Amino acid dipepetide frequency for Herbidospora galbida

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.281AlaAla: 19.281 ± 0.134
1.028AlaCys: 1.028 ± 0.02
8.041AlaAsp: 8.041 ± 0.06
8.303AlaGlu: 8.303 ± 0.078
3.812AlaPhe: 3.812 ± 0.042
12.43AlaGly: 12.43 ± 0.088
2.547AlaHis: 2.547 ± 0.034
4.491AlaIle: 4.491 ± 0.045
2.88AlaLys: 2.88 ± 0.042
13.886AlaLeu: 13.886 ± 0.1
2.567AlaMet: 2.567 ± 0.031
2.292AlaAsn: 2.292 ± 0.036
6.04AlaPro: 6.04 ± 0.063
3.357AlaGln: 3.357 ± 0.039
9.735AlaArg: 9.735 ± 0.084
5.537AlaSer: 5.537 ± 0.049
7.116AlaThr: 7.116 ± 0.063
11.367AlaVal: 11.367 ± 0.078
1.945AlaTrp: 1.945 ± 0.032
2.778AlaTyr: 2.778 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
0.948CysAla: 0.948 ± 0.018
0.092CysCys: 0.092 ± 0.007
0.511CysAsp: 0.511 ± 0.014
0.373CysGlu: 0.373 ± 0.013
0.216CysPhe: 0.216 ± 0.01
0.887CysGly: 0.887 ± 0.022
0.219CysHis: 0.219 ± 0.01
0.132CysIle: 0.132 ± 0.007
0.114CysLys: 0.114 ± 0.007
0.72CysLeu: 0.72 ± 0.019
0.114CysMet: 0.114 ± 0.006
0.139CysAsn: 0.139 ± 0.008
0.481CysPro: 0.481 ± 0.015
0.173CysGln: 0.173 ± 0.009
0.561CysArg: 0.561 ± 0.016
0.401CysSer: 0.401 ± 0.015
0.4CysThr: 0.4 ± 0.015
0.666CysVal: 0.666 ± 0.018
0.12CysTrp: 0.12 ± 0.007
0.148CysTyr: 0.148 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
6.834AspAla: 6.834 ± 0.061
0.39AspCys: 0.39 ± 0.014
4.185AspAsp: 4.185 ± 0.05
3.684AspGlu: 3.684 ± 0.044
1.668AspPhe: 1.668 ± 0.026
5.952AspGly: 5.952 ± 0.064
1.578AspHis: 1.578 ± 0.026
1.819AspIle: 1.819 ± 0.034
1.053AspLys: 1.053 ± 0.025
7.298AspLeu: 7.298 ± 0.056
0.813AspMet: 0.813 ± 0.018
0.982AspAsn: 0.982 ± 0.021
4.612AspPro: 4.612 ± 0.045
1.611AspGln: 1.611 ± 0.025
4.979AspArg: 4.979 ± 0.051
2.178AspSer: 2.178 ± 0.033
2.576AspThr: 2.576 ± 0.037
5.315AspVal: 5.315 ± 0.047
1.008AspTrp: 1.008 ± 0.019
1.299AspTyr: 1.299 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
6.885GluAla: 6.885 ± 0.058
0.365GluCys: 0.365 ± 0.011
2.337GluAsp: 2.337 ± 0.034
3.462GluGlu: 3.462 ± 0.039
1.677GluPhe: 1.677 ± 0.028
4.213GluGly: 4.213 ± 0.046
1.319GluHis: 1.319 ± 0.026
2.815GluIle: 2.815 ± 0.037
1.456GluLys: 1.456 ± 0.03
6.454GluLeu: 6.454 ± 0.058
1.023GluMet: 1.023 ± 0.022
1.155GluAsn: 1.155 ± 0.024
3.238GluPro: 3.238 ± 0.048
1.838GluGln: 1.838 ± 0.027
5.006GluArg: 5.006 ± 0.057
2.564GluSer: 2.564 ± 0.034
3.129GluThr: 3.129 ± 0.04
4.78GluVal: 4.78 ± 0.051
0.89GluTrp: 0.89 ± 0.021
1.002GluTyr: 1.002 ± 0.018
0.0GluXaa: 0.0 ± 0.0
Phe
3.97PheAla: 3.97 ± 0.048
0.27PheCys: 0.27 ± 0.011
2.192PheAsp: 2.192 ± 0.03
1.542PheGlu: 1.542 ± 0.03
0.973PhePhe: 0.973 ± 0.023
3.238PheGly: 3.238 ± 0.038
0.674PheHis: 0.674 ± 0.016
0.825PheIle: 0.825 ± 0.02
0.544PheLys: 0.544 ± 0.015
2.765PheLeu: 2.765 ± 0.037
0.447PheMet: 0.447 ± 0.015
0.649PheAsn: 0.649 ± 0.016
1.572PhePro: 1.572 ± 0.025
0.753PheGln: 0.753 ± 0.02
1.996PheArg: 1.996 ± 0.032
1.605PheSer: 1.605 ± 0.027
2.282PheThr: 2.282 ± 0.031
2.481PheVal: 2.481 ± 0.031
0.513PheTrp: 0.513 ± 0.015
0.652PheTyr: 0.652 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
10.071GlyAla: 10.071 ± 0.065
0.767GlyCys: 0.767 ± 0.021
5.519GlyAsp: 5.519 ± 0.047
5.055GlyGlu: 5.055 ± 0.049
3.119GlyPhe: 3.119 ± 0.039
8.498GlyGly: 8.498 ± 0.079
2.289GlyHis: 2.289 ± 0.036
3.379GlyIle: 3.379 ± 0.041
2.331GlyLys: 2.331 ± 0.039
9.785GlyLeu: 9.785 ± 0.084
1.94GlyMet: 1.94 ± 0.026
1.966GlyAsn: 1.966 ± 0.039
4.938GlyPro: 4.938 ± 0.059
2.632GlyGln: 2.632 ± 0.039
7.461GlyArg: 7.461 ± 0.059
4.843GlySer: 4.843 ± 0.053
5.522GlyThr: 5.522 ± 0.066
8.311GlyVal: 8.311 ± 0.067
1.725GlyTrp: 1.725 ± 0.028
2.335GlyTyr: 2.335 ± 0.032
0.0GlyXaa: 0.0 ± 0.0
His
2.509HisAla: 2.509 ± 0.032
0.179HisCys: 0.179 ± 0.009
1.473HisAsp: 1.473 ± 0.024
1.217HisGlu: 1.217 ± 0.024
0.618HisPhe: 0.618 ± 0.017
2.105HisGly: 2.105 ± 0.029
0.664HisHis: 0.664 ± 0.019
0.661HisIle: 0.661 ± 0.019
0.32HisLys: 0.32 ± 0.012
2.463HisLeu: 2.463 ± 0.034
0.329HisMet: 0.329 ± 0.01
0.39HisAsn: 0.39 ± 0.013
1.689HisPro: 1.689 ± 0.026
0.589HisGln: 0.589 ± 0.016
1.889HisArg: 1.889 ± 0.025
0.905HisSer: 0.905 ± 0.018
1.13HisThr: 1.13 ± 0.024
1.81HisVal: 1.81 ± 0.029
0.359HisTrp: 0.359 ± 0.013
0.494HisTyr: 0.494 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
5.315IleAla: 5.315 ± 0.056
0.314IleCys: 0.314 ± 0.011
2.561IleAsp: 2.561 ± 0.033
2.277IleGlu: 2.277 ± 0.034
0.947IlePhe: 0.947 ± 0.02
3.942IleGly: 3.942 ± 0.046
0.681IleHis: 0.681 ± 0.018
1.176IleIle: 1.176 ± 0.025
0.861IleLys: 0.861 ± 0.021
2.985IleLeu: 2.985 ± 0.045
0.654IleMet: 0.654 ± 0.017
0.801IleAsn: 0.801 ± 0.021
2.109IlePro: 2.109 ± 0.031
0.831IleGln: 0.831 ± 0.021
2.696IleArg: 2.696 ± 0.034
2.03IleSer: 2.03 ± 0.032
2.586IleThr: 2.586 ± 0.037
3.419IleVal: 3.419 ± 0.041
0.524IleTrp: 0.524 ± 0.016
0.688IleTyr: 0.688 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
2.869LysAla: 2.869 ± 0.04
0.126LysCys: 0.126 ± 0.008
1.134LysAsp: 1.134 ± 0.024
1.172LysGlu: 1.172 ± 0.024
0.505LysPhe: 0.505 ± 0.015
1.839LysGly: 1.839 ± 0.032
0.411LysHis: 0.411 ± 0.013
1.138LysIle: 1.138 ± 0.024
0.777LysLys: 0.777 ± 0.027
2.005LysLeu: 2.005 ± 0.032
0.414LysMet: 0.414 ± 0.014
0.543LysAsn: 0.543 ± 0.018
1.384LysPro: 1.384 ± 0.029
0.622LysGln: 0.622 ± 0.016
1.516LysArg: 1.516 ± 0.027
1.12LysSer: 1.12 ± 0.025
1.402LysThr: 1.402 ± 0.027
2.092LysVal: 2.092 ± 0.035
0.342LysTrp: 0.342 ± 0.012
0.441LysTyr: 0.441 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
15.108LeuAla: 15.108 ± 0.103
0.707LeuCys: 0.707 ± 0.016
6.823LeuAsp: 6.823 ± 0.06
4.601LeuGlu: 4.601 ± 0.053
2.77LeuPhe: 2.77 ± 0.037
9.141LeuGly: 9.141 ± 0.069
2.081LeuHis: 2.081 ± 0.036
4.007LeuIle: 4.007 ± 0.046
2.209LeuLys: 2.209 ± 0.031
10.973LeuLeu: 10.973 ± 0.096
1.756LeuMet: 1.756 ± 0.027
1.962LeuAsn: 1.962 ± 0.031
6.45LeuPro: 6.45 ± 0.061
2.083LeuGln: 2.083 ± 0.028
8.618LeuArg: 8.618 ± 0.065
5.51LeuSer: 5.51 ± 0.048
7.31LeuThr: 7.31 ± 0.057
9.09LeuVal: 9.09 ± 0.071
1.366LeuTrp: 1.366 ± 0.027
1.908LeuTyr: 1.908 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
2.412MetAla: 2.412 ± 0.033
0.114MetCys: 0.114 ± 0.008
0.881MetAsp: 0.881 ± 0.018
0.802MetGlu: 0.802 ± 0.019
0.521MetPhe: 0.521 ± 0.014
1.434MetGly: 1.434 ± 0.029
0.325MetHis: 0.325 ± 0.012
0.889MetIle: 0.889 ± 0.02
0.483MetLys: 0.483 ± 0.014
1.79MetLeu: 1.79 ± 0.027
0.332MetMet: 0.332 ± 0.013
0.49MetAsn: 0.49 ± 0.013
1.09MetPro: 1.09 ± 0.022
0.382MetGln: 0.382 ± 0.011
1.638MetArg: 1.638 ± 0.027
1.282MetSer: 1.282 ± 0.026
1.599MetThr: 1.599 ± 0.028
1.414MetVal: 1.414 ± 0.023
0.254MetTrp: 0.254 ± 0.012
0.307MetTyr: 0.307 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.375AsnAla: 2.375 ± 0.036
0.165AsnCys: 0.165 ± 0.009
1.085AsnAsp: 1.085 ± 0.023
0.903AsnGlu: 0.903 ± 0.021
0.549AsnPhe: 0.549 ± 0.018
2.194AsnGly: 2.194 ± 0.037
0.42AsnHis: 0.42 ± 0.013
0.657AsnIle: 0.657 ± 0.017
0.4AsnLys: 0.4 ± 0.013
2.024AsnLeu: 2.024 ± 0.032
0.326AsnMet: 0.326 ± 0.012
0.524AsnAsn: 0.524 ± 0.022
1.593AsnPro: 1.593 ± 0.031
0.637AsnGln: 0.637 ± 0.02
1.477AsnArg: 1.477 ± 0.028
0.94AsnSer: 0.94 ± 0.025
1.148AsnThr: 1.148 ± 0.027
1.741AsnVal: 1.741 ± 0.027
0.358AsnTrp: 0.358 ± 0.012
0.503AsnTyr: 0.503 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
7.971ProAla: 7.971 ± 0.067
0.334ProCys: 0.334 ± 0.012
4.264ProAsp: 4.264 ± 0.047
4.204ProGlu: 4.204 ± 0.049
1.687ProPhe: 1.687 ± 0.028
6.59ProGly: 6.59 ± 0.064
1.209ProHis: 1.209 ± 0.023
1.984ProIle: 1.984 ± 0.033
1.334ProLys: 1.334 ± 0.026
5.266ProLeu: 5.266 ± 0.047
1.106ProMet: 1.106 ± 0.021
1.083ProAsn: 1.083 ± 0.022
3.604ProPro: 3.604 ± 0.054
1.565ProGln: 1.565 ± 0.03
3.666ProArg: 3.666 ± 0.044
3.338ProSer: 3.338 ± 0.056
3.04ProThr: 3.04 ± 0.038
5.419ProVal: 5.419 ± 0.04
0.941ProTrp: 0.941 ± 0.021
1.353ProTyr: 1.353 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
3.564GlnAla: 3.564 ± 0.043
0.161GlnCys: 0.161 ± 0.007
1.093GlnAsp: 1.093 ± 0.021
1.274GlnGlu: 1.274 ± 0.026
0.751GlnPhe: 0.751 ± 0.017
2.166GlnGly: 2.166 ± 0.035
0.502GlnHis: 0.502 ± 0.015
1.259GlnIle: 1.259 ± 0.023
0.607GlnLys: 0.607 ± 0.018
2.599GlnLeu: 2.599 ± 0.036
0.495GlnMet: 0.495 ± 0.013
0.569GlnAsn: 0.569 ± 0.016
1.601GlnPro: 1.601 ± 0.031
0.977GlnGln: 0.977 ± 0.031
2.132GlnArg: 2.132 ± 0.034
1.241GlnSer: 1.241 ± 0.022
1.491GlnThr: 1.491 ± 0.028
2.511GlnVal: 2.511 ± 0.03
0.48GlnTrp: 0.48 ± 0.016
0.535GlnTyr: 0.535 ± 0.015
0.0GlnXaa: 0.0 ± 0.0
Arg
9.255ArgAla: 9.255 ± 0.073
0.527ArgCys: 0.527 ± 0.015
4.527ArgAsp: 4.527 ± 0.044
4.69ArgGlu: 4.69 ± 0.052
2.627ArgPhe: 2.627 ± 0.036
5.438ArgGly: 5.438 ± 0.049
2.059ArgHis: 2.059 ± 0.033
3.189ArgIle: 3.189 ± 0.039
1.599ArgLys: 1.599 ± 0.025
9.23ArgLeu: 9.23 ± 0.085
1.781ArgMet: 1.781 ± 0.024
1.454ArgAsn: 1.454 ± 0.026
4.794ArgPro: 4.794 ± 0.06
2.241ArgGln: 2.241 ± 0.033
7.454ArgArg: 7.454 ± 0.072
3.806ArgSer: 3.806 ± 0.04
4.284ArgThr: 4.284 ± 0.045
6.334ArgVal: 6.334 ± 0.048
1.393ArgTrp: 1.393 ± 0.026
1.78ArgTyr: 1.78 ± 0.025
0.0ArgXaa: 0.0 ± 0.0
Ser
6.268SerAla: 6.268 ± 0.055
0.388SerCys: 0.388 ± 0.013
2.567SerAsp: 2.567 ± 0.035
2.288SerGlu: 2.288 ± 0.031
1.611SerPhe: 1.611 ± 0.026
5.797SerGly: 5.797 ± 0.053
1.002SerHis: 1.002 ± 0.02
1.814SerIle: 1.814 ± 0.028
0.985SerLys: 0.985 ± 0.023
4.788SerLeu: 4.788 ± 0.044
1.157SerMet: 1.157 ± 0.02
0.951SerAsn: 0.951 ± 0.022
3.408SerPro: 3.408 ± 0.052
1.229SerGln: 1.229 ± 0.022
3.639SerArg: 3.639 ± 0.042
2.698SerSer: 2.698 ± 0.042
2.892SerThr: 2.892 ± 0.035
4.193SerVal: 4.193 ± 0.041
0.984SerTrp: 0.984 ± 0.022
1.22SerTyr: 1.22 ± 0.022
0.0SerXaa: 0.0 ± 0.0
Thr
7.715ThrAla: 7.715 ± 0.067
0.459ThrCys: 0.459 ± 0.015
3.139ThrAsp: 3.139 ± 0.037
2.921ThrGlu: 2.921 ± 0.039
1.889ThrPhe: 1.889 ± 0.03
6.593ThrGly: 6.593 ± 0.073
1.137ThrHis: 1.137 ± 0.023
2.325ThrIle: 2.325 ± 0.037
1.161ThrLys: 1.161 ± 0.023
5.987ThrLeu: 5.987 ± 0.049
1.083ThrMet: 1.083 ± 0.02
1.155ThrAsn: 1.155 ± 0.025
4.182ThrPro: 4.182 ± 0.045
1.36ThrGln: 1.36 ± 0.025
4.034ThrArg: 4.034 ± 0.043
3.2ThrSer: 3.2 ± 0.045
3.873ThrThr: 3.873 ± 0.06
5.794ThrVal: 5.794 ± 0.059
1.111ThrTrp: 1.111 ± 0.021
1.428ThrTyr: 1.428 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
11.65ValAla: 11.65 ± 0.077
0.694ValCys: 0.694 ± 0.018
5.131ValAsp: 5.131 ± 0.046
4.878ValGlu: 4.878 ± 0.044
2.759ValPhe: 2.759 ± 0.035
6.7ValGly: 6.7 ± 0.053
1.847ValHis: 1.847 ± 0.028
3.588ValIle: 3.588 ± 0.047
1.938ValLys: 1.938 ± 0.03
9.271ValLeu: 9.271 ± 0.067
1.525ValMet: 1.525 ± 0.027
1.924ValAsn: 1.924 ± 0.028
5.146ValPro: 5.146 ± 0.043
1.943ValGln: 1.943 ± 0.029
6.675ValArg: 6.675 ± 0.057
4.668ValSer: 4.668 ± 0.043
6.34ValThr: 6.34 ± 0.063
8.894ValVal: 8.894 ± 0.078
1.25ValTrp: 1.25 ± 0.024
1.784ValTyr: 1.784 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.754TrpAla: 1.754 ± 0.027
0.151TrpCys: 0.151 ± 0.008
0.915TrpAsp: 0.915 ± 0.024
0.781TrpGlu: 0.781 ± 0.021
0.556TrpPhe: 0.556 ± 0.014
1.129TrpGly: 1.129 ± 0.023
0.412TrpHis: 0.412 ± 0.014
0.665TrpIle: 0.665 ± 0.017
0.378TrpLys: 0.378 ± 0.013
1.89TrpLeu: 1.89 ± 0.029
0.303TrpMet: 0.303 ± 0.01
0.472TrpAsn: 0.472 ± 0.016
0.928TrpPro: 0.928 ± 0.021
0.536TrpGln: 0.536 ± 0.015
1.467TrpArg: 1.467 ± 0.026
1.007TrpSer: 1.007 ± 0.02
1.146TrpThr: 1.146 ± 0.024
1.101TrpVal: 1.101 ± 0.02
0.388TrpTrp: 0.388 ± 0.014
0.361TrpTyr: 0.361 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.677TyrAla: 2.677 ± 0.034
0.183TyrCys: 0.183 ± 0.009
1.459TyrAsp: 1.459 ± 0.027
1.182TyrGlu: 1.182 ± 0.021
0.685TyrPhe: 0.685 ± 0.014
2.204TyrGly: 2.204 ± 0.033
0.417TyrHis: 0.417 ± 0.013
0.583TyrIle: 0.583 ± 0.016
0.421TyrLys: 0.421 ± 0.013
2.293TyrLeu: 2.293 ± 0.033
0.273TyrMet: 0.273 ± 0.011
0.517TyrAsn: 0.517 ± 0.017
1.1TyrPro: 1.1 ± 0.022
0.65TyrGln: 0.65 ± 0.017
1.822TyrArg: 1.822 ± 0.032
1.007TyrSer: 1.007 ± 0.023
1.278TyrThr: 1.278 ± 0.029
1.874TyrVal: 1.874 ± 0.028
0.389TyrTrp: 0.389 ± 0.014
0.485TyrTyr: 0.485 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7514 proteins (2491651 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski