Amino acid dipepetide frequency for Corynebacterium provencense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.306AlaAla: 17.306 ± 0.221	0.893AlaCys: 0.893 ± 0.033	8.303AlaAsp: 8.303 ± 0.106	7.423AlaGlu: 7.423 ± 0.118	3.067AlaPhe: 3.067 ± 0.063	13.049AlaGly: 13.049 ± 0.16	2.082AlaHis: 2.082 ± 0.05	2.48AlaIle: 2.48 ± 0.061	2.166AlaLys: 2.166 ± 0.06	11.335AlaLeu: 11.335 ± 0.117	2.254AlaMet: 2.254 ± 0.048	1.843AlaAsn: 1.843 ± 0.047	5.715AlaPro: 5.715 ± 0.099	3.0AlaGln: 3.0 ± 0.067	8.273AlaArg: 8.273 ± 0.116	6.21AlaSer: 6.21 ± 0.094	7.332AlaThr: 7.332 ± 0.079	12.804AlaVal: 12.804 ± 0.127	1.483AlaTrp: 1.483 ± 0.046	1.997AlaTyr: 1.997 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.878CysAla: 0.878 ± 0.032	0.087CysCys: 0.087 ± 0.01	0.44CysAsp: 0.44 ± 0.022	0.327CysGlu: 0.327 ± 0.02	0.207CysPhe: 0.207 ± 0.015	0.911CysGly: 0.911 ± 0.041	0.163CysHis: 0.163 ± 0.013	0.25CysIle: 0.25 ± 0.017	0.062CysLys: 0.062 ± 0.007	0.675CysLeu: 0.675 ± 0.029	0.111CysMet: 0.111 ± 0.012	0.151CysAsn: 0.151 ± 0.012	0.446CysPro: 0.446 ± 0.027	0.144CysGln: 0.144 ± 0.012	0.61CysArg: 0.61 ± 0.028	0.534CysSer: 0.534 ± 0.026	0.543CysThr: 0.543 ± 0.028	0.598CysVal: 0.598 ± 0.024	0.113CysTrp: 0.113 ± 0.011	0.135CysTyr: 0.135 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.622AspAla: 8.622 ± 0.102	0.438AspCys: 0.438 ± 0.023	4.092AspAsp: 4.092 ± 0.081	3.593AspGlu: 3.593 ± 0.072	1.793AspPhe: 1.793 ± 0.046	6.765AspGly: 6.765 ± 0.104	1.539AspHis: 1.539 ± 0.042	2.918AspIle: 2.918 ± 0.062	1.079AspLys: 1.079 ± 0.04	6.55AspLeu: 6.55 ± 0.077	1.135AspMet: 1.135 ± 0.034	1.507AspAsn: 1.507 ± 0.042	4.844AspPro: 4.844 ± 0.077	1.569AspGln: 1.569 ± 0.037	5.933AspArg: 5.933 ± 0.085	3.765AspSer: 3.765 ± 0.07	3.89AspThr: 3.89 ± 0.066	4.879AspVal: 4.879 ± 0.074	0.903AspTrp: 0.903 ± 0.03	1.28AspTyr: 1.28 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.843GluAla: 5.843 ± 0.091	0.285GluCys: 0.285 ± 0.019	3.577GluAsp: 3.577 ± 0.066	3.321GluGlu: 3.321 ± 0.075	1.78GluPhe: 1.78 ± 0.038	4.05GluGly: 4.05 ± 0.066	1.282GluHis: 1.282 ± 0.037	2.887GluIle: 2.887 ± 0.052	1.868GluLys: 1.868 ± 0.055	5.986GluLeu: 5.986 ± 0.099	1.06GluMet: 1.06 ± 0.034	1.488GluAsn: 1.488 ± 0.044	2.762GluPro: 2.762 ± 0.07	2.069GluGln: 2.069 ± 0.057	3.65GluArg: 3.65 ± 0.082	2.837GluSer: 2.837 ± 0.053	3.092GluThr: 3.092 ± 0.054	4.623GluVal: 4.623 ± 0.077	0.703GluTrp: 0.703 ± 0.027	1.113GluTyr: 1.113 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.301PheAla: 3.301 ± 0.061	0.28PheCys: 0.28 ± 0.017	2.092PheAsp: 2.092 ± 0.046	1.229PheGlu: 1.229 ± 0.037	1.028PhePhe: 1.028 ± 0.039	3.206PheGly: 3.206 ± 0.056	0.622PheHis: 0.622 ± 0.024	1.386PheIle: 1.386 ± 0.046	0.365PheLys: 0.365 ± 0.022	2.807PheLeu: 2.807 ± 0.055	0.514PheMet: 0.514 ± 0.026	0.751PheAsn: 0.751 ± 0.03	1.529PhePro: 1.529 ± 0.037	0.582PheGln: 0.582 ± 0.026	2.066PheArg: 2.066 ± 0.046	1.92PheSer: 1.92 ± 0.046	2.353PheThr: 2.353 ± 0.051	2.165PheVal: 2.165 ± 0.052	0.414PheTrp: 0.414 ± 0.024	0.602PheTyr: 0.602 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	10.104GlyAla: 10.104 ± 0.126	0.683GlyCys: 0.683 ± 0.029	6.429GlyAsp: 6.429 ± 0.091	5.478GlyGlu: 5.478 ± 0.081	2.986GlyPhe: 2.986 ± 0.05	8.633GlyGly: 8.633 ± 0.15	2.319GlyHis: 2.319 ± 0.051	4.116GlyIle: 4.116 ± 0.08	2.178GlyLys: 2.178 ± 0.049	8.684GlyLeu: 8.684 ± 0.112	2.159GlyMet: 2.159 ± 0.06	2.063GlyAsn: 2.063 ± 0.048	4.723GlyPro: 4.723 ± 0.09	2.814GlyGln: 2.814 ± 0.064	7.374GlyArg: 7.374 ± 0.097	6.066GlySer: 6.066 ± 0.093	7.529GlyThr: 7.529 ± 0.116	8.739GlyVal: 8.739 ± 0.112	1.462GlyTrp: 1.462 ± 0.042	2.25GlyTyr: 2.25 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.972HisAla: 1.972 ± 0.046	0.19HisCys: 0.19 ± 0.016	1.307HisAsp: 1.307 ± 0.037	0.936HisGlu: 0.936 ± 0.03	0.554HisPhe: 0.554 ± 0.026	2.248HisGly: 2.248 ± 0.051	0.588HisHis: 0.588 ± 0.028	0.825HisIle: 0.825 ± 0.035	0.252HisLys: 0.252 ± 0.017	2.042HisLeu: 2.042 ± 0.057	0.395HisMet: 0.395 ± 0.022	0.437HisAsn: 0.437 ± 0.02	1.61HisPro: 1.61 ± 0.043	0.509HisGln: 0.509 ± 0.026	2.041HisArg: 2.041 ± 0.049	1.222HisSer: 1.222 ± 0.039	1.221HisThr: 1.221 ± 0.038	1.613HisVal: 1.613 ± 0.039	0.28HisTrp: 0.28 ± 0.019	0.434HisTyr: 0.434 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.746IleAla: 4.746 ± 0.082	0.356IleCys: 0.356 ± 0.019	2.835IleAsp: 2.835 ± 0.059	1.898IleGlu: 1.898 ± 0.05	1.112IlePhe: 1.112 ± 0.038	3.609IleGly: 3.609 ± 0.075	0.729IleHis: 0.729 ± 0.032	1.816IleIle: 1.816 ± 0.049	0.553IleLys: 0.553 ± 0.027	3.616IleLeu: 3.616 ± 0.064	0.688IleMet: 0.688 ± 0.029	0.968IleAsn: 0.968 ± 0.036	2.264IlePro: 2.264 ± 0.052	0.796IleGln: 0.796 ± 0.029	2.739IleArg: 2.739 ± 0.058	2.359IleSer: 2.359 ± 0.055	2.58IleThr: 2.58 ± 0.059	3.487IleVal: 3.487 ± 0.08	0.428IleTrp: 0.428 ± 0.022	0.731IleTyr: 0.731 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.246LysAla: 2.246 ± 0.066	0.089LysCys: 0.089 ± 0.009	1.256LysAsp: 1.256 ± 0.049	1.074LysGlu: 1.074 ± 0.04	0.621LysPhe: 0.621 ± 0.028	1.518LysGly: 1.518 ± 0.044	0.311LysHis: 0.311 ± 0.019	1.141LysIle: 1.141 ± 0.037	0.986LysLys: 0.986 ± 0.045	1.856LysLeu: 1.856 ± 0.054	0.518LysMet: 0.518 ± 0.024	0.642LysAsn: 0.642 ± 0.03	0.872LysPro: 0.872 ± 0.033	0.505LysGln: 0.505 ± 0.024	1.103LysArg: 1.103 ± 0.038	1.127LysSer: 1.127 ± 0.037	1.265LysThr: 1.265 ± 0.041	1.895LysVal: 1.895 ± 0.054	0.256LysTrp: 0.256 ± 0.017	0.426LysTyr: 0.426 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	11.615LeuAla: 11.615 ± 0.124	0.786LeuCys: 0.786 ± 0.027	6.54LeuAsp: 6.54 ± 0.089	4.47LeuGlu: 4.47 ± 0.084	2.643LeuPhe: 2.643 ± 0.064	8.699LeuGly: 8.699 ± 0.102	1.977LeuHis: 1.977 ± 0.047	3.549LeuIle: 3.549 ± 0.067	1.757LeuLys: 1.757 ± 0.052	9.247LeuLeu: 9.247 ± 0.132	1.659LeuMet: 1.659 ± 0.053	1.891LeuAsn: 1.891 ± 0.047	5.589LeuPro: 5.589 ± 0.072	2.237LeuGln: 2.237 ± 0.048	7.296LeuArg: 7.296 ± 0.097	6.059LeuSer: 6.059 ± 0.091	7.011LeuThr: 7.011 ± 0.093	8.97LeuVal: 8.97 ± 0.121	1.143LeuTrp: 1.143 ± 0.041	1.607LeuTyr: 1.607 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.029MetAla: 2.029 ± 0.051	0.158MetCys: 0.158 ± 0.013	1.014MetAsp: 1.014 ± 0.034	0.842MetGlu: 0.842 ± 0.032	0.571MetPhe: 0.571 ± 0.029	1.342MetGly: 1.342 ± 0.039	0.373MetHis: 0.373 ± 0.021	0.854MetIle: 0.854 ± 0.034	0.538MetLys: 0.538 ± 0.024	1.885MetLeu: 1.885 ± 0.048	0.451MetMet: 0.451 ± 0.026	0.558MetAsn: 0.558 ± 0.024	1.085MetPro: 1.085 ± 0.037	0.506MetGln: 0.506 ± 0.023	1.186MetArg: 1.186 ± 0.033	1.604MetSer: 1.604 ± 0.041	1.923MetThr: 1.923 ± 0.044	1.623MetVal: 1.623 ± 0.046	0.228MetTrp: 0.228 ± 0.015	0.351MetTyr: 0.351 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.327AsnAla: 2.327 ± 0.052	0.182AsnCys: 0.182 ± 0.014	1.165AsnAsp: 1.165 ± 0.04	0.886AsnGlu: 0.886 ± 0.031	0.686AsnPhe: 0.686 ± 0.027	1.99AsnGly: 1.99 ± 0.046	0.452AsnHis: 0.452 ± 0.021	1.025AsnIle: 1.025 ± 0.034	0.395AsnLys: 0.395 ± 0.023	2.113AsnLeu: 2.113 ± 0.048	0.431AsnMet: 0.431 ± 0.022	0.506AsnAsn: 0.506 ± 0.023	1.605AsnPro: 1.605 ± 0.051	0.592AsnGln: 0.592 ± 0.028	1.711AsnArg: 1.711 ± 0.044	1.374AsnSer: 1.374 ± 0.039	1.242AsnThr: 1.242 ± 0.036	1.578AsnVal: 1.578 ± 0.042	0.372AsnTrp: 0.372 ± 0.019	0.558AsnTyr: 0.558 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.377ProAla: 7.377 ± 0.115	0.267ProCys: 0.267 ± 0.02	4.787ProAsp: 4.787 ± 0.085	4.445ProGlu: 4.445 ± 0.071	1.504ProPhe: 1.504 ± 0.035	6.941ProGly: 6.941 ± 0.107	1.098ProHis: 1.098 ± 0.035	0.953ProIle: 0.953 ± 0.04	0.879ProLys: 0.879 ± 0.031	4.49ProLeu: 4.49 ± 0.081	0.812ProMet: 0.812 ± 0.032	0.853ProAsn: 0.853 ± 0.03	2.152ProPro: 2.152 ± 0.057	1.403ProGln: 1.403 ± 0.038	3.424ProArg: 3.424 ± 0.063	3.184ProSer: 3.184 ± 0.062	3.373ProThr: 3.373 ± 0.067	6.638ProVal: 6.638 ± 0.093	0.807ProTrp: 0.807 ± 0.03	1.009ProTyr: 1.009 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.854GlnAla: 2.854 ± 0.063	0.168GlnCys: 0.168 ± 0.014	1.422GlnAsp: 1.422 ± 0.046	1.357GlnGlu: 1.357 ± 0.039	0.839GlnPhe: 0.839 ± 0.03	2.082GlnGly: 2.082 ± 0.05	0.519GlnHis: 0.519 ± 0.023	1.432GlnIle: 1.432 ± 0.04	0.728GlnLys: 0.728 ± 0.033	2.779GlnLeu: 2.779 ± 0.059	0.626GlnMet: 0.626 ± 0.029	0.575GlnAsn: 0.575 ± 0.029	1.127GlnPro: 1.127 ± 0.036	0.986GlnGln: 0.986 ± 0.042	1.916GlnArg: 1.916 ± 0.049	1.409GlnSer: 1.409 ± 0.04	1.427GlnThr: 1.427 ± 0.039	2.471GlnVal: 2.471 ± 0.055	0.471GlnTrp: 0.471 ± 0.023	0.48GlnTyr: 0.48 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.644ArgAla: 7.644 ± 0.112	0.479ArgCys: 0.479 ± 0.022	4.944ArgAsp: 4.944 ± 0.085	4.624ArgGlu: 4.624 ± 0.083	2.177ArgPhe: 2.177 ± 0.048	5.593ArgGly: 5.593 ± 0.083	1.782ArgHis: 1.782 ± 0.05	3.62ArgIle: 3.62 ± 0.06	1.579ArgLys: 1.579 ± 0.047	6.547ArgLeu: 6.547 ± 0.089	1.768ArgMet: 1.768 ± 0.048	1.712ArgAsn: 1.712 ± 0.042	4.152ArgPro: 4.152 ± 0.081	2.37ArgGln: 2.37 ± 0.05	7.324ArgArg: 7.324 ± 0.124	4.538ArgSer: 4.538 ± 0.074	5.027ArgThr: 5.027 ± 0.088	5.749ArgVal: 5.749 ± 0.092	1.27ArgTrp: 1.27 ± 0.042	1.763ArgTyr: 1.763 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.105SerAla: 7.105 ± 0.101	0.432SerCys: 0.432 ± 0.024	3.72SerAsp: 3.72 ± 0.065	2.813SerGlu: 2.813 ± 0.056	1.835SerPhe: 1.835 ± 0.044	7.152SerGly: 7.152 ± 0.098	1.138SerHis: 1.138 ± 0.031	1.582SerIle: 1.582 ± 0.054	0.879SerLys: 0.879 ± 0.031	5.473SerLeu: 5.473 ± 0.076	1.15SerMet: 1.15 ± 0.036	1.036SerAsn: 1.036 ± 0.037	3.842SerPro: 3.842 ± 0.069	1.498SerGln: 1.498 ± 0.043	4.507SerArg: 4.507 ± 0.074	4.01SerSer: 4.01 ± 0.074	4.254SerThr: 4.254 ± 0.069	5.293SerVal: 5.293 ± 0.076	0.875SerTrp: 0.875 ± 0.032	1.27SerTyr: 1.27 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.866ThrAla: 8.866 ± 0.109	0.481ThrCys: 0.481 ± 0.023	4.691ThrAsp: 4.691 ± 0.074	3.246ThrGlu: 3.246 ± 0.075	1.803ThrPhe: 1.803 ± 0.044	8.577ThrGly: 8.577 ± 0.112	1.078ThrHis: 1.078 ± 0.038	1.716ThrIle: 1.716 ± 0.048	0.953ThrLys: 0.953 ± 0.034	5.805ThrLeu: 5.805 ± 0.069	1.137ThrMet: 1.137 ± 0.035	1.094ThrAsn: 1.094 ± 0.032	4.559ThrPro: 4.559 ± 0.077	1.128ThrGln: 1.128 ± 0.034	4.265ThrArg: 4.265 ± 0.071	3.817ThrSer: 3.817 ± 0.068	4.823ThrThr: 4.823 ± 0.095	8.751ThrVal: 8.751 ± 0.125	0.886ThrTrp: 0.886 ± 0.03	1.293ThrTyr: 1.293 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	10.76ValAla: 10.76 ± 0.111	0.808ValCys: 0.808 ± 0.027	6.516ValAsp: 6.516 ± 0.084	4.8ValGlu: 4.8 ± 0.073	2.753ValPhe: 2.753 ± 0.057	7.487ValGly: 7.487 ± 0.102	1.983ValHis: 1.983 ± 0.054	4.263ValIle: 4.263 ± 0.077	1.808ValLys: 1.808 ± 0.046	9.319ValLeu: 9.319 ± 0.13	1.6ValMet: 1.6 ± 0.039	2.198ValAsn: 2.198 ± 0.045	5.728ValPro: 5.728 ± 0.095	1.98ValGln: 1.98 ± 0.046	6.271ValArg: 6.271 ± 0.098	5.566ValSer: 5.566 ± 0.087	7.901ValThr: 7.901 ± 0.101	9.187ValVal: 9.187 ± 0.138	1.096ValTrp: 1.096 ± 0.035	1.547ValTyr: 1.547 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.396TrpAla: 1.396 ± 0.043	0.154TrpCys: 0.154 ± 0.013	0.745TrpAsp: 0.745 ± 0.029	0.663TrpGlu: 0.663 ± 0.029	0.608TrpPhe: 0.608 ± 0.027	0.957TrpGly: 0.957 ± 0.03	0.27TrpHis: 0.27 ± 0.019	0.719TrpIle: 0.719 ± 0.031	0.365TrpLys: 0.365 ± 0.02	1.43TrpLeu: 1.43 ± 0.042	0.321TrpMet: 0.321 ± 0.02	0.446TrpAsn: 0.446 ± 0.021	0.638TrpPro: 0.638 ± 0.028	0.46TrpGln: 0.46 ± 0.021	1.119TrpArg: 1.119 ± 0.037	0.959TrpSer: 0.959 ± 0.03	0.901TrpThr: 0.901 ± 0.032	1.035TrpVal: 1.035 ± 0.036	0.295TrpTrp: 0.295 ± 0.019	0.302TrpTyr: 0.302 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.025TyrAla: 2.025 ± 0.044	0.171TyrCys: 0.171 ± 0.013	1.219TyrAsp: 1.219 ± 0.04	0.851TyrGlu: 0.851 ± 0.033	0.646TyrPhe: 0.646 ± 0.028	1.98TyrGly: 1.98 ± 0.048	0.374TyrHis: 0.374 ± 0.02	0.776TyrIle: 0.776 ± 0.031	0.315TyrLys: 0.315 ± 0.019	2.105TyrLeu: 2.105 ± 0.049	0.333TyrMet: 0.333 ± 0.023	0.47TyrAsn: 0.47 ± 0.021	1.153TyrPro: 1.153 ± 0.035	0.519TyrGln: 0.519 ± 0.027	1.852TyrArg: 1.852 ± 0.046	1.305TyrSer: 1.305 ± 0.038	1.283TyrThr: 1.283 ± 0.039	1.474TyrVal: 1.474 ± 0.043	0.3TyrTrp: 0.3 ± 0.018	0.421TyrTyr: 0.421 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2661 proteins (922959 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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