Amino acid dipepetide frequency for Tetrasphaera japonica T1-X7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.666AlaAla: 19.666 ± 0.15	1.022AlaCys: 1.022 ± 0.027	8.301AlaAsp: 8.301 ± 0.08	7.267AlaGlu: 7.267 ± 0.089	3.42AlaPhe: 3.42 ± 0.054	12.607AlaGly: 12.607 ± 0.111	2.749AlaHis: 2.749 ± 0.05	4.461AlaIle: 4.461 ± 0.071	2.33AlaLys: 2.33 ± 0.051	13.44AlaLeu: 13.44 ± 0.121	2.674AlaMet: 2.674 ± 0.041	1.903AlaAsn: 1.903 ± 0.042	6.258AlaPro: 6.258 ± 0.075	3.489AlaGln: 3.489 ± 0.053	10.215AlaArg: 10.215 ± 0.103	6.995AlaSer: 6.995 ± 0.091	8.325AlaThr: 8.325 ± 0.084	12.2AlaVal: 12.2 ± 0.104	1.93AlaTrp: 1.93 ± 0.038	3.015AlaTyr: 3.015 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.954CysAla: 0.954 ± 0.028	0.12CysCys: 0.12 ± 0.009	0.478CysAsp: 0.478 ± 0.018	0.356CysGlu: 0.356 ± 0.014	0.212CysPhe: 0.212 ± 0.013	0.903CysGly: 0.903 ± 0.028	0.194CysHis: 0.194 ± 0.01	0.234CysIle: 0.234 ± 0.015	0.074CysLys: 0.074 ± 0.008	0.736CysLeu: 0.736 ± 0.024	0.107CysMet: 0.107 ± 0.008	0.133CysAsn: 0.133 ± 0.009	0.471CysPro: 0.471 ± 0.018	0.191CysGln: 0.191 ± 0.012	0.692CysArg: 0.692 ± 0.024	0.483CysSer: 0.483 ± 0.019	0.494CysThr: 0.494 ± 0.022	0.637CysVal: 0.637 ± 0.022	0.123CysTrp: 0.123 ± 0.01	0.163CysTyr: 0.163 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.106AspAla: 8.106 ± 0.088	0.362AspCys: 0.362 ± 0.016	4.247AspAsp: 4.247 ± 0.063	4.028AspGlu: 4.028 ± 0.058	1.405AspPhe: 1.405 ± 0.035	6.333AspGly: 6.333 ± 0.076	1.513AspHis: 1.513 ± 0.035	2.06AspIle: 2.06 ± 0.041	0.931AspLys: 0.931 ± 0.026	7.125AspLeu: 7.125 ± 0.071	0.762AspMet: 0.762 ± 0.021	0.898AspAsn: 0.898 ± 0.026	4.712AspPro: 4.712 ± 0.056	1.409AspGln: 1.409 ± 0.034	5.284AspArg: 5.284 ± 0.057	2.318AspSer: 2.318 ± 0.04	3.092AspThr: 3.092 ± 0.045	6.031AspVal: 6.031 ± 0.074	0.92AspTrp: 0.92 ± 0.025	1.155AspTyr: 1.155 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.771GluAla: 6.771 ± 0.072	0.33GluCys: 0.33 ± 0.017	2.86GluAsp: 2.86 ± 0.055	3.341GluGlu: 3.341 ± 0.056	1.278GluPhe: 1.278 ± 0.037	4.151GluGly: 4.151 ± 0.058	1.473GluHis: 1.473 ± 0.033	2.146GluIle: 2.146 ± 0.037	0.97GluLys: 0.97 ± 0.035	5.615GluLeu: 5.615 ± 0.075	0.839GluMet: 0.839 ± 0.025	0.856GluAsn: 0.856 ± 0.026	3.053GluPro: 3.053 ± 0.056	1.926GluGln: 1.926 ± 0.035	5.05GluArg: 5.05 ± 0.069	2.578GluSer: 2.578 ± 0.042	2.655GluThr: 2.655 ± 0.046	4.92GluVal: 4.92 ± 0.06	0.755GluTrp: 0.755 ± 0.025	0.881GluTyr: 0.881 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.546PheAla: 3.546 ± 0.049	0.23PheCys: 0.23 ± 0.013	1.923PheAsp: 1.923 ± 0.036	1.398PheGlu: 1.398 ± 0.033	0.881PhePhe: 0.881 ± 0.034	3.01PheGly: 3.01 ± 0.052	0.623PheHis: 0.623 ± 0.021	0.793PheIle: 0.793 ± 0.027	0.374PheLys: 0.374 ± 0.016	2.494PheLeu: 2.494 ± 0.045	0.384PheMet: 0.384 ± 0.016	0.513PheAsn: 0.513 ± 0.021	1.285PhePro: 1.285 ± 0.031	0.61PheGln: 0.61 ± 0.022	1.65PheArg: 1.65 ± 0.03	1.414PheSer: 1.414 ± 0.035	1.853PheThr: 1.853 ± 0.04	2.67PheVal: 2.67 ± 0.048	0.442PheTrp: 0.442 ± 0.018	0.571PheTyr: 0.571 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.495GlyAla: 10.495 ± 0.1	0.82GlyCys: 0.82 ± 0.023	5.284GlyAsp: 5.284 ± 0.066	4.552GlyGlu: 4.552 ± 0.072	2.917GlyPhe: 2.917 ± 0.049	8.378GlyGly: 8.378 ± 0.111	2.302GlyHis: 2.302 ± 0.043	4.076GlyIle: 4.076 ± 0.062	1.799GlyLys: 1.799 ± 0.034	9.504GlyLeu: 9.504 ± 0.097	2.085GlyMet: 2.085 ± 0.041	1.531GlyAsn: 1.531 ± 0.039	5.109GlyPro: 5.109 ± 0.071	2.468GlyGln: 2.468 ± 0.043	7.924GlyArg: 7.924 ± 0.093	6.031GlySer: 6.031 ± 0.084	6.028GlyThr: 6.028 ± 0.074	8.176GlyVal: 8.176 ± 0.082	1.766GlyTrp: 1.766 ± 0.041	2.245GlyTyr: 2.245 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.639HisAla: 2.639 ± 0.052	0.203HisCys: 0.203 ± 0.012	1.625HisAsp: 1.625 ± 0.04	1.272HisGlu: 1.272 ± 0.033	0.537HisPhe: 0.537 ± 0.02	2.395HisGly: 2.395 ± 0.042	0.718HisHis: 0.718 ± 0.025	0.665HisIle: 0.665 ± 0.022	0.277HisLys: 0.277 ± 0.014	2.438HisLeu: 2.438 ± 0.052	0.298HisMet: 0.298 ± 0.015	0.349HisAsn: 0.349 ± 0.015	1.848HisPro: 1.848 ± 0.04	0.578HisGln: 0.578 ± 0.02	2.144HisArg: 2.144 ± 0.045	0.902HisSer: 0.902 ± 0.027	1.261HisThr: 1.261 ± 0.03	2.095HisVal: 2.095 ± 0.037	0.34HisTrp: 0.34 ± 0.017	0.424HisTyr: 0.424 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.123IleAla: 5.123 ± 0.069	0.306IleCys: 0.306 ± 0.015	2.519IleAsp: 2.519 ± 0.042	2.104IleGlu: 2.104 ± 0.043	0.839IlePhe: 0.839 ± 0.026	3.786IleGly: 3.786 ± 0.05	0.705IleHis: 0.705 ± 0.018	1.071IleIle: 1.071 ± 0.038	0.569IleLys: 0.569 ± 0.023	3.049IleLeu: 3.049 ± 0.055	0.513IleMet: 0.513 ± 0.022	0.642IleAsn: 0.642 ± 0.026	2.062IlePro: 2.062 ± 0.04	0.766IleGln: 0.766 ± 0.025	2.497IleArg: 2.497 ± 0.052	1.691IleSer: 1.691 ± 0.037	2.143IleThr: 2.143 ± 0.039	3.681IleVal: 3.681 ± 0.061	0.411IleTrp: 0.411 ± 0.015	0.605IleTyr: 0.605 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.346LysAla: 2.346 ± 0.051	0.103LysCys: 0.103 ± 0.01	1.111LysAsp: 1.111 ± 0.035	0.858LysGlu: 0.858 ± 0.029	0.33LysPhe: 0.33 ± 0.017	1.545LysGly: 1.545 ± 0.039	0.356LysHis: 0.356 ± 0.017	0.639LysIle: 0.639 ± 0.024	0.537LysLys: 0.537 ± 0.027	1.268LysLeu: 1.268 ± 0.033	0.276LysMet: 0.276 ± 0.016	0.381LysAsn: 0.381 ± 0.018	0.965LysPro: 0.965 ± 0.028	0.526LysGln: 0.526 ± 0.021	1.207LysArg: 1.207 ± 0.034	0.869LysSer: 0.869 ± 0.03	1.033LysThr: 1.033 ± 0.028	1.652LysVal: 1.652 ± 0.034	0.206LysTrp: 0.206 ± 0.013	0.351LysTyr: 0.351 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.887LeuAla: 14.887 ± 0.12	0.727LeuCys: 0.727 ± 0.026	6.961LeuAsp: 6.961 ± 0.076	4.837LeuGlu: 4.837 ± 0.064	2.421LeuPhe: 2.421 ± 0.054	9.759LeuGly: 9.759 ± 0.094	2.188LeuHis: 2.188 ± 0.048	2.836LeuIle: 2.836 ± 0.054	1.405LeuLys: 1.405 ± 0.038	10.552LeuLeu: 10.552 ± 0.107	1.606LeuMet: 1.606 ± 0.034	1.42LeuAsn: 1.42 ± 0.032	5.752LeuPro: 5.752 ± 0.071	2.134LeuGln: 2.134 ± 0.035	8.263LeuArg: 8.263 ± 0.083	5.446LeuSer: 5.446 ± 0.069	6.603LeuThr: 6.603 ± 0.065	10.425LeuVal: 10.425 ± 0.119	1.297LeuTrp: 1.297 ± 0.034	1.501LeuTyr: 1.501 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.361MetAla: 2.361 ± 0.035	0.149MetCys: 0.149 ± 0.011	0.839MetAsp: 0.839 ± 0.023	0.731MetGlu: 0.731 ± 0.025	0.47MetPhe: 0.47 ± 0.02	1.395MetGly: 1.395 ± 0.032	0.348MetHis: 0.348 ± 0.02	0.657MetIle: 0.657 ± 0.022	0.353MetLys: 0.353 ± 0.015	1.752MetLeu: 1.752 ± 0.039	0.299MetMet: 0.299 ± 0.014	0.343MetAsn: 0.343 ± 0.016	1.256MetPro: 1.256 ± 0.028	0.424MetGln: 0.424 ± 0.018	1.485MetArg: 1.485 ± 0.036	1.529MetSer: 1.529 ± 0.031	1.829MetThr: 1.829 ± 0.032	1.409MetVal: 1.409 ± 0.035	0.226MetTrp: 0.226 ± 0.013	0.299MetTyr: 0.299 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.078AsnAla: 2.078 ± 0.046	0.126AsnCys: 0.126 ± 0.01	0.938AsnAsp: 0.938 ± 0.026	0.69AsnGlu: 0.69 ± 0.025	0.398AsnPhe: 0.398 ± 0.018	1.567AsnGly: 1.567 ± 0.038	0.382AsnHis: 0.382 ± 0.016	0.623AsnIle: 0.623 ± 0.022	0.292AsnLys: 0.292 ± 0.015	1.664AsnLeu: 1.664 ± 0.035	0.236AsnMet: 0.236 ± 0.014	0.337AsnAsn: 0.337 ± 0.018	1.442AsnPro: 1.442 ± 0.034	0.47AsnGln: 0.47 ± 0.02	1.174AsnArg: 1.174 ± 0.028	0.757AsnSer: 0.757 ± 0.026	0.943AsnThr: 0.943 ± 0.028	1.415AsnVal: 1.415 ± 0.033	0.252AsnTrp: 0.252 ± 0.014	0.388AsnTyr: 0.388 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.589ProAla: 7.589 ± 0.081	0.339ProCys: 0.339 ± 0.014	4.48ProAsp: 4.48 ± 0.061	3.549ProGlu: 3.549 ± 0.052	1.555ProPhe: 1.555 ± 0.034	6.111ProGly: 6.111 ± 0.066	1.31ProHis: 1.31 ± 0.03	1.678ProIle: 1.678 ± 0.037	0.922ProLys: 0.922 ± 0.028	4.938ProLeu: 4.938 ± 0.06	1.135ProMet: 1.135 ± 0.029	0.855ProAsn: 0.855 ± 0.02	3.325ProPro: 3.325 ± 0.06	1.459ProGln: 1.459 ± 0.034	4.306ProArg: 4.306 ± 0.069	3.605ProSer: 3.605 ± 0.056	4.03ProThr: 4.03 ± 0.066	5.493ProVal: 5.493 ± 0.069	1.031ProTrp: 1.031 ± 0.026	1.102ProTyr: 1.102 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.324GlnAla: 3.324 ± 0.052	0.154GlnCys: 0.154 ± 0.01	1.191GlnAsp: 1.191 ± 0.031	1.285GlnGlu: 1.285 ± 0.031	0.654GlnPhe: 0.654 ± 0.025	1.928GlnGly: 1.928 ± 0.042	0.622GlnHis: 0.622 ± 0.022	1.111GlnIle: 1.111 ± 0.028	0.442GlnLys: 0.442 ± 0.019	2.862GlnLeu: 2.862 ± 0.054	0.432GlnMet: 0.432 ± 0.018	0.433GlnAsn: 0.433 ± 0.021	1.545GlnPro: 1.545 ± 0.036	1.002GlnGln: 1.002 ± 0.031	2.362GlnArg: 2.362 ± 0.042	1.236GlnSer: 1.236 ± 0.03	1.407GlnThr: 1.407 ± 0.035	2.559GlnVal: 2.559 ± 0.04	0.425GlnTrp: 0.425 ± 0.02	0.485GlnTyr: 0.485 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.602ArgAla: 9.602 ± 0.101	0.681ArgCys: 0.681 ± 0.023	4.705ArgAsp: 4.705 ± 0.062	4.122ArgGlu: 4.122 ± 0.056	2.287ArgPhe: 2.287 ± 0.046	6.035ArgGly: 6.035 ± 0.083	2.217ArgHis: 2.217 ± 0.04	3.338ArgIle: 3.338 ± 0.051	1.221ArgLys: 1.221 ± 0.031	8.83ArgLeu: 8.83 ± 0.101	1.926ArgMet: 1.926 ± 0.033	1.179ArgAsn: 1.179 ± 0.028	5.028ArgPro: 5.028 ± 0.067	2.149ArgGln: 2.149 ± 0.044	8.367ArgArg: 8.367 ± 0.12	4.784ArgSer: 4.784 ± 0.064	5.048ArgThr: 5.048 ± 0.065	6.683ArgVal: 6.683 ± 0.075	1.47ArgTrp: 1.47 ± 0.034	1.728ArgTyr: 1.728 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.01SerAla: 7.01 ± 0.087	0.421SerCys: 0.421 ± 0.018	3.089SerAsp: 3.089 ± 0.043	2.289SerGlu: 2.289 ± 0.039	1.618SerPhe: 1.618 ± 0.034	6.096SerGly: 6.096 ± 0.078	1.162SerHis: 1.162 ± 0.028	1.965SerIle: 1.965 ± 0.046	0.855SerLys: 0.855 ± 0.031	5.066SerLeu: 5.066 ± 0.053	1.264SerMet: 1.264 ± 0.027	0.916SerAsn: 0.916 ± 0.027	3.359SerPro: 3.359 ± 0.051	1.358SerGln: 1.358 ± 0.034	4.356SerArg: 4.356 ± 0.065	3.624SerSer: 3.624 ± 0.077	3.86SerThr: 3.86 ± 0.067	4.66SerVal: 4.66 ± 0.059	0.959SerTrp: 0.959 ± 0.028	1.179SerTyr: 1.179 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	8.109ThrAla: 8.109 ± 0.078	0.518ThrCys: 0.518 ± 0.021	3.655ThrAsp: 3.655 ± 0.057	2.843ThrGlu: 2.843 ± 0.045	1.806ThrPhe: 1.806 ± 0.041	6.298ThrGly: 6.298 ± 0.075	1.319ThrHis: 1.319 ± 0.031	2.446ThrIle: 2.446 ± 0.049	1.116ThrLys: 1.116 ± 0.031	5.853ThrLeu: 5.853 ± 0.081	1.254ThrMet: 1.254 ± 0.028	1.191ThrAsn: 1.191 ± 0.029	4.204ThrPro: 4.204 ± 0.061	1.466ThrGln: 1.466 ± 0.034	4.383ThrArg: 4.383 ± 0.063	3.979ThrSer: 3.979 ± 0.062	4.765ThrThr: 4.765 ± 0.078	6.28ThrVal: 6.28 ± 0.074	1.025ThrTrp: 1.025 ± 0.029	1.361ThrTyr: 1.361 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	12.933ValAla: 12.933 ± 0.112	0.848ValCys: 0.848 ± 0.029	6.281ValAsp: 6.281 ± 0.078	5.321ValGlu: 5.321 ± 0.073	2.489ValPhe: 2.489 ± 0.049	8.215ValGly: 8.215 ± 0.097	2.015ValHis: 2.015 ± 0.04	3.214ValIle: 3.214 ± 0.059	1.522ValLys: 1.522 ± 0.039	9.781ValLeu: 9.781 ± 0.108	1.55ValMet: 1.55 ± 0.035	1.588ValAsn: 1.588 ± 0.037	5.275ValPro: 5.275 ± 0.067	1.986ValGln: 1.986 ± 0.04	7.046ValArg: 7.046 ± 0.07	4.939ValSer: 4.939 ± 0.059	6.413ValThr: 6.413 ± 0.082	10.968ValVal: 10.968 ± 0.128	1.186ValTrp: 1.186 ± 0.031	1.413ValTyr: 1.413 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.636TrpAla: 1.636 ± 0.035	0.143TrpCys: 0.143 ± 0.01	0.831TrpAsp: 0.831 ± 0.025	0.609TrpGlu: 0.609 ± 0.023	0.53TrpPhe: 0.53 ± 0.021	1.148TrpGly: 1.148 ± 0.027	0.397TrpHis: 0.397 ± 0.017	0.553TrpIle: 0.553 ± 0.019	0.276TrpLys: 0.276 ± 0.014	1.848TrpLeu: 1.848 ± 0.043	0.314TrpMet: 0.314 ± 0.014	0.355TrpAsn: 0.355 ± 0.015	0.818TrpPro: 0.818 ± 0.023	0.519TrpGln: 0.519 ± 0.019	1.366TrpArg: 1.366 ± 0.033	1.046TrpSer: 1.046 ± 0.028	1.025TrpThr: 1.025 ± 0.031	1.353TrpVal: 1.353 ± 0.035	0.381TrpTrp: 0.381 ± 0.019	0.315TrpTyr: 0.315 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.091TyrAla: 3.091 ± 0.048	0.154TyrCys: 0.154 ± 0.012	1.374TyrAsp: 1.374 ± 0.034	0.994TyrGlu: 0.994 ± 0.027	0.616TyrPhe: 0.616 ± 0.02	1.83TyrGly: 1.83 ± 0.037	0.415TyrHis: 0.415 ± 0.017	0.517TyrIle: 0.517 ± 0.022	0.297TyrLys: 0.297 ± 0.016	2.205TyrLeu: 2.205 ± 0.039	0.197TyrMet: 0.197 ± 0.011	0.35TyrAsn: 0.35 ± 0.019	1.043TyrPro: 1.043 ± 0.031	0.531TyrGln: 0.531 ± 0.018	1.632TyrArg: 1.632 ± 0.038	0.88TyrSer: 0.88 ± 0.027	1.06TyrThr: 1.06 ± 0.033	1.677TyrVal: 1.677 ± 0.036	0.319TyrTrp: 0.319 ± 0.015	0.427TyrTyr: 0.427 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4595 proteins (1426106 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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