Amino acid dipepetide frequency for Cohaesibacter sp. CAU 1516

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.234AlaAla: 12.234 ± 0.126
1.125AlaCys: 1.125 ± 0.028
6.378AlaAsp: 6.378 ± 0.079
6.652AlaGlu: 6.652 ± 0.09
4.492AlaPhe: 4.492 ± 0.069
8.248AlaGly: 8.248 ± 0.079
2.168AlaHis: 2.168 ± 0.047
6.681AlaIle: 6.681 ± 0.083
4.988AlaLys: 4.988 ± 0.074
12.049AlaLeu: 12.049 ± 0.11
3.568AlaMet: 3.568 ± 0.053
3.225AlaAsn: 3.225 ± 0.052
4.357AlaPro: 4.357 ± 0.073
3.675AlaGln: 3.675 ± 0.065
6.163AlaArg: 6.163 ± 0.073
6.417AlaSer: 6.417 ± 0.085
5.246AlaThr: 5.246 ± 0.064
7.18AlaVal: 7.18 ± 0.088
1.132AlaTrp: 1.132 ± 0.028
2.569AlaTyr: 2.569 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.903CysAla: 0.903 ± 0.029
0.136CysCys: 0.136 ± 0.009
0.592CysAsp: 0.592 ± 0.022
0.542CysGlu: 0.542 ± 0.021
0.415CysPhe: 0.415 ± 0.017
0.906CysGly: 0.906 ± 0.028
0.325CysHis: 0.325 ± 0.019
0.484CysIle: 0.484 ± 0.02
0.333CysLys: 0.333 ± 0.016
1.071CysLeu: 1.071 ± 0.032
0.204CysMet: 0.204 ± 0.013
0.311CysAsn: 0.311 ± 0.017
0.486CysPro: 0.486 ± 0.022
0.309CysGln: 0.309 ± 0.015
0.563CysArg: 0.563 ± 0.022
0.607CysSer: 0.607 ± 0.021
0.439CysThr: 0.439 ± 0.022
0.655CysVal: 0.655 ± 0.022
0.143CysTrp: 0.143 ± 0.011
0.236CysTyr: 0.236 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.436AspAla: 6.436 ± 0.08
0.63AspCys: 0.63 ± 0.022
3.436AspAsp: 3.436 ± 0.064
3.746AspGlu: 3.746 ± 0.061
2.508AspPhe: 2.508 ± 0.052
5.116AspGly: 5.116 ± 0.079
1.608AspHis: 1.608 ± 0.039
3.736AspIle: 3.736 ± 0.056
2.646AspLys: 2.646 ± 0.045
6.433AspLeu: 6.433 ± 0.076
1.763AspMet: 1.763 ± 0.036
1.785AspAsn: 1.785 ± 0.04
3.185AspPro: 3.185 ± 0.053
2.351AspGln: 2.351 ± 0.044
3.89AspArg: 3.89 ± 0.055
2.551AspSer: 2.551 ± 0.045
2.457AspThr: 2.457 ± 0.046
3.989AspVal: 3.989 ± 0.063
0.993AspTrp: 0.993 ± 0.026
1.732AspTyr: 1.732 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
7.48GluAla: 7.48 ± 0.092
0.433GluCys: 0.433 ± 0.018
3.41GluAsp: 3.41 ± 0.056
4.0GluGlu: 4.0 ± 0.075
1.7GluPhe: 1.7 ± 0.04
4.425GluGly: 4.425 ± 0.063
1.18GluHis: 1.18 ± 0.028
3.657GluIle: 3.657 ± 0.061
3.072GluLys: 3.072 ± 0.059
5.397GluLeu: 5.397 ± 0.059
1.785GluMet: 1.785 ± 0.031
1.778GluAsn: 1.778 ± 0.04
2.464GluPro: 2.464 ± 0.049
2.757GluGln: 2.757 ± 0.053
4.061GluArg: 4.061 ± 0.069
2.702GluSer: 2.702 ± 0.048
3.571GluThr: 3.571 ± 0.059
3.777GluVal: 3.777 ± 0.058
0.609GluTrp: 0.609 ± 0.023
0.906GluTyr: 0.906 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.395PheAla: 4.395 ± 0.068
0.488PheCys: 0.488 ± 0.022
2.853PheAsp: 2.853 ± 0.042
2.464PheGlu: 2.464 ± 0.049
1.689PhePhe: 1.689 ± 0.043
3.618PheGly: 3.618 ± 0.057
0.777PheHis: 0.777 ± 0.026
2.035PheIle: 2.035 ± 0.046
1.421PheLys: 1.421 ± 0.036
3.84PheLeu: 3.84 ± 0.07
0.983PheMet: 0.983 ± 0.029
1.217PheAsn: 1.217 ± 0.027
1.527PhePro: 1.527 ± 0.029
1.117PheGln: 1.117 ± 0.025
1.946PheArg: 1.946 ± 0.045
2.529PheSer: 2.529 ± 0.047
1.992PheThr: 1.992 ± 0.043
2.979PheVal: 2.979 ± 0.05
0.561PheTrp: 0.561 ± 0.022
1.037PheTyr: 1.037 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
7.621GlyAla: 7.621 ± 0.085
0.879GlyCys: 0.879 ± 0.028
4.402GlyAsp: 4.402 ± 0.067
4.396GlyGlu: 4.396 ± 0.065
3.57GlyPhe: 3.57 ± 0.058
6.092GlyGly: 6.092 ± 0.089
1.906GlyHis: 1.906 ± 0.041
4.835GlyIle: 4.835 ± 0.065
3.927GlyLys: 3.927 ± 0.066
8.861GlyLeu: 8.861 ± 0.117
2.406GlyMet: 2.406 ± 0.046
2.426GlyAsn: 2.426 ± 0.054
2.945GlyPro: 2.945 ± 0.05
2.958GlyGln: 2.958 ± 0.042
4.592GlyArg: 4.592 ± 0.065
4.64GlySer: 4.64 ± 0.063
4.127GlyThr: 4.127 ± 0.075
5.495GlyVal: 5.495 ± 0.07
1.179GlyTrp: 1.179 ± 0.03
2.353GlyTyr: 2.353 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.062HisAla: 2.062 ± 0.039
0.286HisCys: 0.286 ± 0.014
1.359HisAsp: 1.359 ± 0.04
1.112HisGlu: 1.112 ± 0.027
1.035HisPhe: 1.035 ± 0.025
1.904HisGly: 1.904 ± 0.044
0.655HisHis: 0.655 ± 0.03
1.219HisIle: 1.219 ± 0.029
0.79HisLys: 0.79 ± 0.025
2.277HisLeu: 2.277 ± 0.043
0.634HisMet: 0.634 ± 0.022
0.615HisAsn: 0.615 ± 0.025
1.304HisPro: 1.304 ± 0.035
0.756HisGln: 0.756 ± 0.022
1.222HisArg: 1.222 ± 0.03
1.098HisSer: 1.098 ± 0.029
0.848HisThr: 0.848 ± 0.028
1.515HisVal: 1.515 ± 0.034
0.354HisTrp: 0.354 ± 0.017
0.659HisTyr: 0.659 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
7.186IleAla: 7.186 ± 0.075
0.675IleCys: 0.675 ± 0.024
4.009IleAsp: 4.009 ± 0.057
4.047IleGlu: 4.047 ± 0.055
2.189IlePhe: 2.189 ± 0.048
5.237IleGly: 5.237 ± 0.076
1.106IleHis: 1.106 ± 0.028
3.004IleIle: 3.004 ± 0.062
2.296IleLys: 2.296 ± 0.044
5.927IleLeu: 5.927 ± 0.079
1.268IleMet: 1.268 ± 0.039
1.902IleAsn: 1.902 ± 0.036
2.477IlePro: 2.477 ± 0.045
1.508IleGln: 1.508 ± 0.035
3.251IleArg: 3.251 ± 0.042
3.724IleSer: 3.724 ± 0.063
2.998IleThr: 2.998 ± 0.053
4.131IleVal: 4.131 ± 0.063
0.722IleTrp: 0.722 ± 0.022
1.344IleTyr: 1.344 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
5.478LysAla: 5.478 ± 0.072
0.271LysCys: 0.271 ± 0.016
2.75LysAsp: 2.75 ± 0.047
2.554LysGlu: 2.554 ± 0.05
1.137LysPhe: 1.137 ± 0.029
3.565LysGly: 3.565 ± 0.053
0.835LysHis: 0.835 ± 0.026
2.335LysIle: 2.335 ± 0.049
2.084LysLys: 2.084 ± 0.051
4.088LysLeu: 4.088 ± 0.057
1.203LysMet: 1.203 ± 0.031
1.235LysAsn: 1.235 ± 0.036
2.358LysPro: 2.358 ± 0.045
1.732LysGln: 1.732 ± 0.043
2.829LysArg: 2.829 ± 0.048
2.623LysSer: 2.623 ± 0.046
2.382LysThr: 2.382 ± 0.045
3.0LysVal: 3.0 ± 0.052
0.463LysTrp: 0.463 ± 0.018
0.78LysTyr: 0.78 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
11.572LeuAla: 11.572 ± 0.108
1.008LeuCys: 1.008 ± 0.026
6.31LeuAsp: 6.31 ± 0.078
5.892LeuGlu: 5.892 ± 0.077
4.15LeuPhe: 4.15 ± 0.068
7.711LeuGly: 7.711 ± 0.097
1.894LeuHis: 1.894 ± 0.038
5.93LeuIle: 5.93 ± 0.096
4.532LeuLys: 4.532 ± 0.054
9.928LeuLeu: 9.928 ± 0.144
2.815LeuMet: 2.815 ± 0.051
3.056LeuAsn: 3.056 ± 0.056
5.142LeuPro: 5.142 ± 0.076
3.039LeuGln: 3.039 ± 0.046
5.46LeuArg: 5.46 ± 0.072
7.521LeuSer: 7.521 ± 0.092
5.848LeuThr: 5.848 ± 0.081
7.171LeuVal: 7.171 ± 0.107
1.113LeuTrp: 1.113 ± 0.033
2.375LeuTyr: 2.375 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
3.38MetAla: 3.38 ± 0.05
0.182MetCys: 0.182 ± 0.014
1.505MetAsp: 1.505 ± 0.036
1.466MetGlu: 1.466 ± 0.037
0.806MetPhe: 0.806 ± 0.027
2.221MetGly: 2.221 ± 0.041
0.523MetHis: 0.523 ± 0.019
1.814MetIle: 1.814 ± 0.033
1.305MetLys: 1.305 ± 0.031
2.815MetLeu: 2.815 ± 0.051
0.904MetMet: 0.904 ± 0.032
0.861MetAsn: 0.861 ± 0.029
1.561MetPro: 1.561 ± 0.037
1.043MetGln: 1.043 ± 0.026
1.811MetArg: 1.811 ± 0.042
1.95MetSer: 1.95 ± 0.038
1.962MetThr: 1.962 ± 0.039
2.062MetVal: 2.062 ± 0.043
0.2MetTrp: 0.2 ± 0.012
0.349MetTyr: 0.349 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.261AsnAla: 3.261 ± 0.052
0.305AsnCys: 0.305 ± 0.015
1.749AsnAsp: 1.749 ± 0.045
1.591AsnGlu: 1.591 ± 0.035
1.108AsnPhe: 1.108 ± 0.032
2.732AsnGly: 2.732 ± 0.056
0.716AsnHis: 0.716 ± 0.021
1.68AsnIle: 1.68 ± 0.037
1.294AsnLys: 1.294 ± 0.034
3.043AsnLeu: 3.043 ± 0.054
0.9AsnMet: 0.9 ± 0.023
0.987AsnAsn: 0.987 ± 0.034
1.955AsnPro: 1.955 ± 0.038
1.144AsnGln: 1.144 ± 0.032
1.967AsnArg: 1.967 ± 0.045
1.576AsnSer: 1.576 ± 0.038
1.273AsnThr: 1.273 ± 0.035
2.051AsnVal: 2.051 ± 0.046
0.524AsnTrp: 0.524 ± 0.02
0.769AsnTyr: 0.769 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
4.49ProAla: 4.49 ± 0.069
0.379ProCys: 0.379 ± 0.018
3.709ProAsp: 3.709 ± 0.065
3.152ProGlu: 3.152 ± 0.062
2.042ProPhe: 2.042 ± 0.04
3.311ProGly: 3.311 ± 0.051
1.1ProHis: 1.1 ± 0.031
2.612ProIle: 2.612 ± 0.046
1.953ProLys: 1.953 ± 0.045
4.38ProLeu: 4.38 ± 0.059
1.236ProMet: 1.236 ± 0.031
1.477ProAsn: 1.477 ± 0.035
1.75ProPro: 1.75 ± 0.047
1.641ProGln: 1.641 ± 0.036
2.052ProArg: 2.052 ± 0.049
2.911ProSer: 2.911 ± 0.055
2.44ProThr: 2.44 ± 0.043
3.669ProVal: 3.669 ± 0.058
0.555ProTrp: 0.555 ± 0.021
1.166ProTyr: 1.166 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.019GlnAla: 4.019 ± 0.057
0.252GlnCys: 0.252 ± 0.014
1.897GlnAsp: 1.897 ± 0.044
1.788GlnGlu: 1.788 ± 0.036
1.259GlnPhe: 1.259 ± 0.031
2.503GlnGly: 2.503 ± 0.042
0.681GlnHis: 0.681 ± 0.025
2.252GlnIle: 2.252 ± 0.048
1.603GlnLys: 1.603 ± 0.038
3.251GlnLeu: 3.251 ± 0.051
1.2GlnMet: 1.2 ± 0.034
1.026GlnAsn: 1.026 ± 0.03
1.721GlnPro: 1.721 ± 0.04
1.586GlnGln: 1.586 ± 0.045
2.162GlnArg: 2.162 ± 0.046
2.519GlnSer: 2.519 ± 0.049
2.157GlnThr: 2.157 ± 0.04
2.314GlnVal: 2.314 ± 0.048
0.449GlnTrp: 0.449 ± 0.019
0.644GlnTyr: 0.644 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
5.767ArgAla: 5.767 ± 0.069
0.468ArgCys: 0.468 ± 0.021
3.52ArgAsp: 3.52 ± 0.061
3.266ArgGlu: 3.266 ± 0.056
2.551ArgPhe: 2.551 ± 0.044
3.643ArgGly: 3.643 ± 0.059
1.399ArgHis: 1.399 ± 0.035
3.635ArgIle: 3.635 ± 0.052
2.643ArgLys: 2.643 ± 0.049
6.534ArgLeu: 6.534 ± 0.076
1.771ArgMet: 1.771 ± 0.039
1.92ArgAsn: 1.92 ± 0.039
2.558ArgPro: 2.558 ± 0.052
2.404ArgGln: 2.404 ± 0.044
3.694ArgArg: 3.694 ± 0.063
3.469ArgSer: 3.469 ± 0.051
2.793ArgThr: 2.793 ± 0.048
3.797ArgVal: 3.797 ± 0.058
0.739ArgTrp: 0.739 ± 0.025
1.486ArgTyr: 1.486 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
5.88SerAla: 5.88 ± 0.073
0.539SerCys: 0.539 ± 0.021
3.769SerAsp: 3.769 ± 0.061
3.474SerGlu: 3.474 ± 0.048
2.632SerPhe: 2.632 ± 0.05
5.437SerGly: 5.437 ± 0.055
1.46SerHis: 1.46 ± 0.031
3.571SerIle: 3.571 ± 0.058
2.467SerLys: 2.467 ± 0.05
6.569SerLeu: 6.569 ± 0.087
1.718SerMet: 1.718 ± 0.036
1.963SerAsn: 1.963 ± 0.043
2.577SerPro: 2.577 ± 0.051
2.1SerGln: 2.1 ± 0.046
3.316SerArg: 3.316 ± 0.049
3.47SerSer: 3.47 ± 0.065
2.709SerThr: 2.709 ± 0.048
4.231SerVal: 4.231 ± 0.059
0.791SerTrp: 0.791 ± 0.025
1.497SerTyr: 1.497 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.293ThrAla: 5.293 ± 0.066
0.485ThrCys: 0.485 ± 0.02
2.995ThrAsp: 2.995 ± 0.049
2.84ThrGlu: 2.84 ± 0.052
2.028ThrPhe: 2.028 ± 0.034
4.647ThrGly: 4.647 ± 0.057
1.094ThrHis: 1.094 ± 0.031
3.427ThrIle: 3.427 ± 0.058
2.153ThrLys: 2.153 ± 0.043
5.648ThrLeu: 5.648 ± 0.068
1.377ThrMet: 1.377 ± 0.034
1.631ThrAsn: 1.631 ± 0.039
2.703ThrPro: 2.703 ± 0.058
1.54ThrGln: 1.54 ± 0.038
2.729ThrArg: 2.729 ± 0.046
3.074ThrSer: 3.074 ± 0.049
2.496ThrThr: 2.496 ± 0.048
3.662ThrVal: 3.662 ± 0.061
0.536ThrTrp: 0.536 ± 0.02
1.286ThrTyr: 1.286 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
7.773ValAla: 7.773 ± 0.08
0.675ValCys: 0.675 ± 0.024
4.129ValAsp: 4.129 ± 0.059
4.34ValGlu: 4.34 ± 0.065
2.598ValPhe: 2.598 ± 0.045
5.332ValGly: 5.332 ± 0.071
1.296ValHis: 1.296 ± 0.032
4.27ValIle: 4.27 ± 0.066
2.844ValLys: 2.844 ± 0.055
6.404ValLeu: 6.404 ± 0.09
2.061ValMet: 2.061 ± 0.046
2.074ValAsn: 2.074 ± 0.041
3.233ValPro: 3.233 ± 0.052
1.989ValGln: 1.989 ± 0.038
3.901ValArg: 3.901 ± 0.058
4.637ValSer: 4.637 ± 0.057
4.264ValThr: 4.264 ± 0.07
4.98ValVal: 4.98 ± 0.068
0.842ValTrp: 0.842 ± 0.025
1.471ValTyr: 1.471 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.025TrpAla: 1.025 ± 0.029
0.124TrpCys: 0.124 ± 0.01
0.658TrpAsp: 0.658 ± 0.021
0.532TrpGlu: 0.532 ± 0.02
0.546TrpPhe: 0.546 ± 0.024
0.874TrpGly: 0.874 ± 0.027
0.382TrpHis: 0.382 ± 0.018
0.713TrpIle: 0.713 ± 0.024
0.498TrpLys: 0.498 ± 0.019
1.502TrpLeu: 1.502 ± 0.038
0.388TrpMet: 0.388 ± 0.019
0.418TrpAsn: 0.418 ± 0.017
0.622TrpPro: 0.622 ± 0.022
0.667TrpGln: 0.667 ± 0.024
0.791TrpArg: 0.791 ± 0.021
0.784TrpSer: 0.784 ± 0.025
0.667TrpThr: 0.667 ± 0.024
0.806TrpVal: 0.806 ± 0.026
0.183TrpTrp: 0.183 ± 0.011
0.275TrpTyr: 0.275 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.292TyrAla: 2.292 ± 0.041
0.32TyrCys: 0.32 ± 0.015
1.566TyrAsp: 1.566 ± 0.038
1.312TyrGlu: 1.312 ± 0.038
1.012TyrPhe: 1.012 ± 0.027
2.088TyrGly: 2.088 ± 0.045
0.597TyrHis: 0.597 ± 0.019
1.11TyrIle: 1.11 ± 0.032
0.855TyrLys: 0.855 ± 0.027
2.451TyrLeu: 2.451 ± 0.044
0.533TyrMet: 0.533 ± 0.02
0.718TyrAsn: 0.718 ± 0.025
1.099TyrPro: 1.099 ± 0.032
0.966TyrGln: 0.966 ± 0.027
1.658TyrArg: 1.658 ± 0.038
1.368TyrSer: 1.368 ± 0.035
0.971TyrThr: 0.971 ± 0.028
1.652TyrVal: 1.652 ± 0.039
0.366TyrTrp: 0.366 ± 0.017
0.668TyrTyr: 0.668 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3998 proteins (1310659 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski