Amino acid dipepetide frequency for Thalassobium sp. R2A62

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.255AlaAla: 14.255 ± 0.175	1.051AlaCys: 1.051 ± 0.036	7.202AlaAsp: 7.202 ± 0.077	6.93AlaGlu: 6.93 ± 0.093	4.204AlaPhe: 4.204 ± 0.062	9.421AlaGly: 9.421 ± 0.135	2.14AlaHis: 2.14 ± 0.045	6.106AlaIle: 6.106 ± 0.078	4.114AlaLys: 4.114 ± 0.067	11.508AlaLeu: 11.508 ± 0.121	3.717AlaMet: 3.717 ± 0.06	3.14AlaAsn: 3.14 ± 0.056	4.965AlaPro: 4.965 ± 0.077	4.492AlaGln: 4.492 ± 0.076	7.034AlaArg: 7.034 ± 0.097	5.771AlaSer: 5.771 ± 0.085	6.278AlaThr: 6.278 ± 0.081	7.979AlaVal: 7.979 ± 0.107	1.278AlaTrp: 1.278 ± 0.038	2.532AlaTyr: 2.532 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.043CysAla: 1.043 ± 0.04	0.125CysCys: 0.125 ± 0.011	0.683CysAsp: 0.683 ± 0.025	0.48CysGlu: 0.48 ± 0.023	0.388CysPhe: 0.388 ± 0.02	1.008CysGly: 1.008 ± 0.035	0.266CysHis: 0.266 ± 0.017	0.468CysIle: 0.468 ± 0.022	0.24CysLys: 0.24 ± 0.015	0.904CysLeu: 0.904 ± 0.033	0.18CysMet: 0.18 ± 0.014	0.26CysAsn: 0.26 ± 0.016	0.496CysPro: 0.496 ± 0.024	0.273CysGln: 0.273 ± 0.016	0.489CysArg: 0.489 ± 0.022	0.51CysSer: 0.51 ± 0.027	0.467CysThr: 0.467 ± 0.02	0.718CysVal: 0.718 ± 0.029	0.136CysTrp: 0.136 ± 0.01	0.238CysTyr: 0.238 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.905AspAla: 7.905 ± 0.098	0.565AspCys: 0.565 ± 0.023	4.139AspAsp: 4.139 ± 0.081	3.65AspGlu: 3.65 ± 0.075	2.47AspPhe: 2.47 ± 0.047	5.785AspGly: 5.785 ± 0.081	1.527AspHis: 1.527 ± 0.043	3.511AspIle: 3.511 ± 0.067	1.864AspLys: 1.864 ± 0.042	6.55AspLeu: 6.55 ± 0.086	1.831AspMet: 1.831 ± 0.039	1.596AspAsn: 1.596 ± 0.039	3.322AspPro: 3.322 ± 0.067	2.395AspGln: 2.395 ± 0.045	4.075AspArg: 4.075 ± 0.063	2.238AspSer: 2.238 ± 0.05	3.496AspThr: 3.496 ± 0.07	5.079AspVal: 5.079 ± 0.086	1.118AspTrp: 1.118 ± 0.037	1.652AspTyr: 1.652 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.874GluAla: 6.874 ± 0.102	0.373GluCys: 0.373 ± 0.019	3.214GluAsp: 3.214 ± 0.057	2.964GluGlu: 2.964 ± 0.065	1.975GluPhe: 1.975 ± 0.046	4.253GluGly: 4.253 ± 0.072	1.224GluHis: 1.224 ± 0.034	3.771GluIle: 3.771 ± 0.061	2.046GluLys: 2.046 ± 0.055	5.08GluLeu: 5.08 ± 0.087	2.015GluMet: 2.015 ± 0.044	2.037GluAsn: 2.037 ± 0.043	2.272GluPro: 2.272 ± 0.051	2.092GluGln: 2.092 ± 0.048	3.793GluArg: 3.793 ± 0.073	2.009GluSer: 2.009 ± 0.044	4.144GluThr: 4.144 ± 0.06	4.175GluVal: 4.175 ± 0.069	0.776GluTrp: 0.776 ± 0.03	1.126GluTyr: 1.126 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.38PheAla: 4.38 ± 0.071	0.489PheCys: 0.489 ± 0.022	3.117PheAsp: 3.117 ± 0.057	2.439PheGlu: 2.439 ± 0.048	1.56PhePhe: 1.56 ± 0.048	3.87PheGly: 3.87 ± 0.071	0.805PheHis: 0.805 ± 0.032	1.819PheIle: 1.819 ± 0.043	1.208PheLys: 1.208 ± 0.036	3.454PheLeu: 3.454 ± 0.067	0.963PheMet: 0.963 ± 0.03	1.206PheAsn: 1.206 ± 0.038	1.538PhePro: 1.538 ± 0.038	1.177PheGln: 1.177 ± 0.033	2.002PheArg: 2.002 ± 0.047	2.339PheSer: 2.339 ± 0.047	2.096PheThr: 2.096 ± 0.049	2.971PheVal: 2.971 ± 0.054	0.614PheTrp: 0.614 ± 0.027	0.994PheTyr: 0.994 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.164GlyAla: 9.164 ± 0.108	0.893GlyCys: 0.893 ± 0.029	5.066GlyAsp: 5.066 ± 0.097	4.381GlyGlu: 4.381 ± 0.076	3.718GlyPhe: 3.718 ± 0.067	7.11GlyGly: 7.11 ± 0.135	1.916GlyHis: 1.916 ± 0.043	4.596GlyIle: 4.596 ± 0.069	3.111GlyLys: 3.111 ± 0.065	8.412GlyLeu: 8.412 ± 0.101	2.491GlyMet: 2.491 ± 0.05	2.385GlyAsn: 2.385 ± 0.066	3.359GlyPro: 3.359 ± 0.059	3.126GlyGln: 3.126 ± 0.059	4.997GlyArg: 4.997 ± 0.066	4.375GlySer: 4.375 ± 0.095	4.837GlyThr: 4.837 ± 0.078	6.443GlyVal: 6.443 ± 0.088	1.41GlyTrp: 1.41 ± 0.038	2.292GlyTyr: 2.292 ± 0.05	0.001GlyXaa: 0.001 ± 0.001
His	2.23HisAla: 2.23 ± 0.046	0.236HisCys: 0.236 ± 0.015	1.431HisAsp: 1.431 ± 0.042	1.042HisGlu: 1.042 ± 0.033	0.845HisPhe: 0.845 ± 0.028	1.807HisGly: 1.807 ± 0.046	0.606HisHis: 0.606 ± 0.031	1.122HisIle: 1.122 ± 0.037	0.602HisLys: 0.602 ± 0.024	2.063HisLeu: 2.063 ± 0.052	0.609HisMet: 0.609 ± 0.026	0.526HisAsn: 0.526 ± 0.023	1.329HisPro: 1.329 ± 0.036	0.634HisGln: 0.634 ± 0.023	1.208HisArg: 1.208 ± 0.039	1.052HisSer: 1.052 ± 0.032	0.964HisThr: 0.964 ± 0.03	1.522HisVal: 1.522 ± 0.036	0.317HisTrp: 0.317 ± 0.018	0.567HisTyr: 0.567 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.038IleAla: 7.038 ± 0.073	0.624IleCys: 0.624 ± 0.026	3.935IleAsp: 3.935 ± 0.068	3.867IleGlu: 3.867 ± 0.058	1.926IlePhe: 1.926 ± 0.046	5.066IleGly: 5.066 ± 0.076	0.935IleHis: 0.935 ± 0.032	2.791IleIle: 2.791 ± 0.052	1.969IleLys: 1.969 ± 0.038	5.078IleLeu: 5.078 ± 0.084	1.296IleMet: 1.296 ± 0.042	1.772IleAsn: 1.772 ± 0.044	2.385IlePro: 2.385 ± 0.047	1.473IleGln: 1.473 ± 0.034	2.949IleArg: 2.949 ± 0.056	3.368IleSer: 3.368 ± 0.064	3.32IleThr: 3.32 ± 0.061	4.128IleVal: 4.128 ± 0.068	0.773IleTrp: 0.773 ± 0.031	1.261IleTyr: 1.261 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.663LysAla: 3.663 ± 0.062	0.233LysCys: 0.233 ± 0.016	1.879LysAsp: 1.879 ± 0.044	1.685LysGlu: 1.685 ± 0.047	1.18LysPhe: 1.18 ± 0.033	2.724LysGly: 2.724 ± 0.057	0.768LysHis: 0.768 ± 0.03	2.052LysIle: 2.052 ± 0.039	1.472LysLys: 1.472 ± 0.051	3.175LysLeu: 3.175 ± 0.062	1.077LysMet: 1.077 ± 0.04	1.079LysAsn: 1.079 ± 0.034	1.871LysPro: 1.871 ± 0.051	1.045LysGln: 1.045 ± 0.038	2.522LysArg: 2.522 ± 0.056	2.26LysSer: 2.26 ± 0.047	2.373LysThr: 2.373 ± 0.048	2.229LysVal: 2.229 ± 0.049	0.46LysTrp: 0.46 ± 0.021	0.749LysTyr: 0.749 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.181LeuAla: 11.181 ± 0.129	0.957LeuCys: 0.957 ± 0.03	6.0LeuAsp: 6.0 ± 0.079	5.061LeuGlu: 5.061 ± 0.083	3.557LeuPhe: 3.557 ± 0.071	8.149LeuGly: 8.149 ± 0.096	1.776LeuHis: 1.776 ± 0.039	5.327LeuIle: 5.327 ± 0.081	3.319LeuLys: 3.319 ± 0.062	8.097LeuLeu: 8.097 ± 0.124	2.871LeuMet: 2.871 ± 0.057	3.252LeuAsn: 3.252 ± 0.054	4.674LeuPro: 4.674 ± 0.084	2.547LeuGln: 2.547 ± 0.054	6.173LeuArg: 6.173 ± 0.085	6.551LeuSer: 6.551 ± 0.086	6.081LeuThr: 6.081 ± 0.082	6.554LeuVal: 6.554 ± 0.078	1.25LeuTrp: 1.25 ± 0.037	1.972LeuTyr: 1.972 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.372MetAla: 3.372 ± 0.061	0.221MetCys: 0.221 ± 0.015	1.626MetAsp: 1.626 ± 0.043	1.231MetGlu: 1.231 ± 0.037	0.991MetPhe: 0.991 ± 0.03	2.468MetGly: 2.468 ± 0.047	0.477MetHis: 0.477 ± 0.022	1.855MetIle: 1.855 ± 0.042	1.188MetLys: 1.188 ± 0.036	2.707MetLeu: 2.707 ± 0.048	0.915MetMet: 0.915 ± 0.032	1.054MetAsn: 1.054 ± 0.033	1.5MetPro: 1.5 ± 0.042	1.042MetGln: 1.042 ± 0.029	1.927MetArg: 1.927 ± 0.05	2.062MetSer: 2.062 ± 0.047	2.329MetThr: 2.329 ± 0.046	2.002MetVal: 2.002 ± 0.039	0.303MetTrp: 0.303 ± 0.016	0.423MetTyr: 0.423 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.522AsnAla: 3.522 ± 0.061	0.317AsnCys: 0.317 ± 0.018	2.057AsnAsp: 2.057 ± 0.06	1.474AsnGlu: 1.474 ± 0.034	1.171AsnPhe: 1.171 ± 0.039	2.871AsnGly: 2.871 ± 0.068	0.644AsnHis: 0.644 ± 0.026	1.688AsnIle: 1.688 ± 0.047	0.856AsnLys: 0.856 ± 0.028	2.794AsnLeu: 2.794 ± 0.053	0.871AsnMet: 0.871 ± 0.033	0.942AsnAsn: 0.942 ± 0.032	1.906AsnPro: 1.906 ± 0.041	0.914AsnGln: 0.914 ± 0.03	1.872AsnArg: 1.872 ± 0.042	1.583AsnSer: 1.583 ± 0.041	1.652AsnThr: 1.652 ± 0.044	2.186AsnVal: 2.186 ± 0.046	0.502AsnTrp: 0.502 ± 0.024	0.787AsnTyr: 0.787 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.699ProAla: 4.699 ± 0.073	0.368ProCys: 0.368 ± 0.02	3.684ProAsp: 3.684 ± 0.062	3.391ProGlu: 3.391 ± 0.072	2.027ProPhe: 2.027 ± 0.04	3.0ProGly: 3.0 ± 0.054	1.04ProHis: 1.04 ± 0.035	2.524ProIle: 2.524 ± 0.051	1.887ProLys: 1.887 ± 0.048	4.186ProLeu: 4.186 ± 0.057	1.361ProMet: 1.361 ± 0.036	1.666ProAsn: 1.666 ± 0.044	1.743ProPro: 1.743 ± 0.047	1.651ProGln: 1.651 ± 0.045	2.341ProArg: 2.341 ± 0.051	2.635ProSer: 2.635 ± 0.057	2.799ProThr: 2.799 ± 0.058	3.711ProVal: 3.711 ± 0.062	0.595ProTrp: 0.595 ± 0.024	1.117ProTyr: 1.117 ± 0.035	0.001ProXaa: 0.001 ± 0.001
Gln	3.753GlnAla: 3.753 ± 0.062	0.243GlnCys: 0.243 ± 0.015	1.964GlnAsp: 1.964 ± 0.043	1.745GlnGlu: 1.745 ± 0.039	1.299GlnPhe: 1.299 ± 0.035	2.529GlnGly: 2.529 ± 0.056	0.624GlnHis: 0.624 ± 0.029	2.34GlnIle: 2.34 ± 0.049	1.094GlnLys: 1.094 ± 0.03	2.928GlnLeu: 2.928 ± 0.051	1.224GlnMet: 1.224 ± 0.034	1.129GlnAsn: 1.129 ± 0.033	1.519GlnPro: 1.519 ± 0.034	1.164GlnGln: 1.164 ± 0.036	2.109GlnArg: 2.109 ± 0.048	2.11GlnSer: 2.11 ± 0.046	2.197GlnThr: 2.197 ± 0.048	2.418GlnVal: 2.418 ± 0.046	0.438GlnTrp: 0.438 ± 0.02	0.742GlnTyr: 0.742 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	6.872ArgAla: 6.872 ± 0.096	0.488ArgCys: 0.488 ± 0.025	4.188ArgAsp: 4.188 ± 0.068	3.344ArgGlu: 3.344 ± 0.065	2.432ArgPhe: 2.432 ± 0.052	4.283ArgGly: 4.283 ± 0.066	1.302ArgHis: 1.302 ± 0.037	3.553ArgIle: 3.553 ± 0.058	2.222ArgLys: 2.222 ± 0.05	6.157ArgLeu: 6.157 ± 0.085	1.926ArgMet: 1.926 ± 0.04	1.851ArgAsn: 1.851 ± 0.043	2.68ArgPro: 2.68 ± 0.059	2.124ArgGln: 2.124 ± 0.053	4.069ArgArg: 4.069 ± 0.078	3.193ArgSer: 3.193 ± 0.048	3.133ArgThr: 3.133 ± 0.052	4.428ArgVal: 4.428 ± 0.069	0.843ArgTrp: 0.843 ± 0.03	1.496ArgTyr: 1.496 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.727SerAla: 5.727 ± 0.099	0.521SerCys: 0.521 ± 0.022	3.832SerAsp: 3.832 ± 0.063	3.099SerGlu: 3.099 ± 0.052	2.414SerPhe: 2.414 ± 0.047	5.463SerGly: 5.463 ± 0.081	1.181SerHis: 1.181 ± 0.039	2.944SerIle: 2.944 ± 0.053	1.964SerLys: 1.964 ± 0.045	5.006SerLeu: 5.006 ± 0.075	1.561SerMet: 1.561 ± 0.039	1.709SerAsn: 1.709 ± 0.046	2.418SerPro: 2.418 ± 0.053	1.854SerGln: 1.854 ± 0.044	3.111SerArg: 3.111 ± 0.066	2.91SerSer: 2.91 ± 0.064	2.999SerThr: 2.999 ± 0.062	4.101SerVal: 4.101 ± 0.073	0.73SerTrp: 0.73 ± 0.029	1.438SerTyr: 1.438 ± 0.037	0.001SerXaa: 0.001 ± 0.001
Thr	6.398ThrAla: 6.398 ± 0.107	0.535ThrCys: 0.535 ± 0.025	3.71ThrAsp: 3.71 ± 0.061	3.03ThrGlu: 3.03 ± 0.05	2.265ThrPhe: 2.265 ± 0.053	5.423ThrGly: 5.423 ± 0.085	1.295ThrHis: 1.295 ± 0.035	3.167ThrIle: 3.167 ± 0.064	1.953ThrLys: 1.953 ± 0.049	6.306ThrLeu: 6.306 ± 0.088	1.515ThrMet: 1.515 ± 0.041	1.686ThrAsn: 1.686 ± 0.044	3.435ThrPro: 3.435 ± 0.065	1.99ThrGln: 1.99 ± 0.045	3.361ThrArg: 3.361 ± 0.057	3.303ThrSer: 3.303 ± 0.065	3.382ThrThr: 3.382 ± 0.072	4.518ThrVal: 4.518 ± 0.063	0.717ThrTrp: 0.717 ± 0.029	1.451ThrTyr: 1.451 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.209ValAla: 8.209 ± 0.1	0.751ValCys: 0.751 ± 0.03	4.42ValAsp: 4.42 ± 0.066	4.503ValGlu: 4.503 ± 0.074	2.992ValPhe: 2.992 ± 0.057	5.674ValGly: 5.674 ± 0.086	1.348ValHis: 1.348 ± 0.035	4.488ValIle: 4.488 ± 0.072	2.248ValLys: 2.248 ± 0.052	7.236ValLeu: 7.236 ± 0.09	2.265ValMet: 2.265 ± 0.053	2.133ValAsn: 2.133 ± 0.056	3.362ValPro: 3.362 ± 0.059	2.233ValGln: 2.233 ± 0.046	4.123ValArg: 4.123 ± 0.064	4.493ValSer: 4.493 ± 0.074	4.79ValThr: 4.79 ± 0.076	5.684ValVal: 5.684 ± 0.076	1.006ValTrp: 1.006 ± 0.036	1.494ValTyr: 1.494 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.332TrpAla: 1.332 ± 0.042	0.137TrpCys: 0.137 ± 0.01	0.884TrpAsp: 0.884 ± 0.028	0.627TrpGlu: 0.627 ± 0.028	0.589TrpPhe: 0.589 ± 0.024	0.989TrpGly: 0.989 ± 0.034	0.313TrpHis: 0.313 ± 0.019	0.765TrpIle: 0.765 ± 0.029	0.468TrpLys: 0.468 ± 0.021	1.462TrpLeu: 1.462 ± 0.037	0.457TrpMet: 0.457 ± 0.022	0.483TrpAsn: 0.483 ± 0.021	0.636TrpPro: 0.636 ± 0.03	0.553TrpGln: 0.553 ± 0.024	0.962TrpArg: 0.962 ± 0.032	0.857TrpSer: 0.857 ± 0.028	0.874TrpThr: 0.874 ± 0.036	0.972TrpVal: 0.972 ± 0.035	0.241TrpTrp: 0.241 ± 0.017	0.284TrpTyr: 0.284 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.499TyrAla: 2.499 ± 0.054	0.246TyrCys: 0.246 ± 0.016	1.735TyrAsp: 1.735 ± 0.039	1.267TyrGlu: 1.267 ± 0.037	1.038TyrPhe: 1.038 ± 0.035	2.189TyrGly: 2.189 ± 0.047	0.528TyrHis: 0.528 ± 0.025	1.067TyrIle: 1.067 ± 0.031	0.672TyrLys: 0.672 ± 0.024	2.247TyrLeu: 2.247 ± 0.047	0.547TyrMet: 0.547 ± 0.025	0.705TyrAsn: 0.705 ± 0.027	1.018TyrPro: 1.018 ± 0.029	0.789TyrGln: 0.789 ± 0.024	1.466TyrArg: 1.466 ± 0.042	1.362TyrSer: 1.362 ± 0.04	1.226TyrThr: 1.226 ± 0.036	1.634TyrVal: 1.634 ± 0.042	0.379TyrTrp: 0.379 ± 0.017	0.608TyrTyr: 0.608 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.028XaaXaa: 0.028 ± 0.018

Statistics based on 3672 proteins (1040251 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---