Amino acid dipepetide frequency for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.087AlaAla: 9.087 ± 0.066
1.078AlaCys: 1.078 ± 0.018
4.375AlaAsp: 4.375 ± 0.03
5.304AlaGlu: 5.304 ± 0.048
3.206AlaPhe: 3.206 ± 0.03
5.879AlaGly: 5.879 ± 0.043
1.797AlaHis: 1.797 ± 0.017
4.265AlaIle: 4.265 ± 0.033
3.928AlaLys: 3.928 ± 0.035
7.942AlaLeu: 7.942 ± 0.044
1.99AlaMet: 1.99 ± 0.022
2.969AlaAsn: 2.969 ± 0.024
4.673AlaPro: 4.673 ± 0.047
3.511AlaGln: 3.511 ± 0.032
5.141AlaArg: 5.141 ± 0.033
7.331AlaSer: 7.331 ± 0.054
5.257AlaThr: 5.257 ± 0.031
5.66AlaVal: 5.66 ± 0.038
1.177AlaTrp: 1.177 ± 0.017
2.21AlaTyr: 2.21 ± 0.024
0.001AlaXaa: 0.001 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.016
0.237CysCys: 0.237 ± 0.009
0.687CysAsp: 0.687 ± 0.012
0.606CysGlu: 0.606 ± 0.012
0.536CysPhe: 0.536 ± 0.012
0.922CysGly: 0.922 ± 0.016
0.336CysHis: 0.336 ± 0.009
0.678CysIle: 0.678 ± 0.012
0.492CysLys: 0.492 ± 0.01
1.326CysLeu: 1.326 ± 0.018
0.282CysMet: 0.282 ± 0.008
0.435CysAsn: 0.435 ± 0.011
0.672CysPro: 0.672 ± 0.014
0.492CysGln: 0.492 ± 0.01
0.799CysArg: 0.799 ± 0.015
0.945CysSer: 0.945 ± 0.016
0.683CysThr: 0.683 ± 0.014
0.82CysVal: 0.82 ± 0.013
0.204CysTrp: 0.204 ± 0.007
0.367CysTyr: 0.367 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
4.707AspAla: 4.707 ± 0.03
0.63AspCys: 0.63 ± 0.011
3.898AspAsp: 3.898 ± 0.043
4.375AspGlu: 4.375 ± 0.044
2.164AspPhe: 2.164 ± 0.02
3.949AspGly: 3.949 ± 0.032
1.277AspHis: 1.277 ± 0.016
3.055AspIle: 3.055 ± 0.027
2.253AspLys: 2.253 ± 0.024
5.122AspLeu: 5.122 ± 0.035
1.225AspMet: 1.225 ± 0.016
1.813AspAsn: 1.813 ± 0.02
3.409AspPro: 3.409 ± 0.029
1.94AspGln: 1.94 ± 0.02
3.168AspArg: 3.168 ± 0.028
4.117AspSer: 4.117 ± 0.031
2.88AspThr: 2.88 ± 0.026
3.648AspVal: 3.648 ± 0.03
0.876AspTrp: 0.876 ± 0.012
1.673AspTyr: 1.673 ± 0.019
0.0AspXaa: 0.0 ± 0.0
Glu
5.381GluAla: 5.381 ± 0.044
0.623GluCys: 0.623 ± 0.013
4.119GluAsp: 4.119 ± 0.039
5.523GluGlu: 5.523 ± 0.064
1.989GluPhe: 1.989 ± 0.021
3.702GluGly: 3.702 ± 0.031
1.421GluHis: 1.421 ± 0.017
3.1GluIle: 3.1 ± 0.025
3.624GluLys: 3.624 ± 0.034
5.286GluLeu: 5.286 ± 0.043
1.472GluMet: 1.472 ± 0.018
2.306GluAsn: 2.306 ± 0.022
2.803GluPro: 2.803 ± 0.038
2.585GluGln: 2.585 ± 0.028
4.021GluArg: 4.021 ± 0.032
4.395GluSer: 4.395 ± 0.033
3.549GluThr: 3.549 ± 0.032
3.578GluVal: 3.578 ± 0.027
0.879GluTrp: 0.879 ± 0.013
1.738GluTyr: 1.738 ± 0.016
0.0GluXaa: 0.0 ± 0.0
Phe
3.098PheAla: 3.098 ± 0.027
0.58PheCys: 0.58 ± 0.012
2.269PheAsp: 2.269 ± 0.023
2.141PheGlu: 2.141 ± 0.021
1.67PhePhe: 1.67 ± 0.025
2.784PheGly: 2.784 ± 0.03
0.906PheHis: 0.906 ± 0.014
1.828PheIle: 1.828 ± 0.023
1.441PheLys: 1.441 ± 0.018
3.617PheLeu: 3.617 ± 0.032
0.789PheMet: 0.789 ± 0.013
1.4PheAsn: 1.4 ± 0.018
1.982PhePro: 1.982 ± 0.022
1.414PheGln: 1.414 ± 0.019
2.046PheArg: 2.046 ± 0.019
2.993PheSer: 2.993 ± 0.023
2.089PheThr: 2.089 ± 0.021
2.417PheVal: 2.417 ± 0.027
0.651PheTrp: 0.651 ± 0.013
1.157PheTyr: 1.157 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
5.317GlyAla: 5.317 ± 0.04
0.895GlyCys: 0.895 ± 0.015
3.556GlyAsp: 3.556 ± 0.031
3.595GlyGlu: 3.595 ± 0.029
2.762GlyPhe: 2.762 ± 0.025
5.267GlyGly: 5.267 ± 0.054
1.69GlyHis: 1.69 ± 0.019
3.467GlyIle: 3.467 ± 0.026
3.342GlyLys: 3.342 ± 0.03
6.135GlyLeu: 6.135 ± 0.04
1.545GlyMet: 1.545 ± 0.02
2.417GlyAsn: 2.417 ± 0.024
3.338GlyPro: 3.338 ± 0.033
2.629GlyGln: 2.629 ± 0.026
4.105GlyArg: 4.105 ± 0.034
5.642GlySer: 5.642 ± 0.048
3.93GlyThr: 3.93 ± 0.027
4.448GlyVal: 4.448 ± 0.037
1.173GlyTrp: 1.173 ± 0.017
2.178GlyTyr: 2.178 ± 0.026
0.0GlyXaa: 0.0 ± 0.0
His
1.907HisAla: 1.907 ± 0.022
0.335HisCys: 0.335 ± 0.008
1.3HisAsp: 1.3 ± 0.018
1.343HisGlu: 1.343 ± 0.015
0.934HisPhe: 0.934 ± 0.015
1.738HisGly: 1.738 ± 0.02
0.856HisHis: 0.856 ± 0.015
1.227HisIle: 1.227 ± 0.015
0.854HisLys: 0.854 ± 0.014
2.29HisLeu: 2.29 ± 0.021
0.483HisMet: 0.483 ± 0.009
0.83HisAsn: 0.83 ± 0.013
1.702HisPro: 1.702 ± 0.021
0.983HisGln: 0.983 ± 0.016
1.61HisArg: 1.61 ± 0.019
1.866HisSer: 1.866 ± 0.023
1.25HisThr: 1.25 ± 0.017
1.414HisVal: 1.414 ± 0.018
0.365HisTrp: 0.365 ± 0.008
0.733HisTyr: 0.733 ± 0.013
0.0HisXaa: 0.0 ± 0.0
Ile
4.256IleAla: 4.256 ± 0.029
0.781IleCys: 0.781 ± 0.012
2.796IleAsp: 2.796 ± 0.026
2.844IleGlu: 2.844 ± 0.023
1.996IlePhe: 1.996 ± 0.021
3.123IleGly: 3.123 ± 0.032
1.229IleHis: 1.229 ± 0.017
2.501IleIle: 2.501 ± 0.027
2.087IleLys: 2.087 ± 0.02
4.748IleLeu: 4.748 ± 0.04
0.975IleMet: 0.975 ± 0.016
1.768IleAsn: 1.768 ± 0.021
3.105IlePro: 3.105 ± 0.029
1.945IleGln: 1.945 ± 0.022
2.913IleArg: 2.913 ± 0.025
3.786IleSer: 3.786 ± 0.028
2.756IleThr: 2.756 ± 0.025
3.222IleVal: 3.222 ± 0.03
0.723IleTrp: 0.723 ± 0.012
1.468IleTyr: 1.468 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
4.077LysAla: 4.077 ± 0.04
0.498LysCys: 0.498 ± 0.01
2.697LysAsp: 2.697 ± 0.03
3.351LysGlu: 3.351 ± 0.034
1.378LysPhe: 1.378 ± 0.018
2.872LysGly: 2.872 ± 0.022
1.103LysHis: 1.103 ± 0.014
2.164LysIle: 2.164 ± 0.026
3.054LysLys: 3.054 ± 0.049
3.968LysLeu: 3.968 ± 0.034
0.94LysMet: 0.94 ± 0.013
1.687LysAsn: 1.687 ± 0.02
2.619LysPro: 2.619 ± 0.029
1.843LysGln: 1.843 ± 0.021
3.353LysArg: 3.353 ± 0.033
3.321LysSer: 3.321 ± 0.033
2.645LysThr: 2.645 ± 0.021
2.769LysVal: 2.769 ± 0.027
0.654LysTrp: 0.654 ± 0.011
1.379LysTyr: 1.379 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
8.082LeuAla: 8.082 ± 0.044
1.264LeuCys: 1.264 ± 0.016
5.213LeuAsp: 5.213 ± 0.034
5.578LeuGlu: 5.578 ± 0.04
3.387LeuPhe: 3.387 ± 0.031
5.986LeuGly: 5.986 ± 0.042
2.32LeuHis: 2.32 ± 0.022
4.057LeuIle: 4.057 ± 0.035
4.114LeuLys: 4.114 ± 0.035
8.773LeuLeu: 8.773 ± 0.07
1.821LeuMet: 1.821 ± 0.02
3.223LeuAsn: 3.223 ± 0.027
5.505LeuPro: 5.505 ± 0.04
3.985LeuGln: 3.985 ± 0.034
6.039LeuArg: 6.039 ± 0.04
7.638LeuSer: 7.638 ± 0.049
4.89LeuThr: 4.89 ± 0.035
5.548LeuVal: 5.548 ± 0.035
1.228LeuTrp: 1.228 ± 0.017
2.483LeuTyr: 2.483 ± 0.021
0.0LeuXaa: 0.0 ± 0.0
Met
2.177MetAla: 2.177 ± 0.024
0.238MetCys: 0.238 ± 0.007
1.237MetAsp: 1.237 ± 0.016
1.311MetGlu: 1.311 ± 0.015
0.74MetPhe: 0.74 ± 0.013
1.426MetGly: 1.426 ± 0.018
0.466MetHis: 0.466 ± 0.01
1.004MetIle: 1.004 ± 0.014
0.974MetLys: 0.974 ± 0.013
1.859MetLeu: 1.859 ± 0.021
0.55MetMet: 0.55 ± 0.011
0.791MetAsn: 0.791 ± 0.016
1.183MetPro: 1.183 ± 0.018
0.875MetGln: 0.875 ± 0.015
1.258MetArg: 1.258 ± 0.014
1.798MetSer: 1.798 ± 0.019
1.325MetThr: 1.325 ± 0.016
1.344MetVal: 1.344 ± 0.015
0.253MetTrp: 0.253 ± 0.007
0.546MetTyr: 0.546 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.182AsnAla: 3.182 ± 0.029
0.456AsnCys: 0.456 ± 0.012
1.9AsnAsp: 1.9 ± 0.019
2.025AsnGlu: 2.025 ± 0.018
1.331AsnPhe: 1.331 ± 0.018
2.943AsnGly: 2.943 ± 0.025
0.847AsnHis: 0.847 ± 0.013
1.995AsnIle: 1.995 ± 0.02
1.455AsnLys: 1.455 ± 0.019
3.246AsnLeu: 3.246 ± 0.031
0.8AsnMet: 0.8 ± 0.014
1.413AsnAsn: 1.413 ± 0.017
2.454AsnPro: 2.454 ± 0.024
1.332AsnGln: 1.332 ± 0.019
1.993AsnArg: 1.993 ± 0.022
2.617AsnSer: 2.617 ± 0.022
2.049AsnThr: 2.049 ± 0.022
2.318AsnVal: 2.318 ± 0.019
0.558AsnTrp: 0.558 ± 0.011
1.05AsnTyr: 1.05 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
5.237ProAla: 5.237 ± 0.038
0.559ProCys: 0.559 ± 0.014
3.241ProAsp: 3.241 ± 0.023
3.889ProGlu: 3.889 ± 0.03
2.094ProPhe: 2.094 ± 0.021
3.911ProGly: 3.911 ± 0.032
1.348ProHis: 1.348 ± 0.019
2.429ProIle: 2.429 ± 0.019
2.47ProLys: 2.47 ± 0.029
4.781ProLeu: 4.781 ± 0.035
1.017ProMet: 1.017 ± 0.013
2.125ProAsn: 2.125 ± 0.02
4.766ProPro: 4.766 ± 0.07
2.42ProGln: 2.42 ± 0.03
3.391ProArg: 3.391 ± 0.034
6.229ProSer: 6.229 ± 0.051
3.768ProThr: 3.768 ± 0.042
3.697ProVal: 3.697 ± 0.035
0.787ProTrp: 0.787 ± 0.013
1.54ProTyr: 1.54 ± 0.021
0.0ProXaa: 0.0 ± 0.0
Gln
3.566GlnAla: 3.566 ± 0.03
0.473GlnCys: 0.473 ± 0.009
2.011GlnAsp: 2.011 ± 0.02
2.478GlnGlu: 2.478 ± 0.027
1.33GlnPhe: 1.33 ± 0.016
2.478GlnGly: 2.478 ± 0.027
1.047GlnHis: 1.047 ± 0.014
1.942GlnIle: 1.942 ± 0.02
1.984GlnLys: 1.984 ± 0.022
3.593GlnLeu: 3.593 ± 0.035
0.91GlnMet: 0.91 ± 0.014
1.539GlnAsn: 1.539 ± 0.018
2.531GlnPro: 2.531 ± 0.03
2.355GlnGln: 2.355 ± 0.048
2.758GlnArg: 2.758 ± 0.024
3.308GlnSer: 3.308 ± 0.036
2.404GlnThr: 2.404 ± 0.023
2.257GlnVal: 2.257 ± 0.02
0.606GlnTrp: 0.606 ± 0.012
1.168GlnTyr: 1.168 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
4.843ArgAla: 4.843 ± 0.031
0.711ArgCys: 0.711 ± 0.014
3.377ArgAsp: 3.377 ± 0.033
3.991ArgGlu: 3.991 ± 0.035
2.263ArgPhe: 2.263 ± 0.019
3.678ArgGly: 3.678 ± 0.033
1.579ArgHis: 1.579 ± 0.019
2.971ArgIle: 2.971 ± 0.024
3.484ArgLys: 3.484 ± 0.03
5.801ArgLeu: 5.801 ± 0.042
1.329ArgMet: 1.329 ± 0.016
2.285ArgAsn: 2.285 ± 0.024
3.518ArgPro: 3.518 ± 0.031
2.724ArgGln: 2.724 ± 0.024
5.244ArgArg: 5.244 ± 0.049
4.92ArgSer: 4.92 ± 0.043
3.387ArgThr: 3.387 ± 0.03
3.561ArgVal: 3.561 ± 0.029
0.961ArgTrp: 0.961 ± 0.015
1.748ArgTyr: 1.748 ± 0.019
0.0ArgXaa: 0.0 ± 0.0
Ser
6.879SerAla: 6.879 ± 0.046
0.898SerCys: 0.898 ± 0.013
4.252SerAsp: 4.252 ± 0.033
4.257SerGlu: 4.257 ± 0.033
3.037SerPhe: 3.037 ± 0.022
5.52SerGly: 5.52 ± 0.041
1.973SerHis: 1.973 ± 0.023
3.958SerIle: 3.958 ± 0.029
3.617SerLys: 3.617 ± 0.034
7.472SerLeu: 7.472 ± 0.048
1.71SerMet: 1.71 ± 0.018
2.929SerAsn: 2.929 ± 0.024
5.423SerPro: 5.423 ± 0.051
3.449SerGln: 3.449 ± 0.032
5.168SerArg: 5.168 ± 0.047
8.802SerSer: 8.802 ± 0.077
5.515SerThr: 5.515 ± 0.047
4.788SerVal: 4.788 ± 0.036
1.126SerTrp: 1.126 ± 0.015
2.09SerTyr: 2.09 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
5.32ThrAla: 5.32 ± 0.035
0.74ThrCys: 0.74 ± 0.012
2.919ThrAsp: 2.919 ± 0.025
3.127ThrGlu: 3.127 ± 0.029
2.208ThrPhe: 2.208 ± 0.021
4.226ThrGly: 4.226 ± 0.033
1.263ThrHis: 1.263 ± 0.016
3.03ThrIle: 3.03 ± 0.03
2.449ThrLys: 2.449 ± 0.025
5.232ThrLeu: 5.232 ± 0.036
1.178ThrMet: 1.178 ± 0.015
2.013ThrAsn: 2.013 ± 0.02
4.162ThrPro: 4.162 ± 0.039
2.059ThrGln: 2.059 ± 0.023
3.055ThrArg: 3.055 ± 0.028
5.16ThrSer: 5.16 ± 0.041
4.098ThrThr: 4.098 ± 0.043
3.942ThrVal: 3.942 ± 0.032
0.849ThrTrp: 0.849 ± 0.012
1.632ThrTyr: 1.632 ± 0.018
0.0ThrXaa: 0.0 ± 0.0
Val
5.309ValAla: 5.309 ± 0.041
0.874ValCys: 0.874 ± 0.013
3.778ValAsp: 3.778 ± 0.03
3.897ValGlu: 3.897 ± 0.031
2.49ValPhe: 2.49 ± 0.026
4.001ValGly: 4.001 ± 0.033
1.439ValHis: 1.439 ± 0.02
3.085ValIle: 3.085 ± 0.026
2.845ValLys: 2.845 ± 0.026
5.759ValLeu: 5.759 ± 0.043
1.319ValMet: 1.319 ± 0.016
2.264ValAsn: 2.264 ± 0.024
3.676ValPro: 3.676 ± 0.029
2.491ValGln: 2.491 ± 0.023
3.596ValArg: 3.596 ± 0.03
4.877ValSer: 4.877 ± 0.035
3.609ValThr: 3.609 ± 0.029
4.279ValVal: 4.279 ± 0.04
0.899ValTrp: 0.899 ± 0.015
1.829ValTyr: 1.829 ± 0.02
0.0ValXaa: 0.0 ± 0.0
Trp
1.149TrpAla: 1.149 ± 0.015
0.182TrpCys: 0.182 ± 0.007
0.917TrpAsp: 0.917 ± 0.015
0.86TrpGlu: 0.86 ± 0.013
0.542TrpPhe: 0.542 ± 0.011
0.919TrpGly: 0.919 ± 0.013
0.354TrpHis: 0.354 ± 0.008
0.779TrpIle: 0.779 ± 0.013
0.809TrpLys: 0.809 ± 0.013
1.395TrpLeu: 1.395 ± 0.019
0.391TrpMet: 0.391 ± 0.009
0.625TrpAsn: 0.625 ± 0.011
0.604TrpPro: 0.604 ± 0.012
0.577TrpGln: 0.577 ± 0.011
1.0TrpArg: 1.0 ± 0.016
1.054TrpSer: 1.054 ± 0.017
0.937TrpThr: 0.937 ± 0.014
0.883TrpVal: 0.883 ± 0.015
0.274TrpTrp: 0.274 ± 0.008
0.451TrpTyr: 0.451 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.239TyrAla: 2.239 ± 0.021
0.428TyrCys: 0.428 ± 0.009
1.635TyrAsp: 1.635 ± 0.023
1.601TyrGlu: 1.601 ± 0.018
1.216TyrPhe: 1.216 ± 0.017
2.108TyrGly: 2.108 ± 0.026
0.771TyrHis: 0.771 ± 0.013
1.486TyrIle: 1.486 ± 0.018
1.098TyrLys: 1.098 ± 0.016
2.793TyrLeu: 2.793 ± 0.026
0.626TyrMet: 0.626 ± 0.01
1.132TyrAsn: 1.132 ± 0.017
1.575TyrPro: 1.575 ± 0.017
1.126TyrGln: 1.126 ± 0.018
1.716TyrArg: 1.716 ± 0.017
2.065TyrSer: 2.065 ± 0.025
1.641TyrThr: 1.641 ± 0.022
1.722TyrVal: 1.722 ± 0.018
0.458TyrTrp: 0.458 ± 0.011
0.991TyrTyr: 0.991 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.097XaaXaa: 0.097 ± 0.027
Statistics based on 10409 proteins (5077491 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski