Amino acid dipepetide frequency for Bat hepatitis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.203AlaAla: 6.203 ± 3.296
0.62AlaCys: 0.62 ± 0.325
3.722AlaAsp: 3.722 ± 1.951
1.241AlaGlu: 1.241 ± 0.451
1.241AlaPhe: 1.241 ± 0.65
3.722AlaGly: 3.722 ± 1.745
1.241AlaHis: 1.241 ± 0.65
3.102AlaIle: 3.102 ± 1.248
1.861AlaLys: 1.861 ± 0.797
9.926AlaLeu: 9.926 ± 1.741
0.62AlaMet: 0.62 ± 0.325
1.241AlaAsn: 1.241 ± 0.886
4.342AlaPro: 4.342 ± 0.673
1.861AlaGln: 1.861 ± 0.659
6.203AlaArg: 6.203 ± 2.226
8.685AlaSer: 8.685 ± 2.613
4.342AlaThr: 4.342 ± 1.058
1.861AlaVal: 1.861 ± 0.579
1.241AlaTrp: 1.241 ± 0.65
1.861AlaTyr: 1.861 ± 1.673
0.0AlaXaa: 0.0 ± 0.0
Cys
3.722CysAla: 3.722 ± 2.647
1.241CysCys: 1.241 ± 1.065
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.241CysPhe: 1.241 ± 0.451
1.241CysGly: 1.241 ± 0.65
0.62CysHis: 0.62 ± 0.325
1.241CysIle: 1.241 ± 0.983
0.0CysLys: 0.0 ± 0.0
4.342CysLeu: 4.342 ± 2.035
1.861CysMet: 1.861 ± 1.113
0.62CysAsn: 0.62 ± 0.325
2.481CysPro: 2.481 ± 0.903
1.241CysGln: 1.241 ± 0.886
1.241CysArg: 1.241 ± 0.886
3.102CysSer: 3.102 ± 0.757
3.102CysThr: 3.102 ± 1.791
0.62CysVal: 0.62 ± 0.325
1.861CysTrp: 1.861 ± 0.659
0.62CysTyr: 0.62 ± 0.325
0.0CysXaa: 0.0 ± 0.0
Asp
3.722AspAla: 3.722 ± 1.112
0.0AspCys: 0.0 ± 0.0
1.241AspAsp: 1.241 ± 0.65
1.241AspGlu: 1.241 ± 0.451
1.241AspPhe: 1.241 ± 0.697
0.62AspGly: 0.62 ± 0.532
0.62AspHis: 0.62 ± 0.325
0.62AspIle: 0.62 ± 0.839
1.861AspLys: 1.861 ± 0.579
3.722AspLeu: 3.722 ± 0.702
1.241AspMet: 1.241 ± 0.983
1.241AspAsn: 1.241 ± 0.65
3.102AspPro: 3.102 ± 0.512
1.861AspGln: 1.861 ± 1.253
0.62AspArg: 0.62 ± 0.325
0.62AspSer: 0.62 ± 0.325
1.241AspThr: 1.241 ± 0.697
1.241AspVal: 1.241 ± 0.65
3.102AspTrp: 3.102 ± 1.365
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
1.241GluAla: 1.241 ± 0.65
0.0GluCys: 0.0 ± 0.0
1.241GluAsp: 1.241 ± 0.697
3.102GluGlu: 3.102 ± 2.604
1.241GluPhe: 1.241 ± 1.678
3.102GluGly: 3.102 ± 0.512
3.102GluHis: 3.102 ± 1.248
0.62GluIle: 0.62 ± 0.532
3.102GluLys: 3.102 ± 0.778
3.102GluLeu: 3.102 ± 1.562
0.0GluMet: 0.0 ± 0.0
0.0GluAsn: 0.0 ± 0.0
1.241GluPro: 1.241 ± 0.451
1.241GluGln: 1.241 ± 0.65
0.0GluArg: 0.0 ± 0.0
3.102GluSer: 3.102 ± 1.599
1.861GluThr: 1.861 ± 1.316
1.241GluVal: 1.241 ± 0.451
1.241GluTrp: 1.241 ± 0.886
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
3.722PheAla: 3.722 ± 1.158
1.861PheCys: 1.861 ± 0.692
0.62PheAsp: 0.62 ± 0.325
1.241PheGlu: 1.241 ± 0.451
1.861PhePhe: 1.861 ± 0.659
1.861PheGly: 1.861 ± 2.517
2.481PheHis: 2.481 ± 1.394
1.241PheIle: 1.241 ± 1.065
1.861PheLys: 1.861 ± 0.975
7.444PheLeu: 7.444 ± 2.425
0.62PheMet: 0.62 ± 0.325
1.241PheAsn: 1.241 ± 0.65
3.722PhePro: 3.722 ± 0.702
0.0PheGln: 0.0 ± 0.0
3.102PheArg: 3.102 ± 0.778
3.102PheSer: 3.102 ± 0.778
2.481PheThr: 2.481 ± 1.061
2.481PheVal: 2.481 ± 1.026
0.62PheTrp: 0.62 ± 0.532
1.241PheTyr: 1.241 ± 0.65
0.0PheXaa: 0.0 ± 0.0
Gly
3.722GlyAla: 3.722 ± 0.634
2.481GlyCys: 2.481 ± 1.711
3.102GlyAsp: 3.102 ± 1.11
1.241GlyGlu: 1.241 ± 0.65
4.342GlyPhe: 4.342 ± 2.378
6.203GlyGly: 6.203 ± 1.275
1.241GlyHis: 1.241 ± 0.983
4.342GlyIle: 4.342 ± 1.387
2.481GlyLys: 2.481 ± 0.903
10.546GlyLeu: 10.546 ± 3.039
1.241GlyMet: 1.241 ± 0.697
3.722GlyAsn: 3.722 ± 1.958
3.102GlyPro: 3.102 ± 1.599
4.342GlyGln: 4.342 ± 0.673
4.963GlyArg: 4.963 ± 1.123
2.481GlySer: 2.481 ± 0.824
4.342GlyThr: 4.342 ± 1.505
1.241GlyVal: 1.241 ± 0.65
1.241GlyTrp: 1.241 ± 0.451
0.62GlyTyr: 0.62 ± 0.325
0.0GlyXaa: 0.0 ± 0.0
His
1.241HisAla: 1.241 ± 0.65
3.102HisCys: 3.102 ± 1.049
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
1.861HisPhe: 1.861 ± 0.975
3.102HisGly: 3.102 ± 0.778
3.102HisHis: 3.102 ± 1.049
1.241HisIle: 1.241 ± 0.65
1.241HisLys: 1.241 ± 0.886
6.824HisLeu: 6.824 ± 1.525
0.62HisMet: 0.62 ± 0.325
1.241HisAsn: 1.241 ± 0.65
1.861HisPro: 1.861 ± 0.579
1.861HisGln: 1.861 ± 0.579
1.241HisArg: 1.241 ± 0.65
1.861HisSer: 1.861 ± 0.797
4.342HisThr: 4.342 ± 1.491
1.241HisVal: 1.241 ± 0.886
1.861HisTrp: 1.861 ± 0.922
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
0.62IleAla: 0.62 ± 0.325
1.241IleCys: 1.241 ± 0.886
1.241IleAsp: 1.241 ± 0.697
1.241IleGlu: 1.241 ± 1.359
1.241IlePhe: 1.241 ± 1.065
3.102IleGly: 3.102 ± 1.426
1.241IleHis: 1.241 ± 0.65
1.241IleIle: 1.241 ± 0.451
0.62IleLys: 0.62 ± 0.325
2.481IleLeu: 2.481 ± 0.493
0.62IleMet: 0.62 ± 0.325
0.0IleAsn: 0.0 ± 0.0
7.444IlePro: 7.444 ± 2.34
1.241IleGln: 1.241 ± 0.451
2.481IleArg: 2.481 ± 1.394
4.342IleSer: 4.342 ± 1.491
4.963IleThr: 4.963 ± 1.553
2.481IleVal: 2.481 ± 0.493
1.241IleTrp: 1.241 ± 1.065
0.62IleTyr: 0.62 ± 0.532
0.0IleXaa: 0.0 ± 0.0
Lys
1.241LysAla: 1.241 ± 0.451
0.0LysCys: 0.0 ± 0.0
1.241LysAsp: 1.241 ± 1.065
1.861LysGlu: 1.861 ± 1.173
1.241LysPhe: 1.241 ± 0.451
3.102LysGly: 3.102 ± 0.778
1.241LysHis: 1.241 ± 0.65
2.481LysIle: 2.481 ± 0.824
0.62LysLys: 0.62 ± 0.532
3.722LysLeu: 3.722 ± 1.548
0.0LysMet: 0.0 ± 0.0
1.861LysAsn: 1.861 ± 0.975
3.722LysPro: 3.722 ± 1.414
2.481LysGln: 2.481 ± 1.3
1.241LysArg: 1.241 ± 0.65
3.722LysSer: 3.722 ± 1.414
2.481LysThr: 2.481 ± 1.3
0.62LysVal: 0.62 ± 0.325
0.62LysTrp: 0.62 ± 0.325
1.241LysTyr: 1.241 ± 0.451
0.0LysXaa: 0.0 ± 0.0
Leu
7.444LeuAla: 7.444 ± 1.967
6.203LeuCys: 6.203 ± 1.592
3.102LeuAsp: 3.102 ± 0.864
1.861LeuGlu: 1.861 ± 0.579
3.722LeuPhe: 3.722 ± 0.702
8.065LeuGly: 8.065 ± 2.007
2.481LeuHis: 2.481 ± 1.3
6.203LeuIle: 6.203 ± 1.024
2.481LeuLys: 2.481 ± 1.3
15.509LeuLeu: 15.509 ± 3.65
1.861LeuMet: 1.861 ± 1.615
6.203LeuAsn: 6.203 ± 0.975
12.407LeuPro: 12.407 ± 1.684
3.722LeuGln: 3.722 ± 1.158
8.685LeuArg: 8.685 ± 3.27
7.444LeuSer: 7.444 ± 1.404
4.963LeuThr: 4.963 ± 1.548
7.444LeuVal: 7.444 ± 1.478
4.342LeuTrp: 4.342 ± 1.576
4.342LeuTyr: 4.342 ± 1.269
0.0LeuXaa: 0.0 ± 0.0
Met
1.861MetAla: 1.861 ± 0.922
0.62MetCys: 0.62 ± 0.325
1.241MetAsp: 1.241 ± 0.697
0.62MetGlu: 0.62 ± 0.965
0.62MetPhe: 0.62 ± 0.325
3.102MetGly: 3.102 ± 0.986
1.861MetHis: 1.861 ± 0.692
0.0MetIle: 0.0 ± 0.0
0.62MetLys: 0.62 ± 0.965
1.861MetLeu: 1.861 ± 0.975
0.62MetMet: 0.62 ± 0.532
0.62MetAsn: 0.62 ± 0.965
1.241MetPro: 1.241 ± 0.451
0.0MetGln: 0.0 ± 0.0
0.62MetArg: 0.62 ± 0.839
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
1.241MetTrp: 1.241 ± 1.065
0.62MetTyr: 0.62 ± 0.965
0.0MetXaa: 0.0 ± 0.0
Asn
0.62AsnAla: 0.62 ± 0.839
2.481AsnCys: 2.481 ± 1.44
1.241AsnAsp: 1.241 ± 1.359
0.62AsnGlu: 0.62 ± 0.325
1.861AsnPhe: 1.861 ± 1.823
0.0AsnGly: 0.0 ± 0.0
1.861AsnHis: 1.861 ± 0.975
1.241AsnIle: 1.241 ± 0.65
1.241AsnLys: 1.241 ± 0.65
3.102AsnLeu: 3.102 ± 0.986
1.241AsnMet: 1.241 ± 0.451
2.481AsnAsn: 2.481 ± 0.493
5.583AsnPro: 5.583 ± 1.738
1.861AsnGln: 1.861 ± 0.579
2.481AsnArg: 2.481 ± 0.824
3.102AsnSer: 3.102 ± 0.864
0.0AsnThr: 0.0 ± 0.0
0.62AsnVal: 0.62 ± 0.965
1.241AsnTrp: 1.241 ± 0.451
1.861AsnTyr: 1.861 ± 0.975
0.0AsnXaa: 0.0 ± 0.0
Pro
4.963ProAla: 4.963 ± 1.095
1.861ProCys: 1.861 ± 0.922
1.861ProAsp: 1.861 ± 0.975
4.342ProGlu: 4.342 ± 1.117
4.963ProPhe: 4.963 ± 1.648
4.342ProGly: 4.342 ± 1.387
5.583ProHis: 5.583 ± 0.312
2.481ProIle: 2.481 ± 1.038
2.481ProLys: 2.481 ± 0.824
10.546ProLeu: 10.546 ± 1.76
0.62ProMet: 0.62 ± 0.619
3.722ProAsn: 3.722 ± 0.638
8.065ProPro: 8.065 ± 2.081
1.861ProGln: 1.861 ± 0.659
6.203ProArg: 6.203 ± 1.743
7.444ProSer: 7.444 ± 1.404
9.305ProThr: 9.305 ± 3.027
6.824ProVal: 6.824 ± 1.641
2.481ProTrp: 2.481 ± 0.824
2.481ProTyr: 2.481 ± 0.975
0.0ProXaa: 0.0 ± 0.0
Gln
2.481GlnAla: 2.481 ± 1.44
0.0GlnCys: 0.0 ± 0.0
2.481GlnAsp: 2.481 ± 0.975
1.241GlnGlu: 1.241 ± 0.451
1.241GlnPhe: 1.241 ± 0.65
1.861GlnGly: 1.861 ± 0.975
0.0GlnHis: 0.0 ± 0.0
1.861GlnIle: 1.861 ± 1.597
1.861GlnLys: 1.861 ± 0.975
6.203GlnLeu: 6.203 ± 0.71
0.62GlnMet: 0.62 ± 0.325
1.861GlnAsn: 1.861 ± 0.932
2.481GlnPro: 2.481 ± 0.824
0.62GlnGln: 0.62 ± 0.839
1.861GlnArg: 1.861 ± 0.922
4.963GlnSer: 4.963 ± 1.799
1.241GlnThr: 1.241 ± 1.065
2.481GlnVal: 2.481 ± 0.903
0.62GlnTrp: 0.62 ± 0.532
0.62GlnTyr: 0.62 ± 0.325
0.0GlnXaa: 0.0 ± 0.0
Arg
3.722ArgAla: 3.722 ± 2.424
1.241ArgCys: 1.241 ± 0.983
1.241ArgAsp: 1.241 ± 0.65
3.102ArgGlu: 3.102 ± 1.16
3.722ArgPhe: 3.722 ± 0.808
2.481ArgGly: 2.481 ± 0.824
2.481ArgHis: 2.481 ± 1.771
1.861ArgIle: 1.861 ± 0.975
2.481ArgLys: 2.481 ± 0.824
4.963ArgLeu: 4.963 ± 2.663
0.62ArgMet: 0.62 ± 0.839
0.62ArgAsn: 0.62 ± 0.325
4.963ArgPro: 4.963 ± 2.115
4.342ArgGln: 4.342 ± 0.967
12.407ArgArg: 12.407 ± 7.526
4.963ArgSer: 4.963 ± 2.788
5.583ArgThr: 5.583 ± 1.062
3.722ArgVal: 3.722 ± 1.414
1.861ArgTrp: 1.861 ± 0.659
0.62ArgTyr: 0.62 ± 0.965
0.0ArgXaa: 0.0 ± 0.0
Ser
6.203SerAla: 6.203 ± 1.363
1.861SerCys: 1.861 ± 0.659
0.0SerAsp: 0.0 ± 0.0
1.861SerGlu: 1.861 ± 0.692
4.963SerPhe: 4.963 ± 1.131
5.583SerGly: 5.583 ± 4.351
2.481SerHis: 2.481 ± 0.824
3.102SerIle: 3.102 ± 0.512
3.722SerLys: 3.722 ± 1.158
8.685SerLeu: 8.685 ± 2.024
0.62SerMet: 0.62 ± 0.325
3.722SerAsn: 3.722 ± 0.702
9.305SerPro: 9.305 ± 0.814
3.722SerGln: 3.722 ± 1.212
4.963SerArg: 4.963 ± 1.522
9.305SerSer: 9.305 ± 2.598
6.824SerThr: 6.824 ± 2.511
3.722SerVal: 3.722 ± 0.702
3.102SerTrp: 3.102 ± 1.365
1.241SerTyr: 1.241 ± 0.65
0.0SerXaa: 0.0 ± 0.0
Thr
3.102ThrAla: 3.102 ± 2.154
3.102ThrCys: 3.102 ± 1.427
2.481ThrAsp: 2.481 ± 1.449
0.0ThrGlu: 0.0 ± 0.0
1.241ThrPhe: 1.241 ± 0.697
5.583ThrGly: 5.583 ± 1.28
1.241ThrHis: 1.241 ± 0.451
3.102ThrIle: 3.102 ± 2.114
3.102ThrLys: 3.102 ± 1.11
4.342ThrLeu: 4.342 ± 2.21
0.62ThrMet: 0.62 ± 0.965
2.481ThrAsn: 2.481 ± 0.824
6.824ThrPro: 6.824 ± 2.348
1.241ThrGln: 1.241 ± 0.451
3.102ThrArg: 3.102 ± 0.796
12.407ThrSer: 12.407 ± 3.946
6.824ThrThr: 6.824 ± 2.762
3.722ThrVal: 3.722 ± 2.487
2.481ThrTrp: 2.481 ± 1.976
2.481ThrTyr: 2.481 ± 1.061
0.0ThrXaa: 0.0 ± 0.0
Val
5.583ValAla: 5.583 ± 1.606
1.861ValCys: 1.861 ± 0.932
1.861ValAsp: 1.861 ± 0.692
1.241ValGlu: 1.241 ± 0.697
1.861ValPhe: 1.861 ± 0.692
3.722ValGly: 3.722 ± 1.414
3.722ValHis: 3.722 ± 1.521
3.102ValIle: 3.102 ± 0.757
0.0ValLys: 0.0 ± 0.0
2.481ValLeu: 2.481 ± 1.026
0.0ValMet: 0.0 ± 0.0
1.861ValAsn: 1.861 ± 0.975
5.583ValPro: 5.583 ± 1.28
1.861ValGln: 1.861 ± 2.517
2.481ValArg: 2.481 ± 0.493
1.861ValSer: 1.861 ± 0.797
3.102ValThr: 3.102 ± 2.188
2.481ValVal: 2.481 ± 1.061
0.62ValTrp: 0.62 ± 0.532
1.241ValTyr: 1.241 ± 1.065
0.0ValXaa: 0.0 ± 0.0
Trp
1.861TrpAla: 1.861 ± 1.24
0.0TrpCys: 0.0 ± 0.0
1.241TrpAsp: 1.241 ± 0.983
3.102TrpGlu: 3.102 ± 0.796
1.861TrpPhe: 1.861 ± 1.24
4.342TrpGly: 4.342 ± 0.673
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.861TrpLys: 1.861 ± 0.975
5.583TrpLeu: 5.583 ± 1.339
2.481TrpMet: 2.481 ± 1.363
0.0TrpAsn: 0.0 ± 0.0
3.102TrpPro: 3.102 ± 1.365
0.0TrpGln: 0.0 ± 0.0
1.861TrpArg: 1.861 ± 0.932
0.62TrpSer: 0.62 ± 0.532
1.861TrpThr: 1.861 ± 0.579
1.241TrpVal: 1.241 ± 0.697
2.481TrpTrp: 2.481 ± 0.903
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.861TyrAla: 1.861 ± 0.797
0.62TyrCys: 0.62 ± 0.532
0.0TyrAsp: 0.0 ± 0.0
0.62TyrGlu: 0.62 ± 0.839
1.241TyrPhe: 1.241 ± 0.886
1.861TyrGly: 1.861 ± 0.932
1.241TyrHis: 1.241 ± 0.65
0.62TyrIle: 0.62 ± 0.325
1.241TyrLys: 1.241 ± 0.697
3.102TyrLeu: 3.102 ± 1.11
0.62TyrMet: 0.62 ± 0.325
0.0TyrAsn: 0.0 ± 0.0
2.481TyrPro: 2.481 ± 1.3
1.241TyrGln: 1.241 ± 1.065
1.241TyrArg: 1.241 ± 0.697
1.861TyrSer: 1.861 ± 0.975
0.62TyrThr: 0.62 ± 0.965
1.241TyrVal: 1.241 ± 1.359
0.0TyrTrp: 0.0 ± 0.0
0.62TyrTyr: 0.62 ± 0.325
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski