2.015AsnArg: 2.015 ± 0.021	2.887AsnSer: 2.887 ± 0.023	2.289AsnThr: 2.289 ± 0.024	2.344AsnVal: 2.344 ± 0.021	0.578AsnTrp: 0.578 ± 0.011	1.096AsnTyr: 1.096 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.017ProAla: 5.017 ± 0.049	0.581ProCys: 0.581 ± 0.011	3.184ProAsp: 3.184 ± 0.025	3.888ProGlu: 3.888 ± 0.042	2.161ProPhe: 2.161 ± 0.022	3.849ProGly: 3.849 ± 0.032	1.416ProHis: 1.416 ± 0.018	2.765ProIle: 2.765 ± 0.022	2.625ProLys: 2.625 ± 0.029	4.822ProLeu: 4.822 ± 0.034	1.178ProMet: 1.178 ± 0.017	2.28ProAsn: 2.28 ± 0.025	4.692ProPro: 4.692 ± 0.063	2.461ProGln: 2.461 ± 0.026	3.435ProArg: 3.435 ± 0.033	6.155ProSer: 6.155 ± 0.042	4.168ProThr: 4.168 ± 0.034	3.709ProVal: 3.709 ± 0.036	0.786ProTrp: 0.786 ± 0.013	1.549ProTyr: 1.549 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.28GlnAla: 3.28 ± 0.031	0.472GlnCys: 0.472 ± 0.01	2.037GlnAsp: 2.037 ± 0.022	2.34GlnGlu: 2.34 ± 0.022	1.433GlnPhe: 1.433 ± 0.018	2.422GlnGly: 2.422 ± 0.024	1.064GlnHis: 1.064 ± 0.018	2.08GlnIle: 2.08 ± 0.02	2.006GlnLys: 2.006 ± 0.021	3.503GlnLeu: 3.503 ± 0.029	0.953GlnMet: 0.953 ± 0.016	1.632GlnAsn: 1.632 ± 0.021	2.616GlnPro: 2.616 ± 0.03	2.177GlnGln: 2.177 ± 0.042	2.572GlnArg: 2.572 ± 0.025	3.361GlnSer: 3.361 ± 0.032	2.47GlnThr: 2.47 ± 0.022	2.248GlnVal: 2.248 ± 0.024	0.594GlnTrp: 0.594 ± 0.011	1.224GlnTyr: 1.224 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.457ArgAla: 4.457 ± 0.031	0.715ArgCys: 0.715 ± 0.014	3.28ArgAsp: 3.28 ± 0.031	3.68ArgGlu: 3.68 ± 0.032	2.213ArgPhe: 2.213 ± 0.02	3.686ArgGly: 3.686 ± 0.033	1.563ArgHis: 1.563 ± 0.018	2.881ArgIle: 2.881 ± 0.024	3.267ArgLys: 3.267 ± 0.032	5.424ArgLeu: 5.424 ± 0.033	1.322ArgMet: 1.322 ± 0.016	2.249ArgAsn: 2.249 ± 0.021	3.437ArgPro: 3.437 ± 0.034	2.56ArgGln: 2.56 ± 0.024	4.778ArgArg: 4.778 ± 0.042	4.833ArgSer: 4.833 ± 0.04	3.271ArgThr: 3.271 ± 0.026	3.407ArgVal: 3.407 ± 0.025	0.926ArgTrp: 0.926 ± 0.014	1.659ArgTyr: 1.659 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.526SerAla: 6.526 ± 0.046	0.926SerCys: 0.926 ± 0.016	4.379SerAsp: 4.379 ± 0.034	4.3SerGlu: 4.3 ± 0.03	3.246SerPhe: 3.246 ± 0.023	5.576SerGly: 5.576 ± 0.038	2.114SerHis: 2.114 ± 0.02	4.297SerIle: 4.297 ± 0.029	3.704SerLys: 3.704 ± 0.032	7.654SerLeu: 7.654 ± 0.048	1.85SerMet: 1.85 ± 0.019	3.133SerAsn: 3.133 ± 0.026	5.715SerPro: 5.715 ± 0.044	3.422SerGln: 3.422 ± 0.03	4.994SerArg: 4.994 ± 0.041	8.764SerSer: 8.764 ± 0.065	5.777SerThr: 5.777 ± 0.045	4.794SerVal: 4.794 ± 0.034	1.158SerTrp: 1.158 ± 0.014	2.16SerTyr: 2.16 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.044ThrAla: 5.044 ± 0.034	0.761ThrCys: 0.761 ± 0.012	2.945ThrAsp: 2.945 ± 0.022	3.283ThrGlu: 3.283 ± 0.03	2.26ThrPhe: 2.26 ± 0.02	4.196ThrGly: 4.196 ± 0.031	1.367ThrHis: 1.367 ± 0.016	3.177ThrIle: 3.177 ± 0.027	2.626ThrLys: 2.626 ± 0.026	5.36ThrLeu: 5.36 ± 0.029	1.283ThrMet: 1.283 ± 0.013	2.201ThrAsn: 2.201 ± 0.021	4.402ThrPro: 4.402 ± 0.036	2.224ThrGln: 2.224 ± 0.022	3.197ThrArg: 3.197 ± 0.029	5.419ThrSer: 5.419 ± 0.041	4.188ThrThr: 4.188 ± 0.047	3.756ThrVal: 3.756 ± 0.034	0.868ThrTrp: 0.868 ± 0.013	1.653ThrTyr: 1.653 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.056ValAla: 5.056 ± 0.035	0.876ValCys: 0.876 ± 0.013	3.705ValAsp: 3.705 ± 0.027	3.727ValGlu: 3.727 ± 0.034	2.566ValPhe: 2.566 ± 0.024	4.032ValGly: 4.032 ± 0.033	1.483ValHis: 1.483 ± 0.016	3.204ValIle: 3.204 ± 0.027	2.719ValLys: 2.719 ± 0.022	5.624ValLeu: 5.624 ± 0.036	1.365ValMet: 1.365 ± 0.018	2.294ValAsn: 2.294 ± 0.022	3.607ValPro: 3.607 ± 0.028	2.415ValGln: 2.415 ± 0.02	3.303ValArg: 3.303 ± 0.026	4.899ValSer: 4.899 ± 0.031	3.545ValThr: 3.545 ± 0.026	4.2ValVal: 4.2 ± 0.039	0.856ValTrp: 0.856 ± 0.013	1.772ValTyr: 1.772 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.137TrpAla: 1.137 ± 0.013	0.195TrpCys: 0.195 ± 0.006	0.892TrpAsp: 0.892 ± 0.015	0.846TrpGlu: 0.846 ± 0.014	0.531TrpPhe: 0.531 ± 0.009	0.956TrpGly: 0.956 ± 0.013	0.361TrpHis: 0.361 ± 0.008	0.804TrpIle: 0.804 ± 0.013	0.811TrpLys: 0.811 ± 0.013	1.372TrpLeu: 1.372 ± 0.017	0.389TrpMet: 0.389 ± 0.008	0.636TrpAsn: 0.636 ± 0.011	0.601TrpPro: 0.601 ± 0.013	0.569TrpGln: 0.569 ± 0.011	0.948TrpArg: 0.948 ± 0.012	1.106TrpSer: 1.106 ± 0.014	0.915TrpThr: 0.915 ± 0.014	0.906TrpVal: 0.906 ± 0.015	0.284TrpTrp: 0.284 ± 0.009	0.434TrpTyr: 0.434 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.107TyrAla: 2.107 ± 0.023	0.421TyrCys: 0.421 ± 0.008	1.609TyrAsp: 1.609 ± 0.019	1.528TyrGlu: 1.528 ± 0.019	1.246TyrPhe: 1.246 ± 0.016	2.073TyrGly: 2.073 ± 0.024	0.804TyrHis: 0.804 ± 0.013	1.549TyrIle: 1.549 ± 0.018	1.103TyrLys: 1.103 ± 0.014	2.756TyrLeu: 2.756 ± 0.025	0.651TyrMet: 0.651 ± 0.011	1.163TyrAsn: 1.163 ± 0.013	1.548TyrPro: 1.548 ± 0.019	1.15TyrGln: 1.15 ± 0.017	1.63TyrArg: 1.63 ± 0.018	2.159TyrSer: 2.159 ± 0.024	1.646TyrThr: 1.646 ± 0.019	1.609TyrVal: 1.609 ± 0.018	0.447TyrTrp: 0.447 ± 0.01	0.944TyrTyr: 0.944 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.032XaaXaa: 0.032 ± 0.012

Statistics based on 12938 proteins (5328948 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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