Amino acid dipepetide frequency for Limosilactobacillus fermentum (Lactobacillus fermentum)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.167AlaAla: 9.167 ± 0.171
0.544AlaCys: 0.544 ± 0.035
5.485AlaAsp: 5.485 ± 0.118
4.504AlaGlu: 4.504 ± 0.108
3.358AlaPhe: 3.358 ± 0.077
7.105AlaGly: 7.105 ± 0.112
1.88AlaHis: 1.88 ± 0.06
5.589AlaIle: 5.589 ± 0.103
6.316AlaLys: 6.316 ± 0.118
9.134AlaLeu: 9.134 ± 0.161
2.402AlaMet: 2.402 ± 0.076
3.956AlaAsn: 3.956 ± 0.095
3.326AlaPro: 3.326 ± 0.099
3.859AlaGln: 3.859 ± 0.088
3.622AlaArg: 3.622 ± 0.078
4.867AlaSer: 4.867 ± 0.133
6.41AlaThr: 6.41 ± 0.136
6.747AlaVal: 6.747 ± 0.123
0.914AlaTrp: 0.914 ± 0.043
2.735AlaTyr: 2.735 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.413CysAla: 0.413 ± 0.03
0.043CysCys: 0.043 ± 0.01
0.286CysAsp: 0.286 ± 0.024
0.26CysGlu: 0.26 ± 0.021
0.269CysPhe: 0.269 ± 0.026
0.644CysGly: 0.644 ± 0.037
0.213CysHis: 0.213 ± 0.024
0.252CysIle: 0.252 ± 0.023
0.126CysLys: 0.126 ± 0.016
0.608CysLeu: 0.608 ± 0.036
0.1CysMet: 0.1 ± 0.014
0.177CysAsn: 0.177 ± 0.018
0.318CysPro: 0.318 ± 0.028
0.345CysGln: 0.345 ± 0.026
0.217CysArg: 0.217 ± 0.02
0.318CysSer: 0.318 ± 0.022
0.283CysThr: 0.283 ± 0.024
0.379CysVal: 0.379 ± 0.029
0.083CysTrp: 0.083 ± 0.013
0.224CysTyr: 0.224 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.474AspAla: 4.474 ± 0.102
0.288AspCys: 0.288 ± 0.022
3.511AspAsp: 3.511 ± 0.104
3.746AspGlu: 3.746 ± 0.097
2.72AspPhe: 2.72 ± 0.082
3.784AspGly: 3.784 ± 0.088
1.673AspHis: 1.673 ± 0.054
2.584AspIle: 2.584 ± 0.079
2.635AspLys: 2.635 ± 0.076
6.321AspLeu: 6.321 ± 0.129
1.441AspMet: 1.441 ± 0.057
2.059AspAsn: 2.059 ± 0.065
2.558AspPro: 2.558 ± 0.08
4.101AspGln: 4.101 ± 0.113
3.074AspArg: 3.074 ± 0.075
2.341AspSer: 2.341 ± 0.061
2.53AspThr: 2.53 ± 0.065
3.901AspVal: 3.901 ± 0.105
0.848AspTrp: 0.848 ± 0.04
2.616AspTyr: 2.616 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.095GluAla: 5.095 ± 0.112
0.252GluCys: 0.252 ± 0.022
3.144GluAsp: 3.144 ± 0.101
4.244GluGlu: 4.244 ± 0.109
1.821GluPhe: 1.821 ± 0.053
3.296GluGly: 3.296 ± 0.104
1.394GluHis: 1.394 ± 0.055
3.447GluIle: 3.447 ± 0.082
3.309GluLys: 3.309 ± 0.091
5.939GluLeu: 5.939 ± 0.12
1.804GluMet: 1.804 ± 0.059
2.43GluAsn: 2.43 ± 0.079
1.757GluPro: 1.757 ± 0.057
3.202GluGln: 3.202 ± 0.089
3.343GluArg: 3.343 ± 0.1
2.221GluSer: 2.221 ± 0.066
2.82GluThr: 2.82 ± 0.081
4.242GluVal: 4.242 ± 0.102
0.546GluTrp: 0.546 ± 0.033
1.714GluTyr: 1.714 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.617PheAla: 3.617 ± 0.086
0.256PheCys: 0.256 ± 0.02
2.707PheAsp: 2.707 ± 0.073
2.113PheGlu: 2.113 ± 0.063
1.855PhePhe: 1.855 ± 0.071
3.227PheGly: 3.227 ± 0.077
0.878PheHis: 0.878 ± 0.04
2.443PheIle: 2.443 ± 0.074
2.202PheLys: 2.202 ± 0.06
3.645PheLeu: 3.645 ± 0.102
1.051PheMet: 1.051 ± 0.047
1.85PheAsn: 1.85 ± 0.06
1.467PhePro: 1.467 ± 0.05
1.162PheGln: 1.162 ± 0.04
1.313PheArg: 1.313 ± 0.049
2.473PheSer: 2.473 ± 0.073
2.524PheThr: 2.524 ± 0.072
2.972PheVal: 2.972 ± 0.086
0.48PheTrp: 0.48 ± 0.032
1.364PheTyr: 1.364 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
5.947GlyAla: 5.947 ± 0.112
0.411GlyCys: 0.411 ± 0.03
3.846GlyAsp: 3.846 ± 0.089
3.56GlyGlu: 3.56 ± 0.088
3.01GlyPhe: 3.01 ± 0.08
4.997GlyGly: 4.997 ± 0.122
1.863GlyHis: 1.863 ± 0.062
4.918GlyIle: 4.918 ± 0.11
4.074GlyLys: 4.074 ± 0.109
7.158GlyLeu: 7.158 ± 0.116
2.247GlyMet: 2.247 ± 0.069
2.624GlyAsn: 2.624 ± 0.074
2.017GlyPro: 2.017 ± 0.066
3.622GlyGln: 3.622 ± 0.091
3.277GlyArg: 3.277 ± 0.086
3.765GlySer: 3.765 ± 0.092
4.726GlyThr: 4.726 ± 0.114
5.591GlyVal: 5.591 ± 0.089
0.887GlyTrp: 0.887 ± 0.045
2.831GlyTyr: 2.831 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.605HisAla: 1.605 ± 0.056
0.168HisCys: 0.168 ± 0.02
1.337HisAsp: 1.337 ± 0.054
1.211HisGlu: 1.211 ± 0.049
1.072HisPhe: 1.072 ± 0.042
1.676HisGly: 1.676 ± 0.06
0.887HisHis: 0.887 ± 0.042
1.006HisIle: 1.006 ± 0.045
0.789HisLys: 0.789 ± 0.036
2.539HisLeu: 2.539 ± 0.083
0.501HisMet: 0.501 ± 0.033
0.857HisAsn: 0.857 ± 0.04
1.315HisPro: 1.315 ± 0.057
1.629HisGln: 1.629 ± 0.053
1.373HisArg: 1.373 ± 0.056
1.034HisSer: 1.034 ± 0.052
1.057HisThr: 1.057 ± 0.043
1.556HisVal: 1.556 ± 0.055
0.273HisTrp: 0.273 ± 0.022
1.111HisTyr: 1.111 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
5.489IleAla: 5.489 ± 0.124
0.426IleCys: 0.426 ± 0.028
3.956IleAsp: 3.956 ± 0.092
3.424IleGlu: 3.424 ± 0.098
2.287IlePhe: 2.287 ± 0.079
4.6IleGly: 4.6 ± 0.099
1.268IleHis: 1.268 ± 0.052
3.705IleIle: 3.705 ± 0.099
3.611IleLys: 3.611 ± 0.081
5.299IleLeu: 5.299 ± 0.103
1.522IleMet: 1.522 ± 0.047
2.912IleAsn: 2.912 ± 0.088
2.258IlePro: 2.258 ± 0.07
2.098IleGln: 2.098 ± 0.066
2.255IleArg: 2.255 ± 0.072
3.23IleSer: 3.23 ± 0.073
3.745IleThr: 3.745 ± 0.09
4.404IleVal: 4.404 ± 0.107
0.533IleTrp: 0.533 ± 0.032
1.872IleTyr: 1.872 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
4.351LysAla: 4.351 ± 0.096
0.183LysCys: 0.183 ± 0.02
3.479LysAsp: 3.479 ± 0.082
4.428LysGlu: 4.428 ± 0.106
1.609LysPhe: 1.609 ± 0.06
3.285LysGly: 3.285 ± 0.086
1.038LysHis: 1.038 ± 0.04
2.995LysIle: 2.995 ± 0.086
3.754LysLys: 3.754 ± 0.104
5.05LysLeu: 5.05 ± 0.111
2.015LysMet: 2.015 ± 0.058
2.434LysAsn: 2.434 ± 0.072
1.778LysPro: 1.778 ± 0.064
3.125LysGln: 3.125 ± 0.095
3.261LysArg: 3.261 ± 0.088
2.509LysSer: 2.509 ± 0.07
3.155LysThr: 3.155 ± 0.08
4.159LysVal: 4.159 ± 0.099
0.586LysTrp: 0.586 ± 0.033
2.074LysTyr: 2.074 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
10.995LeuAla: 10.995 ± 0.185
0.542LeuCys: 0.542 ± 0.034
5.449LeuAsp: 5.449 ± 0.108
4.879LeuGlu: 4.879 ± 0.105
3.811LeuPhe: 3.811 ± 0.108
7.199LeuGly: 7.199 ± 0.122
1.944LeuHis: 1.944 ± 0.053
6.188LeuIle: 6.188 ± 0.112
5.909LeuLys: 5.909 ± 0.107
9.318LeuLeu: 9.318 ± 0.181
2.761LeuMet: 2.761 ± 0.065
4.135LeuAsn: 4.135 ± 0.089
4.383LeuPro: 4.383 ± 0.099
3.46LeuGln: 3.46 ± 0.096
4.151LeuArg: 4.151 ± 0.095
5.604LeuSer: 5.604 ± 0.099
7.44LeuThr: 7.44 ± 0.131
8.54LeuVal: 8.54 ± 0.16
0.883LeuTrp: 0.883 ± 0.041
2.769LeuTyr: 2.769 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.712MetAla: 2.712 ± 0.077
0.134MetCys: 0.134 ± 0.017
1.448MetAsp: 1.448 ± 0.056
1.516MetGlu: 1.516 ± 0.058
0.938MetPhe: 0.938 ± 0.046
1.88MetGly: 1.88 ± 0.071
0.445MetHis: 0.445 ± 0.029
1.891MetIle: 1.891 ± 0.067
1.789MetLys: 1.789 ± 0.057
2.388MetLeu: 2.388 ± 0.064
1.047MetMet: 1.047 ± 0.045
1.198MetAsn: 1.198 ± 0.047
1.092MetPro: 1.092 ± 0.044
1.111MetGln: 1.111 ± 0.041
1.085MetArg: 1.085 ± 0.044
1.416MetSer: 1.416 ± 0.045
2.0MetThr: 2.0 ± 0.053
2.328MetVal: 2.328 ± 0.069
0.218MetTrp: 0.218 ± 0.019
0.622MetTyr: 0.622 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.345AsnAla: 3.345 ± 0.079
0.288AsnCys: 0.288 ± 0.026
2.42AsnAsp: 2.42 ± 0.068
2.236AsnGlu: 2.236 ± 0.062
1.712AsnPhe: 1.712 ± 0.057
3.46AsnGly: 3.46 ± 0.075
1.311AsnHis: 1.311 ± 0.062
1.919AsnIle: 1.919 ± 0.059
1.852AsnLys: 1.852 ± 0.067
4.059AsnLeu: 4.059 ± 0.087
1.115AsnMet: 1.115 ± 0.052
1.739AsnAsn: 1.739 ± 0.072
2.172AsnPro: 2.172 ± 0.069
2.671AsnGln: 2.671 ± 0.087
2.078AsnArg: 2.078 ± 0.066
2.0AsnSer: 2.0 ± 0.065
2.017AsnThr: 2.017 ± 0.071
2.737AsnVal: 2.737 ± 0.079
0.623AsnTrp: 0.623 ± 0.035
1.795AsnTyr: 1.795 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
4.089ProAla: 4.089 ± 0.102
0.151ProCys: 0.151 ± 0.017
2.339ProAsp: 2.339 ± 0.07
2.611ProGlu: 2.611 ± 0.077
1.592ProPhe: 1.592 ± 0.056
2.678ProGly: 2.678 ± 0.065
0.814ProHis: 0.814 ± 0.043
1.961ProIle: 1.961 ± 0.066
1.925ProLys: 1.925 ± 0.063
4.104ProLeu: 4.104 ± 0.093
0.772ProMet: 0.772 ± 0.038
1.71ProAsn: 1.71 ± 0.059
0.68ProPro: 0.68 ± 0.035
1.71ProGln: 1.71 ± 0.056
1.486ProArg: 1.486 ± 0.048
2.196ProSer: 2.196 ± 0.068
2.912ProThr: 2.912 ± 0.076
3.519ProVal: 3.519 ± 0.09
0.384ProTrp: 0.384 ± 0.028
1.29ProTyr: 1.29 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
5.186GlnAla: 5.186 ± 0.123
0.156GlnCys: 0.156 ± 0.018
2.125GlnAsp: 2.125 ± 0.065
2.972GlnGlu: 2.972 ± 0.081
1.691GlnPhe: 1.691 ± 0.056
2.667GlnGly: 2.667 ± 0.065
0.861GlnHis: 0.861 ± 0.041
2.914GlnIle: 2.914 ± 0.079
2.415GlnLys: 2.415 ± 0.072
5.51GlnLeu: 5.51 ± 0.11
1.243GlnMet: 1.243 ± 0.053
1.848GlnAsn: 1.848 ± 0.066
1.893GlnPro: 1.893 ± 0.068
2.108GlnGln: 2.108 ± 0.069
2.694GlnArg: 2.694 ± 0.084
2.14GlnSer: 2.14 ± 0.071
3.097GlnThr: 3.097 ± 0.072
4.317GlnVal: 4.317 ± 0.104
0.576GlnTrp: 0.576 ± 0.037
1.435GlnTyr: 1.435 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
3.777ArgAla: 3.777 ± 0.094
0.281ArgCys: 0.281 ± 0.025
2.328ArgAsp: 2.328 ± 0.066
2.714ArgGlu: 2.714 ± 0.079
2.177ArgPhe: 2.177 ± 0.062
2.946ArgGly: 2.946 ± 0.084
1.296ArgHis: 1.296 ± 0.052
2.726ArgIle: 2.726 ± 0.078
2.172ArgLys: 2.172 ± 0.066
5.28ArgLeu: 5.28 ± 0.117
1.211ArgMet: 1.211 ± 0.047
1.488ArgAsn: 1.488 ± 0.056
1.816ArgPro: 1.816 ± 0.055
2.952ArgGln: 2.952 ± 0.093
3.061ArgArg: 3.061 ± 0.087
2.053ArgSer: 2.053 ± 0.056
2.23ArgThr: 2.23 ± 0.073
3.726ArgVal: 3.726 ± 0.086
0.477ArgTrp: 0.477 ± 0.03
1.931ArgTyr: 1.931 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
4.475SerAla: 4.475 ± 0.139
0.234SerCys: 0.234 ± 0.023
2.837SerAsp: 2.837 ± 0.082
2.471SerGlu: 2.471 ± 0.07
2.454SerPhe: 2.454 ± 0.062
4.136SerGly: 4.136 ± 0.096
1.209SerHis: 1.209 ± 0.05
2.986SerIle: 2.986 ± 0.081
2.594SerLys: 2.594 ± 0.077
5.591SerLeu: 5.591 ± 0.106
1.392SerMet: 1.392 ± 0.059
2.07SerAsn: 2.07 ± 0.063
2.012SerPro: 2.012 ± 0.059
2.579SerGln: 2.579 ± 0.081
2.383SerArg: 2.383 ± 0.064
3.664SerSer: 3.664 ± 0.226
3.185SerThr: 3.185 ± 0.099
3.321SerVal: 3.321 ± 0.087
0.718SerTrp: 0.718 ± 0.036
2.027SerTyr: 2.027 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
5.51ThrAla: 5.51 ± 0.129
0.356ThrCys: 0.356 ± 0.028
3.46ThrAsp: 3.46 ± 0.08
2.905ThrGlu: 2.905 ± 0.07
2.469ThrPhe: 2.469 ± 0.071
4.882ThrGly: 4.882 ± 0.091
1.249ThrHis: 1.249 ± 0.047
3.993ThrIle: 3.993 ± 0.089
3.673ThrLys: 3.673 ± 0.09
5.901ThrLeu: 5.901 ± 0.123
1.552ThrMet: 1.552 ± 0.053
2.709ThrAsn: 2.709 ± 0.082
3.119ThrPro: 3.119 ± 0.084
2.095ThrGln: 2.095 ± 0.076
2.326ThrArg: 2.326 ± 0.061
3.739ThrSer: 3.739 ± 0.113
4.826ThrThr: 4.826 ± 0.144
5.489ThrVal: 5.489 ± 0.119
0.612ThrTrp: 0.612 ± 0.035
2.151ThrTyr: 2.151 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
8.491ValAla: 8.491 ± 0.156
0.509ValCys: 0.509 ± 0.035
4.547ValAsp: 4.547 ± 0.097
4.246ValGlu: 4.246 ± 0.092
2.592ValPhe: 2.592 ± 0.069
5.521ValGly: 5.521 ± 0.114
1.448ValHis: 1.448 ± 0.051
5.259ValIle: 5.259 ± 0.091
4.442ValLys: 4.442 ± 0.102
6.913ValLeu: 6.913 ± 0.126
2.017ValMet: 2.017 ± 0.058
3.517ValAsn: 3.517 ± 0.08
3.023ValPro: 3.023 ± 0.066
2.599ValGln: 2.599 ± 0.068
2.993ValArg: 2.993 ± 0.084
4.451ValSer: 4.451 ± 0.093
5.525ValThr: 5.525 ± 0.121
6.461ValVal: 6.461 ± 0.123
0.71ValTrp: 0.71 ± 0.043
2.255ValTyr: 2.255 ± 0.062
0.0ValXaa: 0.0 ± 0.0
Trp
0.814TrpAla: 0.814 ± 0.038
0.098TrpCys: 0.098 ± 0.013
0.535TrpAsp: 0.535 ± 0.037
0.454TrpGlu: 0.454 ± 0.033
0.516TrpPhe: 0.516 ± 0.034
0.78TrpGly: 0.78 ± 0.038
0.275TrpHis: 0.275 ± 0.026
0.503TrpIle: 0.503 ± 0.032
0.392TrpLys: 0.392 ± 0.029
1.531TrpLeu: 1.531 ± 0.058
0.316TrpMet: 0.316 ± 0.031
0.435TrpAsn: 0.435 ± 0.029
0.388TrpPro: 0.388 ± 0.025
0.684TrpGln: 0.684 ± 0.036
0.618TrpArg: 0.618 ± 0.036
0.58TrpSer: 0.58 ± 0.032
0.603TrpThr: 0.603 ± 0.034
0.842TrpVal: 0.842 ± 0.043
0.188TrpTrp: 0.188 ± 0.022
0.422TrpTyr: 0.422 ± 0.039
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.37TyrAla: 2.37 ± 0.068
0.239TyrCys: 0.239 ± 0.018
1.965TyrAsp: 1.965 ± 0.055
1.528TyrGlu: 1.528 ± 0.056
1.644TyrPhe: 1.644 ± 0.054
2.607TyrGly: 2.607 ± 0.08
1.053TyrHis: 1.053 ± 0.046
1.614TyrIle: 1.614 ± 0.059
1.29TyrLys: 1.29 ± 0.055
4.072TyrLeu: 4.072 ± 0.094
0.748TyrMet: 0.748 ± 0.037
1.405TyrAsn: 1.405 ± 0.052
1.55TyrPro: 1.55 ± 0.051
2.735TyrGln: 2.735 ± 0.087
2.031TyrArg: 2.031 ± 0.059
1.733TyrSer: 1.733 ± 0.061
1.933TyrThr: 1.933 ± 0.073
2.289TyrVal: 2.289 ± 0.065
0.433TyrTrp: 0.433 ± 0.029
1.503TyrTyr: 1.503 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1789 proteins (530899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski