Amino acid dipepetide frequency for Listeria phage vB_LmoS_293

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.173AlaAla: 6.173 ± 2.625
0.317AlaCys: 0.317 ± 0.169
4.749AlaAsp: 4.749 ± 0.691
6.094AlaGlu: 6.094 ± 0.791
3.878AlaPhe: 3.878 ± 0.919
5.778AlaGly: 5.778 ± 1.473
0.633AlaHis: 0.633 ± 0.244
5.778AlaIle: 5.778 ± 1.328
8.231AlaLys: 8.231 ± 1.503
6.727AlaLeu: 6.727 ± 1.312
2.058AlaMet: 2.058 ± 0.407
5.144AlaAsn: 5.144 ± 1.018
1.899AlaPro: 1.899 ± 0.422
2.454AlaGln: 2.454 ± 0.496
2.137AlaArg: 2.137 ± 0.452
3.957AlaSer: 3.957 ± 0.804
4.353AlaThr: 4.353 ± 0.49
5.144AlaVal: 5.144 ± 1.006
1.029AlaTrp: 1.029 ± 0.224
2.612AlaTyr: 2.612 ± 0.416
0.0AlaXaa: 0.0 ± 0.0
Cys
0.237CysAla: 0.237 ± 0.15
0.079CysCys: 0.079 ± 0.083
0.554CysAsp: 0.554 ± 0.235
0.396CysGlu: 0.396 ± 0.177
0.079CysPhe: 0.079 ± 0.077
1.187CysGly: 1.187 ± 0.389
0.0CysHis: 0.0 ± 0.0
0.079CysIle: 0.079 ± 0.067
0.633CysLys: 0.633 ± 0.246
0.791CysLeu: 0.791 ± 0.292
0.237CysMet: 0.237 ± 0.137
0.317CysAsn: 0.317 ± 0.155
0.317CysPro: 0.317 ± 0.191
0.158CysGln: 0.158 ± 0.1
0.554CysArg: 0.554 ± 0.25
0.396CysSer: 0.396 ± 0.17
0.237CysThr: 0.237 ± 0.149
0.317CysVal: 0.317 ± 0.145
0.0CysTrp: 0.0 ± 0.0
0.712CysTyr: 0.712 ± 0.277
0.0CysXaa: 0.0 ± 0.0
Asp
3.957AspAla: 3.957 ± 0.761
0.237AspCys: 0.237 ± 0.133
3.799AspAsp: 3.799 ± 0.716
5.382AspGlu: 5.382 ± 0.988
3.245AspPhe: 3.245 ± 0.572
4.511AspGly: 4.511 ± 0.698
0.475AspHis: 0.475 ± 0.195
4.432AspIle: 4.432 ± 0.567
5.224AspLys: 5.224 ± 0.623
5.936AspLeu: 5.936 ± 0.65
1.741AspMet: 1.741 ± 0.451
3.482AspAsn: 3.482 ± 0.513
1.029AspPro: 1.029 ± 0.31
0.95AspGln: 0.95 ± 0.249
1.583AspArg: 1.583 ± 0.416
3.957AspSer: 3.957 ± 0.743
2.454AspThr: 2.454 ± 0.329
3.087AspVal: 3.087 ± 0.437
0.712AspTrp: 0.712 ± 0.221
2.691AspTyr: 2.691 ± 0.68
0.0AspXaa: 0.0 ± 0.0
Glu
6.965GluAla: 6.965 ± 0.892
0.791GluCys: 0.791 ± 0.3
3.562GluAsp: 3.562 ± 0.695
6.886GluGlu: 6.886 ± 1.168
3.403GluPhe: 3.403 ± 0.6
2.691GluGly: 2.691 ± 0.482
1.187GluHis: 1.187 ± 0.293
5.936GluIle: 5.936 ± 0.931
8.152GluLys: 8.152 ± 0.8
7.756GluLeu: 7.756 ± 0.889
3.008GluMet: 3.008 ± 0.505
4.828GluAsn: 4.828 ± 0.562
1.425GluPro: 1.425 ± 0.408
2.849GluGln: 2.849 ± 0.569
3.087GluArg: 3.087 ± 0.656
3.878GluSer: 3.878 ± 0.588
4.511GluThr: 4.511 ± 0.664
4.59GluVal: 4.59 ± 0.805
1.425GluTrp: 1.425 ± 0.371
2.849GluTyr: 2.849 ± 0.486
0.079GluXaa: 0.079 ± 0.082
Phe
2.928PheAla: 2.928 ± 0.291
0.633PheCys: 0.633 ± 0.268
2.849PheAsp: 2.849 ± 0.661
3.166PheGlu: 3.166 ± 0.619
0.791PhePhe: 0.791 ± 0.233
1.979PheGly: 1.979 ± 0.299
0.475PheHis: 0.475 ± 0.208
2.454PheIle: 2.454 ± 0.436
2.454PheLys: 2.454 ± 0.389
3.008PheLeu: 3.008 ± 0.365
0.791PheMet: 0.791 ± 0.253
2.928PheAsn: 2.928 ± 0.356
0.633PhePro: 0.633 ± 0.249
1.345PheGln: 1.345 ± 0.369
1.266PheArg: 1.266 ± 0.411
3.641PheSer: 3.641 ± 0.534
2.533PheThr: 2.533 ± 0.466
3.482PheVal: 3.482 ± 0.431
0.396PheTrp: 0.396 ± 0.242
1.345PheTyr: 1.345 ± 0.397
0.0PheXaa: 0.0 ± 0.0
Gly
3.562GlyAla: 3.562 ± 1.023
0.95GlyCys: 0.95 ± 0.349
3.008GlyAsp: 3.008 ± 0.592
3.562GlyGlu: 3.562 ± 0.434
2.849GlyPhe: 2.849 ± 0.49
3.087GlyGly: 3.087 ± 0.499
0.475GlyHis: 0.475 ± 0.195
4.116GlyIle: 4.116 ± 0.595
5.778GlyLys: 5.778 ± 0.518
5.144GlyLeu: 5.144 ± 0.65
1.662GlyMet: 1.662 ± 0.444
4.195GlyAsn: 4.195 ± 0.622
0.158GlyPro: 0.158 ± 0.107
1.266GlyGln: 1.266 ± 0.431
1.899GlyArg: 1.899 ± 0.389
4.195GlySer: 4.195 ± 0.976
3.087GlyThr: 3.087 ± 0.643
4.59GlyVal: 4.59 ± 0.574
0.396GlyTrp: 0.396 ± 0.175
2.849GlyTyr: 2.849 ± 0.573
0.079GlyXaa: 0.079 ± 0.082
His
0.871HisAla: 0.871 ± 0.286
0.079HisCys: 0.079 ± 0.082
0.712HisAsp: 0.712 ± 0.241
1.187HisGlu: 1.187 ± 0.359
0.475HisPhe: 0.475 ± 0.244
0.475HisGly: 0.475 ± 0.214
0.633HisHis: 0.633 ± 0.253
0.871HisIle: 0.871 ± 0.271
0.871HisLys: 0.871 ± 0.343
0.237HisLeu: 0.237 ± 0.139
0.0HisMet: 0.0 ± 0.0
1.029HisAsn: 1.029 ± 0.326
0.554HisPro: 0.554 ± 0.241
0.317HisGln: 0.317 ± 0.171
0.791HisArg: 0.791 ± 0.281
0.475HisSer: 0.475 ± 0.189
0.871HisThr: 0.871 ± 0.356
0.95HisVal: 0.95 ± 0.331
0.317HisTrp: 0.317 ± 0.139
0.475HisTyr: 0.475 ± 0.195
0.0HisXaa: 0.0 ± 0.0
Ile
4.907IleAla: 4.907 ± 0.722
0.554IleCys: 0.554 ± 0.225
4.986IleAsp: 4.986 ± 0.608
6.727IleGlu: 6.727 ± 1.014
2.374IlePhe: 2.374 ± 0.567
2.295IleGly: 2.295 ± 0.453
1.187IleHis: 1.187 ± 0.374
4.195IleIle: 4.195 ± 0.567
7.281IleLys: 7.281 ± 1.215
4.274IleLeu: 4.274 ± 0.625
1.662IleMet: 1.662 ± 0.392
4.986IleAsn: 4.986 ± 0.477
2.058IlePro: 2.058 ± 0.357
2.691IleGln: 2.691 ± 0.529
2.216IleArg: 2.216 ± 0.504
4.59IleSer: 4.59 ± 0.639
3.957IleThr: 3.957 ± 0.626
4.511IleVal: 4.511 ± 0.547
0.633IleTrp: 0.633 ± 0.244
2.295IleTyr: 2.295 ± 0.507
0.0IleXaa: 0.0 ± 0.0
Lys
7.519LysAla: 7.519 ± 1.492
0.475LysCys: 0.475 ± 0.206
4.749LysAsp: 4.749 ± 0.507
7.123LysGlu: 7.123 ± 0.953
2.295LysPhe: 2.295 ± 0.426
5.619LysGly: 5.619 ± 0.56
1.029LysHis: 1.029 ± 0.367
4.274LysIle: 4.274 ± 0.585
7.835LysLys: 7.835 ± 1.169
7.044LysLeu: 7.044 ± 0.761
3.087LysMet: 3.087 ± 0.468
6.49LysAsn: 6.49 ± 0.822
2.77LysPro: 2.77 ± 0.634
4.116LysGln: 4.116 ± 0.671
3.562LysArg: 3.562 ± 0.607
6.411LysSer: 6.411 ± 1.906
6.569LysThr: 6.569 ± 0.687
5.619LysVal: 5.619 ± 0.643
1.266LysTrp: 1.266 ± 0.379
4.036LysTyr: 4.036 ± 0.659
0.0LysXaa: 0.0 ± 0.0
Leu
6.965LeuAla: 6.965 ± 0.813
0.396LeuCys: 0.396 ± 0.202
5.619LeuAsp: 5.619 ± 0.645
6.727LeuGlu: 6.727 ± 0.928
2.454LeuPhe: 2.454 ± 0.563
4.195LeuGly: 4.195 ± 0.663
0.791LeuHis: 0.791 ± 0.235
5.303LeuIle: 5.303 ± 0.737
8.785LeuLys: 8.785 ± 0.771
5.857LeuLeu: 5.857 ± 0.781
1.82LeuMet: 1.82 ± 0.427
4.67LeuAsn: 4.67 ± 0.557
2.533LeuPro: 2.533 ± 0.38
2.612LeuGln: 2.612 ± 0.527
3.641LeuArg: 3.641 ± 0.575
5.224LeuSer: 5.224 ± 0.678
5.698LeuThr: 5.698 ± 0.605
4.67LeuVal: 4.67 ± 0.449
0.712LeuTrp: 0.712 ± 0.248
2.691LeuTyr: 2.691 ± 0.398
0.079LeuXaa: 0.079 ± 0.082
Met
1.741MetAla: 1.741 ± 0.346
0.317MetCys: 0.317 ± 0.207
0.871MetAsp: 0.871 ± 0.299
1.662MetGlu: 1.662 ± 0.349
0.791MetPhe: 0.791 ± 0.233
1.741MetGly: 1.741 ± 0.379
0.317MetHis: 0.317 ± 0.151
1.504MetIle: 1.504 ± 0.396
2.295MetLys: 2.295 ± 0.467
1.741MetLeu: 1.741 ± 0.332
0.712MetMet: 0.712 ± 0.272
2.137MetAsn: 2.137 ± 0.381
0.554MetPro: 0.554 ± 0.213
1.425MetGln: 1.425 ± 0.292
1.108MetArg: 1.108 ± 0.212
1.899MetSer: 1.899 ± 0.392
2.454MetThr: 2.454 ± 0.513
1.266MetVal: 1.266 ± 0.255
0.317MetTrp: 0.317 ± 0.133
1.187MetTyr: 1.187 ± 0.243
0.0MetXaa: 0.0 ± 0.0
Asn
4.907AsnAla: 4.907 ± 1.108
0.633AsnCys: 0.633 ± 0.227
3.641AsnAsp: 3.641 ± 0.711
5.224AsnGlu: 5.224 ± 0.791
1.979AsnPhe: 1.979 ± 0.384
4.67AsnGly: 4.67 ± 0.652
1.108AsnHis: 1.108 ± 0.293
4.432AsnIle: 4.432 ± 0.6
5.065AsnLys: 5.065 ± 0.915
4.511AsnLeu: 4.511 ± 0.508
1.345AsnMet: 1.345 ± 0.26
3.878AsnAsn: 3.878 ± 0.545
1.583AsnPro: 1.583 ± 0.422
3.324AsnGln: 3.324 ± 0.414
1.979AsnArg: 1.979 ± 0.304
3.324AsnSer: 3.324 ± 0.591
3.324AsnThr: 3.324 ± 0.72
4.59AsnVal: 4.59 ± 0.468
0.95AsnTrp: 0.95 ± 0.328
2.691AsnTyr: 2.691 ± 0.454
0.079AsnXaa: 0.079 ± 0.088
Pro
2.691ProAla: 2.691 ± 0.525
0.079ProCys: 0.079 ± 0.082
1.029ProAsp: 1.029 ± 0.319
2.454ProGlu: 2.454 ± 0.411
1.108ProPhe: 1.108 ± 0.424
0.871ProGly: 0.871 ± 0.215
0.079ProHis: 0.079 ± 0.08
1.662ProIle: 1.662 ± 0.402
1.345ProLys: 1.345 ± 0.31
2.137ProLeu: 2.137 ± 0.51
0.554ProMet: 0.554 ± 0.217
1.187ProAsn: 1.187 ± 0.32
1.345ProPro: 1.345 ± 0.394
0.791ProGln: 0.791 ± 0.221
0.791ProArg: 0.791 ± 0.24
1.899ProSer: 1.899 ± 0.368
1.425ProThr: 1.425 ± 0.437
2.454ProVal: 2.454 ± 0.363
0.158ProTrp: 0.158 ± 0.101
0.475ProTyr: 0.475 ± 0.203
0.0ProXaa: 0.0 ± 0.0
Gln
3.008GlnAla: 3.008 ± 0.807
0.158GlnCys: 0.158 ± 0.109
2.058GlnAsp: 2.058 ± 0.548
3.245GlnGlu: 3.245 ± 0.511
1.108GlnPhe: 1.108 ± 0.276
1.979GlnGly: 1.979 ± 0.413
0.396GlnHis: 0.396 ± 0.208
2.849GlnIle: 2.849 ± 0.416
3.324GlnLys: 3.324 ± 0.566
2.928GlnLeu: 2.928 ± 0.53
0.712GlnMet: 0.712 ± 0.211
1.979GlnAsn: 1.979 ± 0.373
0.633GlnPro: 0.633 ± 0.241
1.741GlnGln: 1.741 ± 0.374
1.662GlnArg: 1.662 ± 0.359
1.979GlnSer: 1.979 ± 0.677
1.662GlnThr: 1.662 ± 0.35
2.454GlnVal: 2.454 ± 0.512
0.237GlnTrp: 0.237 ± 0.125
1.266GlnTyr: 1.266 ± 0.278
0.0GlnXaa: 0.0 ± 0.0
Arg
2.295ArgAla: 2.295 ± 0.462
0.317ArgCys: 0.317 ± 0.161
1.425ArgAsp: 1.425 ± 0.342
2.77ArgGlu: 2.77 ± 0.514
1.583ArgPhe: 1.583 ± 0.371
1.266ArgGly: 1.266 ± 0.314
0.791ArgHis: 0.791 ± 0.34
2.295ArgIle: 2.295 ± 0.478
3.324ArgLys: 3.324 ± 0.657
3.403ArgLeu: 3.403 ± 0.46
1.108ArgMet: 1.108 ± 0.338
2.216ArgAsn: 2.216 ± 0.42
1.029ArgPro: 1.029 ± 0.244
0.633ArgGln: 0.633 ± 0.332
1.504ArgArg: 1.504 ± 0.396
2.454ArgSer: 2.454 ± 0.59
2.058ArgThr: 2.058 ± 0.497
2.216ArgVal: 2.216 ± 0.435
0.554ArgTrp: 0.554 ± 0.164
1.741ArgTyr: 1.741 ± 0.456
0.0ArgXaa: 0.0 ± 0.0
Ser
5.857SerAla: 5.857 ± 1.446
0.158SerCys: 0.158 ± 0.099
4.511SerAsp: 4.511 ± 0.548
5.065SerGlu: 5.065 ± 0.758
3.166SerPhe: 3.166 ± 0.602
4.986SerGly: 4.986 ± 0.873
0.317SerHis: 0.317 ± 0.165
5.698SerIle: 5.698 ± 0.877
4.749SerLys: 4.749 ± 0.604
5.382SerLeu: 5.382 ± 0.915
1.029SerMet: 1.029 ± 0.233
4.036SerAsn: 4.036 ± 0.581
1.425SerPro: 1.425 ± 0.291
2.137SerGln: 2.137 ± 0.404
1.266SerArg: 1.266 ± 0.259
3.72SerSer: 3.72 ± 0.569
3.403SerThr: 3.403 ± 0.647
4.274SerVal: 4.274 ± 0.543
0.317SerTrp: 0.317 ± 0.147
2.216SerTyr: 2.216 ± 0.369
0.0SerXaa: 0.0 ± 0.0
Thr
6.015ThrAla: 6.015 ± 1.226
0.633ThrCys: 0.633 ± 0.231
2.849ThrAsp: 2.849 ± 0.436
4.67ThrGlu: 4.67 ± 0.545
2.454ThrPhe: 2.454 ± 0.44
3.72ThrGly: 3.72 ± 0.614
0.95ThrHis: 0.95 ± 0.33
5.144ThrIle: 5.144 ± 0.643
6.015ThrLys: 6.015 ± 0.532
4.828ThrLeu: 4.828 ± 0.48
1.583ThrMet: 1.583 ± 0.384
3.166ThrAsn: 3.166 ± 0.467
1.979ThrPro: 1.979 ± 0.403
1.425ThrGln: 1.425 ± 0.449
1.741ThrArg: 1.741 ± 0.358
4.116ThrSer: 4.116 ± 0.528
4.274ThrThr: 4.274 ± 0.513
3.324ThrVal: 3.324 ± 0.512
0.791ThrTrp: 0.791 ± 0.262
1.504ThrTyr: 1.504 ± 0.404
0.0ThrXaa: 0.0 ± 0.0
Val
5.382ValAla: 5.382 ± 0.807
0.079ValCys: 0.079 ± 0.075
5.382ValAsp: 5.382 ± 0.674
4.116ValGlu: 4.116 ± 0.483
2.691ValPhe: 2.691 ± 0.48
3.641ValGly: 3.641 ± 0.472
0.712ValHis: 0.712 ± 0.254
4.036ValIle: 4.036 ± 0.545
5.778ValLys: 5.778 ± 0.727
5.382ValLeu: 5.382 ± 0.626
1.504ValMet: 1.504 ± 0.324
3.166ValAsn: 3.166 ± 0.455
1.504ValPro: 1.504 ± 0.342
2.533ValGln: 2.533 ± 0.369
2.374ValArg: 2.374 ± 0.593
4.59ValSer: 4.59 ± 0.706
5.065ValThr: 5.065 ± 0.719
5.144ValVal: 5.144 ± 0.613
0.317ValTrp: 0.317 ± 0.16
2.295ValTyr: 2.295 ± 0.631
0.0ValXaa: 0.0 ± 0.0
Trp
0.712TrpAla: 0.712 ± 0.229
0.0TrpCys: 0.0 ± 0.0
0.475TrpAsp: 0.475 ± 0.168
0.712TrpGlu: 0.712 ± 0.341
0.396TrpPhe: 0.396 ± 0.175
0.475TrpGly: 0.475 ± 0.201
0.237TrpHis: 0.237 ± 0.142
1.029TrpIle: 1.029 ± 0.346
0.791TrpLys: 0.791 ± 0.245
0.95TrpLeu: 0.95 ± 0.416
0.317TrpMet: 0.317 ± 0.158
0.95TrpAsn: 0.95 ± 0.363
0.158TrpPro: 0.158 ± 0.112
0.554TrpGln: 0.554 ± 0.159
0.475TrpArg: 0.475 ± 0.225
0.475TrpSer: 0.475 ± 0.23
0.712TrpThr: 0.712 ± 0.233
0.95TrpVal: 0.95 ± 0.263
0.079TrpTrp: 0.079 ± 0.091
0.633TrpTyr: 0.633 ± 0.373
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.454TyrAla: 2.454 ± 0.382
0.396TyrCys: 0.396 ± 0.218
2.058TyrAsp: 2.058 ± 0.563
2.612TyrGlu: 2.612 ± 0.538
1.979TyrPhe: 1.979 ± 0.515
1.741TyrGly: 1.741 ± 0.357
0.396TyrHis: 0.396 ± 0.188
2.295TyrIle: 2.295 ± 0.425
3.957TyrLys: 3.957 ± 0.752
3.324TyrLeu: 3.324 ± 0.708
1.029TyrMet: 1.029 ± 0.261
2.454TyrAsn: 2.454 ± 0.63
0.95TyrPro: 0.95 ± 0.275
2.058TyrGln: 2.058 ± 0.491
1.345TyrArg: 1.345 ± 0.346
2.533TyrSer: 2.533 ± 0.435
2.533TyrThr: 2.533 ± 0.442
1.979TyrVal: 1.979 ± 0.423
0.475TyrTrp: 0.475 ± 0.183
2.216TyrTyr: 2.216 ± 0.545
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.079XaaGlu: 0.079 ± 0.082
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.079XaaLys: 0.079 ± 0.082
0.079XaaLeu: 0.079 ± 0.088
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.079XaaVal: 0.079 ± 0.082
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (12636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski