Amino acid dipepetide frequency for Herminiimonas arsenicoxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.918AlaAla: 13.918 ± 0.202	1.168AlaCys: 1.168 ± 0.044	5.873AlaAsp: 5.873 ± 0.083	6.248AlaGlu: 6.248 ± 0.096	3.807AlaPhe: 3.807 ± 0.076	8.517AlaGly: 8.517 ± 0.114	2.527AlaHis: 2.527 ± 0.049	6.49AlaIle: 6.49 ± 0.092	4.785AlaLys: 4.785 ± 0.091	12.366AlaLeu: 12.366 ± 0.152	3.262AlaMet: 3.262 ± 0.065	3.351AlaAsn: 3.351 ± 0.078	4.541AlaPro: 4.541 ± 0.087	5.026AlaGln: 5.026 ± 0.082	6.483AlaArg: 6.483 ± 0.098	6.413AlaSer: 6.413 ± 0.083	5.748AlaThr: 5.748 ± 0.086	7.54AlaVal: 7.54 ± 0.093	1.369AlaTrp: 1.369 ± 0.034	2.604AlaTyr: 2.604 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.049CysAla: 1.049 ± 0.033	0.142CysCys: 0.142 ± 0.012	0.521CysAsp: 0.521 ± 0.023	0.498CysGlu: 0.498 ± 0.024	0.35CysPhe: 0.35 ± 0.018	0.924CysGly: 0.924 ± 0.032	0.277CysHis: 0.277 ± 0.015	0.541CysIle: 0.541 ± 0.025	0.331CysLys: 0.331 ± 0.019	0.826CysLeu: 0.826 ± 0.027	0.234CysMet: 0.234 ± 0.015	0.32CysAsn: 0.32 ± 0.019	0.448CysPro: 0.448 ± 0.026	0.25CysGln: 0.25 ± 0.015	0.51CysArg: 0.51 ± 0.025	0.579CysSer: 0.579 ± 0.024	0.49CysThr: 0.49 ± 0.026	0.714CysVal: 0.714 ± 0.024	0.117CysTrp: 0.117 ± 0.012	0.215CysTyr: 0.215 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.323AspAla: 6.323 ± 0.085	0.481AspCys: 0.481 ± 0.024	2.829AspAsp: 2.829 ± 0.06	3.266AspGlu: 3.266 ± 0.063	2.166AspPhe: 2.166 ± 0.046	4.143AspGly: 4.143 ± 0.075	1.105AspHis: 1.105 ± 0.032	3.329AspIle: 3.329 ± 0.064	2.399AspLys: 2.399 ± 0.047	5.11AspLeu: 5.11 ± 0.081	1.455AspMet: 1.455 ± 0.039	1.5AspAsn: 1.5 ± 0.044	2.378AspPro: 2.378 ± 0.05	1.819AspGln: 1.819 ± 0.045	2.801AspArg: 2.801 ± 0.058	2.479AspSer: 2.479 ± 0.049	2.703AspThr: 2.703 ± 0.074	3.958AspVal: 3.958 ± 0.056	0.812AspTrp: 0.812 ± 0.029	1.577AspTyr: 1.577 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.795GluAla: 5.795 ± 0.086	0.436GluCys: 0.436 ± 0.022	2.341GluAsp: 2.341 ± 0.06	3.243GluGlu: 3.243 ± 0.076	2.046GluPhe: 2.046 ± 0.046	3.337GluGly: 3.337 ± 0.064	1.36GluHis: 1.36 ± 0.041	3.588GluIle: 3.588 ± 0.067	3.156GluLys: 3.156 ± 0.061	5.802GluLeu: 5.802 ± 0.095	1.649GluMet: 1.649 ± 0.043	1.975GluAsn: 1.975 ± 0.049	2.032GluPro: 2.032 ± 0.05	2.911GluGln: 2.911 ± 0.066	3.939GluArg: 3.939 ± 0.071	2.862GluSer: 2.862 ± 0.052	2.829GluThr: 2.829 ± 0.053	3.862GluVal: 3.862 ± 0.068	0.745GluTrp: 0.745 ± 0.025	1.37GluTyr: 1.37 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.122PheAla: 4.122 ± 0.075	0.432PheCys: 0.432 ± 0.025	2.461PheAsp: 2.461 ± 0.059	2.051PheGlu: 2.051 ± 0.047	1.733PhePhe: 1.733 ± 0.045	3.446PheGly: 3.446 ± 0.071	0.764PheHis: 0.764 ± 0.032	2.203PheIle: 2.203 ± 0.045	1.487PheLys: 1.487 ± 0.037	3.398PheLeu: 3.398 ± 0.072	0.954PheMet: 0.954 ± 0.03	1.45PheAsn: 1.45 ± 0.038	1.622PhePro: 1.622 ± 0.041	1.128PheGln: 1.128 ± 0.035	1.849PheArg: 1.849 ± 0.045	2.81PheSer: 2.81 ± 0.063	2.019PheThr: 2.019 ± 0.048	2.699PheVal: 2.699 ± 0.062	0.557PheTrp: 0.557 ± 0.025	1.059PheTyr: 1.059 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.207GlyAla: 7.207 ± 0.11	0.8GlyCys: 0.8 ± 0.031	3.693GlyAsp: 3.693 ± 0.077	3.994GlyGlu: 3.994 ± 0.07	3.16GlyPhe: 3.16 ± 0.063	5.605GlyGly: 5.605 ± 0.113	1.681GlyHis: 1.681 ± 0.04	4.85GlyIle: 4.85 ± 0.071	4.259GlyLys: 4.259 ± 0.075	7.584GlyLeu: 7.584 ± 0.109	2.47GlyMet: 2.47 ± 0.051	2.651GlyAsn: 2.651 ± 0.07	2.171GlyPro: 2.171 ± 0.054	2.61GlyGln: 2.61 ± 0.052	4.128GlyArg: 4.128 ± 0.07	4.455GlySer: 4.455 ± 0.08	4.128GlyThr: 4.128 ± 0.079	5.717GlyVal: 5.717 ± 0.087	1.169GlyTrp: 1.169 ± 0.037	2.176GlyTyr: 2.176 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.734HisAla: 2.734 ± 0.054	0.276HisCys: 0.276 ± 0.016	1.227HisAsp: 1.227 ± 0.035	1.14HisGlu: 1.14 ± 0.036	0.99HisPhe: 0.99 ± 0.034	1.878HisGly: 1.878 ± 0.048	0.67HisHis: 0.67 ± 0.024	1.3HisIle: 1.3 ± 0.041	0.783HisLys: 0.783 ± 0.03	2.151HisLeu: 2.151 ± 0.044	0.561HisMet: 0.561 ± 0.024	0.688HisAsn: 0.688 ± 0.025	1.318HisPro: 1.318 ± 0.037	0.853HisGln: 0.853 ± 0.027	1.25HisArg: 1.25 ± 0.034	1.166HisSer: 1.166 ± 0.035	1.142HisThr: 1.142 ± 0.038	1.474HisVal: 1.474 ± 0.037	0.296HisTrp: 0.296 ± 0.018	0.726HisTyr: 0.726 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	7.618IleAla: 7.618 ± 0.089	0.574IleCys: 0.574 ± 0.026	3.852IleAsp: 3.852 ± 0.065	3.843IleGlu: 3.843 ± 0.061	2.002IlePhe: 2.002 ± 0.047	4.944IleGly: 4.944 ± 0.071	1.143IleHis: 1.143 ± 0.033	2.849IleIle: 2.849 ± 0.058	2.636IleLys: 2.636 ± 0.063	5.097IleLeu: 5.097 ± 0.08	1.287IleMet: 1.287 ± 0.034	2.1IleAsn: 2.1 ± 0.048	2.686IlePro: 2.686 ± 0.052	1.737IleGln: 1.737 ± 0.042	3.105IleArg: 3.105 ± 0.06	3.646IleSer: 3.646 ± 0.061	3.247IleThr: 3.247 ± 0.058	4.527IleVal: 4.527 ± 0.073	0.649IleTrp: 0.649 ± 0.027	1.386IleTyr: 1.386 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.517LysAla: 4.517 ± 0.078	0.259LysCys: 0.259 ± 0.018	2.132LysAsp: 2.132 ± 0.047	2.352LysGlu: 2.352 ± 0.058	1.446LysPhe: 1.446 ± 0.041	2.828LysGly: 2.828 ± 0.059	0.959LysHis: 0.959 ± 0.03	2.785LysIle: 2.785 ± 0.058	2.662LysLys: 2.662 ± 0.086	4.682LysLeu: 4.682 ± 0.079	1.42LysMet: 1.42 ± 0.037	1.886LysAsn: 1.886 ± 0.043	2.416LysPro: 2.416 ± 0.055	1.885LysGln: 1.885 ± 0.047	2.698LysArg: 2.698 ± 0.057	2.624LysSer: 2.624 ± 0.054	2.801LysThr: 2.801 ± 0.056	3.049LysVal: 3.049 ± 0.065	0.523LysTrp: 0.523 ± 0.027	1.006LysTyr: 1.006 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	12.262LeuAla: 12.262 ± 0.141	0.991LeuCys: 0.991 ± 0.034	5.331LeuAsp: 5.331 ± 0.08	5.331LeuGlu: 5.331 ± 0.086	3.943LeuPhe: 3.943 ± 0.075	7.283LeuGly: 7.283 ± 0.092	2.406LeuHis: 2.406 ± 0.051	5.903LeuIle: 5.903 ± 0.103	4.485LeuLys: 4.485 ± 0.079	11.202LeuLeu: 11.202 ± 0.17	2.634LeuMet: 2.634 ± 0.058	3.57LeuAsn: 3.57 ± 0.065	5.465LeuPro: 5.465 ± 0.082	4.33LeuGln: 4.33 ± 0.089	6.266LeuArg: 6.266 ± 0.089	6.743LeuSer: 6.743 ± 0.091	5.788LeuThr: 5.788 ± 0.076	6.668LeuVal: 6.668 ± 0.093	1.088LeuTrp: 1.088 ± 0.041	2.231LeuTyr: 2.231 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.821MetAla: 2.821 ± 0.054	0.21MetCys: 0.21 ± 0.013	1.246MetAsp: 1.246 ± 0.035	1.346MetGlu: 1.346 ± 0.041	0.934MetPhe: 0.934 ± 0.035	1.808MetGly: 1.808 ± 0.046	0.699MetHis: 0.699 ± 0.029	1.439MetIle: 1.439 ± 0.037	1.39MetLys: 1.39 ± 0.042	2.955MetLeu: 2.955 ± 0.061	0.756MetMet: 0.756 ± 0.027	1.081MetAsn: 1.081 ± 0.03	1.513MetPro: 1.513 ± 0.045	1.507MetGln: 1.507 ± 0.045	1.773MetArg: 1.773 ± 0.038	1.846MetSer: 1.846 ± 0.041	1.728MetThr: 1.728 ± 0.039	1.744MetVal: 1.744 ± 0.044	0.247MetTrp: 0.247 ± 0.017	0.48MetTyr: 0.48 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.779AsnAla: 3.779 ± 0.073	0.339AsnCys: 0.339 ± 0.017	1.777AsnAsp: 1.777 ± 0.05	1.745AsnGlu: 1.745 ± 0.038	1.278AsnPhe: 1.278 ± 0.039	2.79AsnGly: 2.79 ± 0.062	0.689AsnHis: 0.689 ± 0.026	2.046AsnIle: 2.046 ± 0.059	1.461AsnLys: 1.461 ± 0.042	3.315AsnLeu: 3.315 ± 0.059	0.918AsnMet: 0.918 ± 0.032	1.221AsnAsn: 1.221 ± 0.045	2.065AsnPro: 2.065 ± 0.055	1.329AsnGln: 1.329 ± 0.04	1.994AsnArg: 1.994 ± 0.047	1.708AsnSer: 1.708 ± 0.048	1.882AsnThr: 1.882 ± 0.06	2.419AsnVal: 2.419 ± 0.051	0.485AsnTrp: 0.485 ± 0.022	0.923AsnTyr: 0.923 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.35ProAla: 5.35 ± 0.087	0.341ProCys: 0.341 ± 0.017	2.878ProAsp: 2.878 ± 0.053	3.009ProGlu: 3.009 ± 0.063	1.761ProPhe: 1.761 ± 0.043	3.226ProGly: 3.226 ± 0.061	1.093ProHis: 1.093 ± 0.031	2.355ProIle: 2.355 ± 0.047	1.744ProLys: 1.744 ± 0.045	4.706ProLeu: 4.706 ± 0.079	1.117ProMet: 1.117 ± 0.03	1.51ProAsn: 1.51 ± 0.041	1.862ProPro: 1.862 ± 0.047	1.943ProGln: 1.943 ± 0.048	2.083ProArg: 2.083 ± 0.046	2.515ProSer: 2.515 ± 0.054	2.296ProThr: 2.296 ± 0.047	3.727ProVal: 3.727 ± 0.069	0.556ProTrp: 0.556 ± 0.028	1.172ProTyr: 1.172 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.838GlnAla: 4.838 ± 0.081	0.292GlnCys: 0.292 ± 0.019	1.766GlnAsp: 1.766 ± 0.046	2.016GlnGlu: 2.016 ± 0.048	1.477GlnPhe: 1.477 ± 0.039	2.602GlnGly: 2.602 ± 0.057	1.005GlnHis: 1.005 ± 0.029	2.407GlnIle: 2.407 ± 0.048	1.812GlnLys: 1.812 ± 0.045	4.206GlnLeu: 4.206 ± 0.068	1.13GlnMet: 1.13 ± 0.034	1.342GlnAsn: 1.342 ± 0.042	1.839GlnPro: 1.839 ± 0.045	2.21GlnGln: 2.21 ± 0.059	2.719GlnArg: 2.719 ± 0.062	2.247GlnSer: 2.247 ± 0.046	2.227GlnThr: 2.227 ± 0.049	2.746GlnVal: 2.746 ± 0.049	0.559GlnTrp: 0.559 ± 0.024	0.994GlnTyr: 0.994 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	5.778ArgAla: 5.778 ± 0.078	0.487ArgCys: 0.487 ± 0.022	3.142ArgAsp: 3.142 ± 0.057	3.547ArgGlu: 3.547 ± 0.059	2.406ArgPhe: 2.406 ± 0.054	3.63ArgGly: 3.63 ± 0.058	1.467ArgHis: 1.467 ± 0.038	3.869ArgIle: 3.869 ± 0.062	2.608ArgLys: 2.608 ± 0.054	6.146ArgLeu: 6.146 ± 0.093	1.759ArgMet: 1.759 ± 0.041	2.245ArgAsn: 2.245 ± 0.051	2.26ArgPro: 2.26 ± 0.053	2.499ArgGln: 2.499 ± 0.054	3.682ArgArg: 3.682 ± 0.07	3.246ArgSer: 3.246 ± 0.057	2.885ArgThr: 2.885 ± 0.055	3.949ArgVal: 3.949 ± 0.073	0.758ArgTrp: 0.758 ± 0.026	1.808ArgTyr: 1.808 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.433SerAla: 6.433 ± 0.079	0.539SerCys: 0.539 ± 0.024	3.176SerAsp: 3.176 ± 0.055	3.1SerGlu: 3.1 ± 0.053	2.363SerPhe: 2.363 ± 0.051	5.369SerGly: 5.369 ± 0.087	1.288SerHis: 1.288 ± 0.037	3.412SerIle: 3.412 ± 0.07	2.47SerLys: 2.47 ± 0.055	5.969SerLeu: 5.969 ± 0.091	1.579SerMet: 1.579 ± 0.036	2.14SerAsn: 2.14 ± 0.054	2.46SerPro: 2.46 ± 0.052	1.954SerGln: 1.954 ± 0.042	3.192SerArg: 3.192 ± 0.051	3.719SerSer: 3.719 ± 0.064	3.247SerThr: 3.247 ± 0.066	4.077SerVal: 4.077 ± 0.064	0.756SerTrp: 0.756 ± 0.027	1.587SerTyr: 1.587 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.793ThrAla: 5.793 ± 0.11	0.434ThrCys: 0.434 ± 0.024	2.696ThrAsp: 2.696 ± 0.051	2.682ThrGlu: 2.682 ± 0.054	2.045ThrPhe: 2.045 ± 0.053	4.469ThrGly: 4.469 ± 0.097	1.185ThrHis: 1.185 ± 0.032	3.193ThrIle: 3.193 ± 0.062	1.823ThrLys: 1.823 ± 0.045	6.399ThrLeu: 6.399 ± 0.089	1.353ThrMet: 1.353 ± 0.035	1.562ThrAsn: 1.562 ± 0.042	3.183ThrPro: 3.183 ± 0.054	2.105ThrGln: 2.105 ± 0.037	3.012ThrArg: 3.012 ± 0.052	3.194ThrSer: 3.194 ± 0.062	2.919ThrThr: 2.919 ± 0.059	4.174ThrVal: 4.174 ± 0.08	0.613ThrTrp: 0.613 ± 0.025	1.297ThrTyr: 1.297 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.017ValAla: 8.017 ± 0.098	0.686ValCys: 0.686 ± 0.028	3.751ValAsp: 3.751 ± 0.074	4.038ValGlu: 4.038 ± 0.07	2.62ValPhe: 2.62 ± 0.049	4.886ValGly: 4.886 ± 0.074	1.448ValHis: 1.448 ± 0.042	4.377ValIle: 4.377 ± 0.074	3.104ValLys: 3.104 ± 0.067	7.543ValLeu: 7.543 ± 0.102	2.017ValMet: 2.017 ± 0.045	2.362ValAsn: 2.362 ± 0.052	3.223ValPro: 3.223 ± 0.054	2.558ValGln: 2.558 ± 0.056	4.079ValArg: 4.079 ± 0.068	4.364ValSer: 4.364 ± 0.071	4.163ValThr: 4.163 ± 0.07	5.442ValVal: 5.442 ± 0.097	0.846ValTrp: 0.846 ± 0.03	1.586ValTyr: 1.586 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	0.991TrpAla: 0.991 ± 0.03	0.141TrpCys: 0.141 ± 0.013	0.548TrpAsp: 0.548 ± 0.023	0.568TrpGlu: 0.568 ± 0.023	0.528TrpPhe: 0.528 ± 0.024	0.784TrpGly: 0.784 ± 0.031	0.373TrpHis: 0.373 ± 0.018	0.77TrpIle: 0.77 ± 0.031	0.512TrpLys: 0.512 ± 0.023	1.833TrpLeu: 1.833 ± 0.051	0.397TrpMet: 0.397 ± 0.019	0.456TrpAsn: 0.456 ± 0.023	0.533TrpPro: 0.533 ± 0.023	0.729TrpGln: 0.729 ± 0.028	0.905TrpArg: 0.905 ± 0.033	0.752TrpSer: 0.752 ± 0.028	0.579TrpThr: 0.579 ± 0.028	0.854TrpVal: 0.854 ± 0.03	0.221TrpTrp: 0.221 ± 0.016	0.285TrpTyr: 0.285 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.061	0.306TyrCys: 0.306 ± 0.02	1.392TyrAsp: 1.392 ± 0.042	1.267TyrGlu: 1.267 ± 0.033	1.189TyrPhe: 1.189 ± 0.034	2.038TyrGly: 2.038 ± 0.047	0.482TyrHis: 0.482 ± 0.022	1.223TyrIle: 1.223 ± 0.033	1.025TyrLys: 1.025 ± 0.033	2.632TyrLeu: 2.632 ± 0.05	0.569TyrMet: 0.569 ± 0.025	0.751TyrAsn: 0.751 ± 0.025	1.228TyrPro: 1.228 ± 0.034	1.05TyrGln: 1.05 ± 0.035	1.702TyrArg: 1.702 ± 0.043	1.461TyrSer: 1.461 ± 0.037	1.31TyrThr: 1.31 ± 0.04	1.772TyrVal: 1.772 ± 0.046	0.394TyrTrp: 0.394 ± 0.02	0.719TyrTyr: 0.719 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3272 proteins (1004082 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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