Amino acid dipepetide frequency for Caulifigura coniformis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.323AlaAla: 14.323 ± 0.123	1.167AlaCys: 1.167 ± 0.026	6.127AlaAsp: 6.127 ± 0.065	6.787AlaGlu: 6.787 ± 0.063	3.722AlaPhe: 3.722 ± 0.052	9.271AlaGly: 9.271 ± 0.078	1.797AlaHis: 1.797 ± 0.037	5.42AlaIle: 5.42 ± 0.054	3.89AlaLys: 3.89 ± 0.056	9.582AlaLeu: 9.582 ± 0.08	2.541AlaMet: 2.541 ± 0.036	2.726AlaAsn: 2.726 ± 0.044	5.374AlaPro: 5.374 ± 0.066	3.223AlaGln: 3.223 ± 0.048	7.187AlaArg: 7.187 ± 0.073	6.39AlaSer: 6.39 ± 0.063	6.044AlaThr: 6.044 ± 0.055	8.053AlaVal: 8.053 ± 0.07	1.616AlaTrp: 1.616 ± 0.032	2.006AlaTyr: 2.006 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.922CysAla: 0.922 ± 0.024	0.231CysCys: 0.231 ± 0.014	0.634CysAsp: 0.634 ± 0.019	0.633CysGlu: 0.633 ± 0.018	0.421CysPhe: 0.421 ± 0.015	1.134CysGly: 1.134 ± 0.034	0.396CysHis: 0.396 ± 0.016	0.439CysIle: 0.439 ± 0.015	0.301CysLys: 0.301 ± 0.012	1.141CysLeu: 1.141 ± 0.03	0.181CysMet: 0.181 ± 0.01	0.282CysAsn: 0.282 ± 0.013	0.642CysPro: 0.642 ± 0.02	0.368CysGln: 0.368 ± 0.015	0.894CysArg: 0.894 ± 0.028	0.635CysSer: 0.635 ± 0.02	0.55CysThr: 0.55 ± 0.019	0.81CysVal: 0.81 ± 0.023	0.173CysTrp: 0.173 ± 0.009	0.27CysTyr: 0.27 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.058AspAla: 6.058 ± 0.062	0.588AspCys: 0.588 ± 0.019	3.526AspAsp: 3.526 ± 0.046	3.766AspGlu: 3.766 ± 0.045	2.179AspPhe: 2.179 ± 0.033	5.23AspGly: 5.23 ± 0.069	1.321AspHis: 1.321 ± 0.028	2.235AspIle: 2.235 ± 0.035	1.579AspLys: 1.579 ± 0.033	5.849AspLeu: 5.849 ± 0.055	0.903AspMet: 0.903 ± 0.023	1.304AspAsn: 1.304 ± 0.03	3.609AspPro: 3.609 ± 0.043	2.059AspGln: 2.059 ± 0.032	4.448AspArg: 4.448 ± 0.055	3.143AspSer: 3.143 ± 0.051	2.092AspThr: 2.092 ± 0.039	4.482AspVal: 4.482 ± 0.056	1.056AspTrp: 1.056 ± 0.025	1.359AspTyr: 1.359 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.369GluAla: 6.369 ± 0.061	0.542GluCys: 0.542 ± 0.019	2.501GluAsp: 2.501 ± 0.037	3.402GluGlu: 3.402 ± 0.049	2.525GluPhe: 2.525 ± 0.035	4.053GluGly: 4.053 ± 0.051	1.286GluHis: 1.286 ± 0.027	3.12GluIle: 3.12 ± 0.046	2.766GluLys: 2.766 ± 0.047	6.481GluLeu: 6.481 ± 0.061	1.389GluMet: 1.389 ± 0.029	1.755GluAsn: 1.755 ± 0.035	3.039GluPro: 3.039 ± 0.045	2.692GluGln: 2.692 ± 0.045	4.708GluArg: 4.708 ± 0.057	3.734GluSer: 3.734 ± 0.049	3.508GluThr: 3.508 ± 0.048	4.055GluVal: 4.055 ± 0.05	0.949GluTrp: 0.949 ± 0.022	1.271GluTyr: 1.271 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.786PheAla: 3.786 ± 0.05	0.459PheCys: 0.459 ± 0.017	2.692PheAsp: 2.692 ± 0.038	2.382PheGlu: 2.382 ± 0.034	1.253PhePhe: 1.253 ± 0.029	3.34PheGly: 3.34 ± 0.043	0.853PheHis: 0.853 ± 0.023	1.413PheIle: 1.413 ± 0.029	1.058PheLys: 1.058 ± 0.022	3.64PheLeu: 3.64 ± 0.052	0.638PheMet: 0.638 ± 0.021	1.167PheAsn: 1.167 ± 0.027	1.763PhePro: 1.763 ± 0.031	1.382PheGln: 1.382 ± 0.029	2.615PheArg: 2.615 ± 0.037	2.284PheSer: 2.284 ± 0.035	2.051PheThr: 2.051 ± 0.035	2.881PheVal: 2.881 ± 0.041	0.515PheTrp: 0.515 ± 0.018	0.858PheTyr: 0.858 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	7.073GlyAla: 7.073 ± 0.064	1.051GlyCys: 1.051 ± 0.024	4.625GlyAsp: 4.625 ± 0.053	4.753GlyGlu: 4.753 ± 0.057	3.236GlyPhe: 3.236 ± 0.043	6.963GlyGly: 6.963 ± 0.101	1.729GlyHis: 1.729 ± 0.033	3.738GlyIle: 3.738 ± 0.047	3.644GlyLys: 3.644 ± 0.05	7.702GlyLeu: 7.702 ± 0.065	1.979GlyMet: 1.979 ± 0.037	2.388GlyAsn: 2.388 ± 0.051	3.782GlyPro: 3.782 ± 0.049	3.069GlyGln: 3.069 ± 0.047	6.213GlyArg: 6.213 ± 0.067	4.876GlySer: 4.876 ± 0.06	4.533GlyThr: 4.533 ± 0.064	5.998GlyVal: 5.998 ± 0.063	1.485GlyTrp: 1.485 ± 0.028	2.032GlyTyr: 2.032 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.033HisAla: 2.033 ± 0.036	0.316HisCys: 0.316 ± 0.014	1.234HisAsp: 1.234 ± 0.027	1.199HisGlu: 1.199 ± 0.023	0.89HisPhe: 0.89 ± 0.018	1.812HisGly: 1.812 ± 0.036	0.633HisHis: 0.633 ± 0.022	0.773HisIle: 0.773 ± 0.022	0.559HisLys: 0.559 ± 0.017	2.13HisLeu: 2.13 ± 0.032	0.367HisMet: 0.367 ± 0.013	0.588HisAsn: 0.588 ± 0.019	1.446HisPro: 1.446 ± 0.029	0.695HisGln: 0.695 ± 0.02	1.623HisArg: 1.623 ± 0.027	1.219HisSer: 1.219 ± 0.028	0.948HisThr: 0.948 ± 0.024	1.551HisVal: 1.551 ± 0.026	0.43HisTrp: 0.43 ± 0.016	0.525HisTyr: 0.525 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.679IleAla: 5.679 ± 0.057	0.563IleCys: 0.563 ± 0.016	3.356IleAsp: 3.356 ± 0.049	3.352IleGlu: 3.352 ± 0.046	1.257IlePhe: 1.257 ± 0.029	3.968IleGly: 3.968 ± 0.053	0.988IleHis: 0.988 ± 0.023	1.629IleIle: 1.629 ± 0.031	1.227IleLys: 1.227 ± 0.029	4.034IleLeu: 4.034 ± 0.056	0.616IleMet: 0.616 ± 0.017	1.344IleAsn: 1.344 ± 0.03	2.629IlePro: 2.629 ± 0.041	1.454IleGln: 1.454 ± 0.026	3.357IleArg: 3.357 ± 0.046	2.634IleSer: 2.634 ± 0.035	2.494IleThr: 2.494 ± 0.041	3.865IleVal: 3.865 ± 0.045	0.544IleTrp: 0.544 ± 0.016	0.942IleTyr: 0.942 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.903LysAla: 3.903 ± 0.058	0.31LysCys: 0.31 ± 0.012	1.935LysAsp: 1.935 ± 0.038	2.19LysGlu: 2.19 ± 0.037	1.248LysPhe: 1.248 ± 0.024	2.549LysGly: 2.549 ± 0.042	0.765LysHis: 0.765 ± 0.021	1.524LysIle: 1.524 ± 0.028	1.83LysLys: 1.83 ± 0.039	3.642LysLeu: 3.642 ± 0.047	0.835LysMet: 0.835 ± 0.02	1.139LysAsn: 1.139 ± 0.027	2.471LysPro: 2.471 ± 0.045	1.485LysGln: 1.485 ± 0.031	2.419LysArg: 2.419 ± 0.035	2.466LysSer: 2.466 ± 0.04	2.182LysThr: 2.182 ± 0.032	2.542LysVal: 2.542 ± 0.045	0.536LysTrp: 0.536 ± 0.015	0.86LysTyr: 0.86 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	11.589LeuAla: 11.589 ± 0.095	1.148LeuCys: 1.148 ± 0.024	5.471LeuAsp: 5.471 ± 0.06	5.858LeuGlu: 5.858 ± 0.063	3.504LeuPhe: 3.504 ± 0.048	7.257LeuGly: 7.257 ± 0.076	1.926LeuHis: 1.926 ± 0.033	4.467LeuIle: 4.467 ± 0.05	4.441LeuLys: 4.441 ± 0.057	9.926LeuLeu: 9.926 ± 0.093	2.034LeuMet: 2.034 ± 0.028	2.858LeuAsn: 2.858 ± 0.038	5.734LeuPro: 5.734 ± 0.059	3.378LeuGln: 3.378 ± 0.046	6.817LeuArg: 6.817 ± 0.059	6.169LeuSer: 6.169 ± 0.053	5.755LeuThr: 5.755 ± 0.062	7.1LeuVal: 7.1 ± 0.079	1.42LeuTrp: 1.42 ± 0.029	1.902LeuTyr: 1.902 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.245MetAla: 2.245 ± 0.036	0.212MetCys: 0.212 ± 0.011	0.914MetAsp: 0.914 ± 0.021	0.986MetGlu: 0.986 ± 0.024	0.764MetPhe: 0.764 ± 0.018	1.464MetGly: 1.464 ± 0.031	0.453MetHis: 0.453 ± 0.018	1.005MetIle: 1.005 ± 0.022	0.926MetLys: 0.926 ± 0.024	2.251MetLeu: 2.251 ± 0.038	0.496MetMet: 0.496 ± 0.015	0.753MetAsn: 0.753 ± 0.019	1.359MetPro: 1.359 ± 0.028	0.846MetGln: 0.846 ± 0.021	1.403MetArg: 1.403 ± 0.025	1.657MetSer: 1.657 ± 0.033	1.529MetThr: 1.529 ± 0.031	1.357MetVal: 1.357 ± 0.028	0.258MetTrp: 0.258 ± 0.013	0.363MetTyr: 0.363 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.873AsnAla: 2.873 ± 0.049	0.338AsnCys: 0.338 ± 0.014	1.692AsnAsp: 1.692 ± 0.034	1.523AsnGlu: 1.523 ± 0.028	0.983AsnPhe: 0.983 ± 0.022	2.752AsnGly: 2.752 ± 0.056	0.623AsnHis: 0.623 ± 0.017	1.221AsnIle: 1.221 ± 0.027	0.695AsnLys: 0.695 ± 0.019	2.675AsnLeu: 2.675 ± 0.034	0.525AsnMet: 0.525 ± 0.015	0.885AsnAsn: 0.885 ± 0.038	2.004AsnPro: 2.004 ± 0.037	0.964AsnGln: 0.964 ± 0.023	2.129AsnArg: 2.129 ± 0.033	1.751AsnSer: 1.751 ± 0.036	1.432AsnThr: 1.432 ± 0.033	2.217AsnVal: 2.217 ± 0.041	0.498AsnTrp: 0.498 ± 0.015	0.734AsnTyr: 0.734 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.022ProAla: 7.022 ± 0.073	0.416ProCys: 0.416 ± 0.017	3.583ProAsp: 3.583 ± 0.046	4.194ProGlu: 4.194 ± 0.047	1.977ProPhe: 1.977 ± 0.032	4.983ProGly: 4.983 ± 0.062	1.141ProHis: 1.141 ± 0.029	2.36ProIle: 2.36 ± 0.037	2.046ProLys: 2.046 ± 0.037	4.931ProLeu: 4.931 ± 0.054	1.21ProMet: 1.21 ± 0.033	1.595ProAsn: 1.595 ± 0.029	3.544ProPro: 3.544 ± 0.07	2.043ProGln: 2.043 ± 0.037	3.468ProArg: 3.468 ± 0.049	3.366ProSer: 3.366 ± 0.05	3.037ProThr: 3.037 ± 0.043	4.497ProVal: 4.497 ± 0.055	0.783ProTrp: 0.783 ± 0.021	1.135ProTyr: 1.135 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.003GlnAla: 4.003 ± 0.055	0.383GlnCys: 0.383 ± 0.015	1.46GlnAsp: 1.46 ± 0.031	1.825GlnGlu: 1.825 ± 0.036	1.545GlnPhe: 1.545 ± 0.025	2.468GlnGly: 2.468 ± 0.038	0.746GlnHis: 0.746 ± 0.017	1.793GlnIle: 1.793 ± 0.033	1.473GlnLys: 1.473 ± 0.031	3.756GlnLeu: 3.756 ± 0.049	0.874GlnMet: 0.874 ± 0.022	0.988GlnAsn: 0.988 ± 0.023	2.179GlnPro: 2.179 ± 0.045	1.739GlnGln: 1.739 ± 0.04	2.717GlnArg: 2.717 ± 0.042	2.257GlnSer: 2.257 ± 0.036	2.08GlnThr: 2.08 ± 0.033	2.573GlnVal: 2.573 ± 0.04	0.542GlnTrp: 0.542 ± 0.017	0.744GlnTyr: 0.744 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	5.917ArgAla: 5.917 ± 0.064	0.762ArgCys: 0.762 ± 0.02	4.008ArgAsp: 4.008 ± 0.051	4.539ArgGlu: 4.539 ± 0.055	3.043ArgPhe: 3.043 ± 0.042	4.881ArgGly: 4.881 ± 0.066	1.593ArgHis: 1.593 ± 0.029	3.849ArgIle: 3.849 ± 0.051	2.746ArgLys: 2.746 ± 0.04	7.853ArgLeu: 7.853 ± 0.078	1.864ArgMet: 1.864 ± 0.029	2.097ArgAsn: 2.097 ± 0.033	4.232ArgPro: 4.232 ± 0.053	2.936ArgGln: 2.936 ± 0.046	6.246ArgArg: 6.246 ± 0.076	4.445ArgSer: 4.445 ± 0.054	3.825ArgThr: 3.825 ± 0.043	4.904ArgVal: 4.904 ± 0.054	1.283ArgTrp: 1.283 ± 0.027	1.647ArgTyr: 1.647 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.177SerAla: 6.177 ± 0.068	0.567SerCys: 0.567 ± 0.02	3.315SerAsp: 3.315 ± 0.041	3.3SerGlu: 3.3 ± 0.049	2.174SerPhe: 2.174 ± 0.035	5.555SerGly: 5.555 ± 0.062	1.262SerHis: 1.262 ± 0.025	2.836SerIle: 2.836 ± 0.044	1.998SerLys: 1.998 ± 0.037	6.305SerLeu: 6.305 ± 0.066	1.388SerMet: 1.388 ± 0.029	1.741SerAsn: 1.741 ± 0.037	3.986SerPro: 3.986 ± 0.054	2.175SerGln: 2.175 ± 0.036	4.614SerArg: 4.614 ± 0.054	4.093SerSer: 4.093 ± 0.059	3.559SerThr: 3.559 ± 0.041	4.25SerVal: 4.25 ± 0.047	0.9SerTrp: 0.9 ± 0.021	1.271SerTyr: 1.271 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.012ThrAla: 6.012 ± 0.063	0.575ThrCys: 0.575 ± 0.023	2.965ThrAsp: 2.965 ± 0.044	2.769ThrGlu: 2.769 ± 0.042	2.121ThrPhe: 2.121 ± 0.036	5.047ThrGly: 5.047 ± 0.076	1.061ThrHis: 1.061 ± 0.026	2.902ThrIle: 2.902 ± 0.045	1.686ThrLys: 1.686 ± 0.036	5.707ThrLeu: 5.707 ± 0.053	1.055ThrMet: 1.055 ± 0.024	1.517ThrAsn: 1.517 ± 0.036	3.929ThrPro: 3.929 ± 0.052	1.663ThrGln: 1.663 ± 0.032	3.494ThrArg: 3.494 ± 0.042	3.419ThrSer: 3.419 ± 0.045	3.304ThrThr: 3.304 ± 0.06	4.261ThrVal: 4.261 ± 0.056	0.893ThrTrp: 0.893 ± 0.022	1.206ThrTyr: 1.206 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.099ValAla: 8.099 ± 0.073	0.903ValCys: 0.903 ± 0.022	4.554ValAsp: 4.554 ± 0.053	4.635ValGlu: 4.635 ± 0.061	2.651ValPhe: 2.651 ± 0.041	5.196ValGly: 5.196 ± 0.059	1.486ValHis: 1.486 ± 0.027	3.635ValIle: 3.635 ± 0.049	2.568ValLys: 2.568 ± 0.038	7.207ValLeu: 7.207 ± 0.068	1.54ValMet: 1.54 ± 0.031	2.13ValAsn: 2.13 ± 0.034	3.784ValPro: 3.784 ± 0.046	2.497ValGln: 2.497 ± 0.038	5.226ValArg: 5.226 ± 0.054	4.515ValSer: 4.515 ± 0.051	4.585ValThr: 4.585 ± 0.059	6.209ValVal: 6.209 ± 0.062	1.061ValTrp: 1.061 ± 0.024	1.616ValTyr: 1.616 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.201TrpAla: 1.201 ± 0.026	0.203TrpCys: 0.203 ± 0.01	0.777TrpAsp: 0.777 ± 0.018	0.741TrpGlu: 0.741 ± 0.02	0.602TrpPhe: 0.602 ± 0.02	0.996TrpGly: 0.996 ± 0.026	0.369TrpHis: 0.369 ± 0.014	0.828TrpIle: 0.828 ± 0.021	0.803TrpLys: 0.803 ± 0.021	1.797TrpLeu: 1.797 ± 0.033	0.46TrpMet: 0.46 ± 0.016	0.611TrpAsn: 0.611 ± 0.019	0.792TrpPro: 0.792 ± 0.021	0.644TrpGln: 0.644 ± 0.016	1.183TrpArg: 1.183 ± 0.026	1.07TrpSer: 1.07 ± 0.026	1.023TrpThr: 1.023 ± 0.029	0.897TrpVal: 0.897 ± 0.024	0.32TrpTrp: 0.32 ± 0.014	0.325TrpTyr: 0.325 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.962TyrAla: 1.962 ± 0.033	0.324TyrCys: 0.324 ± 0.014	1.416TyrAsp: 1.416 ± 0.034	1.312TyrGlu: 1.312 ± 0.025	0.936TyrPhe: 0.936 ± 0.028	1.951TyrGly: 1.951 ± 0.037	0.541TyrHis: 0.541 ± 0.018	0.744TyrIle: 0.744 ± 0.02	0.594TyrLys: 0.594 ± 0.019	2.149TyrLeu: 2.149 ± 0.036	0.345TyrMet: 0.345 ± 0.014	0.644TyrAsn: 0.644 ± 0.021	1.036TyrPro: 1.036 ± 0.026	0.834TyrGln: 0.834 ± 0.018	1.909TyrArg: 1.909 ± 0.032	1.341TyrSer: 1.341 ± 0.03	1.055TyrThr: 1.055 ± 0.028	1.596TyrVal: 1.596 ± 0.028	0.378TyrTrp: 0.378 ± 0.014	0.613TyrTyr: 0.613 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5497 proteins (1946564 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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