Amino acid dipepetide frequency for Hubei picorna-like virus 74

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.799AlaAla: 5.799 ± 1.945
0.87AlaCys: 0.87 ± 0.422
5.219AlaAsp: 5.219 ± 1.52
3.189AlaGlu: 3.189 ± 1.108
3.189AlaPhe: 3.189 ± 1.108
6.379AlaGly: 6.379 ± 1.23
0.58AlaHis: 0.58 ± 0.281
1.16AlaIle: 1.16 ± 0.361
4.059AlaLys: 4.059 ± 0.899
5.509AlaLeu: 5.509 ± 0.763
2.899AlaMet: 2.899 ± 1.21
2.609AlaAsn: 2.609 ± 0.76
2.899AlaPro: 2.899 ± 0.973
2.899AlaGln: 2.899 ± 1.21
3.189AlaArg: 3.189 ± 0.698
6.089AlaSer: 6.089 ± 1.222
4.929AlaThr: 4.929 ± 0.525
5.219AlaVal: 5.219 ± 0.616
1.74AlaTrp: 1.74 ± 0.372
0.87AlaTyr: 0.87 ± 0.471
0.0AlaXaa: 0.0 ± 0.0
Cys
2.899CysAla: 2.899 ± 1.405
0.0CysCys: 0.0 ± 0.0
1.16CysAsp: 1.16 ± 0.562
1.45CysGlu: 1.45 ± 0.339
0.58CysPhe: 0.58 ± 0.281
1.74CysGly: 1.74 ± 0.372
0.58CysHis: 0.58 ± 0.281
2.32CysIle: 2.32 ± 1.124
0.58CysLys: 0.58 ± 0.529
0.58CysLeu: 0.58 ± 0.281
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
2.03CysPro: 2.03 ± 0.782
0.87CysGln: 0.87 ± 0.422
0.58CysArg: 0.58 ± 0.281
0.29CysSer: 0.29 ± 0.141
0.58CysThr: 0.58 ± 0.281
2.03CysVal: 2.03 ± 0.782
0.0CysTrp: 0.0 ± 0.0
0.87CysTyr: 0.87 ± 1.17
0.0CysXaa: 0.0 ± 0.0
Asp
2.899AspAla: 2.899 ± 0.677
1.74AspCys: 1.74 ± 0.843
2.899AspAsp: 2.899 ± 0.552
4.929AspGlu: 4.929 ± 0.852
5.509AspPhe: 5.509 ± 1.098
2.32AspGly: 2.32 ± 0.744
0.29AspHis: 0.29 ± 0.141
3.189AspIle: 3.189 ± 1.193
2.609AspLys: 2.609 ± 1.265
6.669AspLeu: 6.669 ± 0.139
1.45AspMet: 1.45 ± 0.339
1.74AspAsn: 1.74 ± 0.861
2.03AspPro: 2.03 ± 0.639
2.609AspGln: 2.609 ± 0.686
2.609AspArg: 2.609 ± 1.265
4.639AspSer: 4.639 ± 2.248
4.349AspThr: 4.349 ± 0.294
6.089AspVal: 6.089 ± 0.958
1.74AspTrp: 1.74 ± 1.091
2.03AspTyr: 2.03 ± 1.71
0.0AspXaa: 0.0 ± 0.0
Glu
4.639GluAla: 4.639 ± 0.402
0.87GluCys: 0.87 ± 0.431
4.639GluAsp: 4.639 ± 1.772
2.899GluGlu: 2.899 ± 0.677
4.639GluPhe: 4.639 ± 1.597
2.32GluGly: 2.32 ± 0.552
0.87GluHis: 0.87 ± 0.422
3.479GluIle: 3.479 ± 1.101
3.769GluLys: 3.769 ± 0.614
5.219GluLeu: 5.219 ± 1.338
1.16GluMet: 1.16 ± 0.562
2.609GluAsn: 2.609 ± 0.669
2.899GluPro: 2.899 ± 1.405
0.87GluGln: 0.87 ± 0.422
4.059GluArg: 4.059 ± 0.899
3.479GluSer: 3.479 ± 0.581
2.899GluThr: 2.899 ± 1.21
4.349GluVal: 4.349 ± 1.636
0.87GluTrp: 0.87 ± 0.422
0.87GluTyr: 0.87 ± 0.812
0.0GluXaa: 0.0 ± 0.0
Phe
2.03PheAla: 2.03 ± 0.967
0.58PheCys: 0.58 ± 0.281
3.769PheAsp: 3.769 ± 0.236
4.929PheGlu: 4.929 ± 2.389
2.32PhePhe: 2.32 ± 0.722
4.929PheGly: 4.929 ± 1.037
1.16PheHis: 1.16 ± 1.812
1.16PheIle: 1.16 ± 1.368
2.32PheLys: 2.32 ± 0.818
5.509PheLeu: 5.509 ± 0.562
1.16PheMet: 1.16 ± 0.458
1.45PheAsn: 1.45 ± 0.703
0.87PhePro: 0.87 ± 0.431
2.32PheGln: 2.32 ± 0.155
5.799PheArg: 5.799 ± 1.805
3.479PheSer: 3.479 ± 1.886
2.32PheThr: 2.32 ± 0.722
6.379PheVal: 6.379 ± 0.744
0.58PheTrp: 0.58 ± 0.281
2.609PheTyr: 2.609 ± 0.686
0.0PheXaa: 0.0 ± 0.0
Gly
3.769GlyAla: 3.769 ± 3.726
0.58GlyCys: 0.58 ± 0.281
2.899GlyAsp: 2.899 ± 1.319
2.03GlyGlu: 2.03 ± 0.782
3.189GlyPhe: 3.189 ± 0.615
5.509GlyGly: 5.509 ± 1.733
1.45GlyHis: 1.45 ± 0.339
3.479GlyIle: 3.479 ± 1.2
4.349GlyLys: 4.349 ± 1.636
5.509GlyLeu: 5.509 ± 1.741
1.45GlyMet: 1.45 ± 0.703
2.03GlyAsn: 2.03 ± 0.919
1.45GlyPro: 1.45 ± 0.486
2.609GlyGln: 2.609 ± 0.934
4.059GlyArg: 4.059 ± 1.967
3.479GlySer: 3.479 ± 1.886
3.769GlyThr: 3.769 ± 1.135
4.929GlyVal: 4.929 ± 0.916
0.87GlyTrp: 0.87 ± 0.422
2.32GlyTyr: 2.32 ± 0.155
0.0GlyXaa: 0.0 ± 0.0
His
0.58HisAla: 0.58 ± 0.281
0.58HisCys: 0.58 ± 0.281
0.87HisAsp: 0.87 ± 0.422
0.87HisGlu: 0.87 ± 0.471
1.74HisPhe: 1.74 ± 0.372
0.87HisGly: 0.87 ± 0.431
0.0HisHis: 0.0 ± 0.0
0.29HisIle: 0.29 ± 0.141
0.58HisLys: 0.58 ± 0.529
1.74HisLeu: 1.74 ± 0.372
0.87HisMet: 0.87 ± 0.471
0.0HisAsn: 0.0 ± 0.0
0.58HisPro: 0.58 ± 0.281
1.16HisGln: 1.16 ± 0.361
0.87HisArg: 0.87 ± 0.812
2.03HisSer: 2.03 ± 0.639
0.58HisThr: 0.58 ± 0.524
1.16HisVal: 1.16 ± 0.361
0.58HisTrp: 0.58 ± 0.281
0.87HisTyr: 0.87 ± 0.422
0.0HisXaa: 0.0 ± 0.0
Ile
2.899IleAla: 2.899 ± 0.677
1.16IleCys: 1.16 ± 0.562
2.899IleAsp: 2.899 ± 0.216
3.189IleGlu: 3.189 ± 0.343
2.32IlePhe: 2.32 ± 0.722
4.059IleGly: 4.059 ± 1.232
0.58IleHis: 0.58 ± 0.281
1.74IleIle: 1.74 ± 0.372
1.45IleLys: 1.45 ± 0.703
4.639IleLeu: 4.639 ± 1.636
0.87IleMet: 0.87 ± 0.422
2.03IleAsn: 2.03 ± 1.484
1.45IlePro: 1.45 ± 0.535
1.45IleGln: 1.45 ± 1.205
2.03IleArg: 2.03 ± 0.449
2.899IleSer: 2.899 ± 0.552
1.45IleThr: 1.45 ± 0.703
6.669IleVal: 6.669 ± 0.843
1.45IleTrp: 1.45 ± 0.339
2.03IleTyr: 2.03 ± 0.782
0.0IleXaa: 0.0 ± 0.0
Lys
1.74LysAla: 1.74 ± 0.372
0.58LysCys: 0.58 ± 0.529
4.059LysAsp: 4.059 ± 1.967
2.609LysGlu: 2.609 ± 1.265
1.74LysPhe: 1.74 ± 0.861
3.189LysGly: 3.189 ± 1.139
0.29LysHis: 0.29 ± 0.643
3.189LysIle: 3.189 ± 0.698
2.899LysLys: 2.899 ± 0.793
3.769LysLeu: 3.769 ± 1.188
1.45LysMet: 1.45 ± 0.703
2.609LysAsn: 2.609 ± 0.86
2.32LysPro: 2.32 ± 0.916
2.03LysGln: 2.03 ± 0.268
2.899LysArg: 2.899 ± 0.793
3.189LysSer: 3.189 ± 1.546
2.609LysThr: 2.609 ± 0.669
3.189LysVal: 3.189 ± 0.922
1.16LysTrp: 1.16 ± 0.562
3.189LysTyr: 3.189 ± 0.427
0.0LysXaa: 0.0 ± 0.0
Leu
5.219LeuAla: 5.219 ± 1.338
2.32LeuCys: 2.32 ± 0.552
3.769LeuAsp: 3.769 ± 0.236
4.929LeuGlu: 4.929 ± 1.218
5.219LeuPhe: 5.219 ± 1.338
2.899LeuGly: 2.899 ± 2.065
2.32LeuHis: 2.32 ± 0.552
3.769LeuIle: 3.769 ± 1.188
4.639LeuLys: 4.639 ± 1.772
4.929LeuLeu: 4.929 ± 1.401
2.32LeuMet: 2.32 ± 0.209
5.509LeuAsn: 5.509 ± 2.07
6.089LeuPro: 6.089 ± 2.004
3.769LeuGln: 3.769 ± 0.813
3.769LeuArg: 3.769 ± 1.639
7.538LeuSer: 7.538 ± 1.432
4.349LeuThr: 4.349 ± 1.499
4.929LeuVal: 4.929 ± 0.245
0.87LeuTrp: 0.87 ± 0.422
4.059LeuTyr: 4.059 ± 1.02
0.0LeuXaa: 0.0 ± 0.0
Met
2.609MetAla: 2.609 ± 0.125
1.16MetCys: 1.16 ± 0.562
1.16MetAsp: 1.16 ± 0.562
0.58MetGlu: 0.58 ± 0.281
1.45MetPhe: 1.45 ± 0.535
0.87MetGly: 0.87 ± 0.422
0.29MetHis: 0.29 ± 0.141
1.74MetIle: 1.74 ± 0.55
0.87MetLys: 0.87 ± 0.422
2.609MetLeu: 2.609 ± 1.265
0.87MetMet: 0.87 ± 0.422
0.87MetAsn: 0.87 ± 0.422
2.03MetPro: 2.03 ± 0.268
0.87MetGln: 0.87 ± 0.471
1.16MetArg: 1.16 ± 0.361
2.609MetSer: 2.609 ± 1.292
1.16MetThr: 1.16 ± 0.562
2.03MetVal: 2.03 ± 0.449
0.0MetTrp: 0.0 ± 0.0
0.58MetTyr: 0.58 ± 0.281
0.0MetXaa: 0.0 ± 0.0
Asn
2.609AsnAla: 2.609 ± 1.447
1.16AsnCys: 1.16 ± 0.562
0.87AsnAsp: 0.87 ± 0.812
1.74AsnGlu: 1.74 ± 0.372
1.74AsnPhe: 1.74 ± 1.623
1.45AsnGly: 1.45 ± 0.703
1.16AsnHis: 1.16 ± 0.458
3.479AsnIle: 3.479 ± 0.799
0.87AsnLys: 0.87 ± 0.422
4.349AsnLeu: 4.349 ± 0.416
2.03AsnMet: 2.03 ± 0.699
1.45AsnAsn: 1.45 ± 1.9
1.45AsnPro: 1.45 ± 0.703
1.74AsnGln: 1.74 ± 0.943
2.609AsnArg: 2.609 ± 0.669
4.059AsnSer: 4.059 ± 0.612
1.74AsnThr: 1.74 ± 2.245
4.349AsnVal: 4.349 ± 1.016
0.87AsnTrp: 0.87 ± 0.422
3.769AsnTyr: 3.769 ± 2.045
0.0AsnXaa: 0.0 ± 0.0
Pro
2.32ProAla: 2.32 ± 0.744
0.29ProCys: 0.29 ± 0.643
2.899ProAsp: 2.899 ± 1.973
3.479ProGlu: 3.479 ± 0.745
3.189ProPhe: 3.189 ± 1.373
4.349ProGly: 4.349 ± 2.253
1.16ProHis: 1.16 ± 0.562
2.03ProIle: 2.03 ± 1.508
2.03ProLys: 2.03 ± 0.449
2.32ProLeu: 2.32 ± 0.818
0.87ProMet: 0.87 ± 0.422
3.189ProAsn: 3.189 ± 1.139
2.609ProPro: 2.609 ± 2.868
1.45ProGln: 1.45 ± 0.339
1.45ProArg: 1.45 ± 0.954
5.509ProSer: 5.509 ± 0.763
4.349ProThr: 4.349 ± 1.636
4.349ProVal: 4.349 ± 0.294
0.0ProTrp: 0.0 ± 0.0
2.03ProTyr: 2.03 ± 0.268
0.0ProXaa: 0.0 ± 0.0
Gln
1.74GlnAla: 1.74 ± 0.55
1.16GlnCys: 1.16 ± 0.361
2.32GlnAsp: 2.32 ± 1.124
2.32GlnGlu: 2.32 ± 1.124
2.32GlnPhe: 2.32 ± 0.552
0.87GlnGly: 0.87 ± 1.123
0.87GlnHis: 0.87 ± 0.422
2.609GlnIle: 2.609 ± 0.669
1.74GlnLys: 1.74 ± 0.372
3.189GlnLeu: 3.189 ± 1.193
1.45GlnMet: 1.45 ± 0.703
2.899GlnAsn: 2.899 ± 1.726
3.479GlnPro: 3.479 ± 1.083
1.74GlnGln: 1.74 ± 1.091
2.899GlnArg: 2.899 ± 0.981
3.189GlnSer: 3.189 ± 1.598
2.32GlnThr: 2.32 ± 0.722
0.87GlnVal: 0.87 ± 0.431
0.0GlnTrp: 0.0 ± 0.0
2.609GlnTyr: 2.609 ± 1.461
0.0GlnXaa: 0.0 ± 0.0
Arg
5.219ArgAla: 5.219 ± 1.872
1.16ArgCys: 1.16 ± 0.562
4.929ArgAsp: 4.929 ± 3.024
3.479ArgGlu: 3.479 ± 0.745
2.899ArgPhe: 2.899 ± 0.677
2.899ArgGly: 2.899 ± 0.216
0.29ArgHis: 0.29 ± 0.141
2.899ArgIle: 2.899 ± 0.793
2.03ArgLys: 2.03 ± 0.782
4.929ArgLeu: 4.929 ± 1.218
1.16ArgMet: 1.16 ± 0.526
2.03ArgAsn: 2.03 ± 0.984
2.03ArgPro: 2.03 ± 1.508
3.189ArgGln: 3.189 ± 0.922
4.349ArgArg: 4.349 ± 1.46
2.609ArgSer: 2.609 ± 0.684
3.479ArgThr: 3.479 ± 0.477
4.059ArgVal: 4.059 ± 0.752
0.87ArgTrp: 0.87 ± 0.422
1.74ArgTyr: 1.74 ± 0.861
0.0ArgXaa: 0.0 ± 0.0
Ser
6.959SerAla: 6.959 ± 2.401
0.58SerCys: 0.58 ± 0.281
7.248SerAsp: 7.248 ± 1.266
3.479SerGlu: 3.479 ± 1.373
4.059SerPhe: 4.059 ± 1.908
5.219SerGly: 5.219 ± 4.06
1.74SerHis: 1.74 ± 0.943
3.479SerIle: 3.479 ± 1.071
4.059SerLys: 4.059 ± 1.967
6.379SerLeu: 6.379 ± 0.111
1.16SerMet: 1.16 ± 0.562
2.03SerAsn: 2.03 ± 0.449
1.74SerPro: 1.74 ± 0.55
2.899SerGln: 2.899 ± 0.216
3.479SerArg: 3.479 ± 1.2
7.248SerSer: 7.248 ± 5.754
3.189SerThr: 3.189 ± 1.594
6.089SerVal: 6.089 ± 1.499
0.29SerTrp: 0.29 ± 0.141
2.899SerTyr: 2.899 ± 0.552
0.0SerXaa: 0.0 ± 0.0
Thr
4.349ThrAla: 4.349 ± 0.891
1.16ThrCys: 1.16 ± 0.562
3.479ThrAsp: 3.479 ± 1.101
2.609ThrGlu: 2.609 ± 1.265
3.769ThrPhe: 3.769 ± 0.236
2.03ThrGly: 2.03 ± 0.984
0.0ThrHis: 0.0 ± 0.0
2.32ThrIle: 2.32 ± 1.383
3.189ThrLys: 3.189 ± 0.698
3.769ThrLeu: 3.769 ± 0.58
1.16ThrMet: 1.16 ± 0.458
3.769ThrAsn: 3.769 ± 1.314
5.509ThrPro: 5.509 ± 1.235
3.189ThrGln: 3.189 ± 0.343
2.899ThrArg: 2.899 ± 1.387
2.899ThrSer: 2.899 ± 1.319
3.479ThrThr: 3.479 ± 1.373
3.479ThrVal: 3.479 ± 1.054
0.29ThrTrp: 0.29 ± 0.643
2.03ThrTyr: 2.03 ± 0.449
0.0ThrXaa: 0.0 ± 0.0
Val
6.669ValAla: 6.669 ± 0.139
1.74ValCys: 1.74 ± 0.861
2.32ValAsp: 2.32 ± 0.155
5.509ValGlu: 5.509 ± 1.183
3.769ValPhe: 3.769 ± 1.042
4.349ValGly: 4.349 ± 1.46
2.03ValHis: 2.03 ± 0.919
2.899ValIle: 2.899 ± 0.677
3.769ValLys: 3.769 ± 0.614
8.118ValLeu: 8.118 ± 1.763
0.87ValMet: 0.87 ± 0.431
4.349ValAsn: 4.349 ± 0.672
6.089ValPro: 6.089 ± 0.211
2.32ValGln: 2.32 ± 0.859
5.509ValArg: 5.509 ± 0.562
4.639ValSer: 4.639 ± 1.489
5.799ValThr: 5.799 ± 0.925
6.089ValVal: 6.089 ± 1.715
0.58ValTrp: 0.58 ± 0.281
3.479ValTyr: 3.479 ± 1.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.87TrpAla: 0.87 ± 0.422
0.58TrpCys: 0.58 ± 0.281
0.87TrpAsp: 0.87 ± 0.422
0.0TrpGlu: 0.0 ± 0.0
0.58TrpPhe: 0.58 ± 0.281
1.16TrpGly: 1.16 ± 0.458
0.58TrpHis: 0.58 ± 0.281
0.29TrpIle: 0.29 ± 0.141
1.74TrpLys: 1.74 ± 0.861
1.16TrpLeu: 1.16 ± 0.562
1.16TrpMet: 1.16 ± 0.562
1.16TrpAsn: 1.16 ± 0.361
0.0TrpPro: 0.0 ± 0.0
0.29TrpGln: 0.29 ± 0.141
0.87TrpArg: 0.87 ± 0.422
0.87TrpSer: 0.87 ± 0.431
0.29TrpThr: 0.29 ± 0.141
0.58TrpVal: 0.58 ± 0.529
0.58TrpTrp: 0.58 ± 0.281
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.479TyrAla: 3.479 ± 0.477
0.87TyrCys: 0.87 ± 1.17
4.059TyrAsp: 4.059 ± 1.02
3.189TyrGlu: 3.189 ± 0.343
1.45TyrPhe: 1.45 ± 1.978
2.32TyrGly: 2.32 ± 0.859
0.58TyrHis: 0.58 ± 0.529
1.74TyrIle: 1.74 ± 1.587
1.16TyrLys: 1.16 ± 0.361
2.32TyrLeu: 2.32 ± 0.155
0.87TyrMet: 0.87 ± 0.812
1.45TyrAsn: 1.45 ± 1.698
2.32TyrPro: 2.32 ± 0.818
2.32TyrGln: 2.32 ± 0.818
1.16TyrArg: 1.16 ± 0.562
3.479TyrSer: 3.479 ± 2.675
1.74TyrThr: 1.74 ± 0.55
4.059TyrVal: 4.059 ± 1.323
0.29TyrTrp: 0.29 ± 0.141
1.74TyrTyr: 1.74 ± 1.587
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3450 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski