Amino acid dipepetide frequency for Algibacter aquaticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.38AlaAla: 3.38 ± 0.071	0.554AlaCys: 0.554 ± 0.022	2.736AlaAsp: 2.736 ± 0.055	3.322AlaGlu: 3.322 ± 0.06	3.153AlaPhe: 3.153 ± 0.05	3.595AlaGly: 3.595 ± 0.073	0.991AlaHis: 0.991 ± 0.028	5.383AlaIle: 5.383 ± 0.076	4.443AlaLys: 4.443 ± 0.073	5.763AlaLeu: 5.763 ± 0.08	1.204AlaMet: 1.204 ± 0.034	3.458AlaAsn: 3.458 ± 0.053	1.725AlaPro: 1.725 ± 0.044	1.977AlaGln: 1.977 ± 0.047	1.726AlaArg: 1.726 ± 0.042	4.113AlaSer: 4.113 ± 0.07	3.329AlaThr: 3.329 ± 0.071	3.388AlaVal: 3.388 ± 0.053	0.56AlaTrp: 0.56 ± 0.02	2.412AlaTyr: 2.412 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.386CysAla: 0.386 ± 0.018	0.099CysCys: 0.099 ± 0.009	0.414CysAsp: 0.414 ± 0.021	0.487CysGlu: 0.487 ± 0.019	0.457CysPhe: 0.457 ± 0.019	0.583CysGly: 0.583 ± 0.025	0.184CysHis: 0.184 ± 0.014	0.64CysIle: 0.64 ± 0.024	0.585CysLys: 0.585 ± 0.023	0.683CysLeu: 0.683 ± 0.021	0.145CysMet: 0.145 ± 0.01	0.465CysAsn: 0.465 ± 0.02	0.315CysPro: 0.315 ± 0.021	0.211CysGln: 0.211 ± 0.013	0.198CysArg: 0.198 ± 0.014	0.597CysSer: 0.597 ± 0.027	0.438CysThr: 0.438 ± 0.024	0.434CysVal: 0.434 ± 0.021	0.084CysTrp: 0.084 ± 0.009	0.32CysTyr: 0.32 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.456AspAla: 3.456 ± 0.067	0.416AspCys: 0.416 ± 0.018	3.028AspAsp: 3.028 ± 0.057	3.37AspGlu: 3.37 ± 0.056	3.532AspPhe: 3.532 ± 0.06	3.438AspGly: 3.438 ± 0.067	0.839AspHis: 0.839 ± 0.027	5.055AspIle: 5.055 ± 0.066	4.374AspLys: 4.374 ± 0.068	5.305AspLeu: 5.305 ± 0.07	1.041AspMet: 1.041 ± 0.028	3.599AspAsn: 3.599 ± 0.06	1.588AspPro: 1.588 ± 0.043	1.284AspGln: 1.284 ± 0.041	1.793AspArg: 1.793 ± 0.035	3.267AspSer: 3.267 ± 0.063	2.844AspThr: 2.844 ± 0.053	3.529AspVal: 3.529 ± 0.054	0.723AspTrp: 0.723 ± 0.023	2.848AspTyr: 2.848 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.147GluAla: 4.147 ± 0.066	0.352GluCys: 0.352 ± 0.018	3.657GluAsp: 3.657 ± 0.061	4.42GluGlu: 4.42 ± 0.08	2.874GluPhe: 2.874 ± 0.048	3.542GluGly: 3.542 ± 0.058	1.142GluHis: 1.142 ± 0.031	5.378GluIle: 5.378 ± 0.068	5.693GluLys: 5.693 ± 0.083	5.924GluLeu: 5.924 ± 0.066	1.245GluMet: 1.245 ± 0.032	4.701GluAsn: 4.701 ± 0.064	1.43GluPro: 1.43 ± 0.035	2.077GluGln: 2.077 ± 0.048	2.302GluArg: 2.302 ± 0.049	3.541GluSer: 3.541 ± 0.067	3.887GluThr: 3.887 ± 0.061	4.062GluVal: 4.062 ± 0.06	0.559GluTrp: 0.559 ± 0.023	2.341GluTyr: 2.341 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.523PheAla: 2.523 ± 0.047	0.418PheCys: 0.418 ± 0.017	3.172PheAsp: 3.172 ± 0.061	3.186PheGlu: 3.186 ± 0.042	2.739PhePhe: 2.739 ± 0.053	3.338PheGly: 3.338 ± 0.059	0.866PheHis: 0.866 ± 0.027	4.31PheIle: 4.31 ± 0.065	4.475PheLys: 4.475 ± 0.067	4.579PheLeu: 4.579 ± 0.08	0.986PheMet: 0.986 ± 0.03	3.957PheAsn: 3.957 ± 0.069	1.545PhePro: 1.545 ± 0.037	1.407PheGln: 1.407 ± 0.035	1.491PheArg: 1.491 ± 0.036	4.169PheSer: 4.169 ± 0.071	3.122PheThr: 3.122 ± 0.063	2.912PheVal: 2.912 ± 0.056	0.539PheTrp: 0.539 ± 0.024	2.167PheTyr: 2.167 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	3.811GlyAla: 3.811 ± 0.064	0.58GlyCys: 0.58 ± 0.035	3.395GlyAsp: 3.395 ± 0.063	3.513GlyGlu: 3.513 ± 0.059	3.476GlyPhe: 3.476 ± 0.055	4.408GlyGly: 4.408 ± 0.09	1.146GlyHis: 1.146 ± 0.03	5.289GlyIle: 5.289 ± 0.077	4.927GlyLys: 4.927 ± 0.063	5.468GlyLeu: 5.468 ± 0.07	1.329GlyMet: 1.329 ± 0.032	3.912GlyAsn: 3.912 ± 0.065	1.195GlyPro: 1.195 ± 0.04	1.697GlyGln: 1.697 ± 0.035	2.035GlyArg: 2.035 ± 0.041	3.894GlySer: 3.894 ± 0.068	3.789GlyThr: 3.789 ± 0.071	4.17GlyVal: 4.17 ± 0.068	0.717GlyTrp: 0.717 ± 0.022	2.792GlyTyr: 2.792 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	0.939HisAla: 0.939 ± 0.03	0.19HisCys: 0.19 ± 0.01	0.855HisAsp: 0.855 ± 0.029	0.935HisGlu: 0.935 ± 0.029	1.144HisPhe: 1.144 ± 0.028	1.035HisGly: 1.035 ± 0.028	0.472HisHis: 0.472 ± 0.02	1.602HisIle: 1.602 ± 0.034	1.381HisLys: 1.381 ± 0.033	1.795HisLeu: 1.795 ± 0.035	0.303HisMet: 0.303 ± 0.016	1.049HisAsn: 1.049 ± 0.027	0.82HisPro: 0.82 ± 0.026	0.622HisGln: 0.622 ± 0.021	0.6HisArg: 0.6 ± 0.023	1.094HisSer: 1.094 ± 0.029	0.943HisThr: 0.943 ± 0.031	0.986HisVal: 0.986 ± 0.03	0.214HisTrp: 0.214 ± 0.013	0.87HisTyr: 0.87 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.265IleAla: 5.265 ± 0.079	0.677IleCys: 0.677 ± 0.025	5.387IleAsp: 5.387 ± 0.059	6.012IleGlu: 6.012 ± 0.08	3.706IlePhe: 3.706 ± 0.056	5.13IleGly: 5.13 ± 0.076	1.412IleHis: 1.412 ± 0.035	7.152IleIle: 7.152 ± 0.101	7.245IleLys: 7.245 ± 0.088	7.288IleLeu: 7.288 ± 0.089	1.401IleMet: 1.401 ± 0.039	5.967IleAsn: 5.967 ± 0.085	3.314IlePro: 3.314 ± 0.058	2.561IleGln: 2.561 ± 0.048	2.481IleArg: 2.481 ± 0.047	6.379IleSer: 6.379 ± 0.071	5.531IleThr: 5.531 ± 0.075	4.844IleVal: 4.844 ± 0.069	0.71IleTrp: 0.71 ± 0.025	3.12IleTyr: 3.12 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.042LysAla: 5.042 ± 0.082	0.381LysCys: 0.381 ± 0.017	4.915LysAsp: 4.915 ± 0.074	6.436LysGlu: 6.436 ± 0.08	3.123LysPhe: 3.123 ± 0.049	4.898LysGly: 4.898 ± 0.064	1.728LysHis: 1.728 ± 0.036	6.832LysIle: 6.832 ± 0.084	7.904LysLys: 7.904 ± 0.107	7.259LysLeu: 7.259 ± 0.094	1.912LysMet: 1.912 ± 0.038	6.165LysAsn: 6.165 ± 0.076	2.569LysPro: 2.569 ± 0.045	3.141LysGln: 3.141 ± 0.053	3.092LysArg: 3.092 ± 0.053	5.195LysSer: 5.195 ± 0.074	5.532LysThr: 5.532 ± 0.07	4.691LysVal: 4.691 ± 0.062	0.872LysTrp: 0.872 ± 0.027	3.293LysTyr: 3.293 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.014LeuAla: 5.014 ± 0.066	0.687LeuCys: 0.687 ± 0.026	5.079LeuAsp: 5.079 ± 0.066	6.083LeuGlu: 6.083 ± 0.08	4.88LeuPhe: 4.88 ± 0.073	5.608LeuGly: 5.608 ± 0.072	1.543LeuHis: 1.543 ± 0.033	7.326LeuIle: 7.326 ± 0.097	8.534LeuLys: 8.534 ± 0.104	8.464LeuLeu: 8.464 ± 0.096	1.825LeuMet: 1.825 ± 0.04	6.386LeuAsn: 6.386 ± 0.088	3.357LeuPro: 3.357 ± 0.059	3.056LeuGln: 3.056 ± 0.062	3.034LeuArg: 3.034 ± 0.05	6.72LeuSer: 6.72 ± 0.086	5.028LeuThr: 5.028 ± 0.071	4.99LeuVal: 4.99 ± 0.074	0.823LeuTrp: 0.823 ± 0.026	3.297LeuTyr: 3.297 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.324MetAla: 1.324 ± 0.036	0.152MetCys: 0.152 ± 0.009	0.95MetAsp: 0.95 ± 0.026	1.073MetGlu: 1.073 ± 0.03	0.85MetPhe: 0.85 ± 0.026	1.162MetGly: 1.162 ± 0.032	0.392MetHis: 0.392 ± 0.017	1.425MetIle: 1.425 ± 0.032	1.907MetLys: 1.907 ± 0.038	1.807MetLeu: 1.807 ± 0.042	0.481MetMet: 0.481 ± 0.019	1.202MetAsn: 1.202 ± 0.031	0.725MetPro: 0.725 ± 0.022	0.741MetGln: 0.741 ± 0.023	0.722MetArg: 0.722 ± 0.026	1.372MetSer: 1.372 ± 0.043	1.04MetThr: 1.04 ± 0.028	1.186MetVal: 1.186 ± 0.036	0.163MetTrp: 0.163 ± 0.01	0.71MetTyr: 0.71 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.838AsnAla: 3.838 ± 0.053	0.562AsnCys: 0.562 ± 0.025	3.791AsnAsp: 3.791 ± 0.058	3.994AsnGlu: 3.994 ± 0.059	3.215AsnPhe: 3.215 ± 0.067	4.279AsnGly: 4.279 ± 0.069	1.217AsnHis: 1.217 ± 0.031	6.23AsnIle: 6.23 ± 0.083	5.749AsnLys: 5.749 ± 0.088	6.04AsnLeu: 6.04 ± 0.083	1.27AsnMet: 1.27 ± 0.031	5.466AsnAsn: 5.466 ± 0.093	2.771AsnPro: 2.771 ± 0.054	2.229AsnGln: 2.229 ± 0.041	2.306AsnArg: 2.306 ± 0.048	4.418AsnSer: 4.418 ± 0.072	4.48AsnThr: 4.48 ± 0.074	3.673AsnVal: 3.673 ± 0.056	0.813AsnTrp: 0.813 ± 0.026	3.196AsnTyr: 3.196 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.571ProAla: 1.571 ± 0.05	0.213ProCys: 0.213 ± 0.013	1.865ProAsp: 1.865 ± 0.041	2.56ProGlu: 2.56 ± 0.051	1.83ProPhe: 1.83 ± 0.041	1.636ProGly: 1.636 ± 0.04	0.584ProHis: 0.584 ± 0.022	2.845ProIle: 2.845 ± 0.054	2.682ProLys: 2.682 ± 0.044	2.81ProLeu: 2.81 ± 0.045	0.619ProMet: 0.619 ± 0.023	2.517ProAsn: 2.517 ± 0.054	0.765ProPro: 0.765 ± 0.031	1.011ProGln: 1.011 ± 0.03	0.906ProArg: 0.906 ± 0.027	2.177ProSer: 2.177 ± 0.054	1.934ProThr: 1.934 ± 0.052	2.024ProVal: 2.024 ± 0.04	0.328ProTrp: 0.328 ± 0.016	1.326ProTyr: 1.326 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.768GlnAla: 1.768 ± 0.039	0.204GlnCys: 0.204 ± 0.014	1.611GlnAsp: 1.611 ± 0.035	2.248GlnGlu: 2.248 ± 0.051	1.663GlnPhe: 1.663 ± 0.035	1.814GlnGly: 1.814 ± 0.041	0.566GlnHis: 0.566 ± 0.02	2.619GlnIle: 2.619 ± 0.045	2.645GlnLys: 2.645 ± 0.049	3.255GlnLeu: 3.255 ± 0.058	0.66GlnMet: 0.66 ± 0.02	2.111GlnAsn: 2.111 ± 0.045	0.959GlnPro: 0.959 ± 0.026	1.208GlnGln: 1.208 ± 0.037	1.075GlnArg: 1.075 ± 0.029	1.837GlnSer: 1.837 ± 0.043	1.807GlnThr: 1.807 ± 0.041	1.863GlnVal: 1.863 ± 0.042	0.349GlnTrp: 0.349 ± 0.015	1.327GlnTyr: 1.327 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	1.875ArgAla: 1.875 ± 0.044	0.206ArgCys: 0.206 ± 0.013	1.687ArgAsp: 1.687 ± 0.037	2.016ArgGlu: 2.016 ± 0.049	1.836ArgPhe: 1.836 ± 0.037	1.902ArgGly: 1.902 ± 0.047	0.635ArgHis: 0.635 ± 0.023	2.797ArgIle: 2.797 ± 0.046	2.783ArgLys: 2.783 ± 0.056	3.124ArgLeu: 3.124 ± 0.053	0.724ArgMet: 0.724 ± 0.022	2.089ArgAsn: 2.089 ± 0.045	1.016ArgPro: 1.016 ± 0.028	1.005ArgGln: 1.005 ± 0.032	1.286ArgArg: 1.286 ± 0.036	1.919ArgSer: 1.919 ± 0.038	1.8ArgThr: 1.8 ± 0.038	2.02ArgVal: 2.02 ± 0.04	0.37ArgTrp: 0.37 ± 0.016	1.498ArgTyr: 1.498 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	3.363SerAla: 3.363 ± 0.053	0.685SerCys: 0.685 ± 0.023	3.432SerAsp: 3.432 ± 0.068	3.843SerGlu: 3.843 ± 0.055	3.939SerPhe: 3.939 ± 0.054	4.584SerGly: 4.584 ± 0.075	1.132SerHis: 1.132 ± 0.031	6.292SerIle: 6.292 ± 0.077	5.926SerLys: 5.926 ± 0.078	6.062SerLeu: 6.062 ± 0.079	1.213SerMet: 1.213 ± 0.032	4.775SerAsn: 4.775 ± 0.072	2.053SerPro: 2.053 ± 0.049	2.143SerGln: 2.143 ± 0.045	2.134SerArg: 2.134 ± 0.046	4.685SerSer: 4.685 ± 0.088	3.698SerThr: 3.698 ± 0.059	3.875SerVal: 3.875 ± 0.06	0.698SerTrp: 0.698 ± 0.026	2.846SerTyr: 2.846 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.274ThrAla: 3.274 ± 0.063	0.406ThrCys: 0.406 ± 0.022	3.101ThrAsp: 3.101 ± 0.053	3.267ThrGlu: 3.267 ± 0.05	3.074ThrPhe: 3.074 ± 0.063	3.997ThrGly: 3.997 ± 0.084	1.05ThrHis: 1.05 ± 0.03	5.515ThrIle: 5.515 ± 0.081	4.501ThrLys: 4.501 ± 0.061	5.613ThrLeu: 5.613 ± 0.075	0.937ThrMet: 0.937 ± 0.031	3.94ThrAsn: 3.94 ± 0.072	2.509ThrPro: 2.509 ± 0.06	1.868ThrGln: 1.868 ± 0.038	1.615ThrArg: 1.615 ± 0.035	4.194ThrSer: 4.194 ± 0.069	3.703ThrThr: 3.703 ± 0.073	3.713ThrVal: 3.713 ± 0.09	0.65ThrTrp: 0.65 ± 0.029	2.535ThrTyr: 2.535 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	3.44ValAla: 3.44 ± 0.06	0.49ValCys: 0.49 ± 0.02	3.404ValAsp: 3.404 ± 0.054	3.604ValGlu: 3.604 ± 0.063	3.421ValPhe: 3.421 ± 0.054	3.444ValGly: 3.444 ± 0.058	0.9ValHis: 0.9 ± 0.025	4.925ValIle: 4.925 ± 0.068	4.581ValLys: 4.581 ± 0.068	5.733ValLeu: 5.733 ± 0.075	1.114ValMet: 1.114 ± 0.032	3.831ValAsn: 3.831 ± 0.062	1.927ValPro: 1.927 ± 0.042	1.551ValGln: 1.551 ± 0.036	1.837ValArg: 1.837 ± 0.042	4.428ValSer: 4.428 ± 0.058	3.54ValThr: 3.54 ± 0.082	3.709ValVal: 3.709 ± 0.069	0.594ValTrp: 0.594 ± 0.022	2.313ValTyr: 2.313 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.547TrpAla: 0.547 ± 0.021	0.111TrpCys: 0.111 ± 0.01	0.567TrpAsp: 0.567 ± 0.019	0.664TrpGlu: 0.664 ± 0.025	0.591TrpPhe: 0.591 ± 0.022	0.636TrpGly: 0.636 ± 0.021	0.251TrpHis: 0.251 ± 0.013	0.77TrpIle: 0.77 ± 0.026	0.857TrpLys: 0.857 ± 0.029	0.942TrpLeu: 0.942 ± 0.03	0.272TrpMet: 0.272 ± 0.015	0.757TrpAsn: 0.757 ± 0.024	0.212TrpPro: 0.212 ± 0.014	0.393TrpGln: 0.393 ± 0.018	0.384TrpArg: 0.384 ± 0.018	0.657TrpSer: 0.657 ± 0.024	0.557TrpThr: 0.557 ± 0.027	0.628TrpVal: 0.628 ± 0.022	0.141TrpTrp: 0.141 ± 0.01	0.439TrpTyr: 0.439 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.249TyrAla: 2.249 ± 0.039	0.341TyrCys: 0.341 ± 0.017	2.283TyrAsp: 2.283 ± 0.045	2.24TyrGlu: 2.24 ± 0.043	2.399TyrPhe: 2.399 ± 0.052	2.515TyrGly: 2.515 ± 0.055	0.797TyrHis: 0.797 ± 0.027	3.191TyrIle: 3.191 ± 0.053	3.787TyrLys: 3.787 ± 0.061	3.819TyrLeu: 3.819 ± 0.06	0.702TyrMet: 0.702 ± 0.022	3.19TyrAsn: 3.19 ± 0.061	1.407TyrPro: 1.407 ± 0.037	1.409TyrGln: 1.409 ± 0.035	1.572TyrArg: 1.572 ± 0.037	2.725TyrSer: 2.725 ± 0.05	2.461TyrThr: 2.461 ± 0.049	2.093TyrVal: 2.093 ± 0.04	0.47TyrTrp: 0.47 ± 0.02	1.917TyrTyr: 1.917 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3717 proteins (1300701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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