Amino acid dipepetide frequency for Chondrocystis sp. NIES-4102

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.424AlaAla: 6.424 ± 0.094
0.754AlaCys: 0.754 ± 0.024
3.821AlaAsp: 3.821 ± 0.067
4.674AlaGlu: 4.674 ± 0.07
2.612AlaPhe: 2.612 ± 0.038
4.998AlaGly: 4.998 ± 0.075
1.166AlaHis: 1.166 ± 0.028
7.763AlaIle: 7.763 ± 0.093
4.524AlaLys: 4.524 ± 0.075
7.706AlaLeu: 7.706 ± 0.087
1.495AlaMet: 1.495 ± 0.039
3.672AlaAsn: 3.672 ± 0.074
2.415AlaPro: 2.415 ± 0.042
4.277AlaGln: 4.277 ± 0.07
3.123AlaArg: 3.123 ± 0.05
4.486AlaSer: 4.486 ± 0.059
4.76AlaThr: 4.76 ± 0.065
4.877AlaVal: 4.877 ± 0.069
0.951AlaTrp: 0.951 ± 0.025
2.349AlaTyr: 2.349 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.606CysAla: 0.606 ± 0.026
0.171CysCys: 0.171 ± 0.011
0.6CysAsp: 0.6 ± 0.023
0.477CysGlu: 0.477 ± 0.018
0.413CysPhe: 0.413 ± 0.019
0.748CysGly: 0.748 ± 0.026
0.268CysHis: 0.268 ± 0.014
0.629CysIle: 0.629 ± 0.024
0.388CysLys: 0.388 ± 0.015
1.25CysLeu: 1.25 ± 0.039
0.141CysMet: 0.141 ± 0.01
0.399CysAsn: 0.399 ± 0.021
0.535CysPro: 0.535 ± 0.021
0.669CysGln: 0.669 ± 0.023
0.483CysArg: 0.483 ± 0.019
0.626CysSer: 0.626 ± 0.025
0.408CysThr: 0.408 ± 0.016
0.518CysVal: 0.518 ± 0.018
0.155CysTrp: 0.155 ± 0.012
0.357CysTyr: 0.357 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.349AspAla: 3.349 ± 0.061
0.529AspCys: 0.529 ± 0.02
2.351AspAsp: 2.351 ± 0.081
2.617AspGlu: 2.617 ± 0.063
2.404AspPhe: 2.404 ± 0.054
3.091AspGly: 3.091 ± 0.079
0.862AspHis: 0.862 ± 0.025
3.744AspIle: 3.744 ± 0.06
2.471AspLys: 2.471 ± 0.045
6.417AspLeu: 6.417 ± 0.102
0.715AspMet: 0.715 ± 0.026
2.827AspAsn: 2.827 ± 0.064
2.351AspPro: 2.351 ± 0.049
2.18AspGln: 2.18 ± 0.047
3.396AspArg: 3.396 ± 0.052
3.114AspSer: 3.114 ± 0.057
2.655AspThr: 2.655 ± 0.07
2.706AspVal: 2.706 ± 0.054
0.869AspTrp: 0.869 ± 0.025
2.091AspTyr: 2.091 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.056GluAla: 5.056 ± 0.074
0.439GluCys: 0.439 ± 0.018
2.811GluAsp: 2.811 ± 0.058
3.823GluGlu: 3.823 ± 0.067
2.382GluPhe: 2.382 ± 0.05
3.096GluGly: 3.096 ± 0.064
0.933GluHis: 0.933 ± 0.029
5.611GluIle: 5.611 ± 0.078
3.58GluLys: 3.58 ± 0.054
6.829GluLeu: 6.829 ± 0.104
1.226GluMet: 1.226 ± 0.029
2.792GluAsn: 2.792 ± 0.044
1.99GluPro: 1.99 ± 0.041
3.754GluGln: 3.754 ± 0.06
2.742GluArg: 2.742 ± 0.049
3.549GluSer: 3.549 ± 0.104
3.397GluThr: 3.397 ± 0.056
3.994GluVal: 3.994 ± 0.059
0.651GluTrp: 0.651 ± 0.023
2.05GluTyr: 2.05 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
2.872PheAla: 2.872 ± 0.044
0.502PheCys: 0.502 ± 0.021
2.193PheAsp: 2.193 ± 0.042
2.222PheGlu: 2.222 ± 0.042
1.571PhePhe: 1.571 ± 0.036
2.672PheGly: 2.672 ± 0.052
0.585PheHis: 0.585 ± 0.022
2.812PheIle: 2.812 ± 0.049
1.952PheLys: 1.952 ± 0.043
3.94PheLeu: 3.94 ± 0.067
0.628PheMet: 0.628 ± 0.022
2.211PheAsn: 2.211 ± 0.048
1.626PhePro: 1.626 ± 0.032
1.596PheGln: 1.596 ± 0.035
1.549PheArg: 1.549 ± 0.041
2.768PheSer: 2.768 ± 0.06
2.295PheThr: 2.295 ± 0.044
2.081PheVal: 2.081 ± 0.04
0.684PheTrp: 0.684 ± 0.024
1.44PheTyr: 1.44 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
4.34GlyAla: 4.34 ± 0.079
0.773GlyCys: 0.773 ± 0.025
3.419GlyAsp: 3.419 ± 0.093
3.942GlyGlu: 3.942 ± 0.066
2.799GlyPhe: 2.799 ± 0.047
4.535GlyGly: 4.535 ± 0.101
1.082GlyHis: 1.082 ± 0.035
5.535GlyIle: 5.535 ± 0.07
4.391GlyLys: 4.391 ± 0.064
6.361GlyLeu: 6.361 ± 0.075
1.444GlyMet: 1.444 ± 0.035
3.226GlyAsn: 3.226 ± 0.099
0.809GlyPro: 0.809 ± 0.026
2.528GlyGln: 2.528 ± 0.048
2.664GlyArg: 2.664 ± 0.051
3.866GlySer: 3.866 ± 0.079
3.481GlyThr: 3.481 ± 0.077
4.393GlyVal: 4.393 ± 0.067
1.022GlyTrp: 1.022 ± 0.03
2.469GlyTyr: 2.469 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
0.899HisAla: 0.899 ± 0.027
0.257HisCys: 0.257 ± 0.015
0.749HisAsp: 0.749 ± 0.025
0.69HisGlu: 0.69 ± 0.021
0.712HisPhe: 0.712 ± 0.023
1.018HisGly: 1.018 ± 0.027
0.559HisHis: 0.559 ± 0.027
1.057HisIle: 1.057 ± 0.029
0.734HisLys: 0.734 ± 0.025
2.192HisLeu: 2.192 ± 0.043
0.217HisMet: 0.217 ± 0.013
0.879HisAsn: 0.879 ± 0.025
1.188HisPro: 1.188 ± 0.032
1.29HisGln: 1.29 ± 0.035
0.945HisArg: 0.945 ± 0.03
1.101HisSer: 1.101 ± 0.033
0.848HisThr: 0.848 ± 0.028
0.628HisVal: 0.628 ± 0.023
0.338HisTrp: 0.338 ± 0.016
0.677HisTyr: 0.677 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
8.029IleAla: 8.029 ± 0.084
0.838IleCys: 0.838 ± 0.026
4.484IleAsp: 4.484 ± 0.067
5.29IleGlu: 5.29 ± 0.066
2.987IlePhe: 2.987 ± 0.055
4.711IleGly: 4.711 ± 0.068
1.176IleHis: 1.176 ± 0.031
5.833IleIle: 5.833 ± 0.085
4.635IleLys: 4.635 ± 0.066
7.583IleLeu: 7.583 ± 0.1
1.112IleMet: 1.112 ± 0.032
4.533IleAsn: 4.533 ± 0.071
3.843IlePro: 3.843 ± 0.045
2.978IleGln: 2.978 ± 0.044
2.985IleArg: 2.985 ± 0.055
5.197IleSer: 5.197 ± 0.064
4.693IleThr: 4.693 ± 0.066
4.763IleVal: 4.763 ± 0.061
0.875IleTrp: 0.875 ± 0.025
2.503IleTyr: 2.503 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.033LysAla: 4.033 ± 0.06
0.35LysCys: 0.35 ± 0.015
2.588LysAsp: 2.588 ± 0.049
3.292LysGlu: 3.292 ± 0.06
1.877LysPhe: 1.877 ± 0.043
2.769LysGly: 2.769 ± 0.053
0.882LysHis: 0.882 ± 0.029
4.933LysIle: 4.933 ± 0.063
2.869LysLys: 2.869 ± 0.056
6.309LysLeu: 6.309 ± 0.076
1.076LysMet: 1.076 ± 0.029
2.597LysAsn: 2.597 ± 0.049
2.533LysPro: 2.533 ± 0.051
3.437LysGln: 3.437 ± 0.064
2.239LysArg: 2.239 ± 0.042
3.458LysSer: 3.458 ± 0.059
3.314LysThr: 3.314 ± 0.054
3.46LysVal: 3.46 ± 0.051
0.527LysTrp: 0.527 ± 0.023
1.904LysTyr: 1.904 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
9.362LeuAla: 9.362 ± 0.1
0.94LeuCys: 0.94 ± 0.03
5.898LeuAsp: 5.898 ± 0.085
7.516LeuGlu: 7.516 ± 0.092
3.754LeuPhe: 3.754 ± 0.058
7.451LeuGly: 7.451 ± 0.085
1.636LeuHis: 1.636 ± 0.04
8.341LeuIle: 8.341 ± 0.091
6.301LeuLys: 6.301 ± 0.065
10.97LeuLeu: 10.97 ± 0.139
1.931LeuMet: 1.931 ± 0.04
5.598LeuAsn: 5.598 ± 0.077
5.272LeuPro: 5.272 ± 0.07
5.174LeuGln: 5.174 ± 0.074
4.53LeuArg: 4.53 ± 0.061
7.527LeuSer: 7.527 ± 0.084
6.604LeuThr: 6.604 ± 0.077
6.708LeuVal: 6.708 ± 0.087
1.262LeuTrp: 1.262 ± 0.034
2.852LeuTyr: 2.852 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
1.664MetAla: 1.664 ± 0.039
0.112MetCys: 0.112 ± 0.009
0.719MetAsp: 0.719 ± 0.021
0.94MetGlu: 0.94 ± 0.032
0.593MetPhe: 0.593 ± 0.022
1.349MetGly: 1.349 ± 0.031
0.213MetHis: 0.213 ± 0.011
1.208MetIle: 1.208 ± 0.034
0.915MetLys: 0.915 ± 0.03
1.864MetLeu: 1.864 ± 0.037
0.414MetMet: 0.414 ± 0.019
0.915MetAsn: 0.915 ± 0.027
0.806MetPro: 0.806 ± 0.025
0.821MetGln: 0.821 ± 0.026
0.816MetArg: 0.816 ± 0.025
1.399MetSer: 1.399 ± 0.028
1.211MetThr: 1.211 ± 0.031
1.114MetVal: 1.114 ± 0.029
0.144MetTrp: 0.144 ± 0.012
0.413MetTyr: 0.413 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.89AsnAla: 2.89 ± 0.063
0.625AsnCys: 0.625 ± 0.027
2.067AsnAsp: 2.067 ± 0.059
1.976AsnGlu: 1.976 ± 0.045
2.236AsnPhe: 2.236 ± 0.053
2.652AsnGly: 2.652 ± 0.073
1.0AsnHis: 1.0 ± 0.029
3.972AsnIle: 3.972 ± 0.074
2.583AsnLys: 2.583 ± 0.047
6.572AsnLeu: 6.572 ± 0.095
0.75AsnMet: 0.75 ± 0.024
3.327AsnAsn: 3.327 ± 0.072
2.897AsnPro: 2.897 ± 0.05
3.38AsnGln: 3.38 ± 0.057
2.246AsnArg: 2.246 ± 0.042
3.9AsnSer: 3.9 ± 0.064
2.739AsnThr: 2.739 ± 0.059
2.359AsnVal: 2.359 ± 0.044
0.917AsnTrp: 0.917 ± 0.023
2.153AsnTyr: 2.153 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.651ProAla: 2.651 ± 0.043
0.329ProCys: 0.329 ± 0.015
2.528ProAsp: 2.528 ± 0.045
3.319ProGlu: 3.319 ± 0.058
1.494ProPhe: 1.494 ± 0.031
2.676ProGly: 2.676 ± 0.06
0.794ProHis: 0.794 ± 0.026
3.286ProIle: 3.286 ± 0.055
2.121ProLys: 2.121 ± 0.042
4.3ProLeu: 4.3 ± 0.058
0.636ProMet: 0.636 ± 0.021
2.245ProAsn: 2.245 ± 0.043
1.83ProPro: 1.83 ± 0.041
2.917ProGln: 2.917 ± 0.063
1.467ProArg: 1.467 ± 0.033
2.498ProSer: 2.498 ± 0.048
2.661ProThr: 2.661 ± 0.046
2.77ProVal: 2.77 ± 0.054
0.575ProTrp: 0.575 ± 0.018
1.306ProTyr: 1.306 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.803GlnAla: 4.803 ± 0.07
0.35GlnCys: 0.35 ± 0.019
2.541GlnAsp: 2.541 ± 0.046
3.586GlnGlu: 3.586 ± 0.058
1.654GlnPhe: 1.654 ± 0.035
3.262GlnGly: 3.262 ± 0.056
0.938GlnHis: 0.938 ± 0.028
4.221GlnIle: 4.221 ± 0.064
3.016GlnLys: 3.016 ± 0.05
6.401GlnLeu: 6.401 ± 0.101
1.009GlnMet: 1.009 ± 0.027
2.283GlnAsn: 2.283 ± 0.045
2.543GlnPro: 2.543 ± 0.049
4.579GlnGln: 4.579 ± 0.093
2.478GlnArg: 2.478 ± 0.048
3.024GlnSer: 3.024 ± 0.055
3.082GlnThr: 3.082 ± 0.052
3.671GlnVal: 3.671 ± 0.055
0.709GlnTrp: 0.709 ± 0.024
1.498GlnTyr: 1.498 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.764ArgAla: 2.764 ± 0.046
0.434ArgCys: 0.434 ± 0.017
2.368ArgAsp: 2.368 ± 0.044
2.737ArgGlu: 2.737 ± 0.052
1.819ArgPhe: 1.819 ± 0.041
2.553ArgGly: 2.553 ± 0.05
0.938ArgHis: 0.938 ± 0.031
3.156ArgIle: 3.156 ± 0.051
2.089ArgLys: 2.089 ± 0.038
5.16ArgLeu: 5.16 ± 0.065
0.804ArgMet: 0.804 ± 0.023
2.144ArgAsn: 2.144 ± 0.04
1.688ArgPro: 1.688 ± 0.038
2.983ArgGln: 2.983 ± 0.049
2.518ArgArg: 2.518 ± 0.051
3.008ArgSer: 3.008 ± 0.047
2.025ArgThr: 2.025 ± 0.044
2.657ArgVal: 2.657 ± 0.048
0.676ArgTrp: 0.676 ± 0.023
1.755ArgTyr: 1.755 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.267SerAla: 4.267 ± 0.055
0.701SerCys: 0.701 ± 0.026
3.359SerAsp: 3.359 ± 0.053
3.754SerGlu: 3.754 ± 0.115
2.583SerPhe: 2.583 ± 0.052
4.209SerGly: 4.209 ± 0.073
1.148SerHis: 1.148 ± 0.032
4.406SerIle: 4.406 ± 0.058
3.354SerLys: 3.354 ± 0.053
8.026SerLeu: 8.026 ± 0.086
1.186SerMet: 1.186 ± 0.033
3.606SerAsn: 3.606 ± 0.067
2.92SerPro: 2.92 ± 0.045
3.79SerGln: 3.79 ± 0.053
2.762SerArg: 2.762 ± 0.048
4.553SerSer: 4.553 ± 0.07
3.452SerThr: 3.452 ± 0.06
3.578SerVal: 3.578 ± 0.053
0.915SerTrp: 0.915 ± 0.03
2.061SerTyr: 2.061 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.742ThrAla: 4.742 ± 0.072
0.484ThrCys: 0.484 ± 0.021
2.616ThrAsp: 2.616 ± 0.05
3.275ThrGlu: 3.275 ± 0.054
1.954ThrPhe: 1.954 ± 0.047
4.123ThrGly: 4.123 ± 0.091
0.918ThrHis: 0.918 ± 0.022
4.777ThrIle: 4.777 ± 0.07
2.927ThrLys: 2.927 ± 0.05
5.83ThrLeu: 5.83 ± 0.083
0.815ThrMet: 0.815 ± 0.025
2.698ThrAsn: 2.698 ± 0.052
3.106ThrPro: 3.106 ± 0.053
2.988ThrGln: 2.988 ± 0.047
2.154ThrArg: 2.154 ± 0.042
3.589ThrSer: 3.589 ± 0.059
3.644ThrThr: 3.644 ± 0.082
4.039ThrVal: 4.039 ± 0.084
0.71ThrTrp: 0.71 ± 0.022
1.72ThrTyr: 1.72 ± 0.04
0.0ThrXaa: 0.0 ± 0.0
Val
5.362ValAla: 5.362 ± 0.068
0.641ValCys: 0.641 ± 0.022
3.404ValAsp: 3.404 ± 0.058
4.13ValGlu: 4.13 ± 0.065
2.333ValPhe: 2.333 ± 0.05
4.126ValGly: 4.126 ± 0.065
0.83ValHis: 0.83 ± 0.026
4.796ValIle: 4.796 ± 0.066
3.574ValLys: 3.574 ± 0.055
5.782ValLeu: 5.782 ± 0.074
1.317ValMet: 1.317 ± 0.037
3.114ValAsn: 3.114 ± 0.053
2.3ValPro: 2.3 ± 0.042
2.218ValGln: 2.218 ± 0.038
2.534ValArg: 2.534 ± 0.043
3.914ValSer: 3.914 ± 0.06
3.603ValThr: 3.603 ± 0.077
4.182ValVal: 4.182 ± 0.068
0.754ValTrp: 0.754 ± 0.025
1.867ValTyr: 1.867 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.762TrpAla: 0.762 ± 0.024
0.173TrpCys: 0.173 ± 0.01
0.611TrpAsp: 0.611 ± 0.031
0.757TrpGlu: 0.757 ± 0.024
0.544TrpPhe: 0.544 ± 0.022
0.894TrpGly: 0.894 ± 0.029
0.35TrpHis: 0.35 ± 0.016
0.877TrpIle: 0.877 ± 0.031
0.577TrpLys: 0.577 ± 0.024
1.878TrpLeu: 1.878 ± 0.045
0.272TrpMet: 0.272 ± 0.015
0.588TrpAsn: 0.588 ± 0.02
0.128TrpPro: 0.128 ± 0.01
1.477TrpGln: 1.477 ± 0.034
0.74TrpArg: 0.74 ± 0.026
0.909TrpSer: 0.909 ± 0.028
0.579TrpThr: 0.579 ± 0.022
0.767TrpVal: 0.767 ± 0.026
0.223TrpTrp: 0.223 ± 0.015
0.462TrpTyr: 0.462 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.973TyrAla: 1.973 ± 0.034
0.437TyrCys: 0.437 ± 0.02
1.611TyrAsp: 1.611 ± 0.039
1.689TyrGlu: 1.689 ± 0.042
1.478TyrPhe: 1.478 ± 0.035
2.146TyrGly: 2.146 ± 0.047
0.699TyrHis: 0.699 ± 0.026
2.09TyrIle: 2.09 ± 0.049
1.443TyrLys: 1.443 ± 0.035
4.258TyrLeu: 4.258 ± 0.059
0.443TyrMet: 0.443 ± 0.018
1.585TyrAsn: 1.585 ± 0.036
1.625TyrPro: 1.625 ± 0.037
2.611TyrGln: 2.611 ± 0.051
1.905TyrArg: 1.905 ± 0.037
2.143TyrSer: 2.143 ± 0.035
1.659TyrThr: 1.659 ± 0.046
1.518TyrVal: 1.518 ± 0.028
0.613TyrTrp: 0.613 ± 0.023
1.287TyrTyr: 1.287 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4342 proteins (1365604 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski