Amino acid dipepetide frequency for Lactobacillus phage LR1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.487AlaAla: 4.487 ± 0.667
0.345AlaCys: 0.345 ± 0.198
6.731AlaAsp: 6.731 ± 0.78
3.797AlaGlu: 3.797 ± 0.561
2.761AlaPhe: 2.761 ± 0.519
3.797AlaGly: 3.797 ± 0.636
0.863AlaHis: 0.863 ± 0.24
4.66AlaIle: 4.66 ± 0.816
6.299AlaLys: 6.299 ± 0.698
5.35AlaLeu: 5.35 ± 0.764
2.33AlaMet: 2.33 ± 0.352
5.005AlaAsn: 5.005 ± 0.703
1.639AlaPro: 1.639 ± 0.393
4.832AlaGln: 4.832 ± 0.728
3.365AlaArg: 3.365 ± 0.665
5.091AlaSer: 5.091 ± 0.972
5.091AlaThr: 5.091 ± 0.641
4.66AlaVal: 4.66 ± 0.713
0.863AlaTrp: 0.863 ± 0.189
2.244AlaTyr: 2.244 ± 0.347
0.0AlaXaa: 0.0 ± 0.0
Cys
0.173CysAla: 0.173 ± 0.128
0.0CysCys: 0.0 ± 0.0
0.173CysAsp: 0.173 ± 0.164
0.345CysGlu: 0.345 ± 0.172
0.345CysPhe: 0.345 ± 0.156
0.863CysGly: 0.863 ± 0.244
0.086CysHis: 0.086 ± 0.07
0.086CysIle: 0.086 ± 0.089
0.259CysLys: 0.259 ± 0.137
0.173CysLeu: 0.173 ± 0.122
0.173CysMet: 0.173 ± 0.131
0.345CysAsn: 0.345 ± 0.215
0.345CysPro: 0.345 ± 0.188
0.173CysGln: 0.173 ± 0.11
0.345CysArg: 0.345 ± 0.158
0.259CysSer: 0.259 ± 0.153
0.259CysThr: 0.259 ± 0.135
0.173CysVal: 0.173 ± 0.115
0.0CysTrp: 0.0 ± 0.0
0.259CysTyr: 0.259 ± 0.149
0.0CysXaa: 0.0 ± 0.0
Asp
4.314AspAla: 4.314 ± 0.546
0.345AspCys: 0.345 ± 0.159
4.66AspAsp: 4.66 ± 0.938
5.005AspGlu: 5.005 ± 1.0
3.106AspPhe: 3.106 ± 0.536
6.385AspGly: 6.385 ± 0.657
0.863AspHis: 0.863 ± 0.332
3.365AspIle: 3.365 ± 0.487
5.091AspLys: 5.091 ± 0.889
5.522AspLeu: 5.522 ± 0.559
1.639AspMet: 1.639 ± 0.348
5.264AspAsn: 5.264 ± 0.773
4.056AspPro: 4.056 ± 0.666
2.934AspGln: 2.934 ± 0.382
1.812AspArg: 1.812 ± 0.378
5.091AspSer: 5.091 ± 0.797
4.487AspThr: 4.487 ± 0.69
3.279AspVal: 3.279 ± 0.55
1.812AspTrp: 1.812 ± 0.502
2.675AspTyr: 2.675 ± 0.482
0.0AspXaa: 0.0 ± 0.0
Glu
4.832GluAla: 4.832 ± 0.548
0.173GluCys: 0.173 ± 0.113
2.589GluAsp: 2.589 ± 0.654
2.589GluGlu: 2.589 ± 0.555
2.157GluPhe: 2.157 ± 0.42
2.848GluGly: 2.848 ± 0.578
0.69GluHis: 0.69 ± 0.259
3.624GluIle: 3.624 ± 0.588
3.797GluLys: 3.797 ± 0.515
4.832GluLeu: 4.832 ± 0.69
1.381GluMet: 1.381 ± 0.302
3.624GluAsn: 3.624 ± 0.423
2.157GluPro: 2.157 ± 0.399
3.02GluGln: 3.02 ± 0.518
3.279GluArg: 3.279 ± 0.569
3.106GluSer: 3.106 ± 0.406
3.02GluThr: 3.02 ± 0.552
3.452GluVal: 3.452 ± 0.493
0.69GluTrp: 0.69 ± 0.283
1.898GluTyr: 1.898 ± 0.403
0.0GluXaa: 0.0 ± 0.0
Phe
2.934PheAla: 2.934 ± 0.539
0.173PheCys: 0.173 ± 0.119
2.848PheAsp: 2.848 ± 0.549
2.071PheGlu: 2.071 ± 0.385
1.381PhePhe: 1.381 ± 0.29
2.33PheGly: 2.33 ± 0.431
0.777PheHis: 0.777 ± 0.203
1.985PheIle: 1.985 ± 0.393
2.244PheLys: 2.244 ± 0.387
1.553PheLeu: 1.553 ± 0.325
1.294PheMet: 1.294 ± 0.344
4.832PheAsn: 4.832 ± 0.53
0.949PhePro: 0.949 ± 0.309
1.553PheGln: 1.553 ± 0.315
1.381PheArg: 1.381 ± 0.372
2.761PheSer: 2.761 ± 0.647
2.33PheThr: 2.33 ± 0.493
2.157PheVal: 2.157 ± 0.328
0.173PheTrp: 0.173 ± 0.116
1.898PheTyr: 1.898 ± 0.41
0.0PheXaa: 0.0 ± 0.0
Gly
4.228GlyAla: 4.228 ± 0.6
0.345GlyCys: 0.345 ± 0.168
4.142GlyAsp: 4.142 ± 0.55
3.71GlyGlu: 3.71 ± 0.589
2.589GlyPhe: 2.589 ± 0.419
4.746GlyGly: 4.746 ± 0.931
1.985GlyHis: 1.985 ± 0.405
4.66GlyIle: 4.66 ± 0.939
5.868GlyLys: 5.868 ± 0.808
5.954GlyLeu: 5.954 ± 0.734
1.898GlyMet: 1.898 ± 0.529
4.228GlyAsn: 4.228 ± 0.679
0.69GlyPro: 0.69 ± 0.303
2.416GlyGln: 2.416 ± 0.444
3.02GlyArg: 3.02 ± 0.505
3.969GlySer: 3.969 ± 0.647
4.401GlyThr: 4.401 ± 0.615
4.401GlyVal: 4.401 ± 0.547
1.122GlyTrp: 1.122 ± 0.258
2.761GlyTyr: 2.761 ± 0.402
0.0GlyXaa: 0.0 ± 0.0
His
0.949HisAla: 0.949 ± 0.409
0.086HisCys: 0.086 ± 0.082
1.122HisAsp: 1.122 ± 0.396
0.863HisGlu: 0.863 ± 0.219
1.898HisPhe: 1.898 ± 0.333
1.294HisGly: 1.294 ± 0.364
0.69HisHis: 0.69 ± 0.238
0.863HisIle: 0.863 ± 0.262
0.863HisLys: 0.863 ± 0.229
1.035HisLeu: 1.035 ± 0.2
0.431HisMet: 0.431 ± 0.174
0.604HisAsn: 0.604 ± 0.182
0.69HisPro: 0.69 ± 0.244
0.518HisGln: 0.518 ± 0.221
0.777HisArg: 0.777 ± 0.168
1.812HisSer: 1.812 ± 0.271
1.294HisThr: 1.294 ± 0.317
1.035HisVal: 1.035 ± 0.245
0.518HisTrp: 0.518 ± 0.177
0.604HisTyr: 0.604 ± 0.223
0.0HisXaa: 0.0 ± 0.0
Ile
5.091IleAla: 5.091 ± 0.47
0.259IleCys: 0.259 ± 0.146
6.126IleAsp: 6.126 ± 0.754
2.761IleGlu: 2.761 ± 0.493
1.467IlePhe: 1.467 ± 0.378
3.969IleGly: 3.969 ± 0.527
1.294IleHis: 1.294 ± 0.287
3.106IleIle: 3.106 ± 0.774
5.695IleLys: 5.695 ± 0.702
2.33IleLeu: 2.33 ± 0.54
1.467IleMet: 1.467 ± 0.346
4.573IleAsn: 4.573 ± 0.584
1.812IlePro: 1.812 ± 0.32
2.761IleGln: 2.761 ± 0.612
2.071IleArg: 2.071 ± 0.489
3.71IleSer: 3.71 ± 0.604
4.228IleThr: 4.228 ± 0.428
3.279IleVal: 3.279 ± 0.45
0.604IleTrp: 0.604 ± 0.254
1.726IleTyr: 1.726 ± 0.348
0.0IleXaa: 0.0 ± 0.0
Lys
5.781LysAla: 5.781 ± 0.861
0.604LysCys: 0.604 ± 0.321
5.35LysAsp: 5.35 ± 0.627
4.832LysGlu: 4.832 ± 0.686
2.675LysPhe: 2.675 ± 0.485
5.264LysGly: 5.264 ± 0.86
1.726LysHis: 1.726 ± 0.423
5.091LysIle: 5.091 ± 0.805
6.04LysLys: 6.04 ± 0.871
5.35LysLeu: 5.35 ± 0.606
2.848LysMet: 2.848 ± 0.519
3.71LysAsn: 3.71 ± 0.456
3.279LysPro: 3.279 ± 0.575
5.264LysGln: 5.264 ± 0.617
2.761LysArg: 2.761 ± 0.53
4.832LysSer: 4.832 ± 0.61
4.487LysThr: 4.487 ± 0.642
5.35LysVal: 5.35 ± 0.739
0.777LysTrp: 0.777 ± 0.267
2.502LysTyr: 2.502 ± 0.455
0.0LysXaa: 0.0 ± 0.0
Leu
6.213LeuAla: 6.213 ± 0.599
0.086LeuCys: 0.086 ± 0.082
5.781LeuAsp: 5.781 ± 0.657
3.279LeuGlu: 3.279 ± 0.617
2.502LeuPhe: 2.502 ± 0.433
4.314LeuGly: 4.314 ± 0.846
0.949LeuHis: 0.949 ± 0.347
4.401LeuIle: 4.401 ± 0.554
5.695LeuLys: 5.695 ± 0.483
4.746LeuLeu: 4.746 ± 0.566
1.726LeuMet: 1.726 ± 0.381
5.264LeuAsn: 5.264 ± 0.68
2.416LeuPro: 2.416 ± 0.409
4.142LeuGln: 4.142 ± 0.634
2.934LeuArg: 2.934 ± 0.511
5.868LeuSer: 5.868 ± 0.565
4.573LeuThr: 4.573 ± 0.693
3.797LeuVal: 3.797 ± 0.38
1.035LeuTrp: 1.035 ± 0.3
1.985LeuTyr: 1.985 ± 0.394
0.0LeuXaa: 0.0 ± 0.0
Met
1.726MetAla: 1.726 ± 0.381
0.0MetCys: 0.0 ± 0.0
2.416MetAsp: 2.416 ± 0.382
1.294MetGlu: 1.294 ± 0.33
0.777MetPhe: 0.777 ± 0.216
1.812MetGly: 1.812 ± 0.398
0.949MetHis: 0.949 ± 0.221
1.812MetIle: 1.812 ± 0.363
2.675MetLys: 2.675 ± 0.368
1.812MetLeu: 1.812 ± 0.397
0.604MetMet: 0.604 ± 0.212
1.553MetAsn: 1.553 ± 0.43
0.777MetPro: 0.777 ± 0.383
1.985MetGln: 1.985 ± 0.357
1.035MetArg: 1.035 ± 0.277
1.553MetSer: 1.553 ± 0.259
1.898MetThr: 1.898 ± 0.42
1.639MetVal: 1.639 ± 0.393
0.086MetTrp: 0.086 ± 0.076
1.035MetTyr: 1.035 ± 0.381
0.0MetXaa: 0.0 ± 0.0
Asn
4.746AsnAla: 4.746 ± 0.498
0.431AsnCys: 0.431 ± 0.18
5.264AsnAsp: 5.264 ± 0.699
3.365AsnGlu: 3.365 ± 0.741
2.416AsnPhe: 2.416 ± 0.323
5.609AsnGly: 5.609 ± 0.692
1.035AsnHis: 1.035 ± 0.247
4.66AsnIle: 4.66 ± 0.689
5.177AsnLys: 5.177 ± 0.61
4.401AsnLeu: 4.401 ± 0.562
1.122AsnMet: 1.122 ± 0.234
4.487AsnAsn: 4.487 ± 0.69
3.106AsnPro: 3.106 ± 0.544
3.71AsnGln: 3.71 ± 0.625
2.33AsnArg: 2.33 ± 0.468
4.056AsnSer: 4.056 ± 0.604
4.66AsnThr: 4.66 ± 0.55
3.02AsnVal: 3.02 ± 0.392
1.467AsnTrp: 1.467 ± 0.393
2.157AsnTyr: 2.157 ± 0.41
0.0AsnXaa: 0.0 ± 0.0
Pro
2.589ProAla: 2.589 ± 0.627
0.173ProCys: 0.173 ± 0.109
2.416ProAsp: 2.416 ± 0.404
2.071ProGlu: 2.071 ± 0.491
1.467ProPhe: 1.467 ± 0.289
2.157ProGly: 2.157 ± 0.501
0.604ProHis: 0.604 ± 0.207
1.639ProIle: 1.639 ± 0.329
2.761ProLys: 2.761 ± 0.579
2.157ProLeu: 2.157 ± 0.419
0.777ProMet: 0.777 ± 0.272
2.33ProAsn: 2.33 ± 0.54
0.777ProPro: 0.777 ± 0.264
2.33ProGln: 2.33 ± 0.422
1.381ProArg: 1.381 ± 0.294
2.416ProSer: 2.416 ± 0.442
2.848ProThr: 2.848 ± 0.416
2.244ProVal: 2.244 ± 0.409
0.345ProTrp: 0.345 ± 0.202
1.208ProTyr: 1.208 ± 0.249
0.0ProXaa: 0.0 ± 0.0
Gln
5.177GlnAla: 5.177 ± 0.702
0.086GlnCys: 0.086 ± 0.086
3.538GlnAsp: 3.538 ± 0.514
3.106GlnGlu: 3.106 ± 0.536
1.294GlnPhe: 1.294 ± 0.351
3.02GlnGly: 3.02 ± 0.591
1.035GlnHis: 1.035 ± 0.3
2.244GlnIle: 2.244 ± 0.349
3.797GlnLys: 3.797 ± 0.735
4.487GlnLeu: 4.487 ± 0.656
1.985GlnMet: 1.985 ± 0.378
3.797GlnAsn: 3.797 ± 0.419
2.071GlnPro: 2.071 ± 0.52
5.177GlnGln: 5.177 ± 0.76
2.157GlnArg: 2.157 ± 0.518
3.797GlnSer: 3.797 ± 0.638
4.056GlnThr: 4.056 ± 0.602
2.761GlnVal: 2.761 ± 0.44
0.777GlnTrp: 0.777 ± 0.374
2.244GlnTyr: 2.244 ± 0.539
0.0GlnXaa: 0.0 ± 0.0
Arg
2.848ArgAla: 2.848 ± 0.554
0.345ArgCys: 0.345 ± 0.166
1.985ArgAsp: 1.985 ± 0.373
2.589ArgGlu: 2.589 ± 0.452
1.294ArgPhe: 1.294 ± 0.323
1.467ArgGly: 1.467 ± 0.374
0.777ArgHis: 0.777 ± 0.179
2.761ArgIle: 2.761 ± 0.389
3.797ArgLys: 3.797 ± 0.658
3.538ArgLeu: 3.538 ± 0.474
1.208ArgMet: 1.208 ± 0.334
1.639ArgAsn: 1.639 ± 0.306
0.863ArgPro: 0.863 ± 0.21
2.502ArgGln: 2.502 ± 0.419
1.726ArgArg: 1.726 ± 0.453
1.553ArgSer: 1.553 ± 0.271
1.553ArgThr: 1.553 ± 0.367
2.416ArgVal: 2.416 ± 0.378
0.086ArgTrp: 0.086 ± 0.085
2.589ArgTyr: 2.589 ± 0.576
0.0ArgXaa: 0.0 ± 0.0
Ser
6.04SerAla: 6.04 ± 1.093
0.086SerCys: 0.086 ± 0.087
5.005SerAsp: 5.005 ± 0.875
3.193SerGlu: 3.193 ± 0.614
2.761SerPhe: 2.761 ± 0.73
5.005SerGly: 5.005 ± 0.648
0.69SerHis: 0.69 ± 0.218
4.228SerIle: 4.228 ± 0.468
5.177SerLys: 5.177 ± 0.785
4.746SerLeu: 4.746 ± 0.633
2.416SerMet: 2.416 ± 0.443
5.091SerAsn: 5.091 ± 0.812
1.726SerPro: 1.726 ± 0.311
3.106SerGln: 3.106 ± 0.605
2.157SerArg: 2.157 ± 0.505
5.091SerSer: 5.091 ± 1.128
4.746SerThr: 4.746 ± 0.628
3.452SerVal: 3.452 ± 0.424
0.949SerTrp: 0.949 ± 0.316
1.467SerTyr: 1.467 ± 0.389
0.0SerXaa: 0.0 ± 0.0
Thr
4.573ThrAla: 4.573 ± 0.781
0.173ThrCys: 0.173 ± 0.115
4.573ThrAsp: 4.573 ± 0.606
3.452ThrGlu: 3.452 ± 0.557
2.589ThrPhe: 2.589 ± 0.452
5.609ThrGly: 5.609 ± 0.72
0.949ThrHis: 0.949 ± 0.25
3.365ThrIle: 3.365 ± 0.524
4.142ThrLys: 4.142 ± 0.678
5.091ThrLeu: 5.091 ± 0.645
1.208ThrMet: 1.208 ± 0.288
3.452ThrAsn: 3.452 ± 0.507
3.279ThrPro: 3.279 ± 0.791
3.71ThrGln: 3.71 ± 0.563
1.553ThrArg: 1.553 ± 0.32
4.832ThrSer: 4.832 ± 0.732
4.228ThrThr: 4.228 ± 0.625
3.624ThrVal: 3.624 ± 0.467
0.863ThrTrp: 0.863 ± 0.313
3.02ThrTyr: 3.02 ± 0.678
0.0ThrXaa: 0.0 ± 0.0
Val
4.228ValAla: 4.228 ± 0.786
0.431ValCys: 0.431 ± 0.213
3.452ValAsp: 3.452 ± 0.675
3.193ValGlu: 3.193 ± 0.455
1.898ValPhe: 1.898 ± 0.425
3.279ValGly: 3.279 ± 0.504
0.777ValHis: 0.777 ± 0.242
3.279ValIle: 3.279 ± 0.67
4.918ValLys: 4.918 ± 0.62
3.969ValLeu: 3.969 ± 0.623
1.381ValMet: 1.381 ± 0.441
3.969ValAsn: 3.969 ± 0.691
2.934ValPro: 2.934 ± 0.639
3.883ValGln: 3.883 ± 0.592
1.553ValArg: 1.553 ± 0.277
4.056ValSer: 4.056 ± 0.398
3.538ValThr: 3.538 ± 0.567
3.193ValVal: 3.193 ± 0.506
1.208ValTrp: 1.208 ± 0.41
2.675ValTyr: 2.675 ± 0.575
0.0ValXaa: 0.0 ± 0.0
Trp
0.777TrpAla: 0.777 ± 0.244
0.0TrpCys: 0.0 ± 0.0
0.69TrpAsp: 0.69 ± 0.237
0.259TrpGlu: 0.259 ± 0.119
0.604TrpPhe: 0.604 ± 0.237
1.208TrpGly: 1.208 ± 0.416
0.345TrpHis: 0.345 ± 0.176
0.69TrpIle: 0.69 ± 0.221
0.949TrpLys: 0.949 ± 0.362
1.122TrpLeu: 1.122 ± 0.348
0.345TrpMet: 0.345 ± 0.173
1.553TrpAsn: 1.553 ± 0.453
0.259TrpPro: 0.259 ± 0.14
1.208TrpGln: 1.208 ± 0.413
0.604TrpArg: 0.604 ± 0.152
1.208TrpSer: 1.208 ± 0.235
0.777TrpThr: 0.777 ± 0.218
1.035TrpVal: 1.035 ± 0.231
0.259TrpTrp: 0.259 ± 0.132
0.518TrpTyr: 0.518 ± 0.293
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.502TyrAla: 2.502 ± 0.362
0.69TyrCys: 0.69 ± 0.206
2.848TyrAsp: 2.848 ± 0.513
2.071TyrGlu: 2.071 ± 0.389
1.639TyrPhe: 1.639 ± 0.412
2.157TyrGly: 2.157 ± 0.458
0.863TyrHis: 0.863 ± 0.308
1.812TyrIle: 1.812 ± 0.518
3.279TyrLys: 3.279 ± 0.616
3.538TyrLeu: 3.538 ± 0.578
1.122TyrMet: 1.122 ± 0.265
1.898TyrAsn: 1.898 ± 0.399
0.863TyrPro: 0.863 ± 0.323
1.381TyrGln: 1.381 ± 0.244
1.294TyrArg: 1.294 ± 0.299
2.071TyrSer: 2.071 ± 0.514
1.812TyrThr: 1.812 ± 0.397
2.848TyrVal: 2.848 ± 0.42
0.777TyrTrp: 0.777 ± 0.218
1.639TyrTyr: 1.639 ± 0.53
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (11590 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski