Amino acid dipepetide frequency for Schleiferia thermophila str. Yellowstone

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.13AlaAla: 5.13 ± 0.102	0.587AlaCys: 0.587 ± 0.031	3.704AlaAsp: 3.704 ± 0.079	4.397AlaGlu: 4.397 ± 0.085	3.376AlaPhe: 3.376 ± 0.069	5.283AlaGly: 5.283 ± 0.088	1.427AlaHis: 1.427 ± 0.053	5.122AlaIle: 5.122 ± 0.085	3.235AlaLys: 3.235 ± 0.075	7.018AlaLeu: 7.018 ± 0.107	1.605AlaMet: 1.605 ± 0.045	3.048AlaAsn: 3.048 ± 0.07	2.274AlaPro: 2.274 ± 0.06	2.566AlaGln: 2.566 ± 0.058	3.416AlaArg: 3.416 ± 0.075	4.101AlaSer: 4.101 ± 0.089	3.398AlaThr: 3.398 ± 0.097	4.47AlaVal: 4.47 ± 0.075	0.803AlaTrp: 0.803 ± 0.035	2.354AlaTyr: 2.354 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.468CysAla: 0.468 ± 0.027	0.088CysCys: 0.088 ± 0.012	0.431CysAsp: 0.431 ± 0.025	0.509CysGlu: 0.509 ± 0.029	0.385CysPhe: 0.385 ± 0.024	0.678CysGly: 0.678 ± 0.037	0.245CysHis: 0.245 ± 0.02	0.614CysIle: 0.614 ± 0.029	0.445CysLys: 0.445 ± 0.026	0.669CysLeu: 0.669 ± 0.029	0.133CysMet: 0.133 ± 0.013	0.415CysAsn: 0.415 ± 0.025	0.357CysPro: 0.357 ± 0.024	0.296CysGln: 0.296 ± 0.018	0.422CysArg: 0.422 ± 0.024	0.544CysSer: 0.544 ± 0.028	0.53CysThr: 0.53 ± 0.027	0.475CysVal: 0.475 ± 0.026	0.077CysTrp: 0.077 ± 0.01	0.253CysTyr: 0.253 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.084AspAla: 3.084 ± 0.064	0.361AspCys: 0.361 ± 0.025	2.247AspAsp: 2.247 ± 0.058	3.462AspGlu: 3.462 ± 0.079	3.325AspPhe: 3.325 ± 0.069	3.254AspGly: 3.254 ± 0.07	0.998AspHis: 0.998 ± 0.041	3.776AspIle: 3.776 ± 0.072	2.902AspLys: 2.902 ± 0.072	4.905AspLeu: 4.905 ± 0.087	0.991AspMet: 0.991 ± 0.039	2.133AspAsn: 2.133 ± 0.059	2.26AspPro: 2.26 ± 0.055	1.763AspGln: 1.763 ± 0.05	2.452AspArg: 2.452 ± 0.058	3.027AspSer: 3.027 ± 0.073	2.779AspThr: 2.779 ± 0.076	3.218AspVal: 3.218 ± 0.058	0.683AspTrp: 0.683 ± 0.029	2.205AspTyr: 2.205 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	4.148GluAla: 4.148 ± 0.087	0.383GluCys: 0.383 ± 0.024	2.78GluAsp: 2.78 ± 0.069	4.239GluGlu: 4.239 ± 0.105	2.935GluPhe: 2.935 ± 0.072	3.318GluGly: 3.318 ± 0.078	1.244GluHis: 1.244 ± 0.039	5.519GluIle: 5.519 ± 0.099	4.97GluLys: 4.97 ± 0.112	6.192GluLeu: 6.192 ± 0.11	1.423GluMet: 1.423 ± 0.049	3.601GluAsn: 3.601 ± 0.072	1.881GluPro: 1.881 ± 0.052	2.19GluGln: 2.19 ± 0.064	2.894GluArg: 2.894 ± 0.073	3.17GluSer: 3.17 ± 0.073	2.676GluThr: 2.676 ± 0.06	4.03GluVal: 4.03 ± 0.088	0.732GluTrp: 0.732 ± 0.03	2.504GluTyr: 2.504 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.036PheAla: 3.036 ± 0.075	0.473PheCys: 0.473 ± 0.027	3.069PheAsp: 3.069 ± 0.068	3.196PheGlu: 3.196 ± 0.062	3.0PhePhe: 3.0 ± 0.081	3.63PheGly: 3.63 ± 0.072	1.069PheHis: 1.069 ± 0.04	3.653PheIle: 3.653 ± 0.076	2.886PheLys: 2.886 ± 0.059	4.946PheLeu: 4.946 ± 0.106	1.031PheMet: 1.031 ± 0.044	2.902PheAsn: 2.902 ± 0.083	1.92PhePro: 1.92 ± 0.052	1.866PheGln: 1.866 ± 0.052	2.491PheArg: 2.491 ± 0.06	3.971PheSer: 3.971 ± 0.09	3.309PheThr: 3.309 ± 0.069	3.074PheVal: 3.074 ± 0.071	0.615PheTrp: 0.615 ± 0.033	2.29PheTyr: 2.29 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.225GlyAla: 4.225 ± 0.083	0.629GlyCys: 0.629 ± 0.037	3.0GlyAsp: 3.0 ± 0.066	3.261GlyGlu: 3.261 ± 0.067	3.691GlyPhe: 3.691 ± 0.071	4.627GlyGly: 4.627 ± 0.115	1.447GlyHis: 1.447 ± 0.048	5.833GlyIle: 5.833 ± 0.095	4.093GlyLys: 4.093 ± 0.087	6.363GlyLeu: 6.363 ± 0.095	1.608GlyMet: 1.608 ± 0.054	3.393GlyAsn: 3.393 ± 0.098	1.932GlyPro: 1.932 ± 0.058	2.542GlyGln: 2.542 ± 0.061	3.207GlyArg: 3.207 ± 0.065	3.915GlySer: 3.915 ± 0.098	4.155GlyThr: 4.155 ± 0.13	4.276GlyVal: 4.276 ± 0.078	0.869GlyTrp: 0.869 ± 0.04	2.902GlyTyr: 2.902 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.162HisAla: 1.162 ± 0.044	0.208HisCys: 0.208 ± 0.017	0.828HisAsp: 0.828 ± 0.032	0.93HisGlu: 0.93 ± 0.034	1.341HisPhe: 1.341 ± 0.048	1.183HisGly: 1.183 ± 0.046	0.736HisHis: 0.736 ± 0.037	1.737HisIle: 1.737 ± 0.054	1.115HisLys: 1.115 ± 0.039	2.519HisLeu: 2.519 ± 0.068	0.435HisMet: 0.435 ± 0.023	0.917HisAsn: 0.917 ± 0.039	1.444HisPro: 1.444 ± 0.052	1.083HisGln: 1.083 ± 0.044	1.138HisArg: 1.138 ± 0.043	1.332HisSer: 1.332 ± 0.045	1.249HisThr: 1.249 ± 0.037	1.032HisVal: 1.032 ± 0.035	0.324HisTrp: 0.324 ± 0.02	1.128HisTyr: 1.128 ± 0.042	0.0HisXaa: 0.0 ± 0.0
Ile	5.584IleAla: 5.584 ± 0.093	0.658IleCys: 0.658 ± 0.031	4.386IleAsp: 4.386 ± 0.078	4.872IleGlu: 4.872 ± 0.1	3.878IlePhe: 3.878 ± 0.083	4.881IleGly: 4.881 ± 0.096	1.784IleHis: 1.784 ± 0.052	4.853IleIle: 4.853 ± 0.098	4.6IleLys: 4.6 ± 0.092	7.138IleLeu: 7.138 ± 0.125	1.263IleMet: 1.263 ± 0.043	4.221IleAsn: 4.221 ± 0.091	3.642IlePro: 3.642 ± 0.074	2.939IleGln: 2.939 ± 0.065	4.028IleArg: 4.028 ± 0.069	5.718IleSer: 5.718 ± 0.09	4.551IleThr: 4.551 ± 0.08	4.536IleVal: 4.536 ± 0.084	0.783IleTrp: 0.783 ± 0.032	2.806IleTyr: 2.806 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.24LysAla: 4.24 ± 0.091	0.374LysCys: 0.374 ± 0.024	2.838LysAsp: 2.838 ± 0.063	4.137LysGlu: 4.137 ± 0.094	2.65LysPhe: 2.65 ± 0.062	3.688LysGly: 3.688 ± 0.074	1.083LysHis: 1.083 ± 0.037	5.551LysIle: 5.551 ± 0.094	5.298LysLys: 5.298 ± 0.108	5.387LysLeu: 5.387 ± 0.106	1.397LysMet: 1.397 ± 0.042	3.94LysAsn: 3.94 ± 0.089	2.563LysPro: 2.563 ± 0.061	1.837LysGln: 1.837 ± 0.055	2.646LysArg: 2.646 ± 0.068	3.778LysSer: 3.778 ± 0.082	3.347LysThr: 3.347 ± 0.075	3.912LysVal: 3.912 ± 0.075	0.675LysTrp: 0.675 ± 0.029	2.65LysTyr: 2.65 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	6.82LeuAla: 6.82 ± 0.108	0.721LeuCys: 0.721 ± 0.029	4.557LeuAsp: 4.557 ± 0.082	5.664LeuGlu: 5.664 ± 0.1	4.743LeuPhe: 4.743 ± 0.102	5.603LeuGly: 5.603 ± 0.1	2.311LeuHis: 2.311 ± 0.061	7.451LeuIle: 7.451 ± 0.12	6.796LeuLys: 6.796 ± 0.109	10.005LeuLeu: 10.005 ± 0.155	2.419LeuMet: 2.419 ± 0.057	5.118LeuAsn: 5.118 ± 0.081	4.668LeuPro: 4.668 ± 0.091	3.63LeuGln: 3.63 ± 0.062	4.722LeuArg: 4.722 ± 0.088	7.359LeuSer: 7.359 ± 0.109	5.408LeuThr: 5.408 ± 0.09	5.768LeuVal: 5.768 ± 0.1	1.072LeuTrp: 1.072 ± 0.038	3.774LeuTyr: 3.774 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	1.896MetAla: 1.896 ± 0.05	0.156MetCys: 0.156 ± 0.015	1.041MetAsp: 1.041 ± 0.033	1.336MetGlu: 1.336 ± 0.048	0.824MetPhe: 0.824 ± 0.031	1.469MetGly: 1.469 ± 0.044	0.541MetHis: 0.541 ± 0.028	1.457MetIle: 1.457 ± 0.045	1.728MetLys: 1.728 ± 0.047	2.111MetLeu: 2.111 ± 0.057	0.546MetMet: 0.546 ± 0.028	1.102MetAsn: 1.102 ± 0.038	1.03MetPro: 1.03 ± 0.033	0.726MetGln: 0.726 ± 0.029	1.154MetArg: 1.154 ± 0.036	1.225MetSer: 1.225 ± 0.036	1.118MetThr: 1.118 ± 0.039	1.46MetVal: 1.46 ± 0.052	0.202MetTrp: 0.202 ± 0.017	0.789MetTyr: 0.789 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	3.435AsnAla: 3.435 ± 0.067	0.447AsnCys: 0.447 ± 0.03	2.338AsnAsp: 2.338 ± 0.056	2.811AsnGlu: 2.811 ± 0.073	2.927AsnPhe: 2.927 ± 0.066	3.429AsnGly: 3.429 ± 0.096	1.129AsnHis: 1.129 ± 0.036	3.758AsnIle: 3.758 ± 0.078	2.812AsnLys: 2.812 ± 0.074	5.094AsnLeu: 5.094 ± 0.095	0.972AsnMet: 0.972 ± 0.039	2.796AsnAsn: 2.796 ± 0.119	3.259AsnPro: 3.259 ± 0.066	2.257AsnGln: 2.257 ± 0.054	2.488AsnArg: 2.488 ± 0.06	3.075AsnSer: 3.075 ± 0.088	3.115AsnThr: 3.115 ± 0.082	2.905AsnVal: 2.905 ± 0.069	0.665AsnTrp: 0.665 ± 0.031	2.19AsnTyr: 2.19 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	3.008ProAla: 3.008 ± 0.073	0.304ProCys: 0.304 ± 0.02	2.875ProAsp: 2.875 ± 0.068	3.327ProGlu: 3.327 ± 0.074	2.179ProPhe: 2.179 ± 0.054	3.378ProGly: 3.378 ± 0.084	0.868ProHis: 0.868 ± 0.033	2.81ProIle: 2.81 ± 0.056	2.132ProLys: 2.132 ± 0.054	3.629ProLeu: 3.629 ± 0.071	0.944ProMet: 0.944 ± 0.035	2.067ProAsn: 2.067 ± 0.061	1.578ProPro: 1.578 ± 0.052	1.421ProGln: 1.421 ± 0.04	1.434ProArg: 1.434 ± 0.044	2.594ProSer: 2.594 ± 0.061	2.211ProThr: 2.211 ± 0.068	3.453ProVal: 3.453 ± 0.07	0.467ProTrp: 0.467 ± 0.025	1.744ProTyr: 1.744 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.312GlnAla: 2.312 ± 0.061	0.255GlnCys: 0.255 ± 0.016	1.304GlnAsp: 1.304 ± 0.039	1.941GlnGlu: 1.941 ± 0.056	1.748GlnPhe: 1.748 ± 0.055	1.957GlnGly: 1.957 ± 0.046	0.746GlnHis: 0.746 ± 0.035	3.161GlnIle: 3.161 ± 0.054	2.606GlnLys: 2.606 ± 0.06	4.09GlnLeu: 4.09 ± 0.079	1.041GlnMet: 1.041 ± 0.035	2.174GlnAsn: 2.174 ± 0.052	1.595GlnPro: 1.595 ± 0.049	1.535GlnGln: 1.535 ± 0.048	1.84GlnArg: 1.84 ± 0.056	2.236GlnSer: 2.236 ± 0.054	1.978GlnThr: 1.978 ± 0.048	2.27GlnVal: 2.27 ± 0.055	0.59GlnTrp: 0.59 ± 0.024	1.536GlnTyr: 1.536 ± 0.047	0.0GlnXaa: 0.0 ± 0.0
Arg	2.948ArgAla: 2.948 ± 0.068	0.329ArgCys: 0.329 ± 0.019	2.262ArgAsp: 2.262 ± 0.055	3.045ArgGlu: 3.045 ± 0.075	2.423ArgPhe: 2.423 ± 0.057	2.668ArgGly: 2.668 ± 0.061	1.115ArgHis: 1.115 ± 0.042	4.138ArgIle: 4.138 ± 0.075	3.366ArgLys: 3.366 ± 0.074	4.867ArgLeu: 4.867 ± 0.095	1.258ArgMet: 1.258 ± 0.037	2.491ArgAsn: 2.491 ± 0.058	1.966ArgPro: 1.966 ± 0.057	1.938ArgGln: 1.938 ± 0.048	2.438ArgArg: 2.438 ± 0.067	2.632ArgSer: 2.632 ± 0.054	2.253ArgThr: 2.253 ± 0.048	2.701ArgVal: 2.701 ± 0.068	0.753ArgTrp: 0.753 ± 0.031	2.225ArgTyr: 2.225 ± 0.063	0.0ArgXaa: 0.0 ± 0.0
Ser	4.582SerAla: 4.582 ± 0.079	0.567SerCys: 0.567 ± 0.028	3.476SerAsp: 3.476 ± 0.067	3.954SerGlu: 3.954 ± 0.076	3.381SerPhe: 3.381 ± 0.073	5.193SerGly: 5.193 ± 0.139	1.189SerHis: 1.189 ± 0.037	4.902SerIle: 4.902 ± 0.09	3.615SerLys: 3.615 ± 0.07	6.19SerLeu: 6.19 ± 0.103	1.365SerMet: 1.365 ± 0.044	3.07SerAsn: 3.07 ± 0.097	2.556SerPro: 2.556 ± 0.056	2.218SerGln: 2.218 ± 0.059	2.911SerArg: 2.911 ± 0.064	4.005SerSer: 4.005 ± 0.103	3.697SerThr: 3.697 ± 0.091	3.996SerVal: 3.996 ± 0.084	0.772SerTrp: 0.772 ± 0.041	2.349SerTyr: 2.349 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	4.025ThrAla: 4.025 ± 0.091	0.42ThrCys: 0.42 ± 0.025	3.037ThrAsp: 3.037 ± 0.055	3.064ThrGlu: 3.064 ± 0.061	3.028ThrPhe: 3.028 ± 0.071	4.835ThrGly: 4.835 ± 0.115	1.168ThrHis: 1.168 ± 0.046	4.208ThrIle: 4.208 ± 0.092	2.404ThrLys: 2.404 ± 0.065	5.637ThrLeu: 5.637 ± 0.078	0.886ThrMet: 0.886 ± 0.031	2.592ThrAsn: 2.592 ± 0.092	2.87ThrPro: 2.87 ± 0.069	1.719ThrGln: 1.719 ± 0.053	2.267ThrArg: 2.267 ± 0.053	3.734ThrSer: 3.734 ± 0.106	3.318ThrThr: 3.318 ± 0.107	3.458ThrVal: 3.458 ± 0.085	0.616ThrTrp: 0.616 ± 0.032	2.205ThrTyr: 2.205 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	4.171ValAla: 4.171 ± 0.09	0.56ValCys: 0.56 ± 0.03	3.064ValAsp: 3.064 ± 0.057	3.78ValGlu: 3.78 ± 0.078	3.463ValPhe: 3.463 ± 0.078	3.563ValGly: 3.563 ± 0.071	1.309ValHis: 1.309 ± 0.049	4.753ValIle: 4.753 ± 0.092	3.921ValLys: 3.921 ± 0.086	6.25ValLeu: 6.25 ± 0.096	1.406ValMet: 1.406 ± 0.044	3.139ValAsn: 3.139 ± 0.067	2.502ValPro: 2.502 ± 0.066	2.038ValGln: 2.038 ± 0.051	3.014ValArg: 3.014 ± 0.068	4.215ValSer: 4.215 ± 0.082	3.325ValThr: 3.325 ± 0.082	4.652ValVal: 4.652 ± 0.088	0.68ValTrp: 0.68 ± 0.028	2.654ValTyr: 2.654 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.685TrpAla: 0.685 ± 0.033	0.119TrpCys: 0.119 ± 0.011	0.596TrpAsp: 0.596 ± 0.028	0.618TrpGlu: 0.618 ± 0.033	0.592TrpPhe: 0.592 ± 0.027	0.725TrpGly: 0.725 ± 0.03	0.299TrpHis: 0.299 ± 0.019	1.039TrpIle: 1.039 ± 0.04	0.833TrpLys: 0.833 ± 0.031	1.307TrpLeu: 1.307 ± 0.045	0.396TrpMet: 0.396 ± 0.026	0.72TrpAsn: 0.72 ± 0.035	0.399TrpPro: 0.399 ± 0.023	0.516TrpGln: 0.516 ± 0.026	0.527TrpArg: 0.527 ± 0.03	0.721TrpSer: 0.721 ± 0.029	0.612TrpThr: 0.612 ± 0.034	0.707TrpVal: 0.707 ± 0.029	0.2TrpTrp: 0.2 ± 0.02	0.5TrpTyr: 0.5 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.354TyrAla: 2.354 ± 0.053	0.394TyrCys: 0.394 ± 0.022	1.993TyrAsp: 1.993 ± 0.054	2.285TyrGlu: 2.285 ± 0.057	2.535TyrPhe: 2.535 ± 0.056	2.608TyrGly: 2.608 ± 0.066	1.136TyrHis: 1.136 ± 0.042	2.788TyrIle: 2.788 ± 0.061	2.236TyrLys: 2.236 ± 0.053	4.294TyrLeu: 4.294 ± 0.079	0.787TyrMet: 0.787 ± 0.035	2.062TyrAsn: 2.062 ± 0.055	1.726TyrPro: 1.726 ± 0.047	1.835TyrGln: 1.835 ± 0.054	2.327TyrArg: 2.327 ± 0.057	2.639TyrSer: 2.639 ± 0.06	2.46TyrThr: 2.46 ± 0.059	2.066TyrVal: 2.066 ± 0.058	0.532TyrTrp: 0.532 ± 0.025	1.974TyrTyr: 1.974 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2301 proteins (783700 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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