Amino acid dipepetide frequency for Frisingicoccus caecimuris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.234AlaAla: 7.234 ± 0.152	1.126AlaCys: 1.126 ± 0.041	4.438AlaAsp: 4.438 ± 0.091	5.785AlaGlu: 5.785 ± 0.096	3.06AlaPhe: 3.06 ± 0.063	6.154AlaGly: 6.154 ± 0.108	1.157AlaHis: 1.157 ± 0.037	5.037AlaIle: 5.037 ± 0.097	4.408AlaLys: 4.408 ± 0.074	7.041AlaLeu: 7.041 ± 0.107	2.562AlaMet: 2.562 ± 0.066	2.458AlaAsn: 2.458 ± 0.052	2.024AlaPro: 2.024 ± 0.058	2.189AlaGln: 2.189 ± 0.057	3.289AlaArg: 3.289 ± 0.066	3.857AlaSer: 3.857 ± 0.069	3.108AlaThr: 3.108 ± 0.069	6.023AlaVal: 6.023 ± 0.11	0.61AlaTrp: 0.61 ± 0.032	2.772AlaTyr: 2.772 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.004CysAla: 1.004 ± 0.034	0.277CysCys: 0.277 ± 0.019	0.809CysAsp: 0.809 ± 0.034	0.943CysGlu: 0.943 ± 0.032	0.635CysPhe: 0.635 ± 0.026	1.596CysGly: 1.596 ± 0.051	0.343CysHis: 0.343 ± 0.02	1.136CysIle: 1.136 ± 0.036	0.748CysLys: 0.748 ± 0.034	1.235CysLeu: 1.235 ± 0.044	0.432CysMet: 0.432 ± 0.021	0.469CysAsn: 0.469 ± 0.027	0.684CysPro: 0.684 ± 0.032	0.481CysGln: 0.481 ± 0.024	0.792CysArg: 0.792 ± 0.036	0.853CysSer: 0.853 ± 0.036	0.726CysThr: 0.726 ± 0.031	1.034CysVal: 1.034 ± 0.037	0.098CysTrp: 0.098 ± 0.011	0.505CysTyr: 0.505 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.148AspAla: 4.148 ± 0.079	0.767AspCys: 0.767 ± 0.034	2.924AspAsp: 2.924 ± 0.069	4.86AspGlu: 4.86 ± 0.077	2.679AspPhe: 2.679 ± 0.068	4.456AspGly: 4.456 ± 0.099	0.898AspHis: 0.898 ± 0.038	5.015AspIle: 5.015 ± 0.073	3.489AspLys: 3.489 ± 0.078	4.651AspLeu: 4.651 ± 0.079	2.078AspMet: 2.078 ± 0.057	2.054AspAsn: 2.054 ± 0.056	1.636AspPro: 1.636 ± 0.041	1.234AspGln: 1.234 ± 0.04	2.434AspArg: 2.434 ± 0.061	3.137AspSer: 3.137 ± 0.066	2.932AspThr: 2.932 ± 0.072	4.215AspVal: 4.215 ± 0.072	0.529AspTrp: 0.529 ± 0.03	2.888AspTyr: 2.888 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	6.071GluAla: 6.071 ± 0.118	0.789GluCys: 0.789 ± 0.031	4.326GluAsp: 4.326 ± 0.087	6.703GluGlu: 6.703 ± 0.119	2.578GluPhe: 2.578 ± 0.058	4.526GluGly: 4.526 ± 0.078	1.425GluHis: 1.425 ± 0.043	5.841GluIle: 5.841 ± 0.079	6.524GluLys: 6.524 ± 0.102	6.583GluLeu: 6.583 ± 0.091	2.685GluMet: 2.685 ± 0.053	4.128GluAsn: 4.128 ± 0.068	2.056GluPro: 2.056 ± 0.055	2.781GluGln: 2.781 ± 0.059	3.856GluArg: 3.856 ± 0.083	3.582GluSer: 3.582 ± 0.081	4.358GluThr: 4.358 ± 0.091	4.666GluVal: 4.666 ± 0.073	0.706GluTrp: 0.706 ± 0.029	3.032GluTyr: 3.032 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.752PheAla: 2.752 ± 0.071	0.738PheCys: 0.738 ± 0.034	2.458PheAsp: 2.458 ± 0.059	2.738PheGlu: 2.738 ± 0.065	1.627PhePhe: 1.627 ± 0.043	3.185PheGly: 3.185 ± 0.066	0.848PheHis: 0.848 ± 0.033	3.063PheIle: 3.063 ± 0.071	2.205PheLys: 2.205 ± 0.054	3.514PheLeu: 3.514 ± 0.076	1.272PheMet: 1.272 ± 0.04	1.594PheAsn: 1.594 ± 0.051	1.305PhePro: 1.305 ± 0.048	1.291PheGln: 1.291 ± 0.043	1.747PheArg: 1.747 ± 0.045	2.709PheSer: 2.709 ± 0.061	2.203PheThr: 2.203 ± 0.057	2.771PheVal: 2.771 ± 0.054	0.386PheTrp: 0.386 ± 0.021	1.677PheTyr: 1.677 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	5.145GlyAla: 5.145 ± 0.114	1.317GlyCys: 1.317 ± 0.051	3.62GlyAsp: 3.62 ± 0.075	4.783GlyGlu: 4.783 ± 0.071	3.095GlyPhe: 3.095 ± 0.067	4.998GlyGly: 4.998 ± 0.105	1.387GlyHis: 1.387 ± 0.049	6.238GlyIle: 6.238 ± 0.094	5.34GlyLys: 5.34 ± 0.09	6.21GlyLeu: 6.21 ± 0.098	2.541GlyMet: 2.541 ± 0.056	3.087GlyAsn: 3.087 ± 0.076	1.414GlyPro: 1.414 ± 0.042	2.362GlyGln: 2.362 ± 0.06	3.487GlyArg: 3.487 ± 0.066	3.861GlySer: 3.861 ± 0.081	4.228GlyThr: 4.228 ± 0.09	5.164GlyVal: 5.164 ± 0.092	0.738GlyTrp: 0.738 ± 0.037	3.191GlyTyr: 3.191 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.052HisAla: 1.052 ± 0.041	0.308HisCys: 0.308 ± 0.019	0.784HisAsp: 0.784 ± 0.034	1.184HisGlu: 1.184 ± 0.047	0.852HisPhe: 0.852 ± 0.035	1.367HisGly: 1.367 ± 0.04	0.457HisHis: 0.457 ± 0.03	1.471HisIle: 1.471 ± 0.045	0.927HisLys: 0.927 ± 0.034	1.701HisLeu: 1.701 ± 0.043	0.648HisMet: 0.648 ± 0.028	0.69HisAsn: 0.69 ± 0.029	0.965HisPro: 0.965 ± 0.037	0.65HisGln: 0.65 ± 0.025	0.889HisArg: 0.889 ± 0.031	0.997HisSer: 0.997 ± 0.038	0.948HisThr: 0.948 ± 0.032	1.175HisVal: 1.175 ± 0.035	0.175HisTrp: 0.175 ± 0.013	0.727HisTyr: 0.727 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.397IleAla: 5.397 ± 0.093	1.471IleCys: 1.471 ± 0.039	4.195IleAsp: 4.195 ± 0.084	5.066IleGlu: 5.066 ± 0.084	3.197IlePhe: 3.197 ± 0.072	5.439IleGly: 5.439 ± 0.106	1.609IleHis: 1.609 ± 0.047	5.395IleIle: 5.395 ± 0.102	3.963IleLys: 3.963 ± 0.075	7.239IleLeu: 7.239 ± 0.105	1.988IleMet: 1.988 ± 0.051	2.827IleAsn: 2.827 ± 0.062	3.194IlePro: 3.194 ± 0.059	2.763IleGln: 2.763 ± 0.058	4.054IleArg: 4.054 ± 0.072	5.057IleSer: 5.057 ± 0.081	3.85IleThr: 3.85 ± 0.081	5.013IleVal: 5.013 ± 0.074	0.6IleTrp: 0.6 ± 0.03	2.989IleTyr: 2.989 ± 0.068	0.0IleXaa: 0.0 ± 0.0
Lys	5.105LysAla: 5.105 ± 0.094	0.657LysCys: 0.657 ± 0.029	4.047LysAsp: 4.047 ± 0.078	5.992LysGlu: 5.992 ± 0.092	1.836LysPhe: 1.836 ± 0.047	3.906LysGly: 3.906 ± 0.073	1.069LysHis: 1.069 ± 0.038	4.867LysIle: 4.867 ± 0.084	5.699LysLys: 5.699 ± 0.095	5.2LysLeu: 5.2 ± 0.077	2.261LysMet: 2.261 ± 0.051	3.536LysAsn: 3.536 ± 0.063	2.037LysPro: 2.037 ± 0.052	2.237LysGln: 2.237 ± 0.064	3.079LysArg: 3.079 ± 0.059	3.36LysSer: 3.36 ± 0.067	3.661LysThr: 3.661 ± 0.075	4.3LysVal: 4.3 ± 0.079	0.506LysTrp: 0.506 ± 0.021	2.792LysTyr: 2.792 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	6.578LeuAla: 6.578 ± 0.09	1.395LeuCys: 1.395 ± 0.042	5.127LeuAsp: 5.127 ± 0.074	6.305LeuGlu: 6.305 ± 0.1	3.57LeuPhe: 3.57 ± 0.079	5.907LeuGly: 5.907 ± 0.085	1.435LeuHis: 1.435 ± 0.045	6.269LeuIle: 6.269 ± 0.092	6.291LeuLys: 6.291 ± 0.114	7.786LeuLeu: 7.786 ± 0.122	2.889LeuMet: 2.889 ± 0.063	4.047LeuAsn: 4.047 ± 0.078	3.385LeuPro: 3.385 ± 0.077	2.621LeuGln: 2.621 ± 0.055	3.936LeuArg: 3.936 ± 0.074	6.041LeuSer: 6.041 ± 0.098	4.906LeuThr: 4.906 ± 0.09	5.407LeuVal: 5.407 ± 0.092	0.779LeuTrp: 0.779 ± 0.032	3.15LeuTyr: 3.15 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.836MetAla: 2.836 ± 0.065	0.368MetCys: 0.368 ± 0.019	2.227MetAsp: 2.227 ± 0.057	2.809MetGlu: 2.809 ± 0.058	1.078MetPhe: 1.078 ± 0.036	2.266MetGly: 2.266 ± 0.058	0.418MetHis: 0.418 ± 0.024	2.299MetIle: 2.299 ± 0.057	2.613MetLys: 2.613 ± 0.052	2.658MetLeu: 2.658 ± 0.058	1.111MetMet: 1.111 ± 0.036	1.824MetAsn: 1.824 ± 0.047	1.172MetPro: 1.172 ± 0.037	0.952MetGln: 0.952 ± 0.033	1.418MetArg: 1.418 ± 0.045	1.894MetSer: 1.894 ± 0.048	1.902MetThr: 1.902 ± 0.048	2.2MetVal: 2.2 ± 0.047	0.188MetTrp: 0.188 ± 0.014	0.96MetTyr: 0.96 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	2.875AsnAla: 2.875 ± 0.062	0.618AsnCys: 0.618 ± 0.032	2.191AsnAsp: 2.191 ± 0.055	2.827AsnGlu: 2.827 ± 0.065	1.62AsnPhe: 1.62 ± 0.044	3.36AsnGly: 3.36 ± 0.089	0.871AsnHis: 0.871 ± 0.036	3.446AsnIle: 3.446 ± 0.065	2.442AsnLys: 2.442 ± 0.056	3.599AsnLeu: 3.599 ± 0.063	1.444AsnMet: 1.444 ± 0.039	1.775AsnAsn: 1.775 ± 0.083	1.966AsnPro: 1.966 ± 0.046	1.506AsnGln: 1.506 ± 0.044	2.181AsnArg: 2.181 ± 0.051	2.248AsnSer: 2.248 ± 0.057	2.184AsnThr: 2.184 ± 0.062	2.993AsnVal: 2.993 ± 0.056	0.379AsnTrp: 0.379 ± 0.021	1.828AsnTyr: 1.828 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	2.282ProAla: 2.282 ± 0.058	0.381ProCys: 0.381 ± 0.024	2.202ProAsp: 2.202 ± 0.054	3.859ProGlu: 3.859 ± 0.076	1.503ProPhe: 1.503 ± 0.051	2.392ProGly: 2.392 ± 0.057	0.507ProHis: 0.507 ± 0.026	2.171ProIle: 2.171 ± 0.061	2.06ProLys: 2.06 ± 0.05	2.69ProLeu: 2.69 ± 0.059	1.029ProMet: 1.029 ± 0.038	1.227ProAsn: 1.227 ± 0.04	0.767ProPro: 0.767 ± 0.031	0.963ProGln: 0.963 ± 0.037	1.053ProArg: 1.053 ± 0.035	1.802ProSer: 1.802 ± 0.049	1.675ProThr: 1.675 ± 0.047	3.077ProVal: 3.077 ± 0.065	0.286ProTrp: 0.286 ± 0.02	1.417ProTyr: 1.417 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.513GlnAla: 2.513 ± 0.061	0.374GlnCys: 0.374 ± 0.023	1.554GlnAsp: 1.554 ± 0.045	2.512GlnGlu: 2.512 ± 0.061	1.134GlnPhe: 1.134 ± 0.037	1.997GlnGly: 1.997 ± 0.051	0.486GlnHis: 0.486 ± 0.023	2.713GlnIle: 2.713 ± 0.06	2.561GlnLys: 2.561 ± 0.06	2.743GlnLeu: 2.743 ± 0.066	1.36GlnMet: 1.36 ± 0.049	1.456GlnAsn: 1.456 ± 0.037	0.937GlnPro: 0.937 ± 0.036	1.141GlnGln: 1.141 ± 0.042	1.608GlnArg: 1.608 ± 0.049	1.61GlnSer: 1.61 ± 0.048	1.694GlnThr: 1.694 ± 0.046	2.231GlnVal: 2.231 ± 0.048	0.389GlnTrp: 0.389 ± 0.022	1.222GlnTyr: 1.222 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.891ArgAla: 2.891 ± 0.069	0.673ArgCys: 0.673 ± 0.031	2.381ArgAsp: 2.381 ± 0.062	4.159ArgGlu: 4.159 ± 0.086	1.892ArgPhe: 1.892 ± 0.047	2.783ArgGly: 2.783 ± 0.069	0.899ArgHis: 0.899 ± 0.033	3.792ArgIle: 3.792 ± 0.07	3.57ArgLys: 3.57 ± 0.066	4.347ArgLeu: 4.347 ± 0.078	1.807ArgMet: 1.807 ± 0.049	2.059ArgAsn: 2.059 ± 0.05	1.55ArgPro: 1.55 ± 0.042	1.96ArgGln: 1.96 ± 0.054	2.722ArgArg: 2.722 ± 0.069	2.202ArgSer: 2.202 ± 0.052	2.294ArgThr: 2.294 ± 0.048	2.933ArgVal: 2.933 ± 0.057	0.452ArgTrp: 0.452 ± 0.025	1.928ArgTyr: 1.928 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.047SerAla: 4.047 ± 0.07	0.806SerCys: 0.806 ± 0.033	3.365SerAsp: 3.365 ± 0.08	4.236SerGlu: 4.236 ± 0.086	2.447SerPhe: 2.447 ± 0.063	5.154SerGly: 5.154 ± 0.087	1.031SerHis: 1.031 ± 0.034	3.96SerIle: 3.96 ± 0.078	3.224SerLys: 3.224 ± 0.065	5.048SerLeu: 5.048 ± 0.082	1.842SerMet: 1.842 ± 0.048	2.112SerAsn: 2.112 ± 0.054	1.684SerPro: 1.684 ± 0.042	1.812SerGln: 1.812 ± 0.045	2.906SerArg: 2.906 ± 0.064	3.295SerSer: 3.295 ± 0.066	2.622SerThr: 2.622 ± 0.061	4.299SerVal: 4.299 ± 0.083	0.567SerTrp: 0.567 ± 0.028	2.202SerTyr: 2.202 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.324ThrAla: 4.324 ± 0.093	0.715ThrCys: 0.715 ± 0.033	3.159ThrAsp: 3.159 ± 0.07	3.95ThrGlu: 3.95 ± 0.093	2.068ThrPhe: 2.068 ± 0.057	4.585ThrGly: 4.585 ± 0.087	0.927ThrHis: 0.927 ± 0.033	3.718ThrIle: 3.718 ± 0.069	2.905ThrLys: 2.905 ± 0.061	4.735ThrLeu: 4.735 ± 0.091	1.55ThrMet: 1.55 ± 0.045	1.997ThrAsn: 1.997 ± 0.052	2.111ThrPro: 2.111 ± 0.049	1.455ThrGln: 1.455 ± 0.048	2.101ThrArg: 2.101 ± 0.045	2.936ThrSer: 2.936 ± 0.073	2.812ThrThr: 2.812 ± 0.076	4.309ThrVal: 4.309 ± 0.081	0.484ThrTrp: 0.484 ± 0.025	2.054ThrTyr: 2.054 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.842ValAla: 4.842 ± 0.093	1.31ValCys: 1.31 ± 0.043	4.156ValAsp: 4.156 ± 0.077	4.876ValGlu: 4.876 ± 0.085	3.051ValPhe: 3.051 ± 0.066	4.456ValGly: 4.456 ± 0.083	1.251ValHis: 1.251 ± 0.043	5.295ValIle: 5.295 ± 0.075	4.276ValLys: 4.276 ± 0.076	6.509ValLeu: 6.509 ± 0.091	2.063ValMet: 2.063 ± 0.051	2.842ValAsn: 2.842 ± 0.067	2.673ValPro: 2.673 ± 0.057	2.006ValGln: 2.006 ± 0.054	3.247ValArg: 3.247 ± 0.072	4.53ValSer: 4.53 ± 0.078	4.157ValThr: 4.157 ± 0.07	4.932ValVal: 4.932 ± 0.085	0.626ValTrp: 0.626 ± 0.029	2.754ValTyr: 2.754 ± 0.066	0.0ValXaa: 0.0 ± 0.0
Trp	0.535TrpAla: 0.535 ± 0.024	0.148TrpCys: 0.148 ± 0.013	0.456TrpAsp: 0.456 ± 0.022	0.655TrpGlu: 0.655 ± 0.027	0.385TrpPhe: 0.385 ± 0.022	0.621TrpGly: 0.621 ± 0.031	0.159TrpHis: 0.159 ± 0.014	0.663TrpIle: 0.663 ± 0.029	0.683TrpLys: 0.683 ± 0.026	0.911TrpLeu: 0.911 ± 0.032	0.338TrpMet: 0.338 ± 0.019	0.47TrpAsn: 0.47 ± 0.023	0.28TrpPro: 0.28 ± 0.016	0.36TrpGln: 0.36 ± 0.023	0.37TrpArg: 0.37 ± 0.023	0.43TrpSer: 0.43 ± 0.022	0.418TrpThr: 0.418 ± 0.022	0.492TrpVal: 0.492 ± 0.028	0.101TrpTrp: 0.101 ± 0.011	0.429TrpTyr: 0.429 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.702TyrAla: 2.702 ± 0.066	0.561TyrCys: 0.561 ± 0.027	2.603TyrAsp: 2.603 ± 0.057	2.974TyrGlu: 2.974 ± 0.065	1.776TyrPhe: 1.776 ± 0.052	3.057TyrGly: 3.057 ± 0.058	0.789TyrHis: 0.789 ± 0.029	2.916TyrIle: 2.916 ± 0.062	2.22TyrLys: 2.22 ± 0.056	3.428TyrLeu: 3.428 ± 0.074	1.29TyrMet: 1.29 ± 0.042	1.699TyrAsn: 1.699 ± 0.051	1.504TyrPro: 1.504 ± 0.041	1.471TyrGln: 1.471 ± 0.046	2.125TyrArg: 2.125 ± 0.052	2.26TyrSer: 2.26 ± 0.056	2.216TyrThr: 2.216 ± 0.058	2.616TyrVal: 2.616 ± 0.061	0.308TyrTrp: 0.308 ± 0.021	1.858TyrTyr: 1.858 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2610 proteins (818533 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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