Amino acid dipepetide frequency for Colwellia ponticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.069AlaAla: 7.069 ± 0.118	0.927AlaCys: 0.927 ± 0.028	4.643AlaAsp: 4.643 ± 0.081	4.993AlaGlu: 4.993 ± 0.086	3.398AlaPhe: 3.398 ± 0.057	5.516AlaGly: 5.516 ± 0.099	1.663AlaHis: 1.663 ± 0.042	6.921AlaIle: 6.921 ± 0.08	5.766AlaLys: 5.766 ± 0.085	10.026AlaLeu: 10.026 ± 0.125	2.46AlaMet: 2.46 ± 0.055	4.297AlaAsn: 4.297 ± 0.069	2.62AlaPro: 2.62 ± 0.057	4.461AlaGln: 4.461 ± 0.065	3.253AlaArg: 3.253 ± 0.053	5.451AlaSer: 5.451 ± 0.075	4.698AlaThr: 4.698 ± 0.076	5.352AlaVal: 5.352 ± 0.082	0.839AlaTrp: 0.839 ± 0.031	2.309AlaTyr: 2.309 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.774CysAla: 0.774 ± 0.031	0.166CysCys: 0.166 ± 0.013	0.578CysAsp: 0.578 ± 0.025	0.521CysGlu: 0.521 ± 0.022	0.432CysPhe: 0.432 ± 0.022	0.795CysGly: 0.795 ± 0.028	0.336CysHis: 0.336 ± 0.017	0.626CysIle: 0.626 ± 0.028	0.432CysLys: 0.432 ± 0.022	1.046CysLeu: 1.046 ± 0.029	0.195CysMet: 0.195 ± 0.014	0.396CysAsn: 0.396 ± 0.019	0.446CysPro: 0.446 ± 0.021	0.664CysGln: 0.664 ± 0.027	0.422CysArg: 0.422 ± 0.021	0.723CysSer: 0.723 ± 0.032	0.467CysThr: 0.467 ± 0.019	0.576CysVal: 0.576 ± 0.025	0.121CysTrp: 0.121 ± 0.011	0.344CysTyr: 0.344 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.065AspAla: 4.065 ± 0.064	0.578AspCys: 0.578 ± 0.024	3.217AspAsp: 3.217 ± 0.078	3.734AspGlu: 3.734 ± 0.069	2.721AspPhe: 2.721 ± 0.055	3.169AspGly: 3.169 ± 0.057	1.049AspHis: 1.049 ± 0.033	4.93AspIle: 4.93 ± 0.063	3.843AspLys: 3.843 ± 0.066	5.032AspLeu: 5.032 ± 0.072	1.326AspMet: 1.326 ± 0.035	3.199AspAsn: 3.199 ± 0.09	1.632AspPro: 1.632 ± 0.035	1.636AspGln: 1.636 ± 0.041	1.861AspArg: 1.861 ± 0.04	3.425AspSer: 3.425 ± 0.06	2.643AspThr: 2.643 ± 0.056	3.706AspVal: 3.706 ± 0.071	0.676AspTrp: 0.676 ± 0.024	2.077AspTyr: 2.077 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	4.506GluAla: 4.506 ± 0.079	0.403GluCys: 0.403 ± 0.02	2.576GluAsp: 2.576 ± 0.053	3.224GluGlu: 3.224 ± 0.067	2.255GluPhe: 2.255 ± 0.046	3.008GluGly: 3.008 ± 0.059	1.563GluHis: 1.563 ± 0.044	3.801GluIle: 3.801 ± 0.063	4.09GluLys: 4.09 ± 0.071	6.614GluLeu: 6.614 ± 0.089	1.372GluMet: 1.372 ± 0.037	2.803GluAsn: 2.803 ± 0.051	1.608GluPro: 1.608 ± 0.04	4.538GluGln: 4.538 ± 0.075	2.689GluArg: 2.689 ± 0.057	3.296GluSer: 3.296 ± 0.053	2.705GluThr: 2.705 ± 0.057	4.014GluVal: 4.014 ± 0.079	0.464GluTrp: 0.464 ± 0.021	1.581GluTyr: 1.581 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.527PheAla: 3.527 ± 0.061	0.479PheCys: 0.479 ± 0.024	2.724PheAsp: 2.724 ± 0.063	2.341PheGlu: 2.341 ± 0.047	1.863PhePhe: 1.863 ± 0.052	2.92PheGly: 2.92 ± 0.058	0.798PheHis: 0.798 ± 0.03	3.44PheIle: 3.44 ± 0.067	2.133PheLys: 2.133 ± 0.046	3.473PheLeu: 3.473 ± 0.067	0.913PheMet: 0.913 ± 0.029	2.283PheAsn: 2.283 ± 0.05	1.285PhePro: 1.285 ± 0.034	1.138PheGln: 1.138 ± 0.032	1.283PheArg: 1.283 ± 0.034	3.712PheSer: 3.712 ± 0.067	2.927PheThr: 2.927 ± 0.058	2.63PheVal: 2.63 ± 0.055	0.49PheTrp: 0.49 ± 0.023	1.393PheTyr: 1.393 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.875GlyAla: 4.875 ± 0.077	0.77GlyCys: 0.77 ± 0.032	3.563GlyAsp: 3.563 ± 0.068	3.864GlyGlu: 3.864 ± 0.066	3.194GlyPhe: 3.194 ± 0.063	4.261GlyGly: 4.261 ± 0.088	1.491GlyHis: 1.491 ± 0.039	4.619GlyIle: 4.619 ± 0.078	3.997GlyLys: 3.997 ± 0.069	6.434GlyLeu: 6.434 ± 0.098	1.715GlyMet: 1.715 ± 0.048	2.635GlyAsn: 2.635 ± 0.059	1.461GlyPro: 1.461 ± 0.037	2.657GlyGln: 2.657 ± 0.051	2.614GlyArg: 2.614 ± 0.048	3.826GlySer: 3.826 ± 0.063	3.151GlyThr: 3.151 ± 0.067	4.674GlyVal: 4.674 ± 0.076	0.792GlyTrp: 0.792 ± 0.029	2.358GlyTyr: 2.358 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.499HisAla: 1.499 ± 0.041	0.363HisCys: 0.363 ± 0.018	1.13HisAsp: 1.13 ± 0.037	1.058HisGlu: 1.058 ± 0.031	1.15HisPhe: 1.15 ± 0.035	1.51HisGly: 1.51 ± 0.043	0.711HisHis: 0.711 ± 0.033	1.487HisIle: 1.487 ± 0.036	1.202HisLys: 1.202 ± 0.032	2.271HisLeu: 2.271 ± 0.051	0.448HisMet: 0.448 ± 0.021	1.13HisAsn: 1.13 ± 0.034	0.927HisPro: 0.927 ± 0.033	1.28HisGln: 1.28 ± 0.036	0.856HisArg: 0.856 ± 0.029	1.463HisSer: 1.463 ± 0.041	1.057HisThr: 1.057 ± 0.037	1.283HisVal: 1.283 ± 0.037	0.371HisTrp: 0.371 ± 0.018	0.9HisTyr: 0.9 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	7.181IleAla: 7.181 ± 0.09	0.687IleCys: 0.687 ± 0.025	4.896IleAsp: 4.896 ± 0.069	4.926IleGlu: 4.926 ± 0.08	2.556IlePhe: 2.556 ± 0.058	4.585IleGly: 4.585 ± 0.072	1.298IleHis: 1.298 ± 0.038	4.961IleIle: 4.961 ± 0.086	4.477IleLys: 4.477 ± 0.059	5.66IleLeu: 5.66 ± 0.085	1.474IleMet: 1.474 ± 0.037	4.346IleAsn: 4.346 ± 0.072	2.607IlePro: 2.607 ± 0.051	2.142IleGln: 2.142 ± 0.041	2.539IleArg: 2.539 ± 0.048	5.302IleSer: 5.302 ± 0.081	4.689IleThr: 4.689 ± 0.072	4.339IleVal: 4.339 ± 0.072	0.564IleTrp: 0.564 ± 0.023	1.881IleTyr: 1.881 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.636LysAla: 5.636 ± 0.082	0.362LysCys: 0.362 ± 0.024	2.853LysAsp: 2.853 ± 0.056	3.469LysGlu: 3.469 ± 0.067	1.738LysPhe: 1.738 ± 0.042	3.25LysGly: 3.25 ± 0.058	1.441LysHis: 1.441 ± 0.043	3.954LysIle: 3.954 ± 0.069	4.142LysLys: 4.142 ± 0.076	5.85LysLeu: 5.85 ± 0.083	1.461LysMet: 1.461 ± 0.034	3.145LysAsn: 3.145 ± 0.06	2.4LysPro: 2.4 ± 0.048	3.376LysGln: 3.376 ± 0.056	2.723LysArg: 2.723 ± 0.053	3.768LysSer: 3.768 ± 0.062	3.49LysThr: 3.49 ± 0.062	4.378LysVal: 4.378 ± 0.074	0.506LysTrp: 0.506 ± 0.021	1.638LysTyr: 1.638 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	10.899LeuAla: 10.899 ± 0.131	1.077LeuCys: 1.077 ± 0.035	5.195LeuAsp: 5.195 ± 0.07	5.026LeuGlu: 5.026 ± 0.079	4.286LeuPhe: 4.286 ± 0.08	6.443LeuGly: 6.443 ± 0.097	2.088LeuHis: 2.088 ± 0.044	7.0LeuIle: 7.0 ± 0.1	5.49LeuLys: 5.49 ± 0.075	11.43LeuLeu: 11.43 ± 0.175	2.509LeuMet: 2.509 ± 0.056	4.986LeuAsn: 4.986 ± 0.067	4.665LeuPro: 4.665 ± 0.076	3.72LeuGln: 3.72 ± 0.063	3.846LeuArg: 3.846 ± 0.063	8.355LeuSer: 8.355 ± 0.112	7.436LeuThr: 7.436 ± 0.091	6.924LeuVal: 6.924 ± 0.095	1.026LeuTrp: 1.026 ± 0.037	2.717LeuTyr: 2.717 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.388MetAla: 2.388 ± 0.053	0.194MetCys: 0.194 ± 0.013	1.014MetAsp: 1.014 ± 0.032	1.026MetGlu: 1.026 ± 0.034	0.84MetPhe: 0.84 ± 0.028	1.518MetGly: 1.518 ± 0.044	0.463MetHis: 0.463 ± 0.023	1.49MetIle: 1.49 ± 0.043	1.383MetLys: 1.383 ± 0.04	2.646MetLeu: 2.646 ± 0.048	0.744MetMet: 0.744 ± 0.03	1.106MetAsn: 1.106 ± 0.03	1.187MetPro: 1.187 ± 0.033	1.082MetGln: 1.082 ± 0.033	1.042MetArg: 1.042 ± 0.035	1.983MetSer: 1.983 ± 0.045	1.604MetThr: 1.604 ± 0.035	1.629MetVal: 1.629 ± 0.037	0.182MetTrp: 0.182 ± 0.011	0.474MetTyr: 0.474 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.905AsnAla: 3.905 ± 0.06	0.482AsnCys: 0.482 ± 0.023	2.798AsnAsp: 2.798 ± 0.057	2.953AsnGlu: 2.953 ± 0.054	1.96AsnPhe: 1.96 ± 0.048	2.95AsnGly: 2.95 ± 0.053	1.082AsnHis: 1.082 ± 0.03	3.948AsnIle: 3.948 ± 0.059	3.49AsnLys: 3.49 ± 0.061	4.328AsnLeu: 4.328 ± 0.073	1.079AsnMet: 1.079 ± 0.037	3.131AsnAsn: 3.131 ± 0.068	1.88AsnPro: 1.88 ± 0.04	2.134AsnGln: 2.134 ± 0.049	1.936AsnArg: 1.936 ± 0.036	3.314AsnSer: 3.314 ± 0.084	3.077AsnThr: 3.077 ± 0.066	2.963AsnVal: 2.963 ± 0.052	0.588AsnTrp: 0.588 ± 0.025	1.596AsnTyr: 1.596 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.871ProAla: 2.871 ± 0.066	0.311ProCys: 0.311 ± 0.016	1.992ProAsp: 1.992 ± 0.048	2.61ProGlu: 2.61 ± 0.051	1.583ProPhe: 1.583 ± 0.037	2.093ProGly: 2.093 ± 0.053	0.763ProHis: 0.763 ± 0.025	2.53ProIle: 2.53 ± 0.045	1.98ProLys: 1.98 ± 0.039	3.977ProLeu: 3.977 ± 0.069	0.924ProMet: 0.924 ± 0.031	1.629ProAsn: 1.629 ± 0.038	0.959ProPro: 0.959 ± 0.035	1.496ProGln: 1.496 ± 0.042	1.137ProArg: 1.137 ± 0.038	2.376ProSer: 2.376 ± 0.052	2.016ProThr: 2.016 ± 0.046	2.753ProVal: 2.753 ± 0.051	0.442ProTrp: 0.442 ± 0.023	1.207ProTyr: 1.207 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.88GlnAla: 4.88 ± 0.068	0.444GlnCys: 0.444 ± 0.021	1.988GlnAsp: 1.988 ± 0.048	2.319GlnGlu: 2.319 ± 0.057	1.63GlnPhe: 1.63 ± 0.036	3.307GlnGly: 3.307 ± 0.056	1.276GlnHis: 1.276 ± 0.034	2.478GlnIle: 2.478 ± 0.051	2.314GlnLys: 2.314 ± 0.052	5.825GlnLeu: 5.825 ± 0.096	0.976GlnMet: 0.976 ± 0.029	1.653GlnAsn: 1.653 ± 0.045	1.564GlnPro: 1.564 ± 0.043	3.627GlnGln: 3.627 ± 0.093	2.166GlnArg: 2.166 ± 0.05	2.859GlnSer: 2.859 ± 0.063	2.215GlnThr: 2.215 ± 0.053	3.539GlnVal: 3.539 ± 0.064	0.682GlnTrp: 0.682 ± 0.023	1.465GlnTyr: 1.465 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.087ArgAla: 3.087 ± 0.06	0.396ArgCys: 0.396 ± 0.019	2.093ArgAsp: 2.093 ± 0.046	2.355ArgGlu: 2.355 ± 0.049	1.982ArgPhe: 1.982 ± 0.039	2.311ArgGly: 2.311 ± 0.053	0.93ArgHis: 0.93 ± 0.026	2.78ArgIle: 2.78 ± 0.057	2.23ArgLys: 2.23 ± 0.048	4.472ArgLeu: 4.472 ± 0.062	0.973ArgMet: 0.973 ± 0.032	1.763ArgAsn: 1.763 ± 0.041	1.277ArgPro: 1.277 ± 0.032	1.923ArgGln: 1.923 ± 0.044	1.801ArgArg: 1.801 ± 0.051	2.31ArgSer: 2.31 ± 0.052	1.823ArgThr: 1.823 ± 0.038	2.71ArgVal: 2.71 ± 0.054	0.515ArgTrp: 0.515 ± 0.024	1.531ArgTyr: 1.531 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.847SerAla: 5.847 ± 0.079	0.692SerCys: 0.692 ± 0.027	3.917SerAsp: 3.917 ± 0.079	3.827SerGlu: 3.827 ± 0.063	3.082SerPhe: 3.082 ± 0.06	4.472SerGly: 4.472 ± 0.082	1.553SerHis: 1.553 ± 0.042	4.649SerIle: 4.649 ± 0.071	3.761SerLys: 3.761 ± 0.064	7.48SerLeu: 7.48 ± 0.103	1.563SerMet: 1.563 ± 0.042	3.178SerAsn: 3.178 ± 0.056	2.429SerPro: 2.429 ± 0.055	3.14SerGln: 3.14 ± 0.06	2.573SerArg: 2.573 ± 0.058	4.662SerSer: 4.662 ± 0.084	3.801SerThr: 3.801 ± 0.063	4.542SerVal: 4.542 ± 0.065	0.738SerTrp: 0.738 ± 0.031	2.182SerTyr: 2.182 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.778ThrAla: 4.778 ± 0.07	0.481ThrCys: 0.481 ± 0.021	3.207ThrAsp: 3.207 ± 0.058	3.26ThrGlu: 3.26 ± 0.065	2.213ThrPhe: 2.213 ± 0.05	4.079ThrGly: 4.079 ± 0.07	1.167ThrHis: 1.167 ± 0.033	3.943ThrIle: 3.943 ± 0.062	3.023ThrLys: 3.023 ± 0.055	6.847ThrLeu: 6.847 ± 0.082	1.23ThrMet: 1.23 ± 0.032	2.563ThrAsn: 2.563 ± 0.054	2.672ThrPro: 2.672 ± 0.05	2.604ThrGln: 2.604 ± 0.055	2.015ThrArg: 2.015 ± 0.044	3.767ThrSer: 3.767 ± 0.063	3.356ThrThr: 3.356 ± 0.069	3.926ThrVal: 3.926 ± 0.058	0.566ThrTrp: 0.566 ± 0.029	1.448ThrTyr: 1.448 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.942ValAla: 5.942 ± 0.083	0.691ValCys: 0.691 ± 0.024	4.11ValAsp: 4.11 ± 0.074	4.019ValGlu: 4.019 ± 0.067	2.791ValPhe: 2.791 ± 0.058	4.147ValGly: 4.147 ± 0.071	1.226ValHis: 1.226 ± 0.04	5.206ValIle: 5.206 ± 0.072	3.902ValLys: 3.902 ± 0.058	6.562ValLeu: 6.562 ± 0.085	1.793ValMet: 1.793 ± 0.043	3.726ValAsn: 3.726 ± 0.064	2.309ValPro: 2.309 ± 0.05	2.12ValGln: 2.12 ± 0.046	2.426ValArg: 2.426 ± 0.051	4.706ValSer: 4.706 ± 0.069	4.165ValThr: 4.165 ± 0.074	4.861ValVal: 4.861 ± 0.086	0.605ValTrp: 0.605 ± 0.026	1.782ValTyr: 1.782 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.683TrpAla: 0.683 ± 0.027	0.146TrpCys: 0.146 ± 0.011	0.469TrpAsp: 0.469 ± 0.023	0.34TrpGlu: 0.34 ± 0.018	0.55TrpPhe: 0.55 ± 0.024	0.665TrpGly: 0.665 ± 0.023	0.376TrpHis: 0.376 ± 0.021	0.496TrpIle: 0.496 ± 0.025	0.371TrpLys: 0.371 ± 0.021	1.668TrpLeu: 1.668 ± 0.047	0.24TrpMet: 0.24 ± 0.018	0.332TrpAsn: 0.332 ± 0.02	0.415TrpPro: 0.415 ± 0.023	1.208TrpGln: 1.208 ± 0.034	0.577TrpArg: 0.577 ± 0.023	0.646TrpSer: 0.646 ± 0.027	0.426TrpThr: 0.426 ± 0.021	0.633TrpVal: 0.633 ± 0.025	0.147TrpTrp: 0.147 ± 0.013	0.342TrpTyr: 0.342 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.252TyrAla: 2.252 ± 0.043	0.41TyrCys: 0.41 ± 0.02	1.557TyrAsp: 1.557 ± 0.044	1.248TyrGlu: 1.248 ± 0.033	1.528TyrPhe: 1.528 ± 0.043	1.952TyrGly: 1.952 ± 0.048	0.821TyrHis: 0.821 ± 0.026	1.848TyrIle: 1.848 ± 0.043	1.555TyrLys: 1.555 ± 0.04	3.476TyrLeu: 3.476 ± 0.058	0.599TyrMet: 0.599 ± 0.021	1.296TyrAsn: 1.296 ± 0.037	1.305TyrPro: 1.305 ± 0.039	2.26TyrGln: 2.26 ± 0.046	1.505TyrArg: 1.505 ± 0.04	2.145TyrSer: 2.145 ± 0.05	1.4TyrThr: 1.4 ± 0.039	1.655TyrVal: 1.655 ± 0.038	0.414TyrTrp: 0.414 ± 0.02	1.059TyrTyr: 1.059 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3200 proteins (1042663 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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