Amino acid dipepetide frequency for Brucella abortus (strain 2308)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.49AlaAla: 14.49 ± 0.185	1.044AlaCys: 1.044 ± 0.037	6.232AlaAsp: 6.232 ± 0.081	7.261AlaGlu: 7.261 ± 0.109	4.379AlaPhe: 4.379 ± 0.085	9.697AlaGly: 9.697 ± 0.135	2.273AlaHis: 2.273 ± 0.055	6.995AlaIle: 6.995 ± 0.104	4.528AlaLys: 4.528 ± 0.085	12.184AlaLeu: 12.184 ± 0.135	3.433AlaMet: 3.433 ± 0.06	3.265AlaAsn: 3.265 ± 0.061	4.898AlaPro: 4.898 ± 0.08	3.744AlaGln: 3.744 ± 0.067	7.748AlaArg: 7.748 ± 0.11	6.238AlaSer: 6.238 ± 0.094	5.271AlaThr: 5.271 ± 0.082	7.942AlaVal: 7.942 ± 0.107	1.211AlaTrp: 1.211 ± 0.043	2.667AlaTyr: 2.667 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.895CysAla: 0.895 ± 0.037	0.127CysCys: 0.127 ± 0.014	0.522CysAsp: 0.522 ± 0.024	0.445CysGlu: 0.445 ± 0.024	0.386CysPhe: 0.386 ± 0.023	0.913CysGly: 0.913 ± 0.033	0.252CysHis: 0.252 ± 0.017	0.496CysIle: 0.496 ± 0.023	0.249CysLys: 0.249 ± 0.016	0.755CysLeu: 0.755 ± 0.033	0.187CysMet: 0.187 ± 0.015	0.222CysAsn: 0.222 ± 0.016	0.44CysPro: 0.44 ± 0.023	0.246CysGln: 0.246 ± 0.019	0.558CysArg: 0.558 ± 0.026	0.487CysSer: 0.487 ± 0.026	0.438CysThr: 0.438 ± 0.024	0.574CysVal: 0.574 ± 0.025	0.121CysTrp: 0.121 ± 0.012	0.184CysTyr: 0.184 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.166AspAla: 6.166 ± 0.091	0.491AspCys: 0.491 ± 0.025	2.901AspAsp: 2.901 ± 0.064	3.664AspGlu: 3.664 ± 0.066	2.162AspPhe: 2.162 ± 0.044	4.798AspGly: 4.798 ± 0.087	1.235AspHis: 1.235 ± 0.04	3.657AspIle: 3.657 ± 0.07	2.202AspLys: 2.202 ± 0.06	5.347AspLeu: 5.347 ± 0.094	1.564AspMet: 1.564 ± 0.045	1.55AspAsn: 1.55 ± 0.045	2.999AspPro: 2.999 ± 0.062	1.599AspGln: 1.599 ± 0.042	3.84AspArg: 3.84 ± 0.076	2.092AspSer: 2.092 ± 0.053	2.525AspThr: 2.525 ± 0.056	3.883AspVal: 3.883 ± 0.061	0.862AspTrp: 0.862 ± 0.031	1.63AspTyr: 1.63 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.377GluAla: 7.377 ± 0.116	0.363GluCys: 0.363 ± 0.022	2.944GluAsp: 2.944 ± 0.067	3.784GluGlu: 3.784 ± 0.093	1.798GluPhe: 1.798 ± 0.051	4.385GluGly: 4.385 ± 0.078	1.222GluHis: 1.222 ± 0.035	3.784GluIle: 3.784 ± 0.069	3.467GluLys: 3.467 ± 0.077	5.126GluLeu: 5.126 ± 0.081	1.714GluMet: 1.714 ± 0.046	2.21GluAsn: 2.21 ± 0.053	2.66GluPro: 2.66 ± 0.058	2.181GluGln: 2.181 ± 0.065	4.775GluArg: 4.775 ± 0.088	2.439GluSer: 2.439 ± 0.061	3.64GluThr: 3.64 ± 0.06	3.616GluVal: 3.616 ± 0.075	0.676GluTrp: 0.676 ± 0.025	1.14GluTyr: 1.14 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.469PheAla: 4.469 ± 0.08	0.437PheCys: 0.437 ± 0.024	2.648PheAsp: 2.648 ± 0.055	2.145PheGlu: 2.145 ± 0.058	1.686PhePhe: 1.686 ± 0.051	3.687PheGly: 3.687 ± 0.067	0.859PheHis: 0.859 ± 0.034	2.219PheIle: 2.219 ± 0.056	1.294PheLys: 1.294 ± 0.039	3.719PheLeu: 3.719 ± 0.076	0.948PheMet: 0.948 ± 0.037	1.373PheAsn: 1.373 ± 0.037	1.596PhePro: 1.596 ± 0.043	1.101PheGln: 1.101 ± 0.038	2.351PheArg: 2.351 ± 0.048	2.644PheSer: 2.644 ± 0.061	2.094PheThr: 2.094 ± 0.053	2.863PheVal: 2.863 ± 0.059	0.541PheTrp: 0.541 ± 0.026	1.021PheTyr: 1.021 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.354GlyAla: 8.354 ± 0.137	0.801GlyCys: 0.801 ± 0.033	4.16GlyAsp: 4.16 ± 0.062	4.915GlyGlu: 4.915 ± 0.077	3.825GlyPhe: 3.825 ± 0.079	6.817GlyGly: 6.817 ± 0.125	1.845GlyHis: 1.845 ± 0.05	5.19GlyIle: 5.19 ± 0.078	4.223GlyLys: 4.223 ± 0.082	8.259GlyLeu: 8.259 ± 0.107	2.31GlyMet: 2.31 ± 0.054	2.565GlyAsn: 2.565 ± 0.074	3.023GlyPro: 3.023 ± 0.056	2.791GlyGln: 2.791 ± 0.059	5.383GlyArg: 5.383 ± 0.073	4.748GlySer: 4.748 ± 0.089	4.469GlyThr: 4.469 ± 0.126	5.795GlyVal: 5.795 ± 0.089	1.192GlyTrp: 1.192 ± 0.036	2.273GlyTyr: 2.273 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.152HisAla: 2.152 ± 0.044	0.224HisCys: 0.224 ± 0.015	1.247HisAsp: 1.247 ± 0.042	1.16HisGlu: 1.16 ± 0.04	0.976HisPhe: 0.976 ± 0.037	1.934HisGly: 1.934 ± 0.042	0.592HisHis: 0.592 ± 0.042	1.25HisIle: 1.25 ± 0.041	0.685HisLys: 0.685 ± 0.03	2.011HisLeu: 2.011 ± 0.058	0.601HisMet: 0.601 ± 0.026	0.599HisAsn: 0.599 ± 0.025	1.251HisPro: 1.251 ± 0.037	0.595HisGln: 0.595 ± 0.029	1.396HisArg: 1.396 ± 0.046	1.046HisSer: 1.046 ± 0.032	0.865HisThr: 0.865 ± 0.032	1.497HisVal: 1.497 ± 0.043	0.275HisTrp: 0.275 ± 0.017	0.635HisTyr: 0.635 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	7.994IleAla: 7.994 ± 0.11	0.641IleCys: 0.641 ± 0.029	3.883IleAsp: 3.883 ± 0.073	3.934IleGlu: 3.934 ± 0.071	2.236IlePhe: 2.236 ± 0.051	5.376IleGly: 5.376 ± 0.091	1.135IleHis: 1.135 ± 0.039	3.165IleIle: 3.165 ± 0.071	1.902IleLys: 1.902 ± 0.055	5.148IleLeu: 5.148 ± 0.083	1.332IleMet: 1.332 ± 0.044	1.892IleAsn: 1.892 ± 0.048	2.56IlePro: 2.56 ± 0.054	1.336IleGln: 1.336 ± 0.043	3.599IleArg: 3.599 ± 0.059	3.503IleSer: 3.503 ± 0.056	2.933IleThr: 2.933 ± 0.06	4.649IleVal: 4.649 ± 0.072	0.641IleTrp: 0.641 ± 0.028	1.363IleTyr: 1.363 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.296LysAla: 5.296 ± 0.097	0.197LysCys: 0.197 ± 0.015	2.19LysAsp: 2.19 ± 0.059	2.176LysGlu: 2.176 ± 0.058	1.13LysPhe: 1.13 ± 0.036	3.341LysGly: 3.341 ± 0.062	0.796LysHis: 0.796 ± 0.033	2.356LysIle: 2.356 ± 0.057	2.018LysLys: 2.018 ± 0.061	4.223LysLeu: 4.223 ± 0.092	1.114LysMet: 1.114 ± 0.04	1.342LysAsn: 1.342 ± 0.038	2.741LysPro: 2.741 ± 0.067	1.353LysGln: 1.353 ± 0.043	2.838LysArg: 2.838 ± 0.056	2.203LysSer: 2.203 ± 0.051	2.441LysThr: 2.441 ± 0.055	2.817LysVal: 2.817 ± 0.064	0.434LysTrp: 0.434 ± 0.023	0.816LysTyr: 0.816 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.952LeuAla: 11.952 ± 0.145	0.921LeuCys: 0.921 ± 0.034	5.669LeuAsp: 5.669 ± 0.094	5.475LeuGlu: 5.475 ± 0.076	3.849LeuPhe: 3.849 ± 0.079	7.915LeuGly: 7.915 ± 0.117	1.906LeuHis: 1.906 ± 0.051	5.499LeuIle: 5.499 ± 0.097	4.46LeuLys: 4.46 ± 0.077	8.937LeuLeu: 8.937 ± 0.162	2.436LeuMet: 2.436 ± 0.059	2.898LeuAsn: 2.898 ± 0.056	5.259LeuPro: 5.259 ± 0.077	2.911LeuGln: 2.911 ± 0.058	5.959LeuArg: 5.959 ± 0.091	6.547LeuSer: 6.547 ± 0.089	5.167LeuThr: 5.167 ± 0.085	7.163LeuVal: 7.163 ± 0.097	1.013LeuTrp: 1.013 ± 0.044	2.29LeuTyr: 2.29 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.165MetAla: 3.165 ± 0.066	0.164MetCys: 0.164 ± 0.015	1.192MetAsp: 1.192 ± 0.04	1.44MetGlu: 1.44 ± 0.037	0.773MetPhe: 0.773 ± 0.029	1.903MetGly: 1.903 ± 0.042	0.465MetHis: 0.465 ± 0.021	1.497MetIle: 1.497 ± 0.037	1.376MetLys: 1.376 ± 0.041	2.591MetLeu: 2.591 ± 0.056	0.753MetMet: 0.753 ± 0.034	0.965MetAsn: 0.965 ± 0.033	1.51MetPro: 1.51 ± 0.036	1.038MetGln: 1.038 ± 0.033	2.01MetArg: 2.01 ± 0.051	1.668MetSer: 1.668 ± 0.038	1.796MetThr: 1.796 ± 0.046	1.847MetVal: 1.847 ± 0.045	0.207MetTrp: 0.207 ± 0.014	0.316MetTyr: 0.316 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.53AsnAla: 3.53 ± 0.061	0.275AsnCys: 0.275 ± 0.017	1.645AsnAsp: 1.645 ± 0.04	1.541AsnGlu: 1.541 ± 0.042	1.22AsnPhe: 1.22 ± 0.042	2.857AsnGly: 2.857 ± 0.077	0.62AsnHis: 0.62 ± 0.026	1.895AsnIle: 1.895 ± 0.058	1.037AsnLys: 1.037 ± 0.03	2.896AsnLeu: 2.896 ± 0.065	0.858AsnMet: 0.858 ± 0.03	0.889AsnAsn: 0.889 ± 0.039	2.066AsnPro: 2.066 ± 0.052	0.905AsnGln: 0.905 ± 0.033	2.154AsnArg: 2.154 ± 0.047	1.579AsnSer: 1.579 ± 0.052	1.408AsnThr: 1.408 ± 0.047	2.197AsnVal: 2.197 ± 0.054	0.521AsnTrp: 0.521 ± 0.022	0.84AsnTyr: 0.84 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.556ProAla: 5.556 ± 0.088	0.322ProCys: 0.322 ± 0.02	3.316ProAsp: 3.316 ± 0.062	3.62ProGlu: 3.62 ± 0.064	2.101ProPhe: 2.101 ± 0.044	3.997ProGly: 3.997 ± 0.066	1.147ProHis: 1.147 ± 0.032	2.352ProIle: 2.352 ± 0.053	1.959ProLys: 1.959 ± 0.05	4.606ProLeu: 4.606 ± 0.08	1.07ProMet: 1.07 ± 0.034	1.363ProAsn: 1.363 ± 0.04	1.894ProPro: 1.894 ± 0.058	1.897ProGln: 1.897 ± 0.053	2.537ProArg: 2.537 ± 0.062	2.579ProSer: 2.579 ± 0.059	2.131ProThr: 2.131 ± 0.052	4.353ProVal: 4.353 ± 0.072	0.587ProTrp: 0.587 ± 0.028	1.204ProTyr: 1.204 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.88GlnAla: 3.88 ± 0.076	0.184GlnCys: 0.184 ± 0.016	1.513GlnAsp: 1.513 ± 0.046	1.632GlnGlu: 1.632 ± 0.045	1.163GlnPhe: 1.163 ± 0.034	2.277GlnGly: 2.277 ± 0.05	0.706GlnHis: 0.706 ± 0.026	2.041GlnIle: 2.041 ± 0.046	1.565GlnLys: 1.565 ± 0.036	2.891GlnLeu: 2.891 ± 0.057	1.035GlnMet: 1.035 ± 0.035	1.123GlnAsn: 1.123 ± 0.038	1.778GlnPro: 1.778 ± 0.055	1.172GlnGln: 1.172 ± 0.044	2.277GlnArg: 2.277 ± 0.052	1.849GlnSer: 1.849 ± 0.044	1.703GlnThr: 1.703 ± 0.039	2.062GlnVal: 2.062 ± 0.051	0.407GlnTrp: 0.407 ± 0.022	0.701GlnTyr: 0.701 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.741ArgAla: 6.741 ± 0.092	0.47ArgCys: 0.47 ± 0.027	3.601ArgAsp: 3.601 ± 0.062	4.249ArgGlu: 4.249 ± 0.083	3.057ArgPhe: 3.057 ± 0.057	4.309ArgGly: 4.309 ± 0.073	1.643ArgHis: 1.643 ± 0.049	4.371ArgIle: 4.371 ± 0.076	2.943ArgLys: 2.943 ± 0.058	7.275ArgLeu: 7.275 ± 0.112	1.822ArgMet: 1.822 ± 0.048	2.24ArgAsn: 2.24 ± 0.05	3.06ArgPro: 3.06 ± 0.066	2.52ArgGln: 2.52 ± 0.058	4.862ArgArg: 4.862 ± 0.103	3.44ArgSer: 3.44 ± 0.074	3.1ArgThr: 3.1 ± 0.06	4.246ArgVal: 4.246 ± 0.075	0.794ArgTrp: 0.794 ± 0.035	1.699ArgTyr: 1.699 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.006SerAla: 6.006 ± 0.086	0.442SerCys: 0.442 ± 0.022	2.901SerAsp: 2.901 ± 0.066	2.874SerGlu: 2.874 ± 0.06	2.482SerPhe: 2.482 ± 0.067	5.747SerGly: 5.747 ± 0.097	1.165SerHis: 1.165 ± 0.032	3.166SerIle: 3.166 ± 0.067	1.967SerLys: 1.967 ± 0.051	5.619SerLeu: 5.619 ± 0.087	1.449SerMet: 1.449 ± 0.038	1.598SerAsn: 1.598 ± 0.044	2.672SerPro: 2.672 ± 0.056	1.74SerGln: 1.74 ± 0.048	3.65SerArg: 3.65 ± 0.065	3.082SerSer: 3.082 ± 0.069	2.668SerThr: 2.668 ± 0.055	4.015SerVal: 4.015 ± 0.068	0.675SerTrp: 0.675 ± 0.032	1.374SerTyr: 1.374 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.693ThrAla: 5.693 ± 0.084	0.412ThrCys: 0.412 ± 0.023	2.702ThrAsp: 2.702 ± 0.065	2.517ThrGlu: 2.517 ± 0.055	2.061ThrPhe: 2.061 ± 0.047	5.076ThrGly: 5.076 ± 0.116	0.984ThrHis: 0.984 ± 0.034	3.239ThrIle: 3.239 ± 0.077	1.654ThrLys: 1.654 ± 0.047	5.469ThrLeu: 5.469 ± 0.11	1.251ThrMet: 1.251 ± 0.039	1.393ThrAsn: 1.393 ± 0.039	2.948ThrPro: 2.948 ± 0.062	1.432ThrGln: 1.432 ± 0.042	3.081ThrArg: 3.081 ± 0.064	2.682ThrSer: 2.682 ± 0.065	2.545ThrThr: 2.545 ± 0.067	4.34ThrVal: 4.34 ± 0.082	0.53ThrTrp: 0.53 ± 0.023	1.188ThrTyr: 1.188 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.232ValAla: 8.232 ± 0.108	0.598ValCys: 0.598 ± 0.029	3.823ValAsp: 3.823 ± 0.064	4.601ValGlu: 4.601 ± 0.077	2.875ValPhe: 2.875 ± 0.062	4.983ValGly: 4.983 ± 0.097	1.357ValHis: 1.357 ± 0.045	4.31ValIle: 4.31 ± 0.076	2.886ValLys: 2.886 ± 0.062	7.304ValLeu: 7.304 ± 0.113	1.894ValMet: 1.894 ± 0.047	2.23ValAsn: 2.23 ± 0.054	3.503ValPro: 3.503 ± 0.074	2.062ValGln: 2.062 ± 0.051	4.671ValArg: 4.671 ± 0.077	4.42ValSer: 4.42 ± 0.071	4.236ValThr: 4.236 ± 0.071	5.462ValVal: 5.462 ± 0.093	0.782ValTrp: 0.782 ± 0.031	1.497ValTyr: 1.497 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.078TrpAla: 1.078 ± 0.037	0.121TrpCys: 0.121 ± 0.012	0.547TrpAsp: 0.547 ± 0.025	0.477TrpGlu: 0.477 ± 0.024	0.524TrpPhe: 0.524 ± 0.025	0.775TrpGly: 0.775 ± 0.033	0.295TrpHis: 0.295 ± 0.019	0.605TrpIle: 0.605 ± 0.031	0.577TrpLys: 0.577 ± 0.024	1.563TrpLeu: 1.563 ± 0.044	0.337TrpMet: 0.337 ± 0.021	0.464TrpAsn: 0.464 ± 0.026	0.612TrpPro: 0.612 ± 0.023	0.558TrpGln: 0.558 ± 0.027	0.956TrpArg: 0.956 ± 0.03	0.728TrpSer: 0.728 ± 0.028	0.608TrpThr: 0.608 ± 0.031	0.71TrpVal: 0.71 ± 0.03	0.216TrpTrp: 0.216 ± 0.017	0.291TrpTyr: 0.291 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.474TyrAla: 2.474 ± 0.06	0.263TyrCys: 0.263 ± 0.017	1.53TyrAsp: 1.53 ± 0.047	1.391TyrGlu: 1.391 ± 0.04	1.012TyrPhe: 1.012 ± 0.031	2.152TyrGly: 2.152 ± 0.05	0.494TyrHis: 0.494 ± 0.022	1.134TyrIle: 1.134 ± 0.035	0.83TyrLys: 0.83 ± 0.03	2.305TyrLeu: 2.305 ± 0.048	0.57TyrMet: 0.57 ± 0.029	0.752TyrAsn: 0.752 ± 0.026	1.123TyrPro: 1.123 ± 0.038	0.778TyrGln: 0.778 ± 0.03	1.797TyrArg: 1.797 ± 0.045	1.315TyrSer: 1.315 ± 0.041	1.16TyrThr: 1.16 ± 0.038	1.693TyrVal: 1.693 ± 0.044	0.357TyrTrp: 0.357 ± 0.019	0.653TyrTyr: 0.653 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3023 proteins (878660 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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