Amino acid dipepetide frequency for Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.725AlaAla: 5.725 ± 1.99
2.181AlaCys: 2.181 ± 0.573
1.363AlaAsp: 1.363 ± 0.526
5.453AlaGlu: 5.453 ± 1.295
1.636AlaPhe: 1.636 ± 0.336
4.907AlaGly: 4.907 ± 1.02
0.818AlaHis: 0.818 ± 0.332
3.817AlaIle: 3.817 ± 0.983
2.726AlaLys: 2.726 ± 0.441
5.453AlaLeu: 5.453 ± 1.063
2.181AlaMet: 2.181 ± 0.52
2.454AlaAsn: 2.454 ± 0.432
2.726AlaPro: 2.726 ± 0.832
2.181AlaGln: 2.181 ± 0.416
2.999AlaArg: 2.999 ± 0.476
4.635AlaSer: 4.635 ± 0.896
3.817AlaThr: 3.817 ± 1.067
5.725AlaVal: 5.725 ± 0.924
1.091AlaTrp: 1.091 ± 0.533
0.818AlaTyr: 0.818 ± 0.332
0.0AlaXaa: 0.0 ± 0.0
Cys
0.273CysAla: 0.273 ± 0.246
0.545CysCys: 0.545 ± 0.541
0.273CysAsp: 0.273 ± 0.185
0.273CysGlu: 0.273 ± 0.292
1.636CysPhe: 1.636 ± 0.849
1.908CysGly: 1.908 ± 0.521
0.0CysHis: 0.0 ± 0.0
0.273CysIle: 0.273 ± 0.246
1.636CysLys: 1.636 ± 0.464
0.273CysLeu: 0.273 ± 0.362
0.273CysMet: 0.273 ± 0.336
1.636CysAsn: 1.636 ± 1.089
0.273CysPro: 0.273 ± 0.246
1.908CysGln: 1.908 ± 0.606
1.363CysArg: 1.363 ± 0.513
1.636CysSer: 1.636 ± 0.928
2.999CysThr: 2.999 ± 0.797
1.636CysVal: 1.636 ± 0.496
0.818CysTrp: 0.818 ± 0.401
1.091CysTyr: 1.091 ± 1.083
0.0CysXaa: 0.0 ± 0.0
Asp
0.545AspAla: 0.545 ± 0.227
2.726AspCys: 2.726 ± 0.886
1.636AspAsp: 1.636 ± 0.538
1.908AspGlu: 1.908 ± 1.02
0.818AspPhe: 0.818 ± 0.554
1.908AspGly: 1.908 ± 0.743
0.0AspHis: 0.0 ± 0.0
3.272AspIle: 3.272 ± 0.532
4.089AspLys: 4.089 ± 0.843
3.817AspLeu: 3.817 ± 1.082
0.273AspMet: 0.273 ± 0.17
1.908AspAsn: 1.908 ± 0.871
3.272AspPro: 3.272 ± 1.386
2.181AspGln: 2.181 ± 0.36
4.089AspArg: 4.089 ± 0.676
2.454AspSer: 2.454 ± 1.093
2.999AspThr: 2.999 ± 0.528
1.636AspVal: 1.636 ± 0.429
0.545AspTrp: 0.545 ± 0.514
0.818AspTyr: 0.818 ± 0.401
0.0AspXaa: 0.0 ± 0.0
Glu
5.725GluAla: 5.725 ± 0.831
0.0GluCys: 0.0 ± 0.0
3.272GluAsp: 3.272 ± 1.438
6.816GluGlu: 6.816 ± 2.093
1.091GluPhe: 1.091 ± 0.488
4.907GluGly: 4.907 ± 0.619
0.818GluHis: 0.818 ± 0.554
4.089GluIle: 4.089 ± 1.154
5.18GluLys: 5.18 ± 1.141
6.27GluLeu: 6.27 ± 1.303
1.908GluMet: 1.908 ± 0.489
2.454GluAsn: 2.454 ± 0.779
5.18GluPro: 5.18 ± 1.201
3.544GluGln: 3.544 ± 0.703
3.817GluArg: 3.817 ± 1.38
2.999GluSer: 2.999 ± 1.105
4.635GluThr: 4.635 ± 1.735
4.362GluVal: 4.362 ± 0.606
1.636GluTrp: 1.636 ± 0.703
0.818GluTyr: 0.818 ± 0.445
0.0GluXaa: 0.0 ± 0.0
Phe
1.363PheAla: 1.363 ± 0.31
0.273PheCys: 0.273 ± 0.246
1.091PheAsp: 1.091 ± 0.67
0.273PheGlu: 0.273 ± 0.246
0.273PhePhe: 0.273 ± 0.246
1.091PheGly: 1.091 ± 0.733
0.273PheHis: 0.273 ± 0.362
1.363PheIle: 1.363 ± 0.517
1.636PheLys: 1.636 ± 0.779
3.817PheLeu: 3.817 ± 0.711
0.0PheMet: 0.0 ± 0.0
1.908PheAsn: 1.908 ± 0.719
1.636PhePro: 1.636 ± 0.73
0.818PheGln: 0.818 ± 0.436
2.726PheArg: 2.726 ± 0.875
2.454PheSer: 2.454 ± 0.578
1.363PheThr: 1.363 ± 0.538
0.273PheVal: 0.273 ± 0.185
0.273PheTrp: 0.273 ± 0.185
1.636PheTyr: 1.636 ± 0.313
0.0PheXaa: 0.0 ± 0.0
Gly
4.362GlyAla: 4.362 ± 0.422
1.908GlyCys: 1.908 ± 0.538
2.454GlyAsp: 2.454 ± 0.896
3.817GlyGlu: 3.817 ± 0.583
1.636GlyPhe: 1.636 ± 0.625
6.816GlyGly: 6.816 ± 1.441
3.544GlyHis: 3.544 ± 1.394
5.725GlyIle: 5.725 ± 1.636
5.725GlyLys: 5.725 ± 1.889
3.544GlyLeu: 3.544 ± 0.933
0.818GlyMet: 0.818 ± 0.33
3.272GlyAsn: 3.272 ± 1.012
5.18GlyPro: 5.18 ± 0.985
4.635GlyGln: 4.635 ± 1.234
3.544GlyArg: 3.544 ± 0.797
5.453GlySer: 5.453 ± 1.083
4.362GlyThr: 4.362 ± 1.42
2.726GlyVal: 2.726 ± 0.595
1.908GlyTrp: 1.908 ± 0.698
1.636GlyTyr: 1.636 ± 0.563
0.0GlyXaa: 0.0 ± 0.0
His
1.363HisAla: 1.363 ± 0.356
1.091HisCys: 1.091 ± 0.705
0.0HisAsp: 0.0 ± 0.0
0.545HisGlu: 0.545 ± 0.227
0.818HisPhe: 0.818 ± 0.81
1.363HisGly: 1.363 ± 0.61
1.091HisHis: 1.091 ± 0.836
2.181HisIle: 2.181 ± 0.766
1.363HisLys: 1.363 ± 0.706
2.726HisLeu: 2.726 ± 0.85
0.545HisMet: 0.545 ± 0.567
0.818HisAsn: 0.818 ± 0.286
2.454HisPro: 2.454 ± 0.971
2.999HisGln: 2.999 ± 1.346
0.818HisArg: 0.818 ± 0.286
1.091HisSer: 1.091 ± 0.703
1.363HisThr: 1.363 ± 0.649
0.545HisVal: 0.545 ± 0.328
0.0HisTrp: 0.0 ± 0.0
0.545HisTyr: 0.545 ± 0.364
0.0HisXaa: 0.0 ± 0.0
Ile
2.454IleAla: 2.454 ± 0.925
1.363IleCys: 1.363 ± 0.436
1.363IleAsp: 1.363 ± 0.672
4.362IleGlu: 4.362 ± 0.715
0.818IlePhe: 0.818 ± 0.436
4.907IleGly: 4.907 ± 1.965
1.908IleHis: 1.908 ± 0.527
4.362IleIle: 4.362 ± 1.232
3.817IleLys: 3.817 ± 1.123
5.998IleLeu: 5.998 ± 1.41
0.818IleMet: 0.818 ± 0.237
1.091IleAsn: 1.091 ± 0.26
3.272IlePro: 3.272 ± 0.819
1.908IleGln: 1.908 ± 1.293
4.907IleArg: 4.907 ± 0.917
3.817IleSer: 3.817 ± 0.695
2.999IleThr: 2.999 ± 1.346
8.179IleVal: 8.179 ± 1.414
1.636IleTrp: 1.636 ± 0.496
2.181IleTyr: 2.181 ± 0.469
0.0IleXaa: 0.0 ± 0.0
Lys
6.27LysAla: 6.27 ± 1.183
2.454LysCys: 2.454 ± 0.535
1.636LysAsp: 1.636 ± 0.631
7.088LysGlu: 7.088 ± 2.08
0.818LysPhe: 0.818 ± 0.33
4.907LysGly: 4.907 ± 0.899
2.454LysHis: 2.454 ± 0.945
5.998LysIle: 5.998 ± 2.204
6.816LysLys: 6.816 ± 1.515
5.453LysLeu: 5.453 ± 1.287
0.545LysMet: 0.545 ± 0.328
3.272LysAsn: 3.272 ± 1.274
1.636LysPro: 1.636 ± 0.767
4.362LysGln: 4.362 ± 1.281
3.272LysArg: 3.272 ± 0.585
3.544LysSer: 3.544 ± 0.789
4.362LysThr: 4.362 ± 0.467
4.907LysVal: 4.907 ± 1.246
2.454LysTrp: 2.454 ± 0.494
1.636LysTyr: 1.636 ± 0.681
0.0LysXaa: 0.0 ± 0.0
Leu
4.362LeuAla: 4.362 ± 0.873
0.818LeuCys: 0.818 ± 0.436
4.635LeuAsp: 4.635 ± 0.972
7.088LeuGlu: 7.088 ± 1.073
1.636LeuPhe: 1.636 ± 0.641
6.27LeuGly: 6.27 ± 1.08
2.454LeuHis: 2.454 ± 0.753
2.726LeuIle: 2.726 ± 0.882
7.634LeuLys: 7.634 ± 1.135
7.906LeuLeu: 7.906 ± 3.787
0.818LeuMet: 0.818 ± 0.579
4.635LeuAsn: 4.635 ± 1.002
2.454LeuPro: 2.454 ± 0.703
5.725LeuGln: 5.725 ± 1.421
3.817LeuArg: 3.817 ± 0.69
3.817LeuSer: 3.817 ± 0.651
4.635LeuThr: 4.635 ± 1.045
5.18LeuVal: 5.18 ± 1.447
3.544LeuTrp: 3.544 ± 1.219
2.454LeuTyr: 2.454 ± 0.874
0.0LeuXaa: 0.0 ± 0.0
Met
1.091MetAla: 1.091 ± 0.58
0.0MetCys: 0.0 ± 0.0
0.818MetAsp: 0.818 ± 0.389
1.908MetGlu: 1.908 ± 0.826
0.818MetPhe: 0.818 ± 0.237
1.908MetGly: 1.908 ± 0.746
0.545MetHis: 0.545 ± 0.227
1.363MetIle: 1.363 ± 0.673
0.545MetLys: 0.545 ± 0.325
2.181MetLeu: 2.181 ± 0.73
0.818MetMet: 0.818 ± 0.237
0.818MetAsn: 0.818 ± 0.372
0.0MetPro: 0.0 ± 0.0
1.363MetGln: 1.363 ± 0.529
1.908MetArg: 1.908 ± 0.484
0.545MetSer: 0.545 ± 0.325
2.454MetThr: 2.454 ± 0.831
0.818MetVal: 0.818 ± 0.237
0.545MetTrp: 0.545 ± 0.493
1.091MetTyr: 1.091 ± 0.336
0.0MetXaa: 0.0 ± 0.0
Asn
2.454AsnAla: 2.454 ± 0.729
2.999AsnCys: 2.999 ± 0.96
1.363AsnAsp: 1.363 ± 0.31
2.454AsnGlu: 2.454 ± 0.62
2.999AsnPhe: 2.999 ± 0.875
2.726AsnGly: 2.726 ± 0.978
0.0AsnHis: 0.0 ± 0.0
1.636AsnIle: 1.636 ± 0.364
2.726AsnLys: 2.726 ± 0.576
3.544AsnLeu: 3.544 ± 1.133
1.636AsnMet: 1.636 ± 1.478
4.362AsnAsn: 4.362 ± 1.985
2.999AsnPro: 2.999 ± 0.931
0.545AsnGln: 0.545 ± 0.227
1.363AsnArg: 1.363 ± 0.493
2.726AsnSer: 2.726 ± 0.588
4.089AsnThr: 4.089 ± 1.375
1.636AsnVal: 1.636 ± 1.155
1.636AsnTrp: 1.636 ± 0.364
1.363AsnTyr: 1.363 ± 0.441
0.0AsnXaa: 0.0 ± 0.0
Pro
3.817ProAla: 3.817 ± 0.658
0.818ProCys: 0.818 ± 0.739
2.454ProAsp: 2.454 ± 0.632
3.817ProGlu: 3.817 ± 0.807
1.363ProPhe: 1.363 ± 0.689
3.272ProGly: 3.272 ± 0.924
0.273ProHis: 0.273 ± 0.185
5.18ProIle: 5.18 ± 1.08
2.999ProLys: 2.999 ± 0.707
3.272ProLeu: 3.272 ± 0.658
0.818ProMet: 0.818 ± 0.451
0.545ProAsn: 0.545 ± 0.493
3.817ProPro: 3.817 ± 1.538
3.544ProGln: 3.544 ± 0.865
4.907ProArg: 4.907 ± 1.22
3.272ProSer: 3.272 ± 1.717
1.908ProThr: 1.908 ± 0.676
4.635ProVal: 4.635 ± 0.834
1.091ProTrp: 1.091 ± 0.694
0.818ProTyr: 0.818 ± 0.441
0.0ProXaa: 0.0 ± 0.0
Gln
5.453GlnAla: 5.453 ± 1.158
0.273GlnCys: 0.273 ± 0.246
2.726GlnAsp: 2.726 ± 1.121
3.272GlnGlu: 3.272 ± 0.702
0.273GlnPhe: 0.273 ± 0.246
5.453GlnGly: 5.453 ± 0.922
1.363GlnHis: 1.363 ± 0.802
4.635GlnIle: 4.635 ± 1.104
4.362GlnLys: 4.362 ± 1.139
5.998GlnLeu: 5.998 ± 1.31
3.544GlnMet: 3.544 ± 1.468
4.089GlnAsn: 4.089 ± 1.33
2.181GlnPro: 2.181 ± 1.125
2.181GlnGln: 2.181 ± 1.082
2.726GlnArg: 2.726 ± 1.053
1.636GlnSer: 1.636 ± 0.464
1.908GlnThr: 1.908 ± 0.473
5.18GlnVal: 5.18 ± 1.387
1.363GlnTrp: 1.363 ± 0.65
1.636GlnTyr: 1.636 ± 0.582
0.0GlnXaa: 0.0 ± 0.0
Arg
4.362ArgAla: 4.362 ± 0.911
0.545ArgCys: 0.545 ± 0.588
5.453ArgAsp: 5.453 ± 0.818
5.453ArgGlu: 5.453 ± 0.786
1.363ArgPhe: 1.363 ± 0.961
3.817ArgGly: 3.817 ± 0.842
0.818ArgHis: 0.818 ± 0.531
4.907ArgIle: 4.907 ± 1.612
4.907ArgLys: 4.907 ± 0.716
4.089ArgLeu: 4.089 ± 1.343
1.363ArgMet: 1.363 ± 0.526
0.818ArgAsn: 0.818 ± 0.582
2.726ArgPro: 2.726 ± 0.976
5.453ArgGln: 5.453 ± 1.384
4.907ArgArg: 4.907 ± 3.072
1.363ArgSer: 1.363 ± 0.936
1.091ArgThr: 1.091 ± 0.436
1.636ArgVal: 1.636 ± 1.155
1.636ArgTrp: 1.636 ± 0.797
1.636ArgTyr: 1.636 ± 0.393
0.0ArgXaa: 0.0 ± 0.0
Ser
2.454SerAla: 2.454 ± 0.451
0.273SerCys: 0.273 ± 0.185
1.908SerAsp: 1.908 ± 0.711
4.362SerGlu: 4.362 ± 0.882
2.181SerPhe: 2.181 ± 0.954
3.544SerGly: 3.544 ± 1.234
1.363SerHis: 1.363 ± 0.826
2.181SerIle: 2.181 ± 0.43
2.454SerLys: 2.454 ± 1.079
5.998SerLeu: 5.998 ± 1.513
0.818SerMet: 0.818 ± 0.451
2.181SerAsn: 2.181 ± 0.872
4.362SerPro: 4.362 ± 1.171
5.998SerGln: 5.998 ± 1.879
3.272SerArg: 3.272 ± 0.919
2.999SerSer: 2.999 ± 0.99
3.272SerThr: 3.272 ± 0.846
2.181SerVal: 2.181 ± 0.39
0.545SerTrp: 0.545 ± 0.227
1.091SerTyr: 1.091 ± 0.705
0.0SerXaa: 0.0 ± 0.0
Thr
3.272ThrAla: 3.272 ± 0.903
0.0ThrCys: 0.0 ± 0.0
2.726ThrAsp: 2.726 ± 0.958
4.362ThrGlu: 4.362 ± 0.719
1.363ThrPhe: 1.363 ± 0.708
4.089ThrGly: 4.089 ± 0.655
1.636ThrHis: 1.636 ± 0.674
3.544ThrIle: 3.544 ± 0.696
3.817ThrLys: 3.817 ± 0.926
6.27ThrLeu: 6.27 ± 1.126
1.636ThrMet: 1.636 ± 0.592
2.726ThrAsn: 2.726 ± 0.787
3.544ThrPro: 3.544 ± 0.679
2.726ThrGln: 2.726 ± 1.12
2.454ThrArg: 2.454 ± 0.97
2.999ThrSer: 2.999 ± 1.026
4.635ThrThr: 4.635 ± 1.632
4.362ThrVal: 4.362 ± 1.439
1.908ThrTrp: 1.908 ± 0.559
1.091ThrTyr: 1.091 ± 0.703
0.0ThrXaa: 0.0 ± 0.0
Val
3.817ValAla: 3.817 ± 0.922
0.545ValCys: 0.545 ± 0.541
3.817ValAsp: 3.817 ± 1.131
3.544ValGlu: 3.544 ± 1.012
1.363ValPhe: 1.363 ± 0.436
5.725ValGly: 5.725 ± 0.74
2.726ValHis: 2.726 ± 0.894
2.999ValIle: 2.999 ± 0.67
4.907ValLys: 4.907 ± 1.432
4.089ValLeu: 4.089 ± 0.754
0.545ValMet: 0.545 ± 0.364
2.454ValAsn: 2.454 ± 0.655
2.726ValPro: 2.726 ± 0.872
4.635ValGln: 4.635 ± 0.83
3.544ValArg: 3.544 ± 0.655
3.817ValSer: 3.817 ± 0.668
3.272ValThr: 3.272 ± 1.103
4.635ValVal: 4.635 ± 1.411
2.454ValTrp: 2.454 ± 0.612
1.363ValTyr: 1.363 ± 0.423
0.0ValXaa: 0.0 ± 0.0
Trp
1.908TrpAla: 1.908 ± 0.386
0.273TrpCys: 0.273 ± 0.362
1.363TrpAsp: 1.363 ± 0.46
1.908TrpGlu: 1.908 ± 0.487
0.545TrpPhe: 0.545 ± 0.364
1.908TrpGly: 1.908 ± 0.619
0.273TrpHis: 0.273 ± 0.292
1.091TrpIle: 1.091 ± 0.471
3.544TrpLys: 3.544 ± 0.464
0.818TrpLeu: 0.818 ± 0.565
1.636TrpMet: 1.636 ± 0.543
1.908TrpAsn: 1.908 ± 1.48
1.091TrpPro: 1.091 ± 0.447
1.908TrpGln: 1.908 ± 0.582
1.363TrpArg: 1.363 ± 0.493
0.818TrpSer: 0.818 ± 0.586
1.908TrpThr: 1.908 ± 0.696
1.363TrpVal: 1.363 ± 0.302
0.818TrpTrp: 0.818 ± 0.332
0.545TrpTyr: 0.545 ± 0.227
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.636TyrAla: 1.636 ± 0.681
1.636TyrCys: 1.636 ± 0.572
0.545TyrAsp: 0.545 ± 0.369
0.818TyrGlu: 0.818 ± 0.435
1.091TyrPhe: 1.091 ± 0.448
1.636TyrGly: 1.636 ± 0.762
1.363TyrHis: 1.363 ± 0.639
0.818TyrIle: 0.818 ± 0.286
2.999TyrLys: 2.999 ± 0.753
1.091TyrLeu: 1.091 ± 0.522
0.273TyrMet: 0.273 ± 0.185
1.908TyrAsn: 1.908 ± 0.523
1.091TyrPro: 1.091 ± 0.733
1.908TyrGln: 1.908 ± 0.871
0.545TyrArg: 0.545 ± 0.279
1.363TyrSer: 1.363 ± 0.288
1.091TyrThr: 1.091 ± 0.482
1.363TyrVal: 1.363 ± 0.689
1.091TyrTrp: 1.091 ± 0.455
1.363TyrTyr: 1.363 ± 0.382
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (3669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski