Amino acid dipepetide frequency for Wheat stripe mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.752AlaAla: 7.752 ± 2.433
1.604AlaCys: 1.604 ± 1.272
4.277AlaAsp: 4.277 ± 1.2
6.415AlaGlu: 6.415 ± 2.392
2.138AlaPhe: 2.138 ± 0.983
6.415AlaGly: 6.415 ± 1.563
1.604AlaHis: 1.604 ± 0.779
5.079AlaIle: 5.079 ± 1.268
4.812AlaLys: 4.812 ± 1.796
9.356AlaLeu: 9.356 ± 1.768
4.01AlaMet: 4.01 ± 0.874
2.406AlaAsn: 2.406 ± 1.191
1.604AlaPro: 1.604 ± 0.429
4.277AlaGln: 4.277 ± 1.267
3.742AlaArg: 3.742 ± 1.216
5.881AlaSer: 5.881 ± 1.651
6.95AlaThr: 6.95 ± 1.796
6.95AlaVal: 6.95 ± 1.629
1.604AlaTrp: 1.604 ± 0.68
2.673AlaTyr: 2.673 ± 0.699
0.0AlaXaa: 0.0 ± 0.0
Cys
1.337CysAla: 1.337 ± 0.702
0.802CysCys: 0.802 ± 1.035
1.069CysAsp: 1.069 ± 0.712
1.069CysGlu: 1.069 ± 0.583
1.337CysPhe: 1.337 ± 0.702
2.138CysGly: 2.138 ± 1.272
0.802CysHis: 0.802 ± 0.762
0.535CysIle: 0.535 ± 0.635
0.802CysLys: 0.802 ± 1.099
0.802CysLeu: 0.802 ± 0.517
0.267CysMet: 0.267 ± 0.625
0.535CysAsn: 0.535 ± 0.345
1.069CysPro: 1.069 ± 0.682
0.267CysGln: 0.267 ± 0.172
0.802CysArg: 0.802 ± 0.384
0.535CysSer: 0.535 ± 0.345
0.802CysThr: 0.802 ± 0.62
0.535CysVal: 0.535 ± 0.635
0.535CysTrp: 0.535 ± 1.36
0.267CysTyr: 0.267 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
4.277AspAla: 4.277 ± 1.36
1.604AspCys: 1.604 ± 0.779
2.94AspAsp: 2.94 ± 1.121
4.277AspGlu: 4.277 ± 0.929
2.94AspPhe: 2.94 ± 0.796
3.208AspGly: 3.208 ± 2.354
0.535AspHis: 0.535 ± 0.291
2.673AspIle: 2.673 ± 1.432
2.94AspLys: 2.94 ± 1.065
6.148AspLeu: 6.148 ± 1.746
1.871AspMet: 1.871 ± 1.091
1.337AspAsn: 1.337 ± 0.55
2.94AspPro: 2.94 ± 1.013
2.406AspGln: 2.406 ± 0.673
2.138AspArg: 2.138 ± 1.029
3.208AspSer: 3.208 ± 1.09
2.406AspThr: 2.406 ± 0.752
5.346AspVal: 5.346 ± 1.476
1.604AspTrp: 1.604 ± 0.626
2.673AspTyr: 2.673 ± 1.266
0.267AspXaa: 0.267 ± 0.362
Glu
6.415GluAla: 6.415 ± 1.205
0.802GluCys: 0.802 ± 0.636
1.604GluAsp: 1.604 ± 0.623
4.544GluGlu: 4.544 ± 2.145
2.94GluPhe: 2.94 ± 1.53
3.742GluGly: 3.742 ± 0.928
1.871GluHis: 1.871 ± 1.183
1.871GluIle: 1.871 ± 0.865
3.208GluLys: 3.208 ± 0.858
6.683GluLeu: 6.683 ± 1.814
0.802GluMet: 0.802 ± 0.313
3.208GluAsn: 3.208 ± 1.306
3.208GluPro: 3.208 ± 0.896
2.673GluGln: 2.673 ± 0.566
3.475GluArg: 3.475 ± 2.057
3.475GluSer: 3.475 ± 0.613
2.406GluThr: 2.406 ± 0.767
5.079GluVal: 5.079 ± 2.304
0.267GluTrp: 0.267 ± 0.172
1.069GluTyr: 1.069 ± 0.491
0.0GluXaa: 0.0 ± 0.0
Phe
2.406PheAla: 2.406 ± 1.288
0.535PheCys: 0.535 ± 0.345
2.406PheAsp: 2.406 ± 1.193
2.138PheGlu: 2.138 ± 0.833
1.069PhePhe: 1.069 ± 0.582
2.673PheGly: 2.673 ± 0.832
1.337PheHis: 1.337 ± 0.628
1.337PheIle: 1.337 ± 0.889
2.406PheLys: 2.406 ± 1.086
3.208PheLeu: 3.208 ± 1.034
0.535PheMet: 0.535 ± 0.345
1.337PheAsn: 1.337 ± 1.243
1.069PhePro: 1.069 ± 0.81
2.406PheGln: 2.406 ± 1.551
3.475PheArg: 3.475 ± 1.233
4.01PheSer: 4.01 ± 0.951
2.94PheThr: 2.94 ± 1.209
5.613PheVal: 5.613 ± 1.92
0.535PheTrp: 0.535 ± 0.881
1.604PheTyr: 1.604 ± 0.734
0.0PheXaa: 0.0 ± 0.0
Gly
6.95GlyAla: 6.95 ± 2.432
1.604GlyCys: 1.604 ± 0.863
5.881GlyAsp: 5.881 ± 1.998
4.01GlyGlu: 4.01 ± 2.123
5.613GlyPhe: 5.613 ± 1.826
13.633GlyGly: 13.633 ± 9.555
2.406GlyHis: 2.406 ± 0.914
2.673GlyIle: 2.673 ± 0.87
2.138GlyLys: 2.138 ± 1.347
6.148GlyLeu: 6.148 ± 1.575
0.802GlyMet: 0.802 ± 0.956
1.337GlyAsn: 1.337 ± 0.327
3.742GlyPro: 3.742 ± 1.205
1.337GlyGln: 1.337 ± 0.628
2.94GlyArg: 2.94 ± 2.148
4.544GlySer: 4.544 ± 1.998
4.277GlyThr: 4.277 ± 0.996
2.94GlyVal: 2.94 ± 1.187
0.267GlyTrp: 0.267 ± 0.848
2.406GlyTyr: 2.406 ± 1.296
0.0GlyXaa: 0.0 ± 0.0
His
2.138HisAla: 2.138 ± 0.581
0.267HisCys: 0.267 ± 0.588
0.802HisAsp: 0.802 ± 0.384
1.069HisGlu: 1.069 ± 0.582
1.069HisPhe: 1.069 ± 0.689
1.069HisGly: 1.069 ± 1.338
0.802HisHis: 0.802 ± 0.796
0.802HisIle: 0.802 ± 0.313
0.802HisLys: 0.802 ± 0.517
1.069HisLeu: 1.069 ± 0.824
0.802HisMet: 0.802 ± 0.384
1.604HisAsn: 1.604 ± 0.974
2.138HisPro: 2.138 ± 0.703
0.802HisGln: 0.802 ± 0.384
3.475HisArg: 3.475 ± 0.556
1.069HisSer: 1.069 ± 1.05
2.138HisThr: 2.138 ± 0.522
2.406HisVal: 2.406 ± 0.568
0.267HisTrp: 0.267 ± 0.362
1.069HisTyr: 1.069 ± 0.491
0.0HisXaa: 0.0 ± 0.0
Ile
2.94IleAla: 2.94 ± 0.646
1.069IleCys: 1.069 ± 1.356
4.01IleAsp: 4.01 ± 0.951
2.406IleGlu: 2.406 ± 1.818
0.535IlePhe: 0.535 ± 0.345
1.337IleGly: 1.337 ± 0.55
0.267IleHis: 0.267 ± 0.172
2.138IleIle: 2.138 ± 1.931
2.406IleLys: 2.406 ± 0.977
4.01IleLeu: 4.01 ± 1.182
1.604IleMet: 1.604 ± 0.623
1.871IleAsn: 1.871 ± 0.668
1.069IlePro: 1.069 ± 0.491
1.337IleGln: 1.337 ± 0.862
2.406IleArg: 2.406 ± 0.851
1.337IleSer: 1.337 ± 0.579
1.337IleThr: 1.337 ± 0.628
2.94IleVal: 2.94 ± 0.92
0.0IleTrp: 0.0 ± 0.0
1.871IleTyr: 1.871 ± 0.673
0.0IleXaa: 0.0 ± 0.0
Lys
2.673LysAla: 2.673 ± 1.183
0.535LysCys: 0.535 ± 0.744
3.475LysAsp: 3.475 ± 1.644
2.94LysGlu: 2.94 ± 1.354
1.069LysPhe: 1.069 ± 0.491
3.475LysGly: 3.475 ± 2.4
1.604LysHis: 1.604 ± 0.863
1.604LysIle: 1.604 ± 1.034
2.673LysLys: 2.673 ± 0.945
5.346LysLeu: 5.346 ± 1.265
0.802LysMet: 0.802 ± 0.502
2.138LysAsn: 2.138 ± 0.639
2.94LysPro: 2.94 ± 1.419
1.604LysGln: 1.604 ± 0.769
2.673LysArg: 2.673 ± 1.257
2.406LysSer: 2.406 ± 0.898
3.208LysThr: 3.208 ± 0.848
4.01LysVal: 4.01 ± 0.69
1.337LysTrp: 1.337 ± 0.327
1.871LysTyr: 1.871 ± 1.611
0.0LysXaa: 0.0 ± 0.0
Leu
10.158LeuAla: 10.158 ± 2.329
2.138LeuCys: 2.138 ± 0.581
4.277LeuAsp: 4.277 ± 0.781
4.812LeuGlu: 4.812 ± 0.926
3.475LeuPhe: 3.475 ± 0.99
7.485LeuGly: 7.485 ± 2.532
1.871LeuHis: 1.871 ± 1.007
1.871LeuIle: 1.871 ± 1.206
5.346LeuLys: 5.346 ± 2.241
10.425LeuLeu: 10.425 ± 1.194
2.673LeuMet: 2.673 ± 1.25
3.208LeuAsn: 3.208 ± 0.902
5.079LeuPro: 5.079 ± 1.035
4.01LeuGln: 4.01 ± 1.092
5.881LeuArg: 5.881 ± 2.874
3.742LeuSer: 3.742 ± 0.741
6.148LeuThr: 6.148 ± 0.859
7.485LeuVal: 7.485 ± 1.692
0.802LeuTrp: 0.802 ± 0.918
2.406LeuTyr: 2.406 ± 0.717
0.0LeuXaa: 0.0 ± 0.0
Met
3.742MetAla: 3.742 ± 1.412
1.069MetCys: 1.069 ± 1.691
0.802MetAsp: 0.802 ± 0.517
0.802MetGlu: 0.802 ± 0.517
1.069MetPhe: 1.069 ± 0.6
1.069MetGly: 1.069 ± 0.575
1.069MetHis: 1.069 ± 0.413
1.604MetIle: 1.604 ± 0.702
0.802MetLys: 0.802 ± 0.517
1.604MetLeu: 1.604 ± 0.484
0.802MetMet: 0.802 ± 0.689
0.535MetAsn: 0.535 ± 0.345
2.406MetPro: 2.406 ± 0.977
0.267MetGln: 0.267 ± 0.372
1.604MetArg: 1.604 ± 0.566
3.475MetSer: 3.475 ± 0.654
1.871MetThr: 1.871 ± 0.581
2.673MetVal: 2.673 ± 0.916
0.267MetTrp: 0.267 ± 0.172
0.802MetTyr: 0.802 ± 0.517
0.0MetXaa: 0.0 ± 0.0
Asn
3.208AsnAla: 3.208 ± 1.351
0.267AsnCys: 0.267 ± 0.172
1.604AsnAsp: 1.604 ± 0.702
2.138AsnGlu: 2.138 ± 0.719
1.337AsnPhe: 1.337 ± 0.862
1.871AsnGly: 1.871 ± 1.921
0.802AsnHis: 0.802 ± 0.517
0.802AsnIle: 0.802 ± 0.517
1.604AsnLys: 1.604 ± 1.435
3.475AsnLeu: 3.475 ± 0.755
1.337AsnMet: 1.337 ± 1.249
0.535AsnAsn: 0.535 ± 0.345
1.069AsnPro: 1.069 ± 0.689
1.069AsnGln: 1.069 ± 0.674
1.604AsnArg: 1.604 ± 0.634
1.871AsnSer: 1.871 ± 0.929
1.604AsnThr: 1.604 ± 0.626
4.01AsnVal: 4.01 ± 1.079
1.069AsnTrp: 1.069 ± 0.81
1.069AsnTyr: 1.069 ± 0.299
0.0AsnXaa: 0.0 ± 0.0
Pro
4.01ProAla: 4.01 ± 1.05
0.0ProCys: 0.0 ± 0.0
2.406ProAsp: 2.406 ± 0.938
4.01ProGlu: 4.01 ± 1.042
1.871ProPhe: 1.871 ± 0.726
4.01ProGly: 4.01 ± 1.071
0.802ProHis: 0.802 ± 0.689
1.604ProIle: 1.604 ± 1.034
2.138ProLys: 2.138 ± 0.587
3.475ProLeu: 3.475 ± 0.99
1.871ProMet: 1.871 ± 0.566
1.604ProAsn: 1.604 ± 0.555
2.138ProPro: 2.138 ± 1.989
1.069ProGln: 1.069 ± 0.674
1.069ProArg: 1.069 ± 0.943
1.337ProSer: 1.337 ± 1.243
3.208ProThr: 3.208 ± 0.826
5.079ProVal: 5.079 ± 0.903
0.535ProTrp: 0.535 ± 0.291
1.337ProTyr: 1.337 ± 0.579
0.0ProXaa: 0.0 ± 0.0
Gln
4.544GlnAla: 4.544 ± 0.84
0.535GlnCys: 0.535 ± 0.345
2.673GlnAsp: 2.673 ± 1.03
1.069GlnGlu: 1.069 ± 0.299
1.069GlnPhe: 1.069 ± 0.413
2.138GlnGly: 2.138 ± 1.705
0.802GlnHis: 0.802 ± 0.384
0.535GlnIle: 0.535 ± 0.345
2.406GlnLys: 2.406 ± 1.041
5.346GlnLeu: 5.346 ± 1.169
1.604GlnMet: 1.604 ± 0.769
1.604GlnAsn: 1.604 ± 0.871
0.802GlnPro: 0.802 ± 0.362
1.871GlnGln: 1.871 ± 1.206
2.673GlnArg: 2.673 ± 0.654
2.406GlnSer: 2.406 ± 0.814
1.871GlnThr: 1.871 ± 0.699
2.94GlnVal: 2.94 ± 1.25
0.267GlnTrp: 0.267 ± 0.172
0.535GlnTyr: 0.535 ± 0.345
0.0GlnXaa: 0.0 ± 0.0
Arg
6.148ArgAla: 6.148 ± 1.233
0.802ArgCys: 0.802 ± 0.313
4.812ArgAsp: 4.812 ± 0.867
4.544ArgGlu: 4.544 ± 1.169
4.01ArgPhe: 4.01 ± 1.374
2.673ArgGly: 2.673 ± 1.747
2.673ArgHis: 2.673 ± 1.042
2.138ArgIle: 2.138 ± 1.081
2.406ArgLys: 2.406 ± 0.777
5.079ArgLeu: 5.079 ± 1.995
1.604ArgMet: 1.604 ± 0.626
1.871ArgAsn: 1.871 ± 0.712
2.673ArgPro: 2.673 ± 1.927
3.475ArgGln: 3.475 ± 0.475
5.079ArgArg: 5.079 ± 2.484
2.94ArgSer: 2.94 ± 0.932
3.208ArgThr: 3.208 ± 1.377
4.277ArgVal: 4.277 ± 1.733
0.0ArgTrp: 0.0 ± 0.0
1.604ArgTyr: 1.604 ± 0.626
0.0ArgXaa: 0.0 ± 0.0
Ser
3.742SerAla: 3.742 ± 1.227
1.069SerCys: 1.069 ± 0.643
2.94SerAsp: 2.94 ± 0.872
3.208SerGlu: 3.208 ± 0.896
3.742SerPhe: 3.742 ± 1.584
8.019SerGly: 8.019 ± 3.327
1.604SerHis: 1.604 ± 0.566
1.604SerIle: 1.604 ± 0.429
2.138SerLys: 2.138 ± 0.908
5.079SerLeu: 5.079 ± 1.698
1.069SerMet: 1.069 ± 0.413
1.871SerAsn: 1.871 ± 1.333
1.604SerPro: 1.604 ± 0.723
3.475SerGln: 3.475 ± 0.768
4.812SerArg: 4.812 ± 1.006
6.683SerSer: 6.683 ± 3.39
2.673SerThr: 2.673 ± 0.562
6.148SerVal: 6.148 ± 1.419
1.069SerTrp: 1.069 ± 0.689
1.337SerTyr: 1.337 ± 0.615
0.0SerXaa: 0.0 ± 0.0
Thr
5.346ThrAla: 5.346 ± 0.635
0.802ThrCys: 0.802 ± 0.384
2.673ThrAsp: 2.673 ± 0.566
2.673ThrGlu: 2.673 ± 0.772
3.475ThrPhe: 3.475 ± 1.675
3.208ThrGly: 3.208 ± 0.902
1.604ThrHis: 1.604 ± 0.729
2.138ThrIle: 2.138 ± 0.844
3.208ThrLys: 3.208 ± 2.091
5.346ThrLeu: 5.346 ± 1.629
1.604ThrMet: 1.604 ± 0.885
0.802ThrAsn: 0.802 ± 0.717
2.406ThrPro: 2.406 ± 0.602
2.138ThrGln: 2.138 ± 1.379
5.346ThrArg: 5.346 ± 0.509
5.613ThrSer: 5.613 ± 0.927
2.406ThrThr: 2.406 ± 0.752
5.346ThrVal: 5.346 ± 1.354
0.267ThrTrp: 0.267 ± 0.172
1.069ThrTyr: 1.069 ± 1.191
0.0ThrXaa: 0.0 ± 0.0
Val
6.683ValAla: 6.683 ± 2.328
1.069ValCys: 1.069 ± 0.987
6.683ValAsp: 6.683 ± 1.63
4.812ValGlu: 4.812 ± 1.512
1.871ValPhe: 1.871 ± 0.581
4.812ValGly: 4.812 ± 2.331
2.138ValHis: 2.138 ± 0.753
3.475ValIle: 3.475 ± 1.91
4.812ValLys: 4.812 ± 2.629
7.485ValLeu: 7.485 ± 1.186
2.94ValMet: 2.94 ± 0.658
3.208ValAsn: 3.208 ± 0.778
4.812ValPro: 4.812 ± 1.614
1.871ValGln: 1.871 ± 0.744
5.881ValArg: 5.881 ± 1.411
5.613ValSer: 5.613 ± 1.311
5.881ValThr: 5.881 ± 1.659
8.554ValVal: 8.554 ± 3.899
0.802ValTrp: 0.802 ± 1.17
2.673ValTyr: 2.673 ± 1.164
0.0ValXaa: 0.0 ± 0.0
Trp
0.802TrpAla: 0.802 ± 0.362
0.0TrpCys: 0.0 ± 0.0
0.535TrpAsp: 0.535 ± 0.705
0.802TrpGlu: 0.802 ± 0.517
1.069TrpPhe: 1.069 ± 1.219
0.535TrpGly: 0.535 ± 0.345
0.535TrpHis: 0.535 ± 0.881
1.069TrpIle: 1.069 ± 0.6
0.0TrpLys: 0.0 ± 0.0
1.871TrpLeu: 1.871 ± 0.756
0.535TrpMet: 0.535 ± 0.291
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.267TrpArg: 0.267 ± 0.172
1.069TrpSer: 1.069 ± 0.582
0.802TrpThr: 0.802 ± 0.762
1.069TrpVal: 1.069 ± 1.074
0.802TrpTrp: 0.802 ± 1.047
0.802TrpTyr: 0.802 ± 0.313
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.277TyrAla: 4.277 ± 1.149
0.0TyrCys: 0.0 ± 0.0
1.871TyrAsp: 1.871 ± 1.083
1.604TyrGlu: 1.604 ± 0.429
1.337TyrPhe: 1.337 ± 0.886
2.138TyrGly: 2.138 ± 1.392
0.535TyrHis: 0.535 ± 0.291
1.337TyrIle: 1.337 ± 0.55
1.337TyrLys: 1.337 ± 0.683
1.337TyrLeu: 1.337 ± 0.686
0.535TyrMet: 0.535 ± 0.345
1.337TyrAsn: 1.337 ± 0.581
0.802TyrPro: 0.802 ± 0.796
1.069TyrGln: 1.069 ± 0.491
2.673TyrArg: 2.673 ± 0.861
2.673TyrSer: 2.673 ± 0.706
1.337TyrThr: 1.337 ± 0.702
2.673TyrVal: 2.673 ± 1.699
0.267TyrTrp: 0.267 ± 0.362
0.802TyrTyr: 0.802 ± 0.517
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.267XaaGln: 0.267 ± 0.362
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (3742 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski