Amino acid dipepetide frequency for Sphingobium sp. MI1205

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.899AlaAla: 17.899 ± 0.17	1.125AlaCys: 1.125 ± 0.033	7.501AlaAsp: 7.501 ± 0.081	7.337AlaGlu: 7.337 ± 0.096	4.217AlaPhe: 4.217 ± 0.056	10.622AlaGly: 10.622 ± 0.125	2.356AlaHis: 2.356 ± 0.035	6.741AlaIle: 6.741 ± 0.076	4.028AlaLys: 4.028 ± 0.064	13.726AlaLeu: 13.726 ± 0.128	3.958AlaMet: 3.958 ± 0.057	3.022AlaAsn: 3.022 ± 0.051	5.8AlaPro: 5.8 ± 0.088	4.74AlaGln: 4.74 ± 0.068	9.622AlaArg: 9.622 ± 0.102	6.759AlaSer: 6.759 ± 0.08	6.179AlaThr: 6.179 ± 0.071	8.399AlaVal: 8.399 ± 0.092	1.573AlaTrp: 1.573 ± 0.036	2.558AlaTyr: 2.558 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.026CysAla: 1.026 ± 0.031	0.102CysCys: 0.102 ± 0.01	0.529CysAsp: 0.529 ± 0.023	0.461CysGlu: 0.461 ± 0.018	0.319CysPhe: 0.319 ± 0.016	0.868CysGly: 0.868 ± 0.028	0.22CysHis: 0.22 ± 0.02	0.379CysIle: 0.379 ± 0.018	0.18CysLys: 0.18 ± 0.012	0.758CysLeu: 0.758 ± 0.025	0.168CysMet: 0.168 ± 0.013	0.214CysAsn: 0.214 ± 0.013	0.506CysPro: 0.506 ± 0.022	0.197CysGln: 0.197 ± 0.013	0.628CysArg: 0.628 ± 0.021	0.465CysSer: 0.465 ± 0.022	0.41CysThr: 0.41 ± 0.018	0.581CysVal: 0.581 ± 0.02	0.155CysTrp: 0.155 ± 0.011	0.171CysTyr: 0.171 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.337AspAla: 7.337 ± 0.075	0.506AspCys: 0.506 ± 0.021	3.279AspAsp: 3.279 ± 0.053	3.544AspGlu: 3.544 ± 0.059	2.157AspPhe: 2.157 ± 0.042	5.504AspGly: 5.504 ± 0.076	1.43AspHis: 1.43 ± 0.039	3.183AspIle: 3.183 ± 0.05	1.709AspLys: 1.709 ± 0.039	5.859AspLeu: 5.859 ± 0.069	1.576AspMet: 1.576 ± 0.035	1.453AspAsn: 1.453 ± 0.037	3.698AspPro: 3.698 ± 0.05	2.0AspGln: 2.0 ± 0.041	5.058AspArg: 5.058 ± 0.072	2.501AspSer: 2.501 ± 0.044	2.387AspThr: 2.387 ± 0.041	4.128AspVal: 4.128 ± 0.056	1.064AspTrp: 1.064 ± 0.027	1.666AspTyr: 1.666 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.623GluAla: 7.623 ± 0.095	0.328GluCys: 0.328 ± 0.016	2.807GluAsp: 2.807 ± 0.05	3.222GluGlu: 3.222 ± 0.064	1.5GluPhe: 1.5 ± 0.038	4.597GluGly: 4.597 ± 0.063	1.164GluHis: 1.164 ± 0.028	3.084GluIle: 3.084 ± 0.048	2.118GluLys: 2.118 ± 0.045	5.134GluLeu: 5.134 ± 0.072	1.479GluMet: 1.479 ± 0.036	1.44GluAsn: 1.44 ± 0.031	2.479GluPro: 2.479 ± 0.05	2.327GluGln: 2.327 ± 0.047	4.98GluArg: 4.98 ± 0.064	2.439GluSer: 2.439 ± 0.046	2.994GluThr: 2.994 ± 0.05	3.527GluVal: 3.527 ± 0.056	0.77GluTrp: 0.77 ± 0.028	0.978GluTyr: 0.978 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.54PheAla: 4.54 ± 0.061	0.341PheCys: 0.341 ± 0.016	2.674PheAsp: 2.674 ± 0.049	2.019PheGlu: 2.019 ± 0.037	1.272PhePhe: 1.272 ± 0.035	3.354PheGly: 3.354 ± 0.054	0.767PheHis: 0.767 ± 0.026	1.578PheIle: 1.578 ± 0.035	0.845PheLys: 0.845 ± 0.029	3.19PheLeu: 3.19 ± 0.06	0.821PheMet: 0.821 ± 0.022	1.044PheAsn: 1.044 ± 0.031	1.55PhePro: 1.55 ± 0.036	0.914PheGln: 0.914 ± 0.027	2.331PheArg: 2.331 ± 0.048	2.144PheSer: 2.144 ± 0.04	1.977PheThr: 1.977 ± 0.041	2.362PheVal: 2.362 ± 0.044	0.518PheTrp: 0.518 ± 0.02	0.896PheTyr: 0.896 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.545GlyAla: 9.545 ± 0.114	0.837GlyCys: 0.837 ± 0.028	4.899GlyAsp: 4.899 ± 0.067	4.72GlyGlu: 4.72 ± 0.065	3.466GlyPhe: 3.466 ± 0.05	7.748GlyGly: 7.748 ± 0.156	1.851GlyHis: 1.851 ± 0.043	4.525GlyIle: 4.525 ± 0.059	3.317GlyLys: 3.317 ± 0.051	8.502GlyLeu: 8.502 ± 0.097	2.481GlyMet: 2.481 ± 0.042	2.229GlyAsn: 2.229 ± 0.048	3.492GlyPro: 3.492 ± 0.057	3.161GlyGln: 3.161 ± 0.053	6.492GlyArg: 6.492 ± 0.082	4.899GlySer: 4.899 ± 0.072	4.425GlyThr: 4.425 ± 0.078	6.05GlyVal: 6.05 ± 0.076	1.524GlyTrp: 1.524 ± 0.039	2.268GlyTyr: 2.268 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.407HisAla: 2.407 ± 0.045	0.246HisCys: 0.246 ± 0.014	1.322HisAsp: 1.322 ± 0.032	1.062HisGlu: 1.062 ± 0.026	0.863HisPhe: 0.863 ± 0.028	2.005HisGly: 2.005 ± 0.043	0.647HisHis: 0.647 ± 0.024	1.066HisIle: 1.066 ± 0.028	0.487HisLys: 0.487 ± 0.019	1.968HisLeu: 1.968 ± 0.045	0.537HisMet: 0.537 ± 0.02	0.459HisAsn: 0.459 ± 0.018	1.285HisPro: 1.285 ± 0.03	0.588HisGln: 0.588 ± 0.022	1.525HisArg: 1.525 ± 0.034	1.032HisSer: 1.032 ± 0.028	0.626HisThr: 0.626 ± 0.02	1.631HisVal: 1.631 ± 0.033	0.355HisTrp: 0.355 ± 0.016	0.605HisTyr: 0.605 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.738IleAla: 7.738 ± 0.089	0.467IleCys: 0.467 ± 0.02	4.1IleAsp: 4.1 ± 0.054	3.542IleGlu: 3.542 ± 0.055	1.72IlePhe: 1.72 ± 0.037	4.988IleGly: 4.988 ± 0.072	0.951IleHis: 0.951 ± 0.03	2.419IleIle: 2.419 ± 0.044	1.31IleLys: 1.31 ± 0.032	4.443IleLeu: 4.443 ± 0.059	1.051IleMet: 1.051 ± 0.029	1.42IleAsn: 1.42 ± 0.034	2.29IlePro: 2.29 ± 0.047	1.259IleGln: 1.259 ± 0.03	3.362IleArg: 3.362 ± 0.047	2.879IleSer: 2.879 ± 0.048	2.549IleThr: 2.549 ± 0.05	4.094IleVal: 4.094 ± 0.059	0.637IleTrp: 0.637 ± 0.021	1.066IleTyr: 1.066 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.276LysAla: 4.276 ± 0.067	0.17LysCys: 0.17 ± 0.014	1.667LysAsp: 1.667 ± 0.037	1.409LysGlu: 1.409 ± 0.036	0.795LysPhe: 0.795 ± 0.024	2.781LysGly: 2.781 ± 0.045	0.531LysHis: 0.531 ± 0.018	1.584LysIle: 1.584 ± 0.034	1.158LysLys: 1.158 ± 0.034	3.237LysLeu: 3.237 ± 0.05	0.74LysMet: 0.74 ± 0.023	0.743LysAsn: 0.743 ± 0.023	1.972LysPro: 1.972 ± 0.045	0.954LysGln: 0.954 ± 0.028	2.312LysArg: 2.312 ± 0.043	1.704LysSer: 1.704 ± 0.042	1.628LysThr: 1.628 ± 0.034	2.2LysVal: 2.2 ± 0.041	0.393LysTrp: 0.393 ± 0.02	0.589LysTyr: 0.589 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.361LeuAla: 13.361 ± 0.116	0.919LeuCys: 0.919 ± 0.026	6.083LeuAsp: 6.083 ± 0.071	4.891LeuGlu: 4.891 ± 0.061	3.777LeuPhe: 3.777 ± 0.059	8.042LeuGly: 8.042 ± 0.076	1.921LeuHis: 1.921 ± 0.044	5.173LeuIle: 5.173 ± 0.075	3.205LeuLys: 3.205 ± 0.049	9.896LeuLeu: 9.896 ± 0.125	2.267LeuMet: 2.267 ± 0.045	2.556LeuAsn: 2.556 ± 0.044	5.686LeuPro: 5.686 ± 0.066	2.598LeuGln: 2.598 ± 0.043	7.132LeuArg: 7.132 ± 0.077	6.422LeuSer: 6.422 ± 0.068	5.649LeuThr: 5.649 ± 0.067	6.798LeuVal: 6.798 ± 0.074	1.278LeuTrp: 1.278 ± 0.034	2.029LeuTyr: 2.029 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.455MetAla: 3.455 ± 0.049	0.154MetCys: 0.154 ± 0.01	1.277MetAsp: 1.277 ± 0.033	1.213MetGlu: 1.213 ± 0.028	0.706MetPhe: 0.706 ± 0.024	1.991MetGly: 1.991 ± 0.04	0.473MetHis: 0.473 ± 0.019	1.456MetIle: 1.456 ± 0.034	0.969MetLys: 0.969 ± 0.025	2.771MetLeu: 2.771 ± 0.043	0.721MetMet: 0.721 ± 0.025	0.758MetAsn: 0.758 ± 0.024	1.561MetPro: 1.561 ± 0.033	0.813MetGln: 0.813 ± 0.023	1.86MetArg: 1.86 ± 0.041	1.627MetSer: 1.627 ± 0.037	1.849MetThr: 1.849 ± 0.034	1.65MetVal: 1.65 ± 0.032	0.231MetTrp: 0.231 ± 0.015	0.256MetTyr: 0.256 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.241AsnAla: 3.241 ± 0.053	0.237AsnCys: 0.237 ± 0.014	1.493AsnAsp: 1.493 ± 0.032	1.199AsnGlu: 1.199 ± 0.03	0.945AsnPhe: 0.945 ± 0.028	2.525AsnGly: 2.525 ± 0.047	0.487AsnHis: 0.487 ± 0.019	1.395AsnIle: 1.395 ± 0.035	0.701AsnLys: 0.701 ± 0.026	2.477AsnLeu: 2.477 ± 0.045	0.622AsnMet: 0.622 ± 0.02	0.695AsnAsn: 0.695 ± 0.026	1.702AsnPro: 1.702 ± 0.036	0.797AsnGln: 0.797 ± 0.023	1.956AsnArg: 1.956 ± 0.044	1.366AsnSer: 1.366 ± 0.039	0.995AsnThr: 0.995 ± 0.029	1.917AsnVal: 1.917 ± 0.04	0.459AsnTrp: 0.459 ± 0.02	0.681AsnTyr: 0.681 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.677ProAla: 6.677 ± 0.086	0.332ProCys: 0.332 ± 0.015	3.771ProAsp: 3.771 ± 0.061	3.349ProGlu: 3.349 ± 0.048	1.882ProPhe: 1.882 ± 0.042	4.497ProGly: 4.497 ± 0.06	1.086ProHis: 1.086 ± 0.029	2.476ProIle: 2.476 ± 0.04	1.475ProLys: 1.475 ± 0.038	4.866ProLeu: 4.866 ± 0.067	1.304ProMet: 1.304 ± 0.027	1.289ProAsn: 1.289 ± 0.035	2.727ProPro: 2.727 ± 0.059	1.73ProGln: 1.73 ± 0.035	3.034ProArg: 3.034 ± 0.052	2.937ProSer: 2.937 ± 0.043	2.5ProThr: 2.5 ± 0.047	4.287ProVal: 4.287 ± 0.061	0.708ProTrp: 0.708 ± 0.025	1.091ProTyr: 1.091 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.5GlnAla: 4.5 ± 0.072	0.259GlnCys: 0.259 ± 0.015	1.611GlnAsp: 1.611 ± 0.034	1.512GlnGlu: 1.512 ± 0.032	1.124GlnPhe: 1.124 ± 0.029	2.621GlnGly: 2.621 ± 0.048	0.6GlnHis: 0.6 ± 0.022	1.852GlnIle: 1.852 ± 0.038	1.012GlnLys: 1.012 ± 0.03	3.317GlnLeu: 3.317 ± 0.051	0.94GlnMet: 0.94 ± 0.025	0.821GlnAsn: 0.821 ± 0.025	1.947GlnPro: 1.947 ± 0.041	1.287GlnGln: 1.287 ± 0.038	2.673GlnArg: 2.673 ± 0.044	1.86GlnSer: 1.86 ± 0.037	1.596GlnThr: 1.596 ± 0.03	2.309GlnVal: 2.309 ± 0.046	0.505GlnTrp: 0.505 ± 0.019	0.64GlnTyr: 0.64 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.619ArgAla: 8.619 ± 0.093	0.542ArgCys: 0.542 ± 0.022	4.399ArgAsp: 4.399 ± 0.064	4.087ArgGlu: 4.087 ± 0.054	3.074ArgPhe: 3.074 ± 0.053	5.052ArgGly: 5.052 ± 0.055	1.881ArgHis: 1.881 ± 0.04	4.197ArgIle: 4.197 ± 0.059	2.34ArgLys: 2.34 ± 0.048	8.386ArgLeu: 8.386 ± 0.096	2.011ArgMet: 2.011 ± 0.041	1.976ArgAsn: 1.976 ± 0.036	3.756ArgPro: 3.756 ± 0.062	2.799ArgGln: 2.799 ± 0.049	6.144ArgArg: 6.144 ± 0.095	4.042ArgSer: 4.042 ± 0.054	3.503ArgThr: 3.503 ± 0.052	4.665ArgVal: 4.665 ± 0.064	1.215ArgTrp: 1.215 ± 0.031	1.932ArgTyr: 1.932 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.649SerAla: 6.649 ± 0.074	0.468SerCys: 0.468 ± 0.023	3.194SerAsp: 3.194 ± 0.056	2.781SerGlu: 2.781 ± 0.044	2.272SerPhe: 2.272 ± 0.044	5.629SerGly: 5.629 ± 0.077	1.079SerHis: 1.079 ± 0.031	2.897SerIle: 2.897 ± 0.052	1.473SerLys: 1.473 ± 0.033	5.416SerLeu: 5.416 ± 0.076	1.381SerMet: 1.381 ± 0.031	1.422SerAsn: 1.422 ± 0.035	2.893SerPro: 2.893 ± 0.046	1.694SerGln: 1.694 ± 0.035	3.806SerArg: 3.806 ± 0.055	3.084SerSer: 3.084 ± 0.047	2.684SerThr: 2.684 ± 0.046	3.876SerVal: 3.876 ± 0.053	0.882SerTrp: 0.882 ± 0.025	1.468SerTyr: 1.468 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	6.146ThrAla: 6.146 ± 0.068	0.391ThrCys: 0.391 ± 0.017	2.847ThrAsp: 2.847 ± 0.052	2.298ThrGlu: 2.298 ± 0.045	1.704ThrPhe: 1.704 ± 0.037	5.09ThrGly: 5.09 ± 0.072	0.986ThrHis: 0.986 ± 0.028	2.922ThrIle: 2.922 ± 0.053	1.291ThrLys: 1.291 ± 0.031	5.664ThrLeu: 5.664 ± 0.076	1.167ThrMet: 1.167 ± 0.03	1.253ThrAsn: 1.253 ± 0.032	3.184ThrPro: 3.184 ± 0.048	1.538ThrGln: 1.538 ± 0.035	3.305ThrArg: 3.305 ± 0.047	2.705ThrSer: 2.705 ± 0.046	2.49ThrThr: 2.49 ± 0.047	4.049ThrVal: 4.049 ± 0.065	0.531ThrTrp: 0.531 ± 0.019	1.097ThrTyr: 1.097 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.066ValAla: 9.066 ± 0.091	0.52ValCys: 0.52 ± 0.02	4.3ValAsp: 4.3 ± 0.06	4.571ValGlu: 4.571 ± 0.066	1.992ValPhe: 1.992 ± 0.036	5.454ValGly: 5.454 ± 0.07	1.406ValHis: 1.406 ± 0.034	3.759ValIle: 3.759 ± 0.06	2.174ValLys: 2.174 ± 0.044	6.203ValLeu: 6.203 ± 0.077	1.702ValMet: 1.702 ± 0.039	1.995ValAsn: 1.995 ± 0.044	3.75ValPro: 3.75 ± 0.057	2.249ValGln: 2.249 ± 0.042	5.167ValArg: 5.167 ± 0.06	4.118ValSer: 4.118 ± 0.057	4.388ValThr: 4.388 ± 0.058	5.009ValVal: 5.009 ± 0.078	0.773ValTrp: 0.773 ± 0.023	1.36ValTyr: 1.36 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.404TrpAla: 1.404 ± 0.033	0.11TrpCys: 0.11 ± 0.009	0.728TrpAsp: 0.728 ± 0.023	0.628TrpGlu: 0.628 ± 0.025	0.54TrpPhe: 0.54 ± 0.022	0.939TrpGly: 0.939 ± 0.027	0.355TrpHis: 0.355 ± 0.015	0.721TrpIle: 0.721 ± 0.023	0.477TrpLys: 0.477 ± 0.018	1.75TrpLeu: 1.75 ± 0.039	0.385TrpMet: 0.385 ± 0.018	0.479TrpAsn: 0.479 ± 0.019	0.703TrpPro: 0.703 ± 0.022	0.589TrpGln: 0.589 ± 0.02	1.331TrpArg: 1.331 ± 0.035	0.831TrpSer: 0.831 ± 0.026	0.856TrpThr: 0.856 ± 0.03	0.813TrpVal: 0.813 ± 0.029	0.249TrpTrp: 0.249 ± 0.013	0.274TrpTyr: 0.274 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.653TyrAla: 2.653 ± 0.047	0.284TyrCys: 0.284 ± 0.015	1.558TyrAsp: 1.558 ± 0.039	1.144TyrGlu: 1.144 ± 0.033	0.813TyrPhe: 0.813 ± 0.025	2.124TyrGly: 2.124 ± 0.047	0.525TyrHis: 0.525 ± 0.02	0.879TyrIle: 0.879 ± 0.025	0.574TyrLys: 0.574 ± 0.022	2.12TyrLeu: 2.12 ± 0.038	0.481TyrMet: 0.481 ± 0.019	0.623TyrAsn: 0.623 ± 0.023	1.035TyrPro: 1.035 ± 0.027	0.753TyrGln: 0.753 ± 0.025	1.899TyrArg: 1.899 ± 0.034	1.235TyrSer: 1.235 ± 0.033	0.972TyrThr: 0.972 ± 0.028	1.612TyrVal: 1.612 ± 0.036	0.34TyrTrp: 0.34 ± 0.017	0.614TyrTyr: 0.614 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4473 proteins (1347481 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---