Amino acid dipepetide frequency for Pseudidiomarina atlantica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.022AlaAla: 12.022 ± 0.179
1.001AlaCys: 1.001 ± 0.039
6.215AlaAsp: 6.215 ± 0.103
7.564AlaGlu: 7.564 ± 0.11
3.674AlaPhe: 3.674 ± 0.075
7.356AlaGly: 7.356 ± 0.107
2.056AlaHis: 2.056 ± 0.057
5.866AlaIle: 5.866 ± 0.1
4.244AlaLys: 4.244 ± 0.083
11.302AlaLeu: 11.302 ± 0.133
2.804AlaMet: 2.804 ± 0.068
3.479AlaAsn: 3.479 ± 0.078
3.77AlaPro: 3.77 ± 0.074
5.65AlaGln: 5.65 ± 0.109
5.286AlaArg: 5.286 ± 0.083
5.397AlaSer: 5.397 ± 0.08
5.473AlaThr: 5.473 ± 0.097
7.585AlaVal: 7.585 ± 0.101
1.364AlaTrp: 1.364 ± 0.05
2.692AlaTyr: 2.692 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.905CysAla: 0.905 ± 0.037
0.137CysCys: 0.137 ± 0.014
0.527CysAsp: 0.527 ± 0.029
0.51CysGlu: 0.51 ± 0.027
0.333CysPhe: 0.333 ± 0.02
0.808CysGly: 0.808 ± 0.04
0.295CysHis: 0.295 ± 0.022
0.443CysIle: 0.443 ± 0.027
0.279CysLys: 0.279 ± 0.018
0.769CysLeu: 0.769 ± 0.035
0.189CysMet: 0.189 ± 0.015
0.251CysAsn: 0.251 ± 0.021
0.437CysPro: 0.437 ± 0.024
0.409CysGln: 0.409 ± 0.024
0.447CysArg: 0.447 ± 0.025
0.545CysSer: 0.545 ± 0.026
0.401CysThr: 0.401 ± 0.025
0.598CysVal: 0.598 ± 0.031
0.107CysTrp: 0.107 ± 0.012
0.28CysTyr: 0.28 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
5.833AspAla: 5.833 ± 0.094
0.522AspCys: 0.522 ± 0.03
3.45AspAsp: 3.45 ± 0.082
3.877AspGlu: 3.877 ± 0.075
2.565AspPhe: 2.565 ± 0.057
4.191AspGly: 4.191 ± 0.102
1.223AspHis: 1.223 ± 0.037
3.216AspIle: 3.216 ± 0.068
2.296AspLys: 2.296 ± 0.062
5.362AspLeu: 5.362 ± 0.087
1.367AspMet: 1.367 ± 0.04
2.035AspAsn: 2.035 ± 0.056
2.416AspPro: 2.416 ± 0.053
2.057AspGln: 2.057 ± 0.05
2.61AspArg: 2.61 ± 0.063
2.869AspSer: 2.869 ± 0.06
2.696AspThr: 2.696 ± 0.059
4.173AspVal: 4.173 ± 0.082
0.99AspTrp: 0.99 ± 0.041
2.298AspTyr: 2.298 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
5.981GluAla: 5.981 ± 0.096
0.395GluCys: 0.395 ± 0.022
2.74GluAsp: 2.74 ± 0.06
3.312GluGlu: 3.312 ± 0.075
2.436GluPhe: 2.436 ± 0.057
3.57GluGly: 3.57 ± 0.08
1.778GluHis: 1.778 ± 0.049
3.414GluIle: 3.414 ± 0.069
2.542GluLys: 2.542 ± 0.063
7.697GluLeu: 7.697 ± 0.119
1.513GluMet: 1.513 ± 0.048
2.101GluAsn: 2.101 ± 0.056
2.449GluPro: 2.449 ± 0.062
5.068GluGln: 5.068 ± 0.109
4.71GluArg: 4.71 ± 0.082
2.834GluSer: 2.834 ± 0.059
3.013GluThr: 3.013 ± 0.067
4.555GluVal: 4.555 ± 0.075
0.798GluTrp: 0.798 ± 0.037
1.618GluTyr: 1.618 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
4.601PheAla: 4.601 ± 0.078
0.399PheCys: 0.399 ± 0.024
2.544PheAsp: 2.544 ± 0.061
2.194PheGlu: 2.194 ± 0.055
1.605PhePhe: 1.605 ± 0.054
3.329PheGly: 3.329 ± 0.07
0.76PheHis: 0.76 ± 0.029
2.32PheIle: 2.32 ± 0.065
1.342PheLys: 1.342 ± 0.05
3.175PheLeu: 3.175 ± 0.067
0.952PheMet: 0.952 ± 0.031
1.724PheAsn: 1.724 ± 0.046
1.403PhePro: 1.403 ± 0.045
1.244PheGln: 1.244 ± 0.039
1.869PheArg: 1.869 ± 0.048
2.721PheSer: 2.721 ± 0.054
2.31PheThr: 2.31 ± 0.06
2.996PheVal: 2.996 ± 0.07
0.595PheTrp: 0.595 ± 0.028
1.272PheTyr: 1.272 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
6.378GlyAla: 6.378 ± 0.097
0.756GlyCys: 0.756 ± 0.033
4.013GlyAsp: 4.013 ± 0.075
4.557GlyGlu: 4.557 ± 0.103
3.204GlyPhe: 3.204 ± 0.074
5.282GlyGly: 5.282 ± 0.121
1.699GlyHis: 1.699 ± 0.049
4.355GlyIle: 4.355 ± 0.084
3.346GlyLys: 3.346 ± 0.075
7.15GlyLeu: 7.15 ± 0.097
2.035GlyMet: 2.035 ± 0.057
2.427GlyAsn: 2.427 ± 0.074
2.019GlyPro: 2.019 ± 0.057
2.919GlyGln: 2.919 ± 0.058
3.65GlyArg: 3.65 ± 0.071
4.093GlySer: 4.093 ± 0.076
3.585GlyThr: 3.585 ± 0.077
5.636GlyVal: 5.636 ± 0.102
1.125GlyTrp: 1.125 ± 0.039
2.61GlyTyr: 2.61 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
2.09HisAla: 2.09 ± 0.055
0.306HisCys: 0.306 ± 0.021
1.3HisAsp: 1.3 ± 0.039
1.424HisGlu: 1.424 ± 0.051
0.99HisPhe: 0.99 ± 0.036
1.827HisGly: 1.827 ± 0.05
0.677HisHis: 0.677 ± 0.033
1.197HisIle: 1.197 ± 0.041
0.835HisLys: 0.835 ± 0.033
2.35HisLeu: 2.35 ± 0.065
0.477HisMet: 0.477 ± 0.023
0.716HisAsn: 0.716 ± 0.031
1.326HisPro: 1.326 ± 0.042
1.135HisGln: 1.135 ± 0.038
1.232HisArg: 1.232 ± 0.035
1.163HisSer: 1.163 ± 0.04
0.986HisThr: 0.986 ± 0.036
1.427HisVal: 1.427 ± 0.043
0.433HisTrp: 0.433 ± 0.027
0.902HisTyr: 0.902 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.534IleAla: 6.534 ± 0.115
0.501IleCys: 0.501 ± 0.026
3.749IleAsp: 3.749 ± 0.082
3.937IleGlu: 3.937 ± 0.075
1.898IlePhe: 1.898 ± 0.058
4.436IleGly: 4.436 ± 0.093
1.086IleHis: 1.086 ± 0.037
2.888IleIle: 2.888 ± 0.069
2.082IleLys: 2.082 ± 0.061
4.371IleLeu: 4.371 ± 0.102
1.161IleMet: 1.161 ± 0.045
2.147IleAsn: 2.147 ± 0.056
2.439IlePro: 2.439 ± 0.061
1.923IleGln: 1.923 ± 0.048
2.819IleArg: 2.819 ± 0.056
3.179IleSer: 3.179 ± 0.063
3.124IleThr: 3.124 ± 0.065
3.945IleVal: 3.945 ± 0.082
0.601IleTrp: 0.601 ± 0.031
1.502IleTyr: 1.502 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
3.914LysAla: 3.914 ± 0.099
0.239LysCys: 0.239 ± 0.019
1.923LysAsp: 1.923 ± 0.055
2.069LysGlu: 2.069 ± 0.065
1.367LysPhe: 1.367 ± 0.041
2.416LysGly: 2.416 ± 0.065
1.019LysHis: 1.019 ± 0.036
1.981LysIle: 1.981 ± 0.06
1.777LysLys: 1.777 ± 0.056
4.244LysLeu: 4.244 ± 0.071
0.955LysMet: 0.955 ± 0.035
1.178LysAsn: 1.178 ± 0.04
1.869LysPro: 1.869 ± 0.061
2.386LysGln: 2.386 ± 0.066
2.456LysArg: 2.456 ± 0.067
1.973LysSer: 1.973 ± 0.056
1.935LysThr: 1.935 ± 0.049
3.074LysVal: 3.074 ± 0.062
0.427LysTrp: 0.427 ± 0.027
1.0LysTyr: 1.0 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
12.414LeuAla: 12.414 ± 0.157
0.894LeuCys: 0.894 ± 0.04
5.511LeuAsp: 5.511 ± 0.079
6.208LeuGlu: 6.208 ± 0.102
3.802LeuPhe: 3.802 ± 0.084
7.199LeuGly: 7.199 ± 0.112
2.377LeuHis: 2.377 ± 0.056
5.385LeuIle: 5.385 ± 0.097
3.897LeuLys: 3.897 ± 0.079
11.653LeuLeu: 11.653 ± 0.182
2.461LeuMet: 2.461 ± 0.055
3.733LeuAsn: 3.733 ± 0.072
5.224LeuPro: 5.224 ± 0.085
5.799LeuGln: 5.799 ± 0.121
6.237LeuArg: 6.237 ± 0.102
6.357LeuSer: 6.357 ± 0.102
6.094LeuThr: 6.094 ± 0.085
7.292LeuVal: 7.292 ± 0.111
1.344LeuTrp: 1.344 ± 0.052
2.6LeuTyr: 2.6 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.706MetAla: 2.706 ± 0.066
0.153MetCys: 0.153 ± 0.013
1.08MetAsp: 1.08 ± 0.032
1.109MetGlu: 1.109 ± 0.038
0.804MetPhe: 0.804 ± 0.032
1.647MetGly: 1.647 ± 0.061
0.517MetHis: 0.517 ± 0.028
1.194MetIle: 1.194 ± 0.044
1.146MetLys: 1.146 ± 0.037
2.696MetLeu: 2.696 ± 0.067
0.631MetMet: 0.631 ± 0.031
0.89MetAsn: 0.89 ± 0.033
1.23MetPro: 1.23 ± 0.038
1.355MetGln: 1.355 ± 0.041
1.503MetArg: 1.503 ± 0.047
1.618MetSer: 1.618 ± 0.043
1.573MetThr: 1.573 ± 0.043
1.727MetVal: 1.727 ± 0.049
0.25MetTrp: 0.25 ± 0.019
0.529MetTyr: 0.529 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.429AsnAla: 3.429 ± 0.077
0.326AsnCys: 0.326 ± 0.018
2.181AsnAsp: 2.181 ± 0.056
2.143AsnGlu: 2.143 ± 0.049
1.444AsnPhe: 1.444 ± 0.052
2.767AsnGly: 2.767 ± 0.061
0.696AsnHis: 0.696 ± 0.033
1.766AsnIle: 1.766 ± 0.061
1.26AsnLys: 1.26 ± 0.041
3.291AsnLeu: 3.291 ± 0.064
0.796AsnMet: 0.796 ± 0.032
1.255AsnAsn: 1.255 ± 0.041
1.835AsnPro: 1.835 ± 0.049
1.568AsnGln: 1.568 ± 0.053
1.816AsnArg: 1.816 ± 0.054
1.915AsnSer: 1.915 ± 0.049
1.827AsnThr: 1.827 ± 0.049
2.386AsnVal: 2.386 ± 0.061
0.559AsnTrp: 0.559 ± 0.027
1.289AsnTyr: 1.289 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
4.276ProAla: 4.276 ± 0.092
0.293ProCys: 0.293 ± 0.02
2.602ProAsp: 2.602 ± 0.063
3.468ProGlu: 3.468 ± 0.072
1.688ProPhe: 1.688 ± 0.041
2.653ProGly: 2.653 ± 0.059
0.919ProHis: 0.919 ± 0.038
2.206ProIle: 2.206 ± 0.055
1.544ProLys: 1.544 ± 0.044
4.722ProLeu: 4.722 ± 0.091
0.981ProMet: 0.981 ± 0.033
1.641ProAsn: 1.641 ± 0.038
1.415ProPro: 1.415 ± 0.054
2.273ProGln: 2.273 ± 0.061
1.966ProArg: 1.966 ± 0.056
2.323ProSer: 2.323 ± 0.057
2.386ProThr: 2.386 ± 0.05
3.251ProVal: 3.251 ± 0.061
0.626ProTrp: 0.626 ± 0.03
1.264ProTyr: 1.264 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
5.648GlnAla: 5.648 ± 0.103
0.308GlnCys: 0.308 ± 0.02
2.066GlnAsp: 2.066 ± 0.06
2.537GlnGlu: 2.537 ± 0.062
1.861GlnPhe: 1.861 ± 0.055
3.257GlnGly: 3.257 ± 0.069
1.488GlnHis: 1.488 ± 0.047
2.294GlnIle: 2.294 ± 0.055
1.54GlnLys: 1.54 ± 0.051
7.106GlnLeu: 7.106 ± 0.144
1.1GlnMet: 1.1 ± 0.039
1.342GlnAsn: 1.342 ± 0.044
2.481GlnPro: 2.481 ± 0.065
5.452GlnGln: 5.452 ± 0.176
4.168GlnArg: 4.168 ± 0.098
2.362GlnSer: 2.362 ± 0.062
2.316GlnThr: 2.316 ± 0.06
3.731GlnVal: 3.731 ± 0.08
0.848GlnTrp: 0.848 ± 0.04
1.163GlnTyr: 1.163 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
5.239ArgAla: 5.239 ± 0.101
0.434ArgCys: 0.434 ± 0.022
3.375ArgAsp: 3.375 ± 0.073
4.001ArgGlu: 4.001 ± 0.084
2.42ArgPhe: 2.42 ± 0.056
3.488ArgGly: 3.488 ± 0.079
1.328ArgHis: 1.328 ± 0.041
3.347ArgIle: 3.347 ± 0.065
2.275ArgLys: 2.275 ± 0.063
5.974ArgLeu: 5.974 ± 0.101
1.489ArgMet: 1.489 ± 0.04
1.941ArgAsn: 1.941 ± 0.052
2.131ArgPro: 2.131 ± 0.048
2.994ArgGln: 2.994 ± 0.066
3.333ArgArg: 3.333 ± 0.076
3.025ArgSer: 3.025 ± 0.068
2.466ArgThr: 2.466 ± 0.059
4.054ArgVal: 4.054 ± 0.077
0.972ArgTrp: 0.972 ± 0.04
2.127ArgTyr: 2.127 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
5.71SerAla: 5.71 ± 0.096
0.523SerCys: 0.523 ± 0.026
3.149SerAsp: 3.149 ± 0.066
3.446SerGlu: 3.446 ± 0.073
2.494SerPhe: 2.494 ± 0.07
4.526SerGly: 4.526 ± 0.089
1.157SerHis: 1.157 ± 0.04
3.061SerIle: 3.061 ± 0.074
2.085SerLys: 2.085 ± 0.053
5.664SerLeu: 5.664 ± 0.09
1.494SerMet: 1.494 ± 0.046
1.956SerAsn: 1.956 ± 0.06
2.193SerPro: 2.193 ± 0.052
2.368SerGln: 2.368 ± 0.055
2.89SerArg: 2.89 ± 0.059
3.336SerSer: 3.336 ± 0.078
2.675SerThr: 2.675 ± 0.063
3.942SerVal: 3.942 ± 0.078
0.83SerTrp: 0.83 ± 0.031
1.87SerTyr: 1.87 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.532ThrAla: 5.532 ± 0.09
0.387ThrCys: 0.387 ± 0.024
3.012ThrAsp: 3.012 ± 0.054
3.326ThrGlu: 3.326 ± 0.066
1.982ThrPhe: 1.982 ± 0.053
4.054ThrGly: 4.054 ± 0.092
1.086ThrHis: 1.086 ± 0.04
2.869ThrIle: 2.869 ± 0.059
1.605ThrLys: 1.605 ± 0.049
5.958ThrLeu: 5.958 ± 0.078
1.121ThrMet: 1.121 ± 0.042
1.578ThrAsn: 1.578 ± 0.053
2.746ThrPro: 2.746 ± 0.065
2.197ThrGln: 2.197 ± 0.065
2.573ThrArg: 2.573 ± 0.051
2.827ThrSer: 2.827 ± 0.066
2.969ThrThr: 2.969 ± 0.069
4.192ThrVal: 4.192 ± 0.077
0.658ThrTrp: 0.658 ± 0.031
1.522ThrTyr: 1.522 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
7.861ValAla: 7.861 ± 0.124
0.638ValCys: 0.638 ± 0.033
4.24ValAsp: 4.24 ± 0.079
4.653ValGlu: 4.653 ± 0.088
2.729ValPhe: 2.729 ± 0.062
4.972ValGly: 4.972 ± 0.095
1.443ValHis: 1.443 ± 0.041
4.584ValIle: 4.584 ± 0.09
2.909ValLys: 2.909 ± 0.071
7.423ValLeu: 7.423 ± 0.112
1.903ValMet: 1.903 ± 0.05
2.79ValAsn: 2.79 ± 0.061
3.059ValPro: 3.059 ± 0.065
2.92ValGln: 2.92 ± 0.062
3.789ValArg: 3.789 ± 0.071
4.408ValSer: 4.408 ± 0.086
4.376ValThr: 4.376 ± 0.073
5.87ValVal: 5.87 ± 0.106
0.871ValTrp: 0.871 ± 0.035
1.958ValTyr: 1.958 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.922TrpAla: 0.922 ± 0.037
0.133TrpCys: 0.133 ± 0.014
0.593TrpAsp: 0.593 ± 0.027
0.501TrpGlu: 0.501 ± 0.028
0.708TrpPhe: 0.708 ± 0.03
0.812TrpGly: 0.812 ± 0.037
0.429TrpHis: 0.429 ± 0.024
0.621TrpIle: 0.621 ± 0.031
0.283TrpLys: 0.283 ± 0.018
2.277TrpLeu: 2.277 ± 0.064
0.346TrpMet: 0.346 ± 0.02
0.36TrpAsn: 0.36 ± 0.021
0.588TrpPro: 0.588 ± 0.034
1.553TrpGln: 1.553 ± 0.063
1.05TrpArg: 1.05 ± 0.049
0.742TrpSer: 0.742 ± 0.036
0.489TrpThr: 0.489 ± 0.027
1.013TrpVal: 1.013 ± 0.041
0.309TrpTrp: 0.309 ± 0.022
0.459TrpTyr: 0.459 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.808TyrAla: 2.808 ± 0.068
0.325TyrCys: 0.325 ± 0.023
1.778TyrAsp: 1.778 ± 0.051
1.685TyrGlu: 1.685 ± 0.053
1.352TyrPhe: 1.352 ± 0.049
2.25TyrGly: 2.25 ± 0.064
0.76TyrHis: 0.76 ± 0.03
1.314TyrIle: 1.314 ± 0.045
0.914TyrLys: 0.914 ± 0.037
3.295TyrLeu: 3.295 ± 0.062
0.58TyrMet: 0.58 ± 0.029
1.005TyrAsn: 1.005 ± 0.041
1.469TyrPro: 1.469 ± 0.05
1.799TyrGln: 1.799 ± 0.048
2.01TyrArg: 2.01 ± 0.054
1.682TyrSer: 1.682 ± 0.046
1.497TyrThr: 1.497 ± 0.04
1.951TyrVal: 1.951 ± 0.053
0.48TyrTrp: 0.48 ± 0.027
0.98TyrTyr: 0.98 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2290 proteins (760291 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski