Amino acid dipepetide frequency for Rhodoluna lacicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.65AlaAla: 14.65 ± 0.245
0.544AlaCys: 0.544 ± 0.035
5.908AlaAsp: 5.908 ± 0.113
7.638AlaGlu: 7.638 ± 0.169
3.677AlaPhe: 3.677 ± 0.1
9.947AlaGly: 9.947 ± 0.219
1.861AlaHis: 1.861 ± 0.08
7.256AlaIle: 7.256 ± 0.149
6.663AlaLys: 6.663 ± 0.199
11.102AlaLeu: 11.102 ± 0.204
2.556AlaMet: 2.556 ± 0.083
4.006AlaAsn: 4.006 ± 0.133
4.125AlaPro: 4.125 ± 0.126
3.706AlaGln: 3.706 ± 0.114
5.478AlaArg: 5.478 ± 0.151
6.677AlaSer: 6.677 ± 0.159
6.524AlaThr: 6.524 ± 0.273
8.584AlaVal: 8.584 ± 0.146
1.279AlaTrp: 1.279 ± 0.06
2.276AlaTyr: 2.276 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.542CysAla: 0.542 ± 0.03
0.024CysCys: 0.024 ± 0.007
0.322CysAsp: 0.322 ± 0.028
0.335CysGlu: 0.335 ± 0.027
0.195CysPhe: 0.195 ± 0.023
0.544CysGly: 0.544 ± 0.039
0.104CysHis: 0.104 ± 0.018
0.233CysIle: 0.233 ± 0.022
0.147CysLys: 0.147 ± 0.019
0.455CysLeu: 0.455 ± 0.03
0.08CysMet: 0.08 ± 0.013
0.182CysAsn: 0.182 ± 0.022
0.298CysPro: 0.298 ± 0.029
0.131CysGln: 0.131 ± 0.016
0.251CysArg: 0.251 ± 0.023
0.373CysSer: 0.373 ± 0.032
0.344CysThr: 0.344 ± 0.029
0.409CysVal: 0.409 ± 0.029
0.058CysTrp: 0.058 ± 0.011
0.12CysTyr: 0.12 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.084AspAla: 6.084 ± 0.115
0.306AspCys: 0.306 ± 0.025
2.607AspAsp: 2.607 ± 0.088
3.761AspGlu: 3.761 ± 0.11
2.28AspPhe: 2.28 ± 0.073
4.543AspGly: 4.543 ± 0.125
0.917AspHis: 0.917 ± 0.048
2.809AspIle: 2.809 ± 0.088
2.145AspLys: 2.145 ± 0.076
5.811AspLeu: 5.811 ± 0.137
0.899AspMet: 0.899 ± 0.046
1.463AspAsn: 1.463 ± 0.06
2.862AspPro: 2.862 ± 0.084
1.847AspGln: 1.847 ± 0.053
2.851AspArg: 2.851 ± 0.095
3.277AspSer: 3.277 ± 0.087
2.285AspThr: 2.285 ± 0.065
4.365AspVal: 4.365 ± 0.113
0.808AspTrp: 0.808 ± 0.042
1.457AspTyr: 1.457 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
6.575GluAla: 6.575 ± 0.164
0.266GluCys: 0.266 ± 0.029
2.833GluAsp: 2.833 ± 0.091
3.348GluGlu: 3.348 ± 0.113
2.496GluPhe: 2.496 ± 0.083
3.539GluGly: 3.539 ± 0.102
1.275GluHis: 1.275 ± 0.063
4.463GluIle: 4.463 ± 0.11
2.935GluLys: 2.935 ± 0.096
7.059GluLeu: 7.059 ± 0.18
1.208GluMet: 1.208 ± 0.054
2.212GluAsn: 2.212 ± 0.069
2.349GluPro: 2.349 ± 0.088
2.283GluGln: 2.283 ± 0.086
3.693GluArg: 3.693 ± 0.113
3.404GluSer: 3.404 ± 0.096
3.195GluThr: 3.195 ± 0.089
5.009GluVal: 5.009 ± 0.125
0.724GluTrp: 0.724 ± 0.045
1.281GluTyr: 1.281 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
4.434PheAla: 4.434 ± 0.1
0.226PheCys: 0.226 ± 0.025
2.485PheAsp: 2.485 ± 0.082
2.458PheGlu: 2.458 ± 0.092
1.485PhePhe: 1.485 ± 0.069
4.054PheGly: 4.054 ± 0.115
0.488PheHis: 0.488 ± 0.037
1.992PheIle: 1.992 ± 0.082
1.648PheLys: 1.648 ± 0.065
3.184PheLeu: 3.184 ± 0.105
0.764PheMet: 0.764 ± 0.041
1.339PheAsn: 1.339 ± 0.052
1.275PhePro: 1.275 ± 0.055
0.97PheGln: 0.97 ± 0.045
1.454PheArg: 1.454 ± 0.053
2.52PheSer: 2.52 ± 0.08
2.422PheThr: 2.422 ± 0.095
2.982PheVal: 2.982 ± 0.094
0.502PheTrp: 0.502 ± 0.041
0.91PheTyr: 0.91 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
8.509GlyAla: 8.509 ± 0.211
0.562GlyCys: 0.562 ± 0.038
3.923GlyAsp: 3.923 ± 0.098
4.641GlyGlu: 4.641 ± 0.122
3.584GlyPhe: 3.584 ± 0.104
6.723GlyGly: 6.723 ± 0.35
1.61GlyHis: 1.61 ± 0.072
5.607GlyIle: 5.607 ± 0.125
4.574GlyLys: 4.574 ± 0.119
8.116GlyLeu: 8.116 ± 0.154
1.807GlyMet: 1.807 ± 0.071
2.751GlyAsn: 2.751 ± 0.138
2.74GlyPro: 2.74 ± 0.075
2.773GlyGln: 2.773 ± 0.076
4.006GlyArg: 4.006 ± 0.125
5.527GlySer: 5.527 ± 0.217
4.914GlyThr: 4.914 ± 0.282
6.814GlyVal: 6.814 ± 0.154
1.215GlyTrp: 1.215 ± 0.067
2.256GlyTyr: 2.256 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.699HisAla: 1.699 ± 0.074
0.102HisCys: 0.102 ± 0.017
1.084HisAsp: 1.084 ± 0.063
1.19HisGlu: 1.19 ± 0.053
0.608HisPhe: 0.608 ± 0.042
1.643HisGly: 1.643 ± 0.064
0.451HisHis: 0.451 ± 0.036
0.95HisIle: 0.95 ± 0.051
0.713HisLys: 0.713 ± 0.045
1.716HisLeu: 1.716 ± 0.065
0.346HisMet: 0.346 ± 0.031
0.551HisAsn: 0.551 ± 0.033
1.064HisPro: 1.064 ± 0.05
0.56HisGln: 0.56 ± 0.039
1.019HisArg: 1.019 ± 0.048
1.09HisSer: 1.09 ± 0.06
0.824HisThr: 0.824 ± 0.049
1.29HisVal: 1.29 ± 0.055
0.213HisTrp: 0.213 ± 0.022
0.404HisTyr: 0.404 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
7.532IleAla: 7.532 ± 0.16
0.395IleCys: 0.395 ± 0.031
3.839IleAsp: 3.839 ± 0.096
4.139IleGlu: 4.139 ± 0.12
2.158IlePhe: 2.158 ± 0.082
5.642IleGly: 5.642 ± 0.131
0.906IleHis: 0.906 ± 0.045
3.062IleIle: 3.062 ± 0.093
2.562IleLys: 2.562 ± 0.078
4.869IleLeu: 4.869 ± 0.133
1.015IleMet: 1.015 ± 0.049
2.143IleAsn: 2.143 ± 0.073
2.74IlePro: 2.74 ± 0.09
1.914IleGln: 1.914 ± 0.065
3.184IleArg: 3.184 ± 0.093
4.561IleSer: 4.561 ± 0.123
3.895IleThr: 3.895 ± 0.169
4.479IleVal: 4.479 ± 0.108
0.779IleTrp: 0.779 ± 0.043
1.401IleTyr: 1.401 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
5.216LysAla: 5.216 ± 0.156
0.169LysCys: 0.169 ± 0.019
2.316LysAsp: 2.316 ± 0.08
2.28LysGlu: 2.28 ± 0.094
1.799LysPhe: 1.799 ± 0.068
3.104LysGly: 3.104 ± 0.099
0.915LysHis: 0.915 ± 0.048
3.064LysIle: 3.064 ± 0.088
3.031LysLys: 3.031 ± 0.158
4.829LysLeu: 4.829 ± 0.117
1.27LysMet: 1.27 ± 0.052
1.894LysAsn: 1.894 ± 0.066
2.609LysPro: 2.609 ± 0.094
1.603LysGln: 1.603 ± 0.068
2.638LysArg: 2.638 ± 0.087
3.2LysSer: 3.2 ± 0.098
2.993LysThr: 2.993 ± 0.072
3.852LysVal: 3.852 ± 0.106
0.517LysTrp: 0.517 ± 0.034
1.195LysTyr: 1.195 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
12.53LeuAla: 12.53 ± 0.232
0.528LeuCys: 0.528 ± 0.036
5.555LeuAsp: 5.555 ± 0.131
6.071LeuGlu: 6.071 ± 0.143
3.149LeuPhe: 3.149 ± 0.106
8.349LeuGly: 8.349 ± 0.167
1.579LeuHis: 1.579 ± 0.064
5.968LeuIle: 5.968 ± 0.136
4.379LeuLys: 4.379 ± 0.111
9.126LeuLeu: 9.126 ± 0.237
1.861LeuMet: 1.861 ± 0.066
3.275LeuAsn: 3.275 ± 0.082
4.521LeuPro: 4.521 ± 0.123
2.795LeuGln: 2.795 ± 0.086
5.127LeuArg: 5.127 ± 0.121
6.361LeuSer: 6.361 ± 0.132
5.815LeuThr: 5.815 ± 0.16
8.084LeuVal: 8.084 ± 0.147
1.048LeuTrp: 1.048 ± 0.049
1.781LeuTyr: 1.781 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.429MetAla: 2.429 ± 0.078
0.102MetCys: 0.102 ± 0.015
0.917MetAsp: 0.917 ± 0.045
0.797MetGlu: 0.797 ± 0.044
0.695MetPhe: 0.695 ± 0.037
1.57MetGly: 1.57 ± 0.064
0.429MetHis: 0.429 ± 0.038
1.188MetIle: 1.188 ± 0.053
0.901MetLys: 0.901 ± 0.039
1.947MetLeu: 1.947 ± 0.071
0.34MetMet: 0.34 ± 0.031
0.857MetAsn: 0.857 ± 0.037
1.104MetPro: 1.104 ± 0.055
0.715MetGln: 0.715 ± 0.036
1.195MetArg: 1.195 ± 0.053
1.767MetSer: 1.767 ± 0.059
1.372MetThr: 1.372 ± 0.056
1.503MetVal: 1.503 ± 0.063
0.215MetTrp: 0.215 ± 0.022
0.304MetTyr: 0.304 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.442AsnAla: 3.442 ± 0.112
0.182AsnCys: 0.182 ± 0.021
1.723AsnAsp: 1.723 ± 0.069
1.938AsnGlu: 1.938 ± 0.063
1.47AsnPhe: 1.47 ± 0.058
2.891AsnGly: 2.891 ± 0.139
0.564AsnHis: 0.564 ± 0.04
1.801AsnIle: 1.801 ± 0.076
1.461AsnLys: 1.461 ± 0.061
3.784AsnLeu: 3.784 ± 0.093
0.733AsnMet: 0.733 ± 0.043
1.155AsnAsn: 1.155 ± 0.065
2.347AsnPro: 2.347 ± 0.087
1.379AsnGln: 1.379 ± 0.067
1.987AsnArg: 1.987 ± 0.068
2.36AsnSer: 2.36 ± 0.117
1.921AsnThr: 1.921 ± 0.114
2.467AsnVal: 2.467 ± 0.095
0.591AsnTrp: 0.591 ± 0.039
0.924AsnTyr: 0.924 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
4.903ProAla: 4.903 ± 0.125
0.164ProCys: 0.164 ± 0.019
2.56ProAsp: 2.56 ± 0.083
3.155ProGlu: 3.155 ± 0.1
1.568ProPhe: 1.568 ± 0.057
3.597ProGly: 3.597 ± 0.091
0.808ProHis: 0.808 ± 0.043
2.787ProIle: 2.787 ± 0.075
2.378ProLys: 2.378 ± 0.089
3.608ProLeu: 3.608 ± 0.106
0.844ProMet: 0.844 ± 0.043
1.885ProAsn: 1.885 ± 0.061
1.044ProPro: 1.044 ± 0.051
1.33ProGln: 1.33 ± 0.053
1.91ProArg: 1.91 ± 0.073
2.691ProSer: 2.691 ± 0.085
2.753ProThr: 2.753 ± 0.088
3.821ProVal: 3.821 ± 0.107
0.54ProTrp: 0.54 ± 0.039
0.979ProTyr: 0.979 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.697GlnAla: 3.697 ± 0.089
0.111GlnCys: 0.111 ± 0.017
1.641GlnAsp: 1.641 ± 0.059
1.685GlnGlu: 1.685 ± 0.071
1.15GlnPhe: 1.15 ± 0.054
2.143GlnGly: 2.143 ± 0.071
0.628GlnHis: 0.628 ± 0.041
2.456GlnIle: 2.456 ± 0.073
1.461GlnLys: 1.461 ± 0.054
3.57GlnLeu: 3.57 ± 0.087
0.753GlnMet: 0.753 ± 0.043
1.226GlnAsn: 1.226 ± 0.058
1.479GlnPro: 1.479 ± 0.078
1.239GlnGln: 1.239 ± 0.052
1.736GlnArg: 1.736 ± 0.072
1.852GlnSer: 1.852 ± 0.068
1.794GlnThr: 1.794 ± 0.081
2.931GlnVal: 2.931 ± 0.088
0.415GlnTrp: 0.415 ± 0.037
0.706GlnTyr: 0.706 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
5.247ArgAla: 5.247 ± 0.128
0.226ArgCys: 0.226 ± 0.018
2.893ArgAsp: 2.893 ± 0.099
3.588ArgGlu: 3.588 ± 0.105
2.014ArgPhe: 2.014 ± 0.069
3.679ArgGly: 3.679 ± 0.103
0.984ArgHis: 0.984 ± 0.056
3.313ArgIle: 3.313 ± 0.078
2.618ArgLys: 2.618 ± 0.075
5.018ArgLeu: 5.018 ± 0.135
1.252ArgMet: 1.252 ± 0.06
1.87ArgAsn: 1.87 ± 0.07
2.152ArgPro: 2.152 ± 0.078
1.679ArgGln: 1.679 ± 0.062
3.137ArgArg: 3.137 ± 0.101
3.104ArgSer: 3.104 ± 0.093
2.718ArgThr: 2.718 ± 0.079
4.432ArgVal: 4.432 ± 0.108
0.728ArgTrp: 0.728 ± 0.042
1.23ArgTyr: 1.23 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
7.154SerAla: 7.154 ± 0.166
0.322SerCys: 0.322 ± 0.027
3.06SerAsp: 3.06 ± 0.093
3.644SerGlu: 3.644 ± 0.104
2.462SerPhe: 2.462 ± 0.088
6.159SerGly: 6.159 ± 0.332
1.09SerHis: 1.09 ± 0.053
3.784SerIle: 3.784 ± 0.1
3.268SerLys: 3.268 ± 0.088
6.128SerLeu: 6.128 ± 0.131
1.372SerMet: 1.372 ± 0.056
2.269SerAsn: 2.269 ± 0.097
2.707SerPro: 2.707 ± 0.076
2.12SerGln: 2.12 ± 0.068
3.442SerArg: 3.442 ± 0.093
4.65SerSer: 4.65 ± 0.243
3.837SerThr: 3.837 ± 0.21
5.154SerVal: 5.154 ± 0.128
0.799SerTrp: 0.799 ± 0.046
1.481SerTyr: 1.481 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
6.328ThrAla: 6.328 ± 0.25
0.266ThrCys: 0.266 ± 0.023
3.2ThrAsp: 3.2 ± 0.082
2.831ThrGlu: 2.831 ± 0.084
2.278ThrPhe: 2.278 ± 0.128
5.52ThrGly: 5.52 ± 0.252
0.973ThrHis: 0.973 ± 0.047
3.266ThrIle: 3.266 ± 0.133
2.769ThrLys: 2.769 ± 0.083
5.471ThrLeu: 5.471 ± 0.163
1.097ThrMet: 1.097 ± 0.051
1.95ThrAsn: 1.95 ± 0.111
3.035ThrPro: 3.035 ± 0.106
1.927ThrGln: 1.927 ± 0.146
2.636ThrArg: 2.636 ± 0.093
3.608ThrSer: 3.608 ± 0.224
3.337ThrThr: 3.337 ± 0.246
4.898ThrVal: 4.898 ± 0.189
0.733ThrTrp: 0.733 ± 0.04
1.414ThrTyr: 1.414 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
9.912ValAla: 9.912 ± 0.162
0.417ValCys: 0.417 ± 0.028
4.736ValAsp: 4.736 ± 0.127
4.792ValGlu: 4.792 ± 0.133
2.958ValPhe: 2.958 ± 0.079
6.199ValGly: 6.199 ± 0.111
1.374ValHis: 1.374 ± 0.062
5.438ValIle: 5.438 ± 0.134
3.382ValLys: 3.382 ± 0.099
7.849ValLeu: 7.849 ± 0.156
1.519ValMet: 1.519 ± 0.06
2.78ValAsn: 2.78 ± 0.118
3.379ValPro: 3.379 ± 0.085
2.303ValGln: 2.303 ± 0.08
4.063ValArg: 4.063 ± 0.105
5.542ValSer: 5.542 ± 0.14
4.807ValThr: 4.807 ± 0.226
6.854ValVal: 6.854 ± 0.12
0.875ValTrp: 0.875 ± 0.045
1.49ValTyr: 1.49 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
1.228TrpAla: 1.228 ± 0.058
0.073TrpCys: 0.073 ± 0.013
0.544TrpAsp: 0.544 ± 0.031
0.477TrpGlu: 0.477 ± 0.037
0.606TrpPhe: 0.606 ± 0.043
0.884TrpGly: 0.884 ± 0.042
0.244TrpHis: 0.244 ± 0.027
0.768TrpIle: 0.768 ± 0.044
0.546TrpLys: 0.546 ± 0.035
1.616TrpLeu: 1.616 ± 0.069
0.289TrpMet: 0.289 ± 0.024
0.58TrpAsn: 0.58 ± 0.034
0.542TrpPro: 0.542 ± 0.04
0.562TrpGln: 0.562 ± 0.036
0.695TrpArg: 0.695 ± 0.04
0.833TrpSer: 0.833 ± 0.044
0.662TrpThr: 0.662 ± 0.053
0.977TrpVal: 0.977 ± 0.053
0.258TrpTrp: 0.258 ± 0.026
0.273TrpTyr: 0.273 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.349TyrAla: 2.349 ± 0.077
0.158TyrCys: 0.158 ± 0.018
1.232TyrAsp: 1.232 ± 0.059
1.377TyrGlu: 1.377 ± 0.056
0.961TyrPhe: 0.961 ± 0.052
1.918TyrGly: 1.918 ± 0.069
0.318TyrHis: 0.318 ± 0.024
1.01TyrIle: 1.01 ± 0.05
0.915TyrLys: 0.915 ± 0.045
2.642TyrLeu: 2.642 ± 0.078
0.342TyrMet: 0.342 ± 0.03
0.733TyrAsn: 0.733 ± 0.059
0.955TyrPro: 0.955 ± 0.048
0.837TyrGln: 0.837 ± 0.039
1.381TyrArg: 1.381 ± 0.05
1.505TyrSer: 1.505 ± 0.07
1.126TyrThr: 1.126 ± 0.082
1.763TyrVal: 1.763 ± 0.06
0.36TyrTrp: 0.36 ± 0.029
0.511TyrTyr: 0.511 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1364 proteins (450371 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski