Amino acid dipepetide frequency for Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.332AlaAla: 6.332 ± 0.108	0.547AlaCys: 0.547 ± 0.028	4.053AlaAsp: 4.053 ± 0.064	5.222AlaGlu: 5.222 ± 0.087	3.767AlaPhe: 3.767 ± 0.064	5.508AlaGly: 5.508 ± 0.097	1.645AlaHis: 1.645 ± 0.042	5.882AlaIle: 5.882 ± 0.092	4.352AlaLys: 4.352 ± 0.072	8.765AlaLeu: 8.765 ± 0.096	2.403AlaMet: 2.403 ± 0.051	2.695AlaAsn: 2.695 ± 0.06	2.479AlaPro: 2.479 ± 0.054	2.349AlaGln: 2.349 ± 0.053	3.58AlaArg: 3.58 ± 0.067	4.895AlaSer: 4.895 ± 0.077	4.927AlaThr: 4.927 ± 0.076	5.876AlaVal: 5.876 ± 0.086	0.795AlaTrp: 0.795 ± 0.033	2.687AlaTyr: 2.687 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.452CysAla: 0.452 ± 0.025	0.064CysCys: 0.064 ± 0.009	0.341CysAsp: 0.341 ± 0.02	0.381CysGlu: 0.381 ± 0.023	0.217CysPhe: 0.217 ± 0.018	0.543CysGly: 0.543 ± 0.025	0.173CysHis: 0.173 ± 0.014	0.273CysIle: 0.273 ± 0.019	0.198CysLys: 0.198 ± 0.015	0.515CysLeu: 0.515 ± 0.028	0.127CysMet: 0.127 ± 0.012	0.154CysAsn: 0.154 ± 0.015	0.295CysPro: 0.295 ± 0.02	0.225CysGln: 0.225 ± 0.017	0.295CysArg: 0.295 ± 0.02	0.324CysSer: 0.324 ± 0.019	0.332CysThr: 0.332 ± 0.019	0.334CysVal: 0.334 ± 0.02	0.057CysTrp: 0.057 ± 0.007	0.183CysTyr: 0.183 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.776AspAla: 4.776 ± 0.077	0.323AspCys: 0.323 ± 0.02	2.935AspAsp: 2.935 ± 0.063	5.264AspGlu: 5.264 ± 0.085	2.272AspPhe: 2.272 ± 0.05	4.258AspGly: 4.258 ± 0.083	1.23AspHis: 1.23 ± 0.035	3.191AspIle: 3.191 ± 0.065	1.953AspLys: 1.953 ± 0.056	5.393AspLeu: 5.393 ± 0.083	1.436AspMet: 1.436 ± 0.045	1.27AspAsn: 1.27 ± 0.044	2.065AspPro: 2.065 ± 0.054	2.074AspGln: 2.074 ± 0.047	3.289AspArg: 3.289 ± 0.066	2.613AspSer: 2.613 ± 0.057	2.856AspThr: 2.856 ± 0.063	5.409AspVal: 5.409 ± 0.084	0.823AspTrp: 0.823 ± 0.034	2.138AspTyr: 2.138 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	7.02GluAla: 7.02 ± 0.103	0.314GluCys: 0.314 ± 0.02	3.818GluAsp: 3.818 ± 0.076	6.847GluGlu: 6.847 ± 0.136	2.225GluPhe: 2.225 ± 0.05	4.428GluGly: 4.428 ± 0.078	1.623GluHis: 1.623 ± 0.042	4.135GluIle: 4.135 ± 0.076	4.225GluLys: 4.225 ± 0.078	7.583GluLeu: 7.583 ± 0.107	2.39GluMet: 2.39 ± 0.054	2.427GluAsn: 2.427 ± 0.061	2.407GluPro: 2.407 ± 0.058	3.822GluGln: 3.822 ± 0.071	5.729GluArg: 5.729 ± 0.096	4.099GluSer: 4.099 ± 0.069	4.961GluThr: 4.961 ± 0.077	5.497GluVal: 5.497 ± 0.097	1.018GluTrp: 1.018 ± 0.037	1.984GluTyr: 1.984 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.216PheAla: 3.216 ± 0.069	0.225PheCys: 0.225 ± 0.015	2.83PheAsp: 2.83 ± 0.062	3.289PheGlu: 3.289 ± 0.065	2.109PhePhe: 2.109 ± 0.06	3.622PheGly: 3.622 ± 0.072	0.912PheHis: 0.912 ± 0.035	2.927PheIle: 2.927 ± 0.06	1.936PheLys: 1.936 ± 0.049	4.171PheLeu: 4.171 ± 0.091	1.194PheMet: 1.194 ± 0.043	1.605PheAsn: 1.605 ± 0.041	1.528PhePro: 1.528 ± 0.041	1.386PheGln: 1.386 ± 0.043	1.776PheArg: 1.776 ± 0.046	2.769PheSer: 2.769 ± 0.062	2.59PheThr: 2.59 ± 0.055	3.467PheVal: 3.467 ± 0.077	0.523PheTrp: 0.523 ± 0.027	1.52PheTyr: 1.52 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.346GlyAla: 5.346 ± 0.086	0.421GlyCys: 0.421 ± 0.024	3.621GlyAsp: 3.621 ± 0.068	4.788GlyGlu: 4.788 ± 0.079	3.224GlyPhe: 3.224 ± 0.069	4.768GlyGly: 4.768 ± 0.107	1.509GlyHis: 1.509 ± 0.045	5.162GlyIle: 5.162 ± 0.084	4.053GlyLys: 4.053 ± 0.076	6.891GlyLeu: 6.891 ± 0.109	2.166GlyMet: 2.166 ± 0.053	2.19GlyAsn: 2.19 ± 0.059	1.854GlyPro: 1.854 ± 0.051	2.426GlyGln: 2.426 ± 0.059	3.358GlyArg: 3.358 ± 0.074	3.772GlySer: 3.772 ± 0.066	4.559GlyThr: 4.559 ± 0.079	5.679GlyVal: 5.679 ± 0.085	0.894GlyTrp: 0.894 ± 0.036	2.736GlyTyr: 2.736 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.714HisAla: 1.714 ± 0.046	0.134HisCys: 0.134 ± 0.013	1.38HisAsp: 1.38 ± 0.036	1.718HisGlu: 1.718 ± 0.043	0.964HisPhe: 0.964 ± 0.03	1.542HisGly: 1.542 ± 0.046	0.836HisHis: 0.836 ± 0.032	1.386HisIle: 1.386 ± 0.043	0.703HisLys: 0.703 ± 0.028	2.356HisLeu: 2.356 ± 0.054	0.548HisMet: 0.548 ± 0.021	0.599HisAsn: 0.599 ± 0.026	1.269HisPro: 1.269 ± 0.041	0.854HisGln: 0.854 ± 0.034	1.206HisArg: 1.206 ± 0.041	1.052HisSer: 1.052 ± 0.035	1.109HisThr: 1.109 ± 0.036	2.063HisVal: 2.063 ± 0.05	0.237HisTrp: 0.237 ± 0.017	0.858HisTyr: 0.858 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.755IleAla: 5.755 ± 0.092	0.418IleCys: 0.418 ± 0.02	4.544IleAsp: 4.544 ± 0.071	5.995IleGlu: 5.995 ± 0.095	2.412IlePhe: 2.412 ± 0.061	5.876IleGly: 5.876 ± 0.096	1.55IleHis: 1.55 ± 0.04	3.771IleIle: 3.771 ± 0.072	2.59IleLys: 2.59 ± 0.062	5.788IleLeu: 5.788 ± 0.094	1.465IleMet: 1.465 ± 0.043	1.916IleAsn: 1.916 ± 0.046	2.986IlePro: 2.986 ± 0.059	2.711IleGln: 2.711 ± 0.047	3.57IleArg: 3.57 ± 0.072	3.573IleSer: 3.573 ± 0.073	3.377IleThr: 3.377 ± 0.069	5.389IleVal: 5.389 ± 0.09	0.654IleTrp: 0.654 ± 0.032	1.906IleTyr: 1.906 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	3.887LysAla: 3.887 ± 0.068	0.159LysCys: 0.159 ± 0.014	2.66LysAsp: 2.66 ± 0.066	4.318LysGlu: 4.318 ± 0.077	1.278LysPhe: 1.278 ± 0.033	3.189LysGly: 3.189 ± 0.068	1.148LysHis: 1.148 ± 0.034	2.627LysIle: 2.627 ± 0.058	3.166LysLys: 3.166 ± 0.076	4.383LysLeu: 4.383 ± 0.085	1.552LysMet: 1.552 ± 0.043	1.622LysAsn: 1.622 ± 0.051	1.858LysPro: 1.858 ± 0.051	2.916LysGln: 2.916 ± 0.054	3.884LysArg: 3.884 ± 0.07	2.729LysSer: 2.729 ± 0.056	3.044LysThr: 3.044 ± 0.065	3.375LysVal: 3.375 ± 0.062	0.665LysTrp: 0.665 ± 0.028	1.324LysTyr: 1.324 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	8.213LeuAla: 8.213 ± 0.113	0.525LeuCys: 0.525 ± 0.025	5.715LeuAsp: 5.715 ± 0.09	7.062LeuGlu: 7.062 ± 0.103	5.024LeuPhe: 5.024 ± 0.101	6.548LeuGly: 6.548 ± 0.111	2.234LeuHis: 2.234 ± 0.057	6.974LeuIle: 6.974 ± 0.108	5.027LeuLys: 5.027 ± 0.084	10.428LeuLeu: 10.428 ± 0.164	2.675LeuMet: 2.675 ± 0.054	3.691LeuAsn: 3.691 ± 0.058	4.138LeuPro: 4.138 ± 0.072	3.408LeuGln: 3.408 ± 0.07	4.738LeuArg: 4.738 ± 0.074	6.524LeuSer: 6.524 ± 0.097	6.328LeuThr: 6.328 ± 0.096	7.422LeuVal: 7.422 ± 0.093	0.875LeuTrp: 0.875 ± 0.036	3.262LeuTyr: 3.262 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.187MetAla: 2.187 ± 0.05	0.132MetCys: 0.132 ± 0.012	1.441MetAsp: 1.441 ± 0.04	1.899MetGlu: 1.899 ± 0.046	1.029MetPhe: 1.029 ± 0.035	1.548MetGly: 1.548 ± 0.044	0.531MetHis: 0.531 ± 0.022	2.056MetIle: 2.056 ± 0.045	2.198MetLys: 2.198 ± 0.052	2.668MetLeu: 2.668 ± 0.058	1.057MetMet: 1.057 ± 0.035	1.496MetAsn: 1.496 ± 0.036	1.112MetPro: 1.112 ± 0.037	0.985MetGln: 0.985 ± 0.031	1.581MetArg: 1.581 ± 0.044	1.745MetSer: 1.745 ± 0.044	2.166MetThr: 2.166 ± 0.053	1.633MetVal: 1.633 ± 0.045	0.266MetTrp: 0.266 ± 0.018	0.793MetTyr: 0.793 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.651AsnAla: 2.651 ± 0.057	0.186AsnCys: 0.186 ± 0.017	1.936AsnAsp: 1.936 ± 0.054	3.082AsnGlu: 3.082 ± 0.068	1.15AsnPhe: 1.15 ± 0.04	3.001AsnGly: 3.001 ± 0.064	0.811AsnHis: 0.811 ± 0.03	2.107AsnIle: 2.107 ± 0.053	1.377AsnLys: 1.377 ± 0.044	2.712AsnLeu: 2.712 ± 0.056	0.893AsnMet: 0.893 ± 0.029	1.015AsnAsn: 1.015 ± 0.034	1.765AsnPro: 1.765 ± 0.041	1.462AsnGln: 1.462 ± 0.037	2.204AsnArg: 2.204 ± 0.041	1.446AsnSer: 1.446 ± 0.047	1.605AsnThr: 1.605 ± 0.046	2.935AsnVal: 2.935 ± 0.062	0.429AsnTrp: 0.429 ± 0.022	1.015AsnTyr: 1.015 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.433ProAla: 2.433 ± 0.061	0.173ProCys: 0.173 ± 0.016	2.244ProAsp: 2.244 ± 0.051	3.029ProGlu: 3.029 ± 0.054	2.114ProPhe: 2.114 ± 0.045	2.29ProGly: 2.29 ± 0.052	0.899ProHis: 0.899 ± 0.032	2.82ProIle: 2.82 ± 0.056	1.874ProLys: 1.874 ± 0.049	3.885ProLeu: 3.885 ± 0.07	0.897ProMet: 0.897 ± 0.031	1.686ProAsn: 1.686 ± 0.048	1.004ProPro: 1.004 ± 0.037	1.036ProGln: 1.036 ± 0.031	1.411ProArg: 1.411 ± 0.041	2.362ProSer: 2.362 ± 0.053	2.476ProThr: 2.476 ± 0.057	3.047ProVal: 3.047 ± 0.066	0.386ProTrp: 0.386 ± 0.023	1.476ProTyr: 1.476 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.252GlnAla: 3.252 ± 0.06	0.125GlnCys: 0.125 ± 0.012	1.831GlnAsp: 1.831 ± 0.047	2.64GlnGlu: 2.64 ± 0.055	1.697GlnPhe: 1.697 ± 0.047	1.958GlnGly: 1.958 ± 0.046	0.859GlnHis: 0.859 ± 0.031	2.404GlnIle: 2.404 ± 0.05	1.839GlnLys: 1.839 ± 0.043	4.637GlnLeu: 4.637 ± 0.075	1.238GlnMet: 1.238 ± 0.039	1.121GlnAsn: 1.121 ± 0.041	1.325GlnPro: 1.325 ± 0.041	1.856GlnGln: 1.856 ± 0.05	1.872GlnArg: 1.872 ± 0.047	2.235GlnSer: 2.235 ± 0.048	2.425GlnThr: 2.425 ± 0.057	2.768GlnVal: 2.768 ± 0.056	0.368GlnTrp: 0.368 ± 0.022	1.192GlnTyr: 1.192 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.678ArgAla: 3.678 ± 0.073	0.23ArgCys: 0.23 ± 0.016	3.019ArgAsp: 3.019 ± 0.065	4.154ArgGlu: 4.154 ± 0.076	2.633ArgPhe: 2.633 ± 0.053	2.993ArgGly: 2.993 ± 0.062	1.453ArgHis: 1.453 ± 0.037	3.571ArgIle: 3.571 ± 0.066	2.567ArgLys: 2.567 ± 0.052	6.091ArgLeu: 6.091 ± 0.089	1.661ArgMet: 1.661 ± 0.039	1.689ArgAsn: 1.689 ± 0.044	1.975ArgPro: 1.975 ± 0.056	2.483ArgGln: 2.483 ± 0.057	2.946ArgArg: 2.946 ± 0.068	2.689ArgSer: 2.689 ± 0.058	2.898ArgThr: 2.898 ± 0.062	3.936ArgVal: 3.936 ± 0.071	0.477ArgTrp: 0.477 ± 0.024	2.23ArgTyr: 2.23 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	3.827SerAla: 3.827 ± 0.072	0.316SerCys: 0.316 ± 0.023	2.957SerAsp: 2.957 ± 0.052	3.767SerGlu: 3.767 ± 0.074	3.095SerPhe: 3.095 ± 0.062	4.445SerGly: 4.445 ± 0.071	1.201SerHis: 1.201 ± 0.037	4.32SerIle: 4.32 ± 0.074	2.814SerLys: 2.814 ± 0.066	5.978SerLeu: 5.978 ± 0.093	1.687SerMet: 1.687 ± 0.044	2.026SerAsn: 2.026 ± 0.055	2.1SerPro: 2.1 ± 0.049	1.878SerGln: 1.878 ± 0.039	2.864SerArg: 2.864 ± 0.067	3.538SerSer: 3.538 ± 0.097	3.491SerThr: 3.491 ± 0.065	4.251SerVal: 4.251 ± 0.072	0.645SerTrp: 0.645 ± 0.031	1.99SerTyr: 1.99 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.435ThrAla: 4.435 ± 0.072	0.379ThrCys: 0.379 ± 0.023	3.216ThrAsp: 3.216 ± 0.059	4.076ThrGlu: 4.076 ± 0.069	3.183ThrPhe: 3.183 ± 0.06	4.418ThrGly: 4.418 ± 0.077	1.272ThrHis: 1.272 ± 0.041	4.516ThrIle: 4.516 ± 0.08	2.988ThrLys: 2.988 ± 0.06	6.622ThrLeu: 6.622 ± 0.091	1.654ThrMet: 1.654 ± 0.036	2.242ThrAsn: 2.242 ± 0.053	2.731ThrPro: 2.731 ± 0.061	1.636ThrGln: 1.636 ± 0.042	2.588ThrArg: 2.588 ± 0.057	3.637ThrSer: 3.637 ± 0.062	3.686ThrThr: 3.686 ± 0.064	4.805ThrVal: 4.805 ± 0.075	0.614ThrTrp: 0.614 ± 0.026	2.324ThrTyr: 2.324 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	6.204ValAla: 6.204 ± 0.09	0.525ValCys: 0.525 ± 0.022	4.432ValAsp: 4.432 ± 0.07	5.618ValGlu: 5.618 ± 0.088	3.076ValPhe: 3.076 ± 0.064	5.266ValGly: 5.266 ± 0.079	1.599ValHis: 1.599 ± 0.044	5.371ValIle: 5.371 ± 0.077	3.949ValLys: 3.949 ± 0.076	7.606ValLeu: 7.606 ± 0.097	2.139ValMet: 2.139 ± 0.051	2.708ValAsn: 2.708 ± 0.059	3.023ValPro: 3.023 ± 0.06	2.433ValGln: 2.433 ± 0.056	3.905ValArg: 3.905 ± 0.066	4.871ValSer: 4.871 ± 0.074	5.521ValThr: 5.521 ± 0.089	5.939ValVal: 5.939 ± 0.102	0.794ValTrp: 0.794 ± 0.031	2.444ValTyr: 2.444 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.656TrpAla: 0.656 ± 0.028	0.075TrpCys: 0.075 ± 0.01	0.524TrpAsp: 0.524 ± 0.023	0.628TrpGlu: 0.628 ± 0.027	0.619TrpPhe: 0.619 ± 0.032	0.655TrpGly: 0.655 ± 0.031	0.237TrpHis: 0.237 ± 0.018	0.835TrpIle: 0.835 ± 0.033	0.578TrpLys: 0.578 ± 0.023	1.307TrpLeu: 1.307 ± 0.041	0.472TrpMet: 0.472 ± 0.024	0.544TrpAsn: 0.544 ± 0.025	0.292TrpPro: 0.292 ± 0.02	0.452TrpGln: 0.452 ± 0.024	0.534TrpArg: 0.534 ± 0.028	0.635TrpSer: 0.635 ± 0.03	0.73TrpThr: 0.73 ± 0.03	0.804TrpVal: 0.804 ± 0.036	0.178TrpTrp: 0.178 ± 0.016	0.369TrpTyr: 0.369 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.722TyrAla: 2.722 ± 0.055	0.212TyrCys: 0.212 ± 0.017	2.072TyrAsp: 2.072 ± 0.056	2.776TyrGlu: 2.776 ± 0.059	1.513TyrPhe: 1.513 ± 0.043	2.562TyrGly: 2.562 ± 0.054	0.806TyrHis: 0.806 ± 0.032	1.918TyrIle: 1.918 ± 0.055	1.395TyrLys: 1.395 ± 0.041	3.032TyrLeu: 3.032 ± 0.063	0.87TyrMet: 0.87 ± 0.033	1.086TyrAsn: 1.086 ± 0.035	1.334TyrPro: 1.334 ± 0.035	1.249TyrGln: 1.249 ± 0.036	2.045TyrArg: 2.045 ± 0.053	1.683TyrSer: 1.683 ± 0.05	1.94TyrThr: 1.94 ± 0.05	2.791TyrVal: 2.791 ± 0.06	0.426TyrTrp: 0.426 ± 0.022	1.202TyrTyr: 1.202 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3020 proteins (894459 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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