Amino acid dipepetide frequency for Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.957AlaAla: 5.957 ± 1.775
2.708AlaCys: 2.708 ± 0.567
1.083AlaAsp: 1.083 ± 0.889
7.853AlaGlu: 7.853 ± 1.595
1.354AlaPhe: 1.354 ± 0.68
2.708AlaGly: 2.708 ± 0.809
0.542AlaHis: 0.542 ± 0.336
5.416AlaIle: 5.416 ± 0.719
2.708AlaLys: 2.708 ± 0.996
7.311AlaLeu: 7.311 ± 1.282
1.895AlaMet: 1.895 ± 0.634
2.708AlaAsn: 2.708 ± 0.518
2.437AlaPro: 2.437 ± 0.688
2.437AlaGln: 2.437 ± 0.559
2.166AlaArg: 2.166 ± 0.588
5.957AlaSer: 5.957 ± 1.238
3.249AlaThr: 3.249 ± 0.723
6.228AlaVal: 6.228 ± 0.903
1.625AlaTrp: 1.625 ± 0.675
1.354AlaTyr: 1.354 ± 0.428
0.0AlaXaa: 0.0 ± 0.0
Cys
1.083CysAla: 1.083 ± 0.401
0.542CysCys: 0.542 ± 0.641
0.0CysAsp: 0.0 ± 0.0
0.812CysGlu: 0.812 ± 0.362
1.354CysPhe: 1.354 ± 0.783
1.625CysGly: 1.625 ± 0.563
1.354CysHis: 1.354 ± 0.656
0.271CysIle: 0.271 ± 0.237
2.437CysLys: 2.437 ± 0.52
0.812CysLeu: 0.812 ± 0.411
0.0CysMet: 0.0 ± 0.0
2.437CysAsn: 2.437 ± 1.093
1.083CysPro: 1.083 ± 0.351
1.354CysGln: 1.354 ± 0.443
0.812CysArg: 0.812 ± 0.249
0.271CysSer: 0.271 ± 0.237
1.625CysThr: 1.625 ± 0.6
1.354CysVal: 1.354 ± 0.613
0.812CysTrp: 0.812 ± 0.372
2.166CysTyr: 2.166 ± 2.09
0.0CysXaa: 0.0 ± 0.0
Asp
1.895AspAla: 1.895 ± 0.523
1.354AspCys: 1.354 ± 0.626
1.083AspAsp: 1.083 ± 0.408
1.083AspGlu: 1.083 ± 0.401
1.625AspPhe: 1.625 ± 0.821
1.083AspGly: 1.083 ± 0.293
0.271AspHis: 0.271 ± 0.179
5.686AspIle: 5.686 ± 1.286
1.895AspLys: 1.895 ± 0.996
3.52AspLeu: 3.52 ± 0.533
0.271AspMet: 0.271 ± 0.237
2.166AspAsn: 2.166 ± 1.097
3.791AspPro: 3.791 ± 2.277
2.708AspGln: 2.708 ± 0.745
3.52AspArg: 3.52 ± 1.668
3.249AspSer: 3.249 ± 0.689
1.895AspThr: 1.895 ± 0.495
0.542AspVal: 0.542 ± 0.336
0.271AspTrp: 0.271 ± 0.367
1.625AspTyr: 1.625 ± 0.432
0.0AspXaa: 0.0 ± 0.0
Glu
6.499GluAla: 6.499 ± 1.243
0.0GluCys: 0.0 ± 0.0
2.437GluAsp: 2.437 ± 1.221
6.228GluGlu: 6.228 ± 1.766
1.083GluPhe: 1.083 ± 0.453
5.416GluGly: 5.416 ± 1.621
1.354GluHis: 1.354 ± 0.724
3.249GluIle: 3.249 ± 0.877
3.52GluLys: 3.52 ± 0.693
5.686GluLeu: 5.686 ± 1.341
1.625GluMet: 1.625 ± 0.493
2.437GluAsn: 2.437 ± 0.696
2.979GluPro: 2.979 ± 0.935
5.686GluGln: 5.686 ± 1.295
2.708GluArg: 2.708 ± 0.657
2.437GluSer: 2.437 ± 0.867
5.957GluThr: 5.957 ± 1.197
5.145GluVal: 5.145 ± 1.495
1.625GluTrp: 1.625 ± 0.462
1.083GluTyr: 1.083 ± 0.799
0.0GluXaa: 0.0 ± 0.0
Phe
1.083PheAla: 1.083 ± 0.621
0.271PheCys: 0.271 ± 0.237
1.625PheAsp: 1.625 ± 0.625
0.542PheGlu: 0.542 ± 0.485
1.083PhePhe: 1.083 ± 0.616
1.083PheGly: 1.083 ± 0.407
0.0PheHis: 0.0 ± 0.0
0.812PheIle: 0.812 ± 0.333
1.083PheLys: 1.083 ± 0.616
2.979PheLeu: 2.979 ± 0.666
1.083PheMet: 1.083 ± 0.541
2.708PheAsn: 2.708 ± 0.86
1.895PhePro: 1.895 ± 1.539
0.271PheGln: 0.271 ± 0.179
2.166PheArg: 2.166 ± 1.196
0.812PheSer: 0.812 ± 0.427
2.166PheThr: 2.166 ± 1.167
0.542PheVal: 0.542 ± 0.359
0.271PheTrp: 0.271 ± 0.179
1.354PheTyr: 1.354 ± 0.393
0.0PheXaa: 0.0 ± 0.0
Gly
4.874GlyAla: 4.874 ± 0.846
1.625GlyCys: 1.625 ± 0.494
2.437GlyAsp: 2.437 ± 0.63
3.249GlyGlu: 3.249 ± 0.851
1.895GlyPhe: 1.895 ± 0.729
6.228GlyGly: 6.228 ± 1.741
2.979GlyHis: 2.979 ± 1.281
5.416GlyIle: 5.416 ± 1.268
3.791GlyLys: 3.791 ± 1.499
5.145GlyLeu: 5.145 ± 1.079
1.083GlyMet: 1.083 ± 0.652
1.625GlyAsn: 1.625 ± 0.625
5.416GlyPro: 5.416 ± 1.485
4.603GlyGln: 4.603 ± 1.011
3.52GlyArg: 3.52 ± 1.299
5.416GlySer: 5.416 ± 1.08
4.874GlyThr: 4.874 ± 1.151
2.708GlyVal: 2.708 ± 0.476
0.812GlyTrp: 0.812 ± 0.681
1.895GlyTyr: 1.895 ± 0.575
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.542HisCys: 0.542 ± 0.641
0.0HisAsp: 0.0 ± 0.0
1.354HisGlu: 1.354 ± 0.54
0.542HisPhe: 0.542 ± 0.523
3.249HisGly: 3.249 ± 1.358
0.812HisHis: 0.812 ± 0.847
1.625HisIle: 1.625 ± 0.281
1.895HisLys: 1.895 ± 0.843
2.979HisLeu: 2.979 ± 0.715
0.271HisMet: 0.271 ± 0.382
1.354HisAsn: 1.354 ± 0.393
2.166HisPro: 2.166 ± 1.011
2.437HisGln: 2.437 ± 0.939
0.812HisArg: 0.812 ± 0.427
1.895HisSer: 1.895 ± 1.041
1.625HisThr: 1.625 ± 0.735
0.271HisVal: 0.271 ± 0.179
0.0HisTrp: 0.0 ± 0.0
1.083HisTyr: 1.083 ± 0.926
0.0HisXaa: 0.0 ± 0.0
Ile
4.062IleAla: 4.062 ± 0.608
0.812IleCys: 0.812 ± 0.333
1.895IleAsp: 1.895 ± 0.825
1.354IleGlu: 1.354 ± 0.486
1.083IlePhe: 1.083 ± 0.453
2.979IleGly: 2.979 ± 0.988
1.354IleHis: 1.354 ± 0.656
6.77IleIle: 6.77 ± 1.985
4.062IleLys: 4.062 ± 0.918
7.04IleLeu: 7.04 ± 1.126
0.542IleMet: 0.542 ± 0.473
2.979IleAsn: 2.979 ± 0.936
4.874IlePro: 4.874 ± 1.209
3.791IleGln: 3.791 ± 1.193
7.04IleArg: 7.04 ± 0.905
3.52IleSer: 3.52 ± 0.737
0.812IleThr: 0.812 ± 0.71
4.333IleVal: 4.333 ± 1.104
2.708IleTrp: 2.708 ± 0.731
2.979IleTyr: 2.979 ± 0.799
0.0IleXaa: 0.0 ± 0.0
Lys
5.686LysAla: 5.686 ± 1.815
1.895LysCys: 1.895 ± 0.469
2.708LysAsp: 2.708 ± 0.721
7.582LysGlu: 7.582 ± 2.1
0.542LysPhe: 0.542 ± 0.336
5.145LysGly: 5.145 ± 0.75
1.354LysHis: 1.354 ± 0.491
3.52LysIle: 3.52 ± 0.953
3.791LysLys: 3.791 ± 1.303
5.416LysLeu: 5.416 ± 1.928
2.166LysMet: 2.166 ± 0.423
4.333LysAsn: 4.333 ± 1.526
2.166LysPro: 2.166 ± 1.086
3.52LysGln: 3.52 ± 0.634
3.791LysArg: 3.791 ± 1.51
2.979LysSer: 2.979 ± 0.651
2.708LysThr: 2.708 ± 0.493
3.791LysVal: 3.791 ± 1.129
2.166LysTrp: 2.166 ± 0.411
1.625LysTyr: 1.625 ± 0.802
0.0LysXaa: 0.0 ± 0.0
Leu
4.062LeuAla: 4.062 ± 1.548
1.895LeuCys: 1.895 ± 0.647
3.791LeuAsp: 3.791 ± 0.716
5.957LeuGlu: 5.957 ± 1.587
2.437LeuPhe: 2.437 ± 1.056
6.499LeuGly: 6.499 ± 1.092
1.354LeuHis: 1.354 ± 0.545
4.603LeuIle: 4.603 ± 2.009
8.394LeuLys: 8.394 ± 1.805
5.957LeuLeu: 5.957 ± 1.106
0.812LeuMet: 0.812 ± 0.635
4.603LeuAsn: 4.603 ± 1.108
3.791LeuPro: 3.791 ± 1.052
5.145LeuGln: 5.145 ± 1.486
3.791LeuArg: 3.791 ± 1.208
3.52LeuSer: 3.52 ± 1.274
4.603LeuThr: 4.603 ± 0.898
4.333LeuVal: 4.333 ± 0.467
4.333LeuTrp: 4.333 ± 0.99
2.166LeuTyr: 2.166 ± 0.779
0.0LeuXaa: 0.0 ± 0.0
Met
3.52MetAla: 3.52 ± 1.009
0.0MetCys: 0.0 ± 0.0
1.083MetAsp: 1.083 ± 0.576
1.625MetGlu: 1.625 ± 0.734
1.083MetPhe: 1.083 ± 0.435
2.166MetGly: 2.166 ± 0.379
0.542MetHis: 0.542 ± 0.485
1.083MetIle: 1.083 ± 0.464
1.895MetLys: 1.895 ± 0.786
1.083MetLeu: 1.083 ± 0.403
0.542MetMet: 0.542 ± 0.27
0.812MetAsn: 0.812 ± 0.362
0.812MetPro: 0.812 ± 0.847
0.812MetGln: 0.812 ± 0.249
0.812MetArg: 0.812 ± 0.507
0.542MetSer: 0.542 ± 0.419
2.166MetThr: 2.166 ± 0.664
1.895MetVal: 1.895 ± 0.716
0.0MetTrp: 0.0 ± 0.0
0.542MetTyr: 0.542 ± 0.27
0.0MetXaa: 0.0 ± 0.0
Asn
3.52AsnAla: 3.52 ± 0.977
2.979AsnCys: 2.979 ± 0.993
1.354AsnAsp: 1.354 ± 0.641
2.708AsnGlu: 2.708 ± 0.599
1.895AsnPhe: 1.895 ± 0.75
2.708AsnGly: 2.708 ± 0.662
0.271AsnHis: 0.271 ± 0.367
3.52AsnIle: 3.52 ± 1.406
2.979AsnLys: 2.979 ± 0.821
3.52AsnLeu: 3.52 ± 2.161
0.542AsnMet: 0.542 ± 0.432
2.979AsnAsn: 2.979 ± 0.7
4.062AsnPro: 4.062 ± 1.081
1.354AsnGln: 1.354 ± 0.554
2.708AsnArg: 2.708 ± 0.642
2.437AsnSer: 2.437 ± 0.59
2.979AsnThr: 2.979 ± 0.878
2.166AsnVal: 2.166 ± 1.07
1.895AsnTrp: 1.895 ± 0.368
1.625AsnTyr: 1.625 ± 0.684
0.0AsnXaa: 0.0 ± 0.0
Pro
3.52ProAla: 3.52 ± 1.11
2.166ProCys: 2.166 ± 1.369
2.708ProAsp: 2.708 ± 0.926
4.062ProGlu: 4.062 ± 1.488
1.895ProPhe: 1.895 ± 0.57
6.228ProGly: 6.228 ± 1.516
1.083ProHis: 1.083 ± 0.652
5.416ProIle: 5.416 ± 1.901
2.708ProLys: 2.708 ± 0.476
3.791ProLeu: 3.791 ± 0.761
1.895ProMet: 1.895 ± 0.6
1.083ProAsn: 1.083 ± 0.301
4.062ProPro: 4.062 ± 0.872
2.166ProGln: 2.166 ± 1.334
2.979ProArg: 2.979 ± 0.659
1.354ProSer: 1.354 ± 0.784
3.249ProThr: 3.249 ± 0.742
5.686ProVal: 5.686 ± 1.078
1.354ProTrp: 1.354 ± 1.042
1.083ProTyr: 1.083 ± 0.518
0.0ProXaa: 0.0 ± 0.0
Gln
5.686GlnAla: 5.686 ± 1.298
0.271GlnCys: 0.271 ± 0.367
3.249GlnAsp: 3.249 ± 0.567
5.957GlnGlu: 5.957 ± 1.512
0.542GlnPhe: 0.542 ± 0.637
5.145GlnGly: 5.145 ± 1.156
1.625GlnHis: 1.625 ± 0.796
4.333GlnIle: 4.333 ± 0.964
4.333GlnLys: 4.333 ± 0.825
5.686GlnLeu: 5.686 ± 0.895
2.979GlnMet: 2.979 ± 0.654
2.437GlnAsn: 2.437 ± 0.691
2.166GlnPro: 2.166 ± 0.476
5.957GlnGln: 5.957 ± 1.239
2.166GlnArg: 2.166 ± 0.835
1.895GlnSer: 1.895 ± 0.525
2.437GlnThr: 2.437 ± 0.554
2.979GlnVal: 2.979 ± 1.054
1.083GlnTrp: 1.083 ± 0.484
1.625GlnTyr: 1.625 ± 0.544
0.0GlnXaa: 0.0 ± 0.0
Arg
3.249ArgAla: 3.249 ± 0.614
0.542ArgCys: 0.542 ± 0.641
3.249ArgAsp: 3.249 ± 0.999
4.874ArgGlu: 4.874 ± 0.7
1.354ArgPhe: 1.354 ± 0.566
2.708ArgGly: 2.708 ± 1.184
0.542ArgHis: 0.542 ± 0.637
4.062ArgIle: 4.062 ± 1.941
5.686ArgLys: 5.686 ± 1.365
4.062ArgLeu: 4.062 ± 0.761
0.542ArgMet: 0.542 ± 0.637
1.895ArgAsn: 1.895 ± 0.901
3.249ArgPro: 3.249 ± 1.172
5.145ArgGln: 5.145 ± 0.677
4.603ArgArg: 4.603 ± 3.062
2.166ArgSer: 2.166 ± 1.308
2.708ArgThr: 2.708 ± 0.966
2.166ArgVal: 2.166 ± 0.73
1.625ArgTrp: 1.625 ± 0.786
1.625ArgTyr: 1.625 ± 0.344
0.0ArgXaa: 0.0 ± 0.0
Ser
3.52SerAla: 3.52 ± 0.929
1.083SerCys: 1.083 ± 0.722
2.708SerAsp: 2.708 ± 0.473
2.708SerGlu: 2.708 ± 0.92
0.812SerPhe: 0.812 ± 0.507
2.708SerGly: 2.708 ± 1.312
2.437SerHis: 2.437 ± 1.751
2.437SerIle: 2.437 ± 0.468
3.791SerLys: 3.791 ± 0.842
3.791SerLeu: 3.791 ± 1.096
1.625SerMet: 1.625 ± 0.543
3.249SerAsn: 3.249 ± 0.985
3.52SerPro: 3.52 ± 1.363
3.249SerGln: 3.249 ± 0.891
4.603SerArg: 4.603 ± 0.941
2.437SerSer: 2.437 ± 1.617
2.437SerThr: 2.437 ± 0.981
3.249SerVal: 3.249 ± 1.052
0.812SerTrp: 0.812 ± 0.71
0.812SerTyr: 0.812 ± 0.649
0.0SerXaa: 0.0 ± 0.0
Thr
3.791ThrAla: 3.791 ± 0.969
1.083ThrCys: 1.083 ± 0.727
2.708ThrAsp: 2.708 ± 1.199
3.791ThrGlu: 3.791 ± 0.832
1.354ThrPhe: 1.354 ± 0.64
5.686ThrGly: 5.686 ± 1.114
2.708ThrHis: 2.708 ± 0.511
2.166ThrIle: 2.166 ± 1.587
3.52ThrLys: 3.52 ± 0.734
4.333ThrLeu: 4.333 ± 0.834
1.083ThrMet: 1.083 ± 0.403
2.708ThrAsn: 2.708 ± 0.6
3.791ThrPro: 3.791 ± 0.843
2.979ThrGln: 2.979 ± 0.723
2.437ThrArg: 2.437 ± 1.008
3.791ThrSer: 3.791 ± 1.161
2.708ThrThr: 2.708 ± 0.577
3.791ThrVal: 3.791 ± 1.227
1.625ThrTrp: 1.625 ± 0.65
1.625ThrTyr: 1.625 ± 0.74
0.0ThrXaa: 0.0 ± 0.0
Val
2.437ValAla: 2.437 ± 0.52
0.542ValCys: 0.542 ± 0.641
3.249ValAsp: 3.249 ± 1.112
1.895ValGlu: 1.895 ± 0.79
0.812ValPhe: 0.812 ± 0.372
4.333ValGly: 4.333 ± 0.716
2.166ValHis: 2.166 ± 0.847
1.895ValIle: 1.895 ± 0.75
5.145ValLys: 5.145 ± 1.362
6.228ValLeu: 6.228 ± 1.304
1.895ValMet: 1.895 ± 0.763
1.895ValAsn: 1.895 ± 0.758
4.062ValPro: 4.062 ± 0.727
4.333ValGln: 4.333 ± 0.832
1.895ValArg: 1.895 ± 0.79
4.603ValSer: 4.603 ± 0.846
4.062ValThr: 4.062 ± 1.136
2.708ValVal: 2.708 ± 0.802
1.895ValTrp: 1.895 ± 0.497
1.625ValTyr: 1.625 ± 0.62
0.0ValXaa: 0.0 ± 0.0
Trp
1.625TrpAla: 1.625 ± 0.458
0.542TrpCys: 0.542 ± 0.27
1.354TrpAsp: 1.354 ± 0.393
2.437TrpGlu: 2.437 ± 0.63
0.271TrpPhe: 0.271 ± 0.237
1.354TrpGly: 1.354 ± 0.445
0.542TrpHis: 0.542 ± 0.641
1.354TrpIle: 1.354 ± 0.258
1.895TrpLys: 1.895 ± 0.523
1.354TrpLeu: 1.354 ± 0.907
1.083TrpMet: 1.083 ± 0.301
1.895TrpAsn: 1.895 ± 0.789
0.812TrpPro: 0.812 ± 0.372
2.166TrpGln: 2.166 ± 1.441
1.625TrpArg: 1.625 ± 0.48
1.083TrpSer: 1.083 ± 0.748
2.979TrpThr: 2.979 ± 0.805
1.083TrpVal: 1.083 ± 0.518
0.542TrpTrp: 0.542 ± 0.359
0.542TrpTyr: 0.542 ± 0.226
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.625TyrAla: 1.625 ± 0.574
1.354TyrCys: 1.354 ± 0.883
0.812TyrAsp: 0.812 ± 0.249
1.083TyrGlu: 1.083 ± 0.78
0.812TyrPhe: 0.812 ± 0.466
0.542TyrGly: 0.542 ± 0.46
1.625TyrHis: 1.625 ± 0.942
1.354TyrIle: 1.354 ± 0.606
1.354TyrLys: 1.354 ± 0.706
1.354TyrLeu: 1.354 ± 0.656
0.812TyrMet: 0.812 ± 0.544
1.895TyrAsn: 1.895 ± 0.758
1.354TyrPro: 1.354 ± 0.744
2.708TyrGln: 2.708 ± 1.22
1.895TyrArg: 1.895 ± 0.673
1.625TyrSer: 1.625 ± 0.281
2.437TyrThr: 2.437 ± 0.607
2.708TyrVal: 2.708 ± 0.654
1.083TyrTrp: 1.083 ± 0.336
0.542TyrTyr: 0.542 ± 0.359
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (3694 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski