Amino acid dipepetide frequency for Pantoea ananatis (strain LMG 20103)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.847AlaAla: 10.847 ± 0.144	1.152AlaCys: 1.152 ± 0.035	5.099AlaAsp: 5.099 ± 0.065	5.765AlaGlu: 5.765 ± 0.084	3.871AlaPhe: 3.871 ± 0.063	8.045AlaGly: 8.045 ± 0.101	1.943AlaHis: 1.943 ± 0.038	5.801AlaIle: 5.801 ± 0.066	3.496AlaLys: 3.496 ± 0.066	12.746AlaLeu: 12.746 ± 0.117	3.095AlaMet: 3.095 ± 0.048	2.997AlaAsn: 2.997 ± 0.053	3.774AlaPro: 3.774 ± 0.058	4.857AlaGln: 4.857 ± 0.074	5.952AlaArg: 5.952 ± 0.062	6.156AlaSer: 6.156 ± 0.079	4.782AlaThr: 4.782 ± 0.066	7.021AlaVal: 7.021 ± 0.084	1.67AlaTrp: 1.67 ± 0.037	1.96AlaTyr: 1.96 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.982CysAla: 0.982 ± 0.03	0.222CysCys: 0.222 ± 0.013	0.57CysAsp: 0.57 ± 0.021	0.563CysGlu: 0.563 ± 0.023	0.481CysPhe: 0.481 ± 0.022	1.006CysGly: 1.006 ± 0.033	0.355CysHis: 0.355 ± 0.017	0.54CysIle: 0.54 ± 0.021	0.293CysLys: 0.293 ± 0.014	1.059CysLeu: 1.059 ± 0.028	0.243CysMet: 0.243 ± 0.015	0.309CysAsn: 0.309 ± 0.015	0.482CysPro: 0.482 ± 0.021	0.496CysGln: 0.496 ± 0.022	0.667CysArg: 0.667 ± 0.022	0.699CysSer: 0.699 ± 0.024	0.459CysThr: 0.459 ± 0.019	0.73CysVal: 0.73 ± 0.025	0.184CysTrp: 0.184 ± 0.011	0.312CysTyr: 0.312 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.448AspAla: 5.448 ± 0.077	0.499AspCys: 0.499 ± 0.022	2.957AspAsp: 2.957 ± 0.054	3.381AspGlu: 3.381 ± 0.06	2.152AspPhe: 2.152 ± 0.044	3.592AspGly: 3.592 ± 0.072	1.07AspHis: 1.07 ± 0.029	3.27AspIle: 3.27 ± 0.054	2.337AspLys: 2.337 ± 0.044	4.683AspLeu: 4.683 ± 0.058	1.351AspMet: 1.351 ± 0.03	2.164AspAsn: 2.164 ± 0.043	2.171AspPro: 2.171 ± 0.039	1.735AspGln: 1.735 ± 0.038	3.047AspArg: 3.047 ± 0.045	3.003AspSer: 3.003 ± 0.05	2.392AspThr: 2.392 ± 0.05	3.914AspVal: 3.914 ± 0.058	0.821AspTrp: 0.821 ± 0.022	1.816AspTyr: 1.816 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.492GluAla: 5.492 ± 0.087	0.407GluCys: 0.407 ± 0.017	2.248GluAsp: 2.248 ± 0.048	2.887GluGlu: 2.887 ± 0.052	1.623GluPhe: 1.623 ± 0.032	3.489GluGly: 3.489 ± 0.054	1.352GluHis: 1.352 ± 0.034	3.094GluIle: 3.094 ± 0.052	2.937GluLys: 2.937 ± 0.055	5.246GluLeu: 5.246 ± 0.069	1.655GluMet: 1.655 ± 0.037	2.224GluAsn: 2.224 ± 0.041	2.025GluPro: 2.025 ± 0.04	3.392GluGln: 3.392 ± 0.059	3.387GluArg: 3.387 ± 0.053	2.889GluSer: 2.889 ± 0.054	2.888GluThr: 2.888 ± 0.05	3.503GluVal: 3.503 ± 0.052	0.723GluTrp: 0.723 ± 0.024	1.232GluTyr: 1.232 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.632PheAla: 3.632 ± 0.052	0.563PheCys: 0.563 ± 0.023	2.33PheAsp: 2.33 ± 0.049	1.682PheGlu: 1.682 ± 0.035	1.715PhePhe: 1.715 ± 0.042	3.102PheGly: 3.102 ± 0.053	0.835PheHis: 0.835 ± 0.027	2.522PheIle: 2.522 ± 0.043	1.203PheLys: 1.203 ± 0.033	3.402PheLeu: 3.402 ± 0.06	1.084PheMet: 1.084 ± 0.027	1.707PheAsn: 1.707 ± 0.036	1.621PhePro: 1.621 ± 0.036	1.316PheGln: 1.316 ± 0.03	1.969PheArg: 1.969 ± 0.038	3.288PheSer: 3.288 ± 0.055	2.411PheThr: 2.411 ± 0.049	2.42PheVal: 2.42 ± 0.048	0.63PheTrp: 0.63 ± 0.025	1.195PheTyr: 1.195 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	6.347GlyAla: 6.347 ± 0.081	0.993GlyCys: 0.993 ± 0.031	3.665GlyAsp: 3.665 ± 0.068	4.5GlyGlu: 4.5 ± 0.062	3.323GlyPhe: 3.323 ± 0.054	5.205GlyGly: 5.205 ± 0.085	1.662GlyHis: 1.662 ± 0.041	4.975GlyIle: 4.975 ± 0.075	3.744GlyLys: 3.744 ± 0.057	7.623GlyLeu: 7.623 ± 0.084	2.361GlyMet: 2.361 ± 0.05	2.818GlyAsn: 2.818 ± 0.067	2.058GlyPro: 2.058 ± 0.041	3.079GlyGln: 3.079 ± 0.054	3.944GlyArg: 3.944 ± 0.059	4.336GlySer: 4.336 ± 0.081	3.689GlyThr: 3.689 ± 0.063	5.471GlyVal: 5.471 ± 0.061	1.343GlyTrp: 1.343 ± 0.033	2.502GlyTyr: 2.502 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.181HisAla: 2.181 ± 0.043	0.335HisCys: 0.335 ± 0.016	1.249HisAsp: 1.249 ± 0.029	1.08HisGlu: 1.08 ± 0.026	1.144HisPhe: 1.144 ± 0.029	1.747HisGly: 1.747 ± 0.044	0.836HisHis: 0.836 ± 0.026	1.294HisIle: 1.294 ± 0.032	0.771HisLys: 0.771 ± 0.027	2.431HisLeu: 2.431 ± 0.048	0.544HisMet: 0.544 ± 0.02	0.849HisAsn: 0.849 ± 0.024	1.451HisPro: 1.451 ± 0.039	1.355HisGln: 1.355 ± 0.035	1.304HisArg: 1.304 ± 0.034	1.36HisSer: 1.36 ± 0.034	1.048HisThr: 1.048 ± 0.026	1.292HisVal: 1.292 ± 0.034	0.474HisTrp: 0.474 ± 0.019	0.972HisTyr: 0.972 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.435IleAla: 6.435 ± 0.076	0.645IleCys: 0.645 ± 0.025	3.449IleAsp: 3.449 ± 0.048	3.048IleGlu: 3.048 ± 0.051	1.847IlePhe: 1.847 ± 0.044	4.41IleGly: 4.41 ± 0.063	1.214IleHis: 1.214 ± 0.029	3.143IleIle: 3.143 ± 0.061	2.254IleLys: 2.254 ± 0.043	4.89IleLeu: 4.89 ± 0.071	1.361IleMet: 1.361 ± 0.036	2.462IleAsn: 2.462 ± 0.043	2.547IlePro: 2.547 ± 0.046	1.902IleGln: 1.902 ± 0.041	2.931IleArg: 2.931 ± 0.044	3.72IleSer: 3.72 ± 0.056	3.612IleThr: 3.612 ± 0.054	3.763IleVal: 3.763 ± 0.055	0.674IleTrp: 0.674 ± 0.025	1.421IleTyr: 1.421 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.002LysAla: 4.002 ± 0.07	0.231LysCys: 0.231 ± 0.014	1.84LysAsp: 1.84 ± 0.041	2.011LysGlu: 2.011 ± 0.045	0.987LysPhe: 0.987 ± 0.029	2.837LysGly: 2.837 ± 0.052	0.863LysHis: 0.863 ± 0.028	2.211LysIle: 2.211 ± 0.044	2.043LysLys: 2.043 ± 0.048	3.86LysLeu: 3.86 ± 0.064	1.211LysMet: 1.211 ± 0.032	1.59LysAsn: 1.59 ± 0.039	2.101LysPro: 2.101 ± 0.04	1.96LysGln: 1.96 ± 0.042	2.526LysArg: 2.526 ± 0.039	2.179LysSer: 2.179 ± 0.041	2.42LysThr: 2.42 ± 0.04	2.717LysVal: 2.717 ± 0.045	0.429LysTrp: 0.429 ± 0.018	0.939LysTyr: 0.939 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.815LeuAla: 11.815 ± 0.106	1.283LeuCys: 1.283 ± 0.034	5.395LeuAsp: 5.395 ± 0.077	5.153LeuGlu: 5.153 ± 0.08	4.423LeuPhe: 4.423 ± 0.069	7.175LeuGly: 7.175 ± 0.091	2.43LeuHis: 2.43 ± 0.046	5.943LeuIle: 5.943 ± 0.086	4.344LeuLys: 4.344 ± 0.066	12.195LeuLeu: 12.195 ± 0.15	3.202LeuMet: 3.202 ± 0.054	4.323LeuAsn: 4.323 ± 0.067	5.887LeuPro: 5.887 ± 0.076	4.646LeuGln: 4.646 ± 0.068	6.404LeuArg: 6.404 ± 0.082	7.973LeuSer: 7.973 ± 0.095	6.652LeuThr: 6.652 ± 0.096	7.062LeuVal: 7.062 ± 0.078	1.426LeuTrp: 1.426 ± 0.038	2.528LeuTyr: 2.528 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.069MetAla: 3.069 ± 0.046	0.208MetCys: 0.208 ± 0.012	1.19MetAsp: 1.19 ± 0.033	1.193MetGlu: 1.193 ± 0.031	0.883MetPhe: 0.883 ± 0.024	1.813MetGly: 1.813 ± 0.038	0.578MetHis: 0.578 ± 0.023	1.537MetIle: 1.537 ± 0.036	1.411MetLys: 1.411 ± 0.035	3.294MetLeu: 3.294 ± 0.052	1.032MetMet: 1.032 ± 0.027	1.122MetAsn: 1.122 ± 0.029	1.38MetPro: 1.38 ± 0.031	1.31MetGln: 1.31 ± 0.029	1.665MetArg: 1.665 ± 0.036	1.98MetSer: 1.98 ± 0.039	1.856MetThr: 1.856 ± 0.032	1.943MetVal: 1.943 ± 0.043	0.279MetTrp: 0.279 ± 0.016	0.461MetTyr: 0.461 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.813AsnAla: 3.813 ± 0.062	0.326AsnCys: 0.326 ± 0.015	2.055AsnAsp: 2.055 ± 0.044	1.707AsnGlu: 1.707 ± 0.035	1.256AsnPhe: 1.256 ± 0.034	3.006AsnGly: 3.006 ± 0.059	0.828AsnHis: 0.828 ± 0.025	2.093AsnIle: 2.093 ± 0.04	1.377AsnLys: 1.377 ± 0.034	3.567AsnLeu: 3.567 ± 0.066	0.896AsnMet: 0.896 ± 0.029	1.535AsnAsn: 1.535 ± 0.05	1.987AsnPro: 1.987 ± 0.036	1.622AsnGln: 1.622 ± 0.036	2.116AsnArg: 2.116 ± 0.039	2.034AsnSer: 2.034 ± 0.05	1.95AsnThr: 1.95 ± 0.044	2.571AsnVal: 2.571 ± 0.051	0.622AsnTrp: 0.622 ± 0.025	1.031AsnTyr: 1.031 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.861ProAla: 4.861 ± 0.063	0.423ProCys: 0.423 ± 0.019	2.928ProAsp: 2.928 ± 0.05	3.106ProGlu: 3.106 ± 0.045	1.813ProPhe: 1.813 ± 0.037	3.538ProGly: 3.538 ± 0.053	1.144ProHis: 1.144 ± 0.024	1.614ProIle: 1.614 ± 0.035	1.323ProLys: 1.323 ± 0.03	5.374ProLeu: 5.374 ± 0.066	1.128ProMet: 1.128 ± 0.03	1.181ProAsn: 1.181 ± 0.031	1.665ProPro: 1.665 ± 0.042	2.314ProGln: 2.314 ± 0.04	2.06ProArg: 2.06 ± 0.039	2.249ProSer: 2.249 ± 0.048	2.038ProThr: 2.038 ± 0.039	4.134ProVal: 4.134 ± 0.066	0.732ProTrp: 0.732 ± 0.024	1.152ProTyr: 1.152 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	5.145GlnAla: 5.145 ± 0.073	0.386GlnCys: 0.386 ± 0.02	2.049GlnAsp: 2.049 ± 0.045	1.923GlnGlu: 1.923 ± 0.038	1.546GlnPhe: 1.546 ± 0.032	3.478GlnGly: 3.478 ± 0.059	1.497GlnHis: 1.497 ± 0.041	2.272GlnIle: 2.272 ± 0.041	1.667GlnLys: 1.667 ± 0.036	5.345GlnLeu: 5.345 ± 0.075	1.267GlnMet: 1.267 ± 0.031	1.493GlnAsn: 1.493 ± 0.033	2.556GlnPro: 2.556 ± 0.05	3.939GlnGln: 3.939 ± 0.099	3.69GlnArg: 3.69 ± 0.061	2.509GlnSer: 2.509 ± 0.05	2.312GlnThr: 2.312 ± 0.046	3.234GlnVal: 3.234 ± 0.052	0.662GlnTrp: 0.662 ± 0.023	1.094GlnTyr: 1.094 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.018ArgAla: 5.018 ± 0.063	0.664ArgCys: 0.664 ± 0.024	3.182ArgAsp: 3.182 ± 0.048	3.603ArgGlu: 3.603 ± 0.055	2.795ArgPhe: 2.795 ± 0.045	3.447ArgGly: 3.447 ± 0.054	1.716ArgHis: 1.716 ± 0.04	3.436ArgIle: 3.436 ± 0.052	2.146ArgLys: 2.146 ± 0.037	6.846ArgLeu: 6.846 ± 0.087	1.616ArgMet: 1.616 ± 0.036	2.116ArgAsn: 2.116 ± 0.042	2.364ArgPro: 2.364 ± 0.048	3.389ArgGln: 3.389 ± 0.057	3.796ArgArg: 3.796 ± 0.071	3.041ArgSer: 3.041 ± 0.051	2.551ArgThr: 2.551 ± 0.052	3.991ArgVal: 3.991 ± 0.057	1.06ArgTrp: 1.06 ± 0.034	2.208ArgTyr: 2.208 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.242SerAla: 6.242 ± 0.073	0.545SerCys: 0.545 ± 0.023	3.274SerAsp: 3.274 ± 0.051	3.225SerGlu: 3.225 ± 0.055	2.297SerPhe: 2.297 ± 0.041	5.535SerGly: 5.535 ± 0.087	1.572SerHis: 1.572 ± 0.037	2.753SerIle: 2.753 ± 0.049	1.903SerLys: 1.903 ± 0.042	7.332SerLeu: 7.332 ± 0.088	1.653SerMet: 1.653 ± 0.035	1.867SerAsn: 1.867 ± 0.04	2.748SerPro: 2.748 ± 0.043	2.865SerGln: 2.865 ± 0.054	3.677SerArg: 3.677 ± 0.051	3.885SerSer: 3.885 ± 0.071	3.073SerThr: 3.073 ± 0.072	4.636SerVal: 4.636 ± 0.065	1.034SerTrp: 1.034 ± 0.028	1.534SerTyr: 1.534 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.186ThrAla: 5.186 ± 0.091	0.502ThrCys: 0.502 ± 0.021	2.635ThrAsp: 2.635 ± 0.059	2.479ThrGlu: 2.479 ± 0.042	2.041ThrPhe: 2.041 ± 0.041	4.469ThrGly: 4.469 ± 0.07	1.313ThrHis: 1.313 ± 0.031	2.679ThrIle: 2.679 ± 0.052	1.371ThrLys: 1.371 ± 0.033	7.706ThrLeu: 7.706 ± 0.088	1.224ThrMet: 1.224 ± 0.029	1.466ThrAsn: 1.466 ± 0.035	2.969ThrPro: 2.969 ± 0.043	2.436ThrGln: 2.436 ± 0.046	3.134ThrArg: 3.134 ± 0.051	3.043ThrSer: 3.043 ± 0.049	2.796ThrThr: 2.796 ± 0.072	3.851ThrVal: 3.851 ± 0.084	0.769ThrTrp: 0.769 ± 0.023	1.114ThrTyr: 1.114 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	7.199ValAla: 7.199 ± 0.097	0.707ValCys: 0.707 ± 0.023	3.588ValAsp: 3.588 ± 0.062	3.788ValGlu: 3.788 ± 0.055	2.655ValPhe: 2.655 ± 0.042	4.758ValGly: 4.758 ± 0.072	1.248ValHis: 1.248 ± 0.036	4.579ValIle: 4.579 ± 0.066	3.022ValLys: 3.022 ± 0.054	7.29ValLeu: 7.29 ± 0.079	2.313ValMet: 2.313 ± 0.046	2.819ValAsn: 2.819 ± 0.053	2.972ValPro: 2.972 ± 0.051	2.473ValGln: 2.473 ± 0.043	3.756ValArg: 3.756 ± 0.053	4.798ValSer: 4.798 ± 0.062	4.377ValThr: 4.377 ± 0.073	5.421ValVal: 5.421 ± 0.071	0.945ValTrp: 0.945 ± 0.026	1.544ValTyr: 1.544 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.972TrpAla: 0.972 ± 0.026	0.192TrpCys: 0.192 ± 0.012	0.63TrpAsp: 0.63 ± 0.023	0.53TrpGlu: 0.53 ± 0.019	0.695TrpPhe: 0.695 ± 0.025	0.912TrpGly: 0.912 ± 0.026	0.519TrpHis: 0.519 ± 0.021	0.742TrpIle: 0.742 ± 0.024	0.472TrpLys: 0.472 ± 0.017	2.402TrpLeu: 2.402 ± 0.054	0.415TrpMet: 0.415 ± 0.018	0.486TrpAsn: 0.486 ± 0.02	0.707TrpPro: 0.707 ± 0.023	1.349TrpGln: 1.349 ± 0.038	1.132TrpArg: 1.132 ± 0.03	0.854TrpSer: 0.854 ± 0.031	0.583TrpThr: 0.583 ± 0.021	0.899TrpVal: 0.899 ± 0.029	0.227TrpTrp: 0.227 ± 0.014	0.413TrpTyr: 0.413 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.342TyrAla: 2.342 ± 0.041	0.369TyrCys: 0.369 ± 0.015	1.474TyrAsp: 1.474 ± 0.041	1.072TyrGlu: 1.072 ± 0.027	1.083TyrPhe: 1.083 ± 0.036	2.073TyrGly: 2.073 ± 0.055	0.74TyrHis: 0.74 ± 0.021	1.23TyrIle: 1.23 ± 0.031	0.843TyrLys: 0.843 ± 0.029	2.971TyrLeu: 2.971 ± 0.053	0.552TyrMet: 0.552 ± 0.02	0.865TyrAsn: 0.865 ± 0.027	1.305TyrPro: 1.305 ± 0.032	1.627TyrGln: 1.627 ± 0.036	1.828TyrArg: 1.828 ± 0.035	1.654TyrSer: 1.654 ± 0.041	1.294TyrThr: 1.294 ± 0.029	1.678TyrVal: 1.678 ± 0.038	0.426TyrTrp: 0.426 ± 0.018	0.834TyrTyr: 0.834 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4241 proteins (1372081 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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