Amino acid dipepetide frequency for Vanilla latent virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.35AlaAla: 5.35 ± 1.876
0.823AlaCys: 0.823 ± 0.458
1.235AlaAsp: 1.235 ± 0.683
4.115AlaGlu: 4.115 ± 0.706
2.058AlaPhe: 2.058 ± 0.47
4.527AlaGly: 4.527 ± 0.853
3.292AlaHis: 3.292 ± 0.831
7.407AlaIle: 7.407 ± 2.864
3.292AlaLys: 3.292 ± 1.264
7.819AlaLeu: 7.819 ± 1.803
0.823AlaMet: 0.823 ± 0.804
5.761AlaAsn: 5.761 ± 1.332
2.058AlaPro: 2.058 ± 0.811
4.527AlaGln: 4.527 ± 1.409
2.469AlaArg: 2.469 ± 0.953
3.292AlaSer: 3.292 ± 1.45
7.407AlaThr: 7.407 ± 2.229
2.881AlaVal: 2.881 ± 0.912
0.823AlaTrp: 0.823 ± 0.825
4.115AlaTyr: 4.115 ± 1.784
0.0AlaXaa: 0.0 ± 0.0
Cys
0.412CysAla: 0.412 ± 0.724
0.0CysCys: 0.0 ± 0.0
0.412CysAsp: 0.412 ± 0.228
0.412CysGlu: 0.412 ± 0.228
0.823CysPhe: 0.823 ± 0.455
0.412CysGly: 0.412 ± 0.228
1.646CysHis: 1.646 ± 1.1
0.412CysIle: 0.412 ± 0.895
0.412CysLys: 0.412 ± 0.228
0.823CysLeu: 0.823 ± 0.455
1.235CysMet: 1.235 ± 1.339
0.412CysAsn: 0.412 ± 0.228
2.058CysPro: 2.058 ± 0.817
0.412CysGln: 0.412 ± 0.228
0.0CysArg: 0.0 ± 0.0
0.823CysSer: 0.823 ± 0.455
1.235CysThr: 1.235 ± 1.346
0.0CysVal: 0.0 ± 0.0
0.412CysTrp: 0.412 ± 0.228
1.646CysTyr: 1.646 ± 0.802
0.0CysXaa: 0.0 ± 0.0
Asp
3.292AspAla: 3.292 ± 0.901
0.412AspCys: 0.412 ± 0.228
1.235AspAsp: 1.235 ± 0.426
4.115AspGlu: 4.115 ± 0.856
4.115AspPhe: 4.115 ± 1.069
2.058AspGly: 2.058 ± 0.776
1.646AspHis: 1.646 ± 0.767
2.058AspIle: 2.058 ± 0.791
3.292AspLys: 3.292 ± 0.865
4.115AspLeu: 4.115 ± 0.645
0.412AspMet: 0.412 ± 0.228
1.646AspAsn: 1.646 ± 0.691
1.646AspPro: 1.646 ± 0.575
4.938AspGln: 4.938 ± 1.087
1.235AspArg: 1.235 ± 0.467
2.881AspSer: 2.881 ± 0.703
3.704AspThr: 3.704 ± 1.331
3.292AspVal: 3.292 ± 1.347
0.412AspTrp: 0.412 ± 0.228
2.469AspTyr: 2.469 ± 1.366
0.0AspXaa: 0.0 ± 0.0
Glu
5.761GluAla: 5.761 ± 0.956
0.823GluCys: 0.823 ± 0.397
2.881GluAsp: 2.881 ± 0.899
2.469GluGlu: 2.469 ± 0.935
1.646GluPhe: 1.646 ± 1.049
2.058GluGly: 2.058 ± 0.74
0.412GluHis: 0.412 ± 0.228
4.115GluIle: 4.115 ± 1.68
4.115GluLys: 4.115 ± 1.803
7.407GluLeu: 7.407 ± 2.267
2.058GluMet: 2.058 ± 0.987
3.704GluAsn: 3.704 ± 2.049
2.058GluPro: 2.058 ± 1.138
1.235GluGln: 1.235 ± 0.426
2.469GluArg: 2.469 ± 0.536
3.292GluSer: 3.292 ± 1.009
3.292GluThr: 3.292 ± 0.854
2.881GluVal: 2.881 ± 0.68
0.823GluTrp: 0.823 ± 0.397
1.646GluTyr: 1.646 ± 0.575
0.0GluXaa: 0.0 ± 0.0
Phe
3.292PheAla: 3.292 ± 0.966
1.235PheCys: 1.235 ± 0.732
4.115PheAsp: 4.115 ± 1.069
3.292PheGlu: 3.292 ± 0.377
0.412PhePhe: 0.412 ± 0.622
0.823PheGly: 0.823 ± 0.458
2.058PheHis: 2.058 ± 0.428
3.704PheIle: 3.704 ± 2.083
2.469PheLys: 2.469 ± 0.931
3.292PheLeu: 3.292 ± 1.06
1.646PheMet: 1.646 ± 0.911
2.058PheAsn: 2.058 ± 0.735
1.235PhePro: 1.235 ± 0.683
1.235PheGln: 1.235 ± 1.05
1.646PheArg: 1.646 ± 1.1
0.823PheSer: 0.823 ± 0.455
2.058PheThr: 2.058 ± 0.47
2.881PheVal: 2.881 ± 0.937
0.0PheTrp: 0.0 ± 0.0
1.235PheTyr: 1.235 ± 0.683
0.0PheXaa: 0.0 ± 0.0
Gly
4.115GlyAla: 4.115 ± 1.356
1.235GlyCys: 1.235 ± 0.68
2.469GlyAsp: 2.469 ± 0.832
1.235GlyGlu: 1.235 ± 0.513
1.235GlyPhe: 1.235 ± 0.467
2.881GlyGly: 2.881 ± 0.912
1.235GlyHis: 1.235 ± 0.814
2.058GlyIle: 2.058 ± 0.428
2.469GlyLys: 2.469 ± 0.935
2.881GlyLeu: 2.881 ± 1.703
1.235GlyMet: 1.235 ± 0.513
4.115GlyAsn: 4.115 ± 1.565
1.646GlyPro: 1.646 ± 0.911
3.704GlyGln: 3.704 ± 0.953
1.646GlyArg: 1.646 ± 0.691
3.704GlySer: 3.704 ± 0.776
2.469GlyThr: 2.469 ± 0.93
2.058GlyVal: 2.058 ± 1.05
0.412GlyTrp: 0.412 ± 0.228
0.823GlyTyr: 0.823 ± 0.523
0.0GlyXaa: 0.0 ± 0.0
His
2.058HisAla: 2.058 ± 0.745
1.646HisCys: 1.646 ± 1.792
0.823HisAsp: 0.823 ± 0.397
2.058HisGlu: 2.058 ± 1.246
2.881HisPhe: 2.881 ± 1.594
3.704HisGly: 3.704 ± 1.124
0.823HisHis: 0.823 ± 0.665
2.058HisIle: 2.058 ± 0.74
0.412HisLys: 0.412 ± 0.228
2.881HisLeu: 2.881 ± 1.598
1.235HisMet: 1.235 ± 0.846
1.235HisAsn: 1.235 ± 1.175
1.235HisPro: 1.235 ± 1.128
1.646HisGln: 1.646 ± 0.911
3.292HisArg: 3.292 ± 1.635
3.704HisSer: 3.704 ± 2.886
1.646HisThr: 1.646 ± 0.911
1.235HisVal: 1.235 ± 1.372
0.0HisTrp: 0.0 ± 0.0
1.646HisTyr: 1.646 ± 0.575
0.0HisXaa: 0.0 ± 0.0
Ile
4.938IleAla: 4.938 ± 1.294
0.0IleCys: 0.0 ± 0.0
2.058IleAsp: 2.058 ± 0.791
3.704IleGlu: 3.704 ± 1.073
3.292IlePhe: 3.292 ± 0.713
2.881IleGly: 2.881 ± 0.662
2.058IleHis: 2.058 ± 1.187
3.292IleIle: 3.292 ± 1.149
4.115IleLys: 4.115 ± 0.706
4.115IleLeu: 4.115 ± 1.73
2.469IleMet: 2.469 ± 0.536
4.115IleAsn: 4.115 ± 2.581
4.115IlePro: 4.115 ± 1.797
4.527IleGln: 4.527 ± 1.072
2.881IleArg: 2.881 ± 0.68
4.115IleSer: 4.115 ± 2.591
6.996IleThr: 6.996 ± 1.4
2.058IleVal: 2.058 ± 0.955
0.412IleTrp: 0.412 ± 0.228
1.646IleTyr: 1.646 ± 0.691
0.0IleXaa: 0.0 ± 0.0
Lys
4.115LysAla: 4.115 ± 1.784
0.412LysCys: 0.412 ± 0.228
3.292LysAsp: 3.292 ± 0.889
2.469LysGlu: 2.469 ± 1.366
1.646LysPhe: 1.646 ± 0.915
1.235LysGly: 1.235 ± 0.513
0.412LysHis: 0.412 ± 0.228
2.881LysIle: 2.881 ± 0.345
1.646LysLys: 1.646 ± 0.575
6.996LysLeu: 6.996 ± 1.629
0.823LysMet: 0.823 ± 0.455
2.058LysAsn: 2.058 ± 0.745
4.527LysPro: 4.527 ± 1.461
2.058LysGln: 2.058 ± 0.854
3.704LysArg: 3.704 ± 1.249
3.292LysSer: 3.292 ± 0.58
4.938LysThr: 4.938 ± 1.327
2.881LysVal: 2.881 ± 0.899
0.0LysTrp: 0.0 ± 0.0
2.469LysTyr: 2.469 ± 1.027
0.0LysXaa: 0.0 ± 0.0
Leu
7.407LeuAla: 7.407 ± 1.198
1.646LeuCys: 1.646 ± 0.556
4.527LeuAsp: 4.527 ± 1.443
7.819LeuGlu: 7.819 ± 2.174
4.527LeuPhe: 4.527 ± 1.614
3.704LeuGly: 3.704 ± 1.113
4.527LeuHis: 4.527 ± 1.821
5.35LeuIle: 5.35 ± 1.076
4.115LeuLys: 4.115 ± 1.179
7.407LeuLeu: 7.407 ± 2.377
0.412LeuMet: 0.412 ± 0.622
1.646LeuAsn: 1.646 ± 0.45
6.173LeuPro: 6.173 ± 1.592
7.819LeuGln: 7.819 ± 2.855
4.938LeuArg: 4.938 ± 0.778
7.819LeuSer: 7.819 ± 1.615
7.819LeuThr: 7.819 ± 1.467
5.35LeuVal: 5.35 ± 1.629
0.823LeuTrp: 0.823 ± 0.455
2.058LeuTyr: 2.058 ± 0.428
0.0LeuXaa: 0.0 ± 0.0
Met
2.469MetAla: 2.469 ± 0.953
0.412MetCys: 0.412 ± 0.228
1.235MetAsp: 1.235 ± 0.633
1.235MetGlu: 1.235 ± 0.426
0.412MetPhe: 0.412 ± 0.228
0.412MetGly: 0.412 ± 0.228
0.823MetHis: 0.823 ± 0.804
0.823MetIle: 0.823 ± 1.244
1.646MetLys: 1.646 ± 0.616
2.058MetLeu: 2.058 ± 0.47
0.0MetMet: 0.0 ± 0.0
1.646MetAsn: 1.646 ± 0.509
3.704MetPro: 3.704 ± 0.959
1.235MetGln: 1.235 ± 0.683
1.235MetArg: 1.235 ± 0.513
2.058MetSer: 2.058 ± 0.956
0.412MetThr: 0.412 ± 0.228
1.646MetVal: 1.646 ± 0.598
0.412MetTrp: 0.412 ± 0.228
0.823MetTyr: 0.823 ± 0.523
0.0MetXaa: 0.0 ± 0.0
Asn
2.058AsnAla: 2.058 ± 0.735
2.058AsnCys: 2.058 ± 1.738
2.881AsnAsp: 2.881 ± 1.177
0.0AsnGlu: 0.0 ± 0.0
1.646AsnPhe: 1.646 ± 0.865
3.292AsnGly: 3.292 ± 1.018
0.823AsnHis: 0.823 ± 0.397
4.527AsnIle: 4.527 ± 1.024
2.058AsnLys: 2.058 ± 0.776
6.173AsnLeu: 6.173 ± 2.175
0.412AsnMet: 0.412 ± 0.622
2.058AsnAsn: 2.058 ± 0.791
3.292AsnPro: 3.292 ± 0.901
2.469AsnGln: 2.469 ± 1.718
2.058AsnArg: 2.058 ± 0.735
2.881AsnSer: 2.881 ± 1.146
4.527AsnThr: 4.527 ± 1.541
1.646AsnVal: 1.646 ± 0.556
0.823AsnTrp: 0.823 ± 0.523
0.823AsnTyr: 0.823 ± 0.455
0.0AsnXaa: 0.0 ± 0.0
Pro
4.527ProAla: 4.527 ± 1.574
0.0ProCys: 0.0 ± 0.0
4.115ProAsp: 4.115 ± 1.411
3.704ProGlu: 3.704 ± 1.069
2.881ProPhe: 2.881 ± 1.123
2.469ProGly: 2.469 ± 1.56
4.115ProHis: 4.115 ± 1.56
2.469ProIle: 2.469 ± 0.931
3.704ProLys: 3.704 ± 0.889
2.058ProLeu: 2.058 ± 0.571
2.058ProMet: 2.058 ± 1.429
1.235ProAsn: 1.235 ± 0.683
4.527ProPro: 4.527 ± 4.173
2.058ProGln: 2.058 ± 0.937
1.646ProArg: 1.646 ± 1.001
3.704ProSer: 3.704 ± 0.959
6.996ProThr: 6.996 ± 2.524
2.881ProVal: 2.881 ± 1.023
0.412ProTrp: 0.412 ± 0.228
2.469ProTyr: 2.469 ± 2.115
0.0ProXaa: 0.0 ± 0.0
Gln
4.115GlnAla: 4.115 ± 1.439
0.412GlnCys: 0.412 ± 0.622
2.469GlnAsp: 2.469 ± 0.854
2.469GlnGlu: 2.469 ± 1.558
1.646GlnPhe: 1.646 ± 0.82
1.646GlnGly: 1.646 ± 0.45
1.646GlnHis: 1.646 ± 1.001
3.292GlnIle: 3.292 ± 0.996
1.646GlnLys: 1.646 ± 0.509
4.938GlnLeu: 4.938 ± 1.206
2.881GlnMet: 2.881 ± 1.123
4.938GlnAsn: 4.938 ± 3.008
2.469GlnPro: 2.469 ± 0.997
3.704GlnGln: 3.704 ± 0.959
3.704GlnArg: 3.704 ± 1.069
4.938GlnSer: 4.938 ± 1.035
5.35GlnThr: 5.35 ± 1.835
3.704GlnVal: 3.704 ± 0.953
0.823GlnTrp: 0.823 ± 0.455
1.235GlnTyr: 1.235 ± 1.011
0.0GlnXaa: 0.0 ± 0.0
Arg
2.469ArgAla: 2.469 ± 0.447
0.0ArgCys: 0.0 ± 0.0
1.235ArgAsp: 1.235 ± 0.683
3.704ArgGlu: 3.704 ± 1.052
2.058ArgPhe: 2.058 ± 0.984
1.646ArgGly: 1.646 ± 1.046
2.058ArgHis: 2.058 ± 0.896
3.292ArgIle: 3.292 ± 1.035
2.058ArgLys: 2.058 ± 0.745
6.173ArgLeu: 6.173 ± 0.884
1.646ArgMet: 1.646 ± 0.627
1.235ArgAsn: 1.235 ± 0.859
2.881ArgPro: 2.881 ± 1.357
4.938ArgGln: 4.938 ± 1.386
2.881ArgArg: 2.881 ± 1.258
2.058ArgSer: 2.058 ± 0.74
3.292ArgThr: 3.292 ± 0.721
2.058ArgVal: 2.058 ± 0.811
0.412ArgTrp: 0.412 ± 0.487
0.823ArgTyr: 0.823 ± 0.397
0.0ArgXaa: 0.0 ± 0.0
Ser
5.35SerAla: 5.35 ± 1.111
0.412SerCys: 0.412 ± 0.228
6.584SerAsp: 6.584 ± 2.611
4.527SerGlu: 4.527 ± 0.913
2.469SerPhe: 2.469 ± 1.225
2.058SerGly: 2.058 ± 0.896
2.881SerHis: 2.881 ± 2.023
3.292SerIle: 3.292 ± 0.377
4.527SerLys: 4.527 ± 1.095
5.35SerLeu: 5.35 ± 1.409
1.646SerMet: 1.646 ± 0.628
1.235SerAsn: 1.235 ± 1.381
4.527SerPro: 4.527 ± 1.567
4.115SerGln: 4.115 ± 1.069
2.469SerArg: 2.469 ± 0.614
6.173SerSer: 6.173 ± 2.295
4.938SerThr: 4.938 ± 1.855
3.292SerVal: 3.292 ± 0.996
0.412SerTrp: 0.412 ± 0.724
3.704SerTyr: 3.704 ± 2.393
0.0SerXaa: 0.0 ± 0.0
Thr
6.173ThrAla: 6.173 ± 1.417
0.0ThrCys: 0.0 ± 0.0
4.115ThrAsp: 4.115 ± 1.437
5.35ThrGlu: 5.35 ± 1.552
3.292ThrPhe: 3.292 ± 0.729
2.881ThrGly: 2.881 ± 1.618
2.469ThrHis: 2.469 ± 0.753
5.35ThrIle: 5.35 ± 0.766
4.938ThrLys: 4.938 ± 0.893
10.7ThrLeu: 10.7 ± 1.897
1.235ThrMet: 1.235 ± 0.523
4.527ThrAsn: 4.527 ± 0.913
4.527ThrPro: 4.527 ± 1.057
4.115ThrGln: 4.115 ± 1.481
3.292ThrArg: 3.292 ± 1.167
6.173ThrSer: 6.173 ± 0.82
6.996ThrThr: 6.996 ± 1.991
3.292ThrVal: 3.292 ± 0.857
0.0ThrTrp: 0.0 ± 0.0
2.469ThrTyr: 2.469 ± 1.361
0.0ThrXaa: 0.0 ± 0.0
Val
2.058ValAla: 2.058 ± 1.913
0.823ValCys: 0.823 ± 0.523
1.235ValAsp: 1.235 ± 1.352
2.058ValGlu: 2.058 ± 1.124
1.235ValPhe: 1.235 ± 0.57
2.881ValGly: 2.881 ± 0.876
2.058ValHis: 2.058 ± 0.911
4.115ValIle: 4.115 ± 1.518
3.292ValLys: 3.292 ± 1.821
6.173ValLeu: 6.173 ± 1.817
1.235ValMet: 1.235 ± 0.513
2.058ValAsn: 2.058 ± 0.745
4.115ValPro: 4.115 ± 0.856
1.235ValGln: 1.235 ± 0.426
3.704ValArg: 3.704 ± 0.953
4.115ValSer: 4.115 ± 0.929
2.881ValThr: 2.881 ± 0.848
3.704ValVal: 3.704 ± 2.95
0.0ValTrp: 0.0 ± 0.0
0.823ValTyr: 0.823 ± 0.455
0.0ValXaa: 0.0 ± 0.0
Trp
0.412TrpAla: 0.412 ± 0.228
0.0TrpCys: 0.0 ± 0.0
0.412TrpAsp: 0.412 ± 0.228
0.0TrpGlu: 0.0 ± 0.0
0.412TrpPhe: 0.412 ± 0.228
0.0TrpGly: 0.0 ± 0.0
0.412TrpHis: 0.412 ± 0.724
0.823TrpIle: 0.823 ± 0.397
0.823TrpLys: 0.823 ± 0.455
1.235TrpLeu: 1.235 ± 0.513
0.0TrpMet: 0.0 ± 0.0
0.412TrpAsn: 0.412 ± 0.228
0.412TrpPro: 0.412 ± 0.228
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.412TrpSer: 0.412 ± 0.895
0.0TrpThr: 0.0 ± 0.0
1.646TrpVal: 1.646 ± 0.556
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.704TyrAla: 3.704 ± 1.331
1.646TyrCys: 1.646 ± 0.911
1.646TyrAsp: 1.646 ± 0.911
0.823TyrGlu: 0.823 ± 0.397
0.823TyrPhe: 0.823 ± 0.825
2.058TyrGly: 2.058 ± 0.781
0.823TyrHis: 0.823 ± 0.455
2.469TyrIle: 2.469 ± 1.769
0.823TyrLys: 0.823 ± 0.742
3.292TyrLeu: 3.292 ± 1.821
0.823TyrMet: 0.823 ± 0.455
0.412TyrAsn: 0.412 ± 0.622
0.823TyrPro: 0.823 ± 0.455
2.058TyrGln: 2.058 ± 1.187
1.646TyrArg: 1.646 ± 0.556
3.704TyrSer: 3.704 ± 1.197
4.938TyrThr: 4.938 ± 1.073
0.412TyrVal: 0.412 ± 0.228
0.0TyrTrp: 0.0 ± 0.0
0.823TyrTyr: 0.823 ± 0.523
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski