Amino acid dipepetide frequency for Yersinia phage fPS-54-ocr

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.133AlaAla: 9.133 ± 1.202
0.838AlaCys: 0.838 ± 0.219
4.943AlaAsp: 4.943 ± 0.761
5.949AlaGlu: 5.949 ± 0.664
3.1AlaPhe: 3.1 ± 0.513
7.792AlaGly: 7.792 ± 0.707
1.341AlaHis: 1.341 ± 0.319
4.189AlaIle: 4.189 ± 0.415
7.122AlaLys: 7.122 ± 0.592
7.373AlaLeu: 7.373 ± 0.707
2.346AlaMet: 2.346 ± 0.49
4.106AlaAsn: 4.106 ± 0.46
2.765AlaPro: 2.765 ± 0.463
4.441AlaGln: 4.441 ± 0.627
4.189AlaArg: 4.189 ± 0.712
4.357AlaSer: 4.357 ± 0.47
3.435AlaThr: 3.435 ± 0.627
5.362AlaVal: 5.362 ± 0.751
1.341AlaTrp: 1.341 ± 0.274
2.262AlaTyr: 2.262 ± 0.419
0.0AlaXaa: 0.0 ± 0.0
Cys
0.838CysAla: 0.838 ± 0.24
0.0CysCys: 0.0 ± 0.0
0.838CysAsp: 0.838 ± 0.323
0.419CysGlu: 0.419 ± 0.192
0.419CysPhe: 0.419 ± 0.186
0.838CysGly: 0.838 ± 0.278
0.419CysHis: 0.419 ± 0.179
0.251CysIle: 0.251 ± 0.126
0.419CysLys: 0.419 ± 0.207
0.838CysLeu: 0.838 ± 0.256
0.0CysMet: 0.0 ± 0.0
0.335CysAsn: 0.335 ± 0.158
0.419CysPro: 0.419 ± 0.169
0.251CysGln: 0.251 ± 0.18
0.838CysArg: 0.838 ± 0.311
0.419CysSer: 0.419 ± 0.236
0.335CysThr: 0.335 ± 0.17
0.67CysVal: 0.67 ± 0.243
0.251CysTrp: 0.251 ± 0.158
0.587CysTyr: 0.587 ± 0.248
0.0CysXaa: 0.0 ± 0.0
Asp
5.279AspAla: 5.279 ± 0.605
0.838AspCys: 0.838 ± 0.287
3.77AspAsp: 3.77 ± 0.755
4.441AspGlu: 4.441 ± 0.726
2.933AspPhe: 2.933 ± 0.514
6.535AspGly: 6.535 ± 0.792
1.257AspHis: 1.257 ± 0.243
3.519AspIle: 3.519 ± 0.351
3.519AspLys: 3.519 ± 0.751
4.776AspLeu: 4.776 ± 0.759
2.095AspMet: 2.095 ± 0.419
2.933AspAsn: 2.933 ± 0.395
2.681AspPro: 2.681 ± 0.539
1.508AspGln: 1.508 ± 0.347
2.765AspArg: 2.765 ± 0.467
3.77AspSer: 3.77 ± 0.509
4.357AspThr: 4.357 ± 0.394
3.854AspVal: 3.854 ± 0.463
0.754AspTrp: 0.754 ± 0.293
1.76AspTyr: 1.76 ± 0.299
0.0AspXaa: 0.0 ± 0.0
Glu
6.368GluAla: 6.368 ± 0.866
0.67GluCys: 0.67 ± 0.252
4.106GluAsp: 4.106 ± 0.527
4.273GluGlu: 4.273 ± 0.838
2.765GluPhe: 2.765 ± 0.448
5.027GluGly: 5.027 ± 0.715
1.424GluHis: 1.424 ± 0.331
3.687GluIle: 3.687 ± 0.462
2.43GluLys: 2.43 ± 0.418
6.284GluLeu: 6.284 ± 0.507
2.262GluMet: 2.262 ± 0.581
2.43GluAsn: 2.43 ± 0.397
1.592GluPro: 1.592 ± 0.388
3.184GluGln: 3.184 ± 0.502
4.357GluArg: 4.357 ± 0.47
4.943GluSer: 4.943 ± 0.683
3.519GluThr: 3.519 ± 0.423
4.357GluVal: 4.357 ± 0.684
0.67GluTrp: 0.67 ± 0.209
3.1GluTyr: 3.1 ± 0.527
0.0GluXaa: 0.0 ± 0.0
Phe
2.597PheAla: 2.597 ± 0.335
0.168PheCys: 0.168 ± 0.137
2.262PheAsp: 2.262 ± 0.474
1.76PheGlu: 1.76 ± 0.332
1.005PhePhe: 1.005 ± 0.264
2.849PheGly: 2.849 ± 0.442
0.419PheHis: 0.419 ± 0.205
1.76PheIle: 1.76 ± 0.483
3.016PheLys: 3.016 ± 0.564
3.268PheLeu: 3.268 ± 0.415
1.257PheMet: 1.257 ± 0.324
2.514PheAsn: 2.514 ± 0.474
1.508PhePro: 1.508 ± 0.346
1.089PheGln: 1.089 ± 0.238
1.089PheArg: 1.089 ± 0.263
2.178PheSer: 2.178 ± 0.446
2.849PheThr: 2.849 ± 0.325
1.843PheVal: 1.843 ± 0.457
0.168PheTrp: 0.168 ± 0.107
0.922PheTyr: 0.922 ± 0.271
0.0PheXaa: 0.0 ± 0.0
Gly
6.452GlyAla: 6.452 ± 0.818
0.922GlyCys: 0.922 ± 0.306
5.362GlyAsp: 5.362 ± 0.777
4.022GlyGlu: 4.022 ± 0.557
2.765GlyPhe: 2.765 ± 0.371
6.116GlyGly: 6.116 ± 0.76
1.173GlyHis: 1.173 ± 0.389
4.692GlyIle: 4.692 ± 0.954
6.284GlyLys: 6.284 ± 0.698
6.452GlyLeu: 6.452 ± 0.671
2.43GlyMet: 2.43 ± 0.474
4.273GlyAsn: 4.273 ± 0.844
0.838GlyPro: 0.838 ± 0.242
2.681GlyGln: 2.681 ± 0.4
4.022GlyArg: 4.022 ± 0.5
4.692GlySer: 4.692 ± 0.76
4.022GlyThr: 4.022 ± 0.419
4.776GlyVal: 4.776 ± 0.479
1.424GlyTrp: 1.424 ± 0.457
3.268GlyTyr: 3.268 ± 0.7
0.0GlyXaa: 0.0 ± 0.0
His
1.341HisAla: 1.341 ± 0.279
0.168HisCys: 0.168 ± 0.116
1.005HisAsp: 1.005 ± 0.288
1.257HisGlu: 1.257 ± 0.277
0.587HisPhe: 0.587 ± 0.2
1.508HisGly: 1.508 ± 0.339
0.335HisHis: 0.335 ± 0.138
1.676HisIle: 1.676 ± 0.347
0.838HisLys: 0.838 ± 0.252
1.592HisLeu: 1.592 ± 0.34
0.335HisMet: 0.335 ± 0.191
0.503HisAsn: 0.503 ± 0.213
0.67HisPro: 0.67 ± 0.248
0.335HisGln: 0.335 ± 0.164
0.838HisArg: 0.838 ± 0.249
1.424HisSer: 1.424 ± 0.256
1.173HisThr: 1.173 ± 0.257
1.005HisVal: 1.005 ± 0.204
0.419HisTrp: 0.419 ± 0.127
0.754HisTyr: 0.754 ± 0.232
0.0HisXaa: 0.0 ± 0.0
Ile
3.77IleAla: 3.77 ± 0.522
0.587IleCys: 0.587 ± 0.204
3.687IleAsp: 3.687 ± 0.455
3.687IleGlu: 3.687 ± 0.511
1.424IlePhe: 1.424 ± 0.311
3.687IleGly: 3.687 ± 0.494
1.592IleHis: 1.592 ± 0.334
2.681IleIle: 2.681 ± 0.475
3.687IleLys: 3.687 ± 0.451
3.519IleLeu: 3.519 ± 0.465
1.173IleMet: 1.173 ± 0.319
3.268IleAsn: 3.268 ± 0.68
2.849IlePro: 2.849 ± 0.452
1.927IleGln: 1.927 ± 0.56
3.184IleArg: 3.184 ± 0.419
2.681IleSer: 2.681 ± 0.485
3.603IleThr: 3.603 ± 0.689
3.687IleVal: 3.687 ± 0.542
0.67IleTrp: 0.67 ± 0.207
1.76IleTyr: 1.76 ± 0.42
0.0IleXaa: 0.0 ± 0.0
Lys
8.714LysAla: 8.714 ± 1.083
0.754LysCys: 0.754 ± 0.222
3.77LysAsp: 3.77 ± 0.503
4.692LysGlu: 4.692 ± 0.626
1.927LysPhe: 1.927 ± 0.386
5.027LysGly: 5.027 ± 0.609
1.424LysHis: 1.424 ± 0.34
3.1LysIle: 3.1 ± 0.38
3.938LysLys: 3.938 ± 0.615
4.525LysLeu: 4.525 ± 0.727
3.603LysMet: 3.603 ± 0.694
1.76LysAsn: 1.76 ± 0.282
2.681LysPro: 2.681 ± 0.542
2.597LysGln: 2.597 ± 0.566
4.189LysArg: 4.189 ± 0.57
4.692LysSer: 4.692 ± 0.647
3.435LysThr: 3.435 ± 0.457
4.776LysVal: 4.776 ± 0.613
0.503LysTrp: 0.503 ± 0.226
2.095LysTyr: 2.095 ± 0.405
0.0LysXaa: 0.0 ± 0.0
Leu
6.954LeuAla: 6.954 ± 0.784
0.503LeuCys: 0.503 ± 0.227
5.195LeuAsp: 5.195 ± 0.483
5.446LeuGlu: 5.446 ± 0.848
2.514LeuPhe: 2.514 ± 0.461
4.86LeuGly: 4.86 ± 0.576
1.676LeuHis: 1.676 ± 0.377
3.268LeuIle: 3.268 ± 0.378
5.949LeuLys: 5.949 ± 0.627
5.949LeuLeu: 5.949 ± 0.667
2.095LeuMet: 2.095 ± 0.416
4.357LeuAsn: 4.357 ± 0.717
3.1LeuPro: 3.1 ± 0.359
3.687LeuGln: 3.687 ± 0.462
6.116LeuArg: 6.116 ± 0.568
4.608LeuSer: 4.608 ± 0.588
5.614LeuThr: 5.614 ± 0.684
5.111LeuVal: 5.111 ± 0.746
1.508LeuTrp: 1.508 ± 0.355
2.178LeuTyr: 2.178 ± 0.526
0.0LeuXaa: 0.0 ± 0.0
Met
2.933MetAla: 2.933 ± 0.466
0.084MetCys: 0.084 ± 0.082
2.011MetAsp: 2.011 ± 0.398
2.346MetGlu: 2.346 ± 0.348
1.005MetPhe: 1.005 ± 0.26
1.341MetGly: 1.341 ± 0.342
0.335MetHis: 0.335 ± 0.151
1.257MetIle: 1.257 ± 0.276
1.508MetLys: 1.508 ± 0.271
2.933MetLeu: 2.933 ± 0.507
0.587MetMet: 0.587 ± 0.192
1.676MetAsn: 1.676 ± 0.302
1.173MetPro: 1.173 ± 0.357
1.089MetGln: 1.089 ± 0.329
1.76MetArg: 1.76 ± 0.338
2.933MetSer: 2.933 ± 0.435
1.508MetThr: 1.508 ± 0.297
2.095MetVal: 2.095 ± 0.463
0.168MetTrp: 0.168 ± 0.126
1.089MetTyr: 1.089 ± 0.222
0.0MetXaa: 0.0 ± 0.0
Asn
3.351AsnAla: 3.351 ± 0.588
0.503AsnCys: 0.503 ± 0.184
3.184AsnAsp: 3.184 ± 0.432
2.681AsnGlu: 2.681 ± 0.444
1.676AsnPhe: 1.676 ± 0.3
3.854AsnGly: 3.854 ± 0.462
0.67AsnHis: 0.67 ± 0.264
2.933AsnIle: 2.933 ± 0.534
2.765AsnLys: 2.765 ± 0.436
3.854AsnLeu: 3.854 ± 0.498
1.005AsnMet: 1.005 ± 0.283
1.676AsnAsn: 1.676 ± 0.324
2.765AsnPro: 2.765 ± 0.437
2.011AsnGln: 2.011 ± 0.38
2.681AsnArg: 2.681 ± 0.618
3.854AsnSer: 3.854 ± 0.574
2.178AsnThr: 2.178 ± 0.421
2.681AsnVal: 2.681 ± 0.412
0.838AsnTrp: 0.838 ± 0.239
1.927AsnTyr: 1.927 ± 0.454
0.0AsnXaa: 0.0 ± 0.0
Pro
2.681ProAla: 2.681 ± 0.38
0.419ProCys: 0.419 ± 0.195
2.933ProAsp: 2.933 ± 0.446
3.184ProGlu: 3.184 ± 0.675
1.341ProPhe: 1.341 ± 0.248
0.084ProGly: 0.084 ± 0.08
0.67ProHis: 0.67 ± 0.185
1.76ProIle: 1.76 ± 0.397
2.681ProLys: 2.681 ± 0.511
2.765ProLeu: 2.765 ± 0.475
1.005ProMet: 1.005 ± 0.308
2.514ProAsn: 2.514 ± 0.425
0.922ProPro: 0.922 ± 0.255
1.005ProGln: 1.005 ± 0.226
1.341ProArg: 1.341 ± 0.287
2.849ProSer: 2.849 ± 0.427
2.262ProThr: 2.262 ± 0.349
2.765ProVal: 2.765 ± 0.528
0.67ProTrp: 0.67 ± 0.149
1.592ProTyr: 1.592 ± 0.471
0.0ProXaa: 0.0 ± 0.0
Gln
3.687GlnAla: 3.687 ± 0.725
0.168GlnCys: 0.168 ± 0.1
1.76GlnAsp: 1.76 ± 0.276
2.933GlnGlu: 2.933 ± 0.404
2.178GlnPhe: 2.178 ± 0.371
2.597GlnGly: 2.597 ± 0.366
0.419GlnHis: 0.419 ± 0.162
2.095GlnIle: 2.095 ± 0.325
2.514GlnLys: 2.514 ± 0.484
3.519GlnLeu: 3.519 ± 0.616
0.922GlnMet: 0.922 ± 0.247
0.838GlnAsn: 0.838 ± 0.289
1.341GlnPro: 1.341 ± 0.302
2.011GlnGln: 2.011 ± 0.421
2.178GlnArg: 2.178 ± 0.378
2.43GlnSer: 2.43 ± 0.504
2.178GlnThr: 2.178 ± 0.425
2.346GlnVal: 2.346 ± 0.372
0.754GlnTrp: 0.754 ± 0.191
1.089GlnTyr: 1.089 ± 0.345
0.0GlnXaa: 0.0 ± 0.0
Arg
3.519ArgAla: 3.519 ± 0.506
0.503ArgCys: 0.503 ± 0.212
3.184ArgAsp: 3.184 ± 0.481
3.77ArgGlu: 3.77 ± 0.615
1.927ArgPhe: 1.927 ± 0.319
4.525ArgGly: 4.525 ± 0.576
0.419ArgHis: 0.419 ± 0.152
3.184ArgIle: 3.184 ± 0.619
3.938ArgLys: 3.938 ± 0.64
5.279ArgLeu: 5.279 ± 0.563
2.43ArgMet: 2.43 ± 0.428
3.016ArgAsn: 3.016 ± 0.49
1.843ArgPro: 1.843 ± 0.331
2.011ArgGln: 2.011 ± 0.344
2.43ArgArg: 2.43 ± 0.366
3.603ArgSer: 3.603 ± 0.501
3.1ArgThr: 3.1 ± 0.39
4.273ArgVal: 4.273 ± 0.545
0.587ArgTrp: 0.587 ± 0.264
1.927ArgTyr: 1.927 ± 0.366
0.0ArgXaa: 0.0 ± 0.0
Ser
5.698SerAla: 5.698 ± 0.704
0.503SerCys: 0.503 ± 0.243
4.692SerAsp: 4.692 ± 0.71
4.86SerGlu: 4.86 ± 0.81
2.178SerPhe: 2.178 ± 0.299
5.027SerGly: 5.027 ± 0.707
1.089SerHis: 1.089 ± 0.281
3.603SerIle: 3.603 ± 0.689
5.195SerLys: 5.195 ± 0.719
4.022SerLeu: 4.022 ± 0.4
1.843SerMet: 1.843 ± 0.327
2.262SerAsn: 2.262 ± 0.418
2.178SerPro: 2.178 ± 0.46
1.927SerGln: 1.927 ± 0.343
3.854SerArg: 3.854 ± 0.453
3.938SerSer: 3.938 ± 0.643
2.849SerThr: 2.849 ± 0.413
4.189SerVal: 4.189 ± 0.519
0.838SerTrp: 0.838 ± 0.252
3.351SerTyr: 3.351 ± 0.623
0.0SerXaa: 0.0 ± 0.0
Thr
4.608ThrAla: 4.608 ± 0.69
0.503ThrCys: 0.503 ± 0.203
3.184ThrAsp: 3.184 ± 0.509
4.273ThrGlu: 4.273 ± 0.451
1.843ThrPhe: 1.843 ± 0.393
5.949ThrGly: 5.949 ± 0.603
1.005ThrHis: 1.005 ± 0.258
3.603ThrIle: 3.603 ± 0.549
4.525ThrLys: 4.525 ± 0.494
4.525ThrLeu: 4.525 ± 0.676
1.257ThrMet: 1.257 ± 0.281
2.178ThrAsn: 2.178 ± 0.495
2.849ThrPro: 2.849 ± 0.375
2.095ThrGln: 2.095 ± 0.394
2.262ThrArg: 2.262 ± 0.371
3.77ThrSer: 3.77 ± 0.678
2.346ThrThr: 2.346 ± 0.446
4.022ThrVal: 4.022 ± 0.745
0.922ThrTrp: 0.922 ± 0.202
1.76ThrTyr: 1.76 ± 0.367
0.0ThrXaa: 0.0 ± 0.0
Val
5.195ValAla: 5.195 ± 0.558
0.503ValCys: 0.503 ± 0.199
4.525ValAsp: 4.525 ± 0.516
3.854ValGlu: 3.854 ± 0.584
1.843ValPhe: 1.843 ± 0.386
4.525ValGly: 4.525 ± 0.55
1.676ValHis: 1.676 ± 0.478
3.351ValIle: 3.351 ± 0.509
4.608ValLys: 4.608 ± 0.541
5.195ValLeu: 5.195 ± 0.497
1.592ValMet: 1.592 ± 0.377
3.938ValAsn: 3.938 ± 0.666
1.843ValPro: 1.843 ± 0.351
2.43ValGln: 2.43 ± 0.314
4.189ValArg: 4.189 ± 0.56
4.441ValSer: 4.441 ± 0.604
4.86ValThr: 4.86 ± 0.584
4.86ValVal: 4.86 ± 0.537
0.838ValTrp: 0.838 ± 0.326
2.095ValTyr: 2.095 ± 0.389
0.0ValXaa: 0.0 ± 0.0
Trp
0.838TrpAla: 0.838 ± 0.218
0.419TrpCys: 0.419 ± 0.196
0.503TrpAsp: 0.503 ± 0.18
0.838TrpGlu: 0.838 ± 0.283
0.335TrpPhe: 0.335 ± 0.174
1.089TrpGly: 1.089 ± 0.382
0.168TrpHis: 0.168 ± 0.116
0.838TrpIle: 0.838 ± 0.379
1.424TrpLys: 1.424 ± 0.291
1.508TrpLeu: 1.508 ± 0.4
0.503TrpMet: 0.503 ± 0.163
0.922TrpAsn: 0.922 ± 0.29
0.251TrpPro: 0.251 ± 0.124
0.251TrpGln: 0.251 ± 0.132
1.173TrpArg: 1.173 ± 0.334
0.754TrpSer: 0.754 ± 0.308
1.341TrpThr: 1.341 ± 0.292
0.67TrpVal: 0.67 ± 0.197
0.168TrpTrp: 0.168 ± 0.102
0.251TrpTyr: 0.251 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.43TyrAla: 2.43 ± 0.325
0.335TyrCys: 0.335 ± 0.142
2.43TyrAsp: 2.43 ± 0.398
2.765TyrGlu: 2.765 ± 0.375
0.754TyrPhe: 0.754 ± 0.255
3.435TyrGly: 3.435 ± 0.455
0.335TyrHis: 0.335 ± 0.17
1.676TyrIle: 1.676 ± 0.38
1.843TyrLys: 1.843 ± 0.422
2.514TyrLeu: 2.514 ± 0.403
1.005TyrMet: 1.005 ± 0.191
1.592TyrAsn: 1.592 ± 0.347
1.173TyrPro: 1.173 ± 0.314
1.424TyrGln: 1.424 ± 0.38
2.011TyrArg: 2.011 ± 0.342
1.76TyrSer: 1.76 ± 0.467
2.514TyrThr: 2.514 ± 0.443
3.016TyrVal: 3.016 ± 0.487
0.754TyrTrp: 0.754 ± 0.232
0.754TyrTyr: 0.754 ± 0.246
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (11936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski