Amino acid dipepetide frequency for marine gamma proteobacterium HTCC2080

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.896AlaAla: 11.896 ± 0.139	1.104AlaCys: 1.104 ± 0.034	5.829AlaAsp: 5.829 ± 0.072	6.497AlaGlu: 6.497 ± 0.087	3.794AlaPhe: 3.794 ± 0.064	8.586AlaGly: 8.586 ± 0.105	1.987AlaHis: 1.987 ± 0.047	5.588AlaIle: 5.588 ± 0.082	3.481AlaLys: 3.481 ± 0.073	12.123AlaLeu: 12.123 ± 0.129	3.039AlaMet: 3.039 ± 0.058	3.237AlaAsn: 3.237 ± 0.06	4.212AlaPro: 4.212 ± 0.064	4.305AlaGln: 4.305 ± 0.073	5.484AlaArg: 5.484 ± 0.08	6.415AlaSer: 6.415 ± 0.081	5.738AlaThr: 5.738 ± 0.081	7.575AlaVal: 7.575 ± 0.083	1.363AlaTrp: 1.363 ± 0.04	2.479AlaTyr: 2.479 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.993CysAla: 0.993 ± 0.039	0.15CysCys: 0.15 ± 0.011	0.678CysAsp: 0.678 ± 0.027	0.584CysGlu: 0.584 ± 0.024	0.359CysPhe: 0.359 ± 0.02	0.969CysGly: 0.969 ± 0.031	0.346CysHis: 0.346 ± 0.02	0.528CysIle: 0.528 ± 0.02	0.311CysLys: 0.311 ± 0.017	0.973CysLeu: 0.973 ± 0.032	0.21CysMet: 0.21 ± 0.013	0.337CysAsn: 0.337 ± 0.021	0.555CysPro: 0.555 ± 0.029	0.409CysGln: 0.409 ± 0.021	0.565CysArg: 0.565 ± 0.027	0.732CysSer: 0.732 ± 0.03	0.503CysThr: 0.503 ± 0.025	0.673CysVal: 0.673 ± 0.027	0.149CysTrp: 0.149 ± 0.012	0.294CysTyr: 0.294 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.008AspAla: 6.008 ± 0.075	0.607AspCys: 0.607 ± 0.024	3.483AspAsp: 3.483 ± 0.152	3.626AspGlu: 3.626 ± 0.057	2.476AspPhe: 2.476 ± 0.047	4.522AspGly: 4.522 ± 0.086	1.258AspHis: 1.258 ± 0.033	3.387AspIle: 3.387 ± 0.059	1.713AspLys: 1.713 ± 0.041	6.01AspLeu: 6.01 ± 0.081	1.392AspMet: 1.392 ± 0.04	1.895AspAsn: 1.895 ± 0.04	2.98AspPro: 2.98 ± 0.057	2.169AspGln: 2.169 ± 0.048	3.469AspArg: 3.469 ± 0.053	3.395AspSer: 3.395 ± 0.063	3.027AspThr: 3.027 ± 0.065	4.143AspVal: 4.143 ± 0.081	1.095AspTrp: 1.095 ± 0.035	1.914AspTyr: 1.914 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.923GluAla: 6.923 ± 0.085	0.459GluCys: 0.459 ± 0.022	3.093GluAsp: 3.093 ± 0.06	3.378GluGlu: 3.378 ± 0.067	2.185GluPhe: 2.185 ± 0.045	4.624GluGly: 4.624 ± 0.064	1.406GluHis: 1.406 ± 0.04	3.416GluIle: 3.416 ± 0.062	2.122GluLys: 2.122 ± 0.054	6.376GluLeu: 6.376 ± 0.081	1.413GluMet: 1.413 ± 0.039	2.002GluAsn: 2.002 ± 0.047	2.538GluPro: 2.538 ± 0.052	3.035GluGln: 3.035 ± 0.056	3.969GluArg: 3.969 ± 0.069	3.674GluSer: 3.674 ± 0.067	3.381GluThr: 3.381 ± 0.056	4.595GluVal: 4.595 ± 0.075	0.759GluTrp: 0.759 ± 0.028	1.452GluTyr: 1.452 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.599PheAla: 3.599 ± 0.061	0.507PheCys: 0.507 ± 0.023	2.713PheAsp: 2.713 ± 0.052	2.412PheGlu: 2.412 ± 0.046	1.566PhePhe: 1.566 ± 0.041	3.342PheGly: 3.342 ± 0.056	0.73PheHis: 0.73 ± 0.029	2.062PheIle: 2.062 ± 0.042	1.26PheLys: 1.26 ± 0.037	3.467PheLeu: 3.467 ± 0.066	0.953PheMet: 0.953 ± 0.026	1.45PheAsn: 1.45 ± 0.044	1.563PhePro: 1.563 ± 0.045	1.235PheGln: 1.235 ± 0.037	1.794PheArg: 1.794 ± 0.043	2.956PheSer: 2.956 ± 0.055	2.188PheThr: 2.188 ± 0.05	2.483PheVal: 2.483 ± 0.054	0.598PheTrp: 0.598 ± 0.026	1.17PheTyr: 1.17 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.87GlyAla: 7.87 ± 0.09	0.993GlyCys: 0.993 ± 0.034	4.646GlyAsp: 4.646 ± 0.074	4.798GlyGlu: 4.798 ± 0.072	3.601GlyPhe: 3.601 ± 0.07	6.632GlyGly: 6.632 ± 0.091	1.772GlyHis: 1.772 ± 0.04	4.546GlyIle: 4.546 ± 0.066	2.967GlyLys: 2.967 ± 0.054	8.207GlyLeu: 8.207 ± 0.09	2.12GlyMet: 2.12 ± 0.052	2.563GlyAsn: 2.563 ± 0.059	2.767GlyPro: 2.767 ± 0.049	3.096GlyGln: 3.096 ± 0.059	4.502GlyArg: 4.502 ± 0.073	5.122GlySer: 5.122 ± 0.078	4.255GlyThr: 4.255 ± 0.073	6.43GlyVal: 6.43 ± 0.074	1.358GlyTrp: 1.358 ± 0.04	2.535GlyTyr: 2.535 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.868HisAla: 1.868 ± 0.044	0.348HisCys: 0.348 ± 0.018	1.107HisAsp: 1.107 ± 0.034	1.12HisGlu: 1.12 ± 0.035	0.989HisPhe: 0.989 ± 0.032	1.76HisGly: 1.76 ± 0.04	0.665HisHis: 0.665 ± 0.029	1.084HisIle: 1.084 ± 0.032	0.606HisLys: 0.606 ± 0.027	2.068HisLeu: 2.068 ± 0.048	0.467HisMet: 0.467 ± 0.022	0.693HisAsn: 0.693 ± 0.027	1.284HisPro: 1.284 ± 0.044	0.901HisGln: 0.901 ± 0.026	1.435HisArg: 1.435 ± 0.038	1.21HisSer: 1.21 ± 0.03	1.044HisThr: 1.044 ± 0.035	1.248HisVal: 1.248 ± 0.035	0.452HisTrp: 0.452 ± 0.02	0.735HisTyr: 0.735 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.108IleAla: 6.108 ± 0.072	0.571IleCys: 0.571 ± 0.023	3.908IleAsp: 3.908 ± 0.06	3.791IleGlu: 3.791 ± 0.063	1.868IlePhe: 1.868 ± 0.042	4.098IleGly: 4.098 ± 0.062	1.007IleHis: 1.007 ± 0.031	2.553IleIle: 2.553 ± 0.053	1.863IleLys: 1.863 ± 0.04	4.39IleLeu: 4.39 ± 0.074	1.084IleMet: 1.084 ± 0.035	2.266IleAsn: 2.266 ± 0.05	2.656IlePro: 2.656 ± 0.048	1.773IleGln: 1.773 ± 0.042	2.894IleArg: 2.894 ± 0.056	3.451IleSer: 3.451 ± 0.063	3.243IleThr: 3.243 ± 0.062	3.591IleVal: 3.591 ± 0.06	0.643IleTrp: 0.643 ± 0.028	1.342IleTyr: 1.342 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.648LysAla: 3.648 ± 0.071	0.219LysCys: 0.219 ± 0.018	1.668LysAsp: 1.668 ± 0.041	1.641LysGlu: 1.641 ± 0.043	1.065LysPhe: 1.065 ± 0.032	2.426LysGly: 2.426 ± 0.059	0.717LysHis: 0.717 ± 0.025	1.912LysIle: 1.912 ± 0.05	1.369LysLys: 1.369 ± 0.058	3.403LysLeu: 3.403 ± 0.06	0.77LysMet: 0.77 ± 0.03	1.178LysAsn: 1.178 ± 0.034	1.818LysPro: 1.818 ± 0.049	1.457LysGln: 1.457 ± 0.036	2.124LysArg: 2.124 ± 0.049	2.141LysSer: 2.141 ± 0.049	2.073LysThr: 2.073 ± 0.048	2.407LysVal: 2.407 ± 0.045	0.373LysTrp: 0.373 ± 0.017	0.7LysTyr: 0.7 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.356LeuAla: 11.356 ± 0.123	1.077LeuCys: 1.077 ± 0.034	6.026LeuAsp: 6.026 ± 0.073	6.564LeuGlu: 6.564 ± 0.079	3.605LeuPhe: 3.605 ± 0.064	8.417LeuGly: 8.417 ± 0.091	2.04LeuHis: 2.04 ± 0.045	5.325LeuIle: 5.325 ± 0.09	3.765LeuLys: 3.765 ± 0.057	10.582LeuLeu: 10.582 ± 0.144	2.51LeuMet: 2.51 ± 0.052	3.619LeuAsn: 3.619 ± 0.059	5.312LeuPro: 5.312 ± 0.076	3.909LeuGln: 3.909 ± 0.064	5.948LeuArg: 5.948 ± 0.084	7.332LeuSer: 7.332 ± 0.091	6.009LeuThr: 6.009 ± 0.086	6.975LeuVal: 6.975 ± 0.093	1.39LeuTrp: 1.39 ± 0.045	2.242LeuTyr: 2.242 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.896MetAla: 2.896 ± 0.052	0.178MetCys: 0.178 ± 0.013	1.128MetAsp: 1.128 ± 0.033	1.219MetGlu: 1.219 ± 0.036	0.734MetPhe: 0.734 ± 0.029	2.081MetGly: 2.081 ± 0.047	0.507MetHis: 0.507 ± 0.022	1.249MetIle: 1.249 ± 0.034	0.949MetLys: 0.949 ± 0.028	2.426MetLeu: 2.426 ± 0.045	0.638MetMet: 0.638 ± 0.024	0.865MetAsn: 0.865 ± 0.032	1.305MetPro: 1.305 ± 0.034	0.918MetGln: 0.918 ± 0.032	1.405MetArg: 1.405 ± 0.038	1.743MetSer: 1.743 ± 0.037	1.753MetThr: 1.753 ± 0.042	1.716MetVal: 1.716 ± 0.047	0.215MetTrp: 0.215 ± 0.014	0.43MetTyr: 0.43 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.4AsnAla: 3.4 ± 0.067	0.372AsnCys: 0.372 ± 0.017	1.868AsnAsp: 1.868 ± 0.051	1.718AsnGlu: 1.718 ± 0.036	1.372AsnPhe: 1.372 ± 0.04	2.518AsnGly: 2.518 ± 0.056	0.696AsnHis: 0.696 ± 0.029	1.915AsnIle: 1.915 ± 0.047	1.028AsnLys: 1.028 ± 0.031	3.37AsnLeu: 3.37 ± 0.058	0.752AsnMet: 0.752 ± 0.025	1.224AsnAsn: 1.224 ± 0.034	2.045AsnPro: 2.045 ± 0.048	1.274AsnGln: 1.274 ± 0.037	2.037AsnArg: 2.037 ± 0.042	2.107AsnSer: 2.107 ± 0.053	2.099AsnThr: 2.099 ± 0.057	2.295AsnVal: 2.295 ± 0.05	0.571AsnTrp: 0.571 ± 0.024	1.014AsnTyr: 1.014 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.319ProAla: 4.319 ± 0.066	0.36ProCys: 0.36 ± 0.017	3.139ProAsp: 3.139 ± 0.059	3.92ProGlu: 3.92 ± 0.063	1.694ProPhe: 1.694 ± 0.046	3.786ProGly: 3.786 ± 0.053	0.937ProHis: 0.937 ± 0.03	2.395ProIle: 2.395 ± 0.048	1.77ProLys: 1.77 ± 0.051	4.693ProLeu: 4.693 ± 0.071	1.195ProMet: 1.195 ± 0.031	1.68ProAsn: 1.68 ± 0.047	2.064ProPro: 2.064 ± 0.053	1.653ProGln: 1.653 ± 0.036	2.188ProArg: 2.188 ± 0.049	3.011ProSer: 3.011 ± 0.048	2.568ProThr: 2.568 ± 0.05	3.432ProVal: 3.432 ± 0.05	0.691ProTrp: 0.691 ± 0.027	1.205ProTyr: 1.205 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.028GlnAla: 4.028 ± 0.068	0.368GlnCys: 0.368 ± 0.021	1.79GlnAsp: 1.79 ± 0.046	2.071GlnGlu: 2.071 ± 0.051	1.406GlnPhe: 1.406 ± 0.036	3.03GlnGly: 3.03 ± 0.054	0.885GlnHis: 0.885 ± 0.032	2.05GlnIle: 2.05 ± 0.04	1.317GlnLys: 1.317 ± 0.039	4.598GlnLeu: 4.598 ± 0.077	0.98GlnMet: 0.98 ± 0.028	1.198GlnAsn: 1.198 ± 0.03	1.892GlnPro: 1.892 ± 0.044	2.053GlnGln: 2.053 ± 0.052	2.987GlnArg: 2.987 ± 0.062	2.507GlnSer: 2.507 ± 0.046	2.084GlnThr: 2.084 ± 0.042	2.8GlnVal: 2.8 ± 0.056	0.704GlnTrp: 0.704 ± 0.025	1.062GlnTyr: 1.062 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.345ArgAla: 5.345 ± 0.067	0.622ArgCys: 0.622 ± 0.028	3.41ArgAsp: 3.41 ± 0.055	3.739ArgGlu: 3.739 ± 0.063	2.451ArgPhe: 2.451 ± 0.047	4.043ArgGly: 4.043 ± 0.065	1.343ArgHis: 1.343 ± 0.04	3.069ArgIle: 3.069 ± 0.055	1.886ArgLys: 1.886 ± 0.046	6.319ArgLeu: 6.319 ± 0.095	1.394ArgMet: 1.394 ± 0.033	1.847ArgAsn: 1.847 ± 0.045	2.338ArgPro: 2.338 ± 0.045	2.576ArgGln: 2.576 ± 0.055	3.71ArgArg: 3.71 ± 0.071	3.58ArgSer: 3.58 ± 0.055	2.5ArgThr: 2.5 ± 0.048	4.299ArgVal: 4.299 ± 0.057	1.056ArgTrp: 1.056 ± 0.032	1.87ArgTyr: 1.87 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.697SerAla: 6.697 ± 0.097	0.6SerCys: 0.6 ± 0.023	4.034SerAsp: 4.034 ± 0.061	4.024SerGlu: 4.024 ± 0.07	2.365SerPhe: 2.365 ± 0.047	6.166SerGly: 6.166 ± 0.083	1.297SerHis: 1.297 ± 0.037	3.211SerIle: 3.211 ± 0.046	2.061SerLys: 2.061 ± 0.046	6.589SerLeu: 6.589 ± 0.089	1.533SerMet: 1.533 ± 0.036	2.178SerAsn: 2.178 ± 0.054	2.984SerPro: 2.984 ± 0.059	2.528SerGln: 2.528 ± 0.051	3.423SerArg: 3.423 ± 0.052	4.047SerSer: 4.047 ± 0.075	3.245SerThr: 3.245 ± 0.059	4.717SerVal: 4.717 ± 0.071	0.931SerTrp: 0.931 ± 0.03	1.606SerTyr: 1.606 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	6.018ThrAla: 6.018 ± 0.092	0.526ThrCys: 0.526 ± 0.024	3.276ThrAsp: 3.276 ± 0.067	3.214ThrGlu: 3.214 ± 0.065	2.009ThrPhe: 2.009 ± 0.046	4.93ThrGly: 4.93 ± 0.076	1.154ThrHis: 1.154 ± 0.035	2.729ThrIle: 2.729 ± 0.058	1.369ThrLys: 1.369 ± 0.033	6.576ThrLeu: 6.576 ± 0.088	1.141ThrMet: 1.141 ± 0.03	1.653ThrAsn: 1.653 ± 0.047	3.24ThrPro: 3.24 ± 0.059	2.202ThrGln: 2.202 ± 0.041	2.902ThrArg: 2.902 ± 0.059	3.264ThrSer: 3.264 ± 0.067	3.285ThrThr: 3.285 ± 0.068	4.272ThrVal: 4.272 ± 0.092	0.749ThrTrp: 0.749 ± 0.028	1.39ThrTyr: 1.39 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	8.113ValAla: 8.113 ± 0.084	0.777ValCys: 0.777 ± 0.031	4.458ValAsp: 4.458 ± 0.079	4.284ValGlu: 4.284 ± 0.071	2.798ValPhe: 2.798 ± 0.046	5.566ValGly: 5.566 ± 0.084	1.349ValHis: 1.349 ± 0.039	4.211ValIle: 4.211 ± 0.067	2.203ValLys: 2.203 ± 0.05	7.196ValLeu: 7.196 ± 0.091	1.851ValMet: 1.851 ± 0.043	2.483ValAsn: 2.483 ± 0.046	3.21ValPro: 3.21 ± 0.055	2.165ValGln: 2.165 ± 0.046	3.605ValArg: 3.605 ± 0.057	4.814ValSer: 4.814 ± 0.076	4.782ValThr: 4.782 ± 0.089	6.032ValVal: 6.032 ± 0.093	0.87ValTrp: 0.87 ± 0.031	1.676ValTyr: 1.676 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.165TrpAla: 1.165 ± 0.036	0.196TrpCys: 0.196 ± 0.014	0.774TrpAsp: 0.774 ± 0.029	0.653TrpGlu: 0.653 ± 0.028	0.603TrpPhe: 0.603 ± 0.025	1.062TrpGly: 1.062 ± 0.036	0.381TrpHis: 0.381 ± 0.019	0.723TrpIle: 0.723 ± 0.029	0.33TrpLys: 0.33 ± 0.017	1.905TrpLeu: 1.905 ± 0.047	0.397TrpMet: 0.397 ± 0.017	0.473TrpAsn: 0.473 ± 0.025	0.648TrpPro: 0.648 ± 0.024	0.918TrpGln: 0.918 ± 0.031	0.996TrpArg: 0.996 ± 0.03	1.059TrpSer: 1.059 ± 0.031	0.7TrpThr: 0.7 ± 0.028	1.046TrpVal: 1.046 ± 0.029	0.264TrpTrp: 0.264 ± 0.018	0.376TrpTyr: 0.376 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.482TyrAla: 2.482 ± 0.046	0.282TyrCys: 0.282 ± 0.017	1.541TyrAsp: 1.541 ± 0.04	1.545TyrGlu: 1.545 ± 0.036	1.106TyrPhe: 1.106 ± 0.031	2.222TyrGly: 2.222 ± 0.048	0.606TyrHis: 0.606 ± 0.029	1.146TyrIle: 1.146 ± 0.033	0.739TyrLys: 0.739 ± 0.025	2.735TyrLeu: 2.735 ± 0.052	0.513TyrMet: 0.513 ± 0.021	0.834TyrAsn: 0.834 ± 0.035	1.291TyrPro: 1.291 ± 0.032	1.233TyrGln: 1.233 ± 0.039	1.96TyrArg: 1.96 ± 0.047	1.679TyrSer: 1.679 ± 0.049	1.423TyrThr: 1.423 ± 0.047	1.715TyrVal: 1.715 ± 0.037	0.44TyrTrp: 0.44 ± 0.022	0.774TyrTyr: 0.774 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3184 proteins (1074267 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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