Amino acid dipepetide frequency for Azobacteroides pseudotrichonymphae genomovar. CFP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.387AlaAla: 3.387 ± 0.122
0.901AlaCys: 0.901 ± 0.063
2.559AlaAsp: 2.559 ± 0.091
3.257AlaGlu: 3.257 ± 0.125
2.826AlaPhe: 2.826 ± 0.099
3.828AlaGly: 3.828 ± 0.144
1.048AlaHis: 1.048 ± 0.066
5.718AlaIle: 5.718 ± 0.142
4.351AlaLys: 4.351 ± 0.145
5.729AlaLeu: 5.729 ± 0.134
1.409AlaMet: 1.409 ± 0.058
2.647AlaAsn: 2.647 ± 0.093
1.308AlaPro: 1.308 ± 0.073
1.921AlaGln: 1.921 ± 0.087
2.724AlaArg: 2.724 ± 0.107
3.755AlaSer: 3.755 ± 0.136
2.836AlaThr: 2.836 ± 0.099
3.604AlaVal: 3.604 ± 0.141
0.473AlaTrp: 0.473 ± 0.041
2.093AlaTyr: 2.093 ± 0.095
0.0AlaXaa: 0.0 ± 0.0
Cys
0.684CysAla: 0.684 ± 0.046
0.235CysCys: 0.235 ± 0.035
0.554CysAsp: 0.554 ± 0.039
0.74CysGlu: 0.74 ± 0.049
0.789CysPhe: 0.789 ± 0.049
1.143CysGly: 1.143 ± 0.063
0.379CysHis: 0.379 ± 0.04
1.336CysIle: 1.336 ± 0.073
0.996CysLys: 0.996 ± 0.06
1.315CysLeu: 1.315 ± 0.066
0.273CysMet: 0.273 ± 0.03
0.862CysAsn: 0.862 ± 0.062
0.526CysPro: 0.526 ± 0.051
0.456CysGln: 0.456 ± 0.041
0.578CysArg: 0.578 ± 0.044
0.94CysSer: 0.94 ± 0.063
0.691CysThr: 0.691 ± 0.045
0.656CysVal: 0.656 ± 0.049
0.182CysTrp: 0.182 ± 0.027
0.459CysTyr: 0.459 ± 0.041
0.0CysXaa: 0.0 ± 0.0
Asp
2.37AspAla: 2.37 ± 0.105
0.656AspCys: 0.656 ± 0.053
1.97AspAsp: 1.97 ± 0.1
3.317AspGlu: 3.317 ± 0.113
3.019AspPhe: 3.019 ± 0.098
2.493AspGly: 2.493 ± 0.102
0.729AspHis: 0.729 ± 0.051
5.368AspIle: 5.368 ± 0.163
4.249AspLys: 4.249 ± 0.164
4.589AspLeu: 4.589 ± 0.114
1.28AspMet: 1.28 ± 0.084
2.594AspAsn: 2.594 ± 0.098
1.543AspPro: 1.543 ± 0.074
0.968AspGln: 0.968 ± 0.059
2.107AspArg: 2.107 ± 0.102
2.98AspSer: 2.98 ± 0.09
2.391AspThr: 2.391 ± 0.099
3.026AspVal: 3.026 ± 0.13
0.582AspTrp: 0.582 ± 0.045
2.475AspTyr: 2.475 ± 0.094
0.0AspXaa: 0.0 ± 0.0
Glu
3.636GluAla: 3.636 ± 0.128
0.722GluCys: 0.722 ± 0.052
2.899GluAsp: 2.899 ± 0.105
5.133GluGlu: 5.133 ± 0.16
2.482GluPhe: 2.482 ± 0.093
3.706GluGly: 3.706 ± 0.114
1.038GluHis: 1.038 ± 0.06
7.075GluIle: 7.075 ± 0.19
6.374GluLys: 6.374 ± 0.161
6.279GluLeu: 6.279 ± 0.158
1.795GluMet: 1.795 ± 0.077
4.035GluAsn: 4.035 ± 0.127
1.28GluPro: 1.28 ± 0.077
2.672GluGln: 2.672 ± 0.095
3.106GluArg: 3.106 ± 0.103
3.289GluSer: 3.289 ± 0.106
3.401GluThr: 3.401 ± 0.112
3.734GluVal: 3.734 ± 0.121
0.743GluTrp: 0.743 ± 0.067
2.679GluTyr: 2.679 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
2.636PheAla: 2.636 ± 0.104
0.838PheCys: 0.838 ± 0.055
2.5PheAsp: 2.5 ± 0.096
2.847PheGlu: 2.847 ± 0.103
2.794PhePhe: 2.794 ± 0.124
3.222PheGly: 3.222 ± 0.111
1.076PheHis: 1.076 ± 0.061
4.2PheIle: 4.2 ± 0.112
2.679PheLys: 2.679 ± 0.097
4.81PheLeu: 4.81 ± 0.172
0.996PheMet: 0.996 ± 0.061
2.437PheAsn: 2.437 ± 0.092
1.869PhePro: 1.869 ± 0.068
1.581PheGln: 1.581 ± 0.085
2.16PheArg: 2.16 ± 0.085
3.765PheSer: 3.765 ± 0.117
2.261PheThr: 2.261 ± 0.08
3.068PheVal: 3.068 ± 0.113
0.438PheTrp: 0.438 ± 0.039
1.995PheTyr: 1.995 ± 0.082
0.0PheXaa: 0.0 ± 0.0
Gly
3.509GlyAla: 3.509 ± 0.145
0.912GlyCys: 0.912 ± 0.064
2.973GlyAsp: 2.973 ± 0.11
3.762GlyGlu: 3.762 ± 0.113
3.173GlyPhe: 3.173 ± 0.106
4.126GlyGly: 4.126 ± 0.151
1.262GlyHis: 1.262 ± 0.07
6.945GlyIle: 6.945 ± 0.197
5.459GlyLys: 5.459 ± 0.136
5.378GlyLeu: 5.378 ± 0.145
1.879GlyMet: 1.879 ± 0.094
3.257GlyAsn: 3.257 ± 0.103
1.132GlyPro: 1.132 ± 0.075
1.844GlyGln: 1.844 ± 0.081
2.861GlyArg: 2.861 ± 0.112
3.439GlySer: 3.439 ± 0.109
3.229GlyThr: 3.229 ± 0.12
3.927GlyVal: 3.927 ± 0.13
0.719GlyTrp: 0.719 ± 0.054
2.489GlyTyr: 2.489 ± 0.104
0.0GlyXaa: 0.0 ± 0.0
His
0.975HisAla: 0.975 ± 0.061
0.323HisCys: 0.323 ± 0.033
0.803HisAsp: 0.803 ± 0.058
0.936HisGlu: 0.936 ± 0.057
1.238HisPhe: 1.238 ± 0.062
1.143HisGly: 1.143 ± 0.063
0.48HisHis: 0.48 ± 0.048
1.907HisIle: 1.907 ± 0.078
1.192HisLys: 1.192 ± 0.07
2.104HisLeu: 2.104 ± 0.104
0.347HisMet: 0.347 ± 0.037
1.097HisAsn: 1.097 ± 0.069
1.171HisPro: 1.171 ± 0.072
0.687HisGln: 0.687 ± 0.049
0.926HisArg: 0.926 ± 0.059
1.36HisSer: 1.36 ± 0.06
0.912HisThr: 0.912 ± 0.058
0.848HisVal: 0.848 ± 0.059
0.172HisTrp: 0.172 ± 0.024
0.936HisTyr: 0.936 ± 0.058
0.0HisXaa: 0.0 ± 0.0
Ile
6.149IleAla: 6.149 ± 0.158
1.56IleCys: 1.56 ± 0.071
5.9IleAsp: 5.9 ± 0.154
6.553IleGlu: 6.553 ± 0.159
4.326IlePhe: 4.326 ± 0.128
6.118IleGly: 6.118 ± 0.16
2.139IleHis: 2.139 ± 0.086
8.439IleIle: 8.439 ± 0.199
6.654IleLys: 6.654 ± 0.158
8.582IleLeu: 8.582 ± 0.216
1.676IleMet: 1.676 ± 0.087
5.077IleAsn: 5.077 ± 0.147
4.042IlePro: 4.042 ± 0.112
3.341IleGln: 3.341 ± 0.109
4.572IleArg: 4.572 ± 0.135
6.602IleSer: 6.602 ± 0.159
4.74IleThr: 4.74 ± 0.137
6.321IleVal: 6.321 ± 0.159
0.736IleTrp: 0.736 ± 0.051
3.481IleTyr: 3.481 ± 0.115
0.0IleXaa: 0.0 ± 0.0
Lys
4.305LysAla: 4.305 ± 0.143
0.684LysCys: 0.684 ± 0.045
3.913LysAsp: 3.913 ± 0.132
6.868LysGlu: 6.868 ± 0.182
2.608LysPhe: 2.608 ± 0.086
4.8LysGly: 4.8 ± 0.134
1.476LysHis: 1.476 ± 0.072
7.965LysIle: 7.965 ± 0.172
7.979LysLys: 7.979 ± 0.202
6.356LysLeu: 6.356 ± 0.147
2.097LysMet: 2.097 ± 0.069
5.245LysAsn: 5.245 ± 0.169
1.855LysPro: 1.855 ± 0.081
3.313LysGln: 3.313 ± 0.109
3.66LysArg: 3.66 ± 0.112
4.218LysSer: 4.218 ± 0.124
4.365LysThr: 4.365 ± 0.123
4.652LysVal: 4.652 ± 0.119
0.743LysTrp: 0.743 ± 0.051
3.376LysTyr: 3.376 ± 0.127
0.0LysXaa: 0.0 ± 0.0
Leu
5.539LeuAla: 5.539 ± 0.153
1.399LeuCys: 1.399 ± 0.076
4.207LeuAsp: 4.207 ± 0.123
5.543LeuGlu: 5.543 ± 0.135
4.554LeuPhe: 4.554 ± 0.172
5.792LeuGly: 5.792 ± 0.14
1.848LeuHis: 1.848 ± 0.078
7.983LeuIle: 7.983 ± 0.208
7.503LeuLys: 7.503 ± 0.139
9.08LeuLeu: 9.08 ± 0.263
2.163LeuMet: 2.163 ± 0.097
5.406LeuAsn: 5.406 ± 0.155
3.551LeuPro: 3.551 ± 0.111
3.474LeuGln: 3.474 ± 0.106
4.116LeuArg: 4.116 ± 0.126
7.106LeuSer: 7.106 ± 0.178
4.526LeuThr: 4.526 ± 0.121
5.164LeuVal: 5.164 ± 0.155
0.869LeuTrp: 0.869 ± 0.062
3.604LeuTyr: 3.604 ± 0.13
0.0LeuXaa: 0.0 ± 0.0
Met
1.479MetAla: 1.479 ± 0.076
0.256MetCys: 0.256 ± 0.029
1.346MetAsp: 1.346 ± 0.074
1.707MetGlu: 1.707 ± 0.075
0.813MetPhe: 0.813 ± 0.058
1.718MetGly: 1.718 ± 0.082
0.445MetHis: 0.445 ± 0.04
1.774MetIle: 1.774 ± 0.078
2.352MetLys: 2.352 ± 0.087
2.111MetLeu: 2.111 ± 0.093
0.568MetMet: 0.568 ± 0.051
1.613MetAsn: 1.613 ± 0.08
0.841MetPro: 0.841 ± 0.054
0.905MetGln: 0.905 ± 0.052
1.104MetArg: 1.104 ± 0.058
1.357MetSer: 1.357 ± 0.07
1.041MetThr: 1.041 ± 0.061
1.367MetVal: 1.367 ± 0.067
0.109MetTrp: 0.109 ± 0.019
0.708MetTyr: 0.708 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
3.211AsnAla: 3.211 ± 0.105
0.698AsnCys: 0.698 ± 0.046
2.601AsnAsp: 2.601 ± 0.107
3.548AsnGlu: 3.548 ± 0.128
2.763AsnPhe: 2.763 ± 0.104
3.38AsnGly: 3.38 ± 0.127
1.101AsnHis: 1.101 ± 0.058
5.925AsnIle: 5.925 ± 0.152
4.449AsnLys: 4.449 ± 0.141
4.807AsnLeu: 4.807 ± 0.146
1.273AsnMet: 1.273 ± 0.06
3.313AsnAsn: 3.313 ± 0.133
2.426AsnPro: 2.426 ± 0.092
1.627AsnGln: 1.627 ± 0.082
2.475AsnArg: 2.475 ± 0.098
3.359AsnSer: 3.359 ± 0.118
2.896AsnThr: 2.896 ± 0.099
3.215AsnVal: 3.215 ± 0.114
0.652AsnTrp: 0.652 ± 0.055
2.549AsnTyr: 2.549 ± 0.1
0.0AsnXaa: 0.0 ± 0.0
Pro
1.7ProAla: 1.7 ± 0.085
0.41ProCys: 0.41 ± 0.041
1.679ProAsp: 1.679 ± 0.081
2.528ProGlu: 2.528 ± 0.095
1.756ProPhe: 1.756 ± 0.073
1.827ProGly: 1.827 ± 0.089
0.684ProHis: 0.684 ± 0.057
3.397ProIle: 3.397 ± 0.114
2.244ProLys: 2.244 ± 0.084
2.984ProLeu: 2.984 ± 0.115
0.712ProMet: 0.712 ± 0.055
1.886ProAsn: 1.886 ± 0.086
0.866ProPro: 0.866 ± 0.065
1.108ProGln: 1.108 ± 0.064
1.02ProArg: 1.02 ± 0.058
2.146ProSer: 2.146 ± 0.09
1.63ProThr: 1.63 ± 0.066
2.156ProVal: 2.156 ± 0.082
0.28ProTrp: 0.28 ± 0.036
1.508ProTyr: 1.508 ± 0.079
0.0ProXaa: 0.0 ± 0.0
Gln
1.96GlnAla: 1.96 ± 0.082
0.445GlnCys: 0.445 ± 0.04
1.36GlnAsp: 1.36 ± 0.072
2.272GlnGlu: 2.272 ± 0.099
1.406GlnPhe: 1.406 ± 0.075
1.588GlnGly: 1.588 ± 0.075
0.582GlnHis: 0.582 ± 0.049
3.415GlnIle: 3.415 ± 0.113
3.099GlnLys: 3.099 ± 0.099
3.783GlnLeu: 3.783 ± 0.135
1.003GlnMet: 1.003 ± 0.068
1.809GlnAsn: 1.809 ± 0.072
0.831GlnPro: 0.831 ± 0.053
1.357GlnGln: 1.357 ± 0.073
1.476GlnArg: 1.476 ± 0.087
2.026GlnSer: 2.026 ± 0.084
1.785GlnThr: 1.785 ± 0.071
1.841GlnVal: 1.841 ± 0.088
0.344GlnTrp: 0.344 ± 0.034
1.43GlnTyr: 1.43 ± 0.075
0.0GlnXaa: 0.0 ± 0.0
Arg
2.16ArgAla: 2.16 ± 0.077
0.561ArgCys: 0.561 ± 0.049
1.988ArgAsp: 1.988 ± 0.092
3.208ArgGlu: 3.208 ± 0.121
2.128ArgPhe: 2.128 ± 0.083
2.661ArgGly: 2.661 ± 0.103
0.834ArgHis: 0.834 ± 0.057
4.712ArgIle: 4.712 ± 0.117
4.158ArgLys: 4.158 ± 0.124
4.207ArgLeu: 4.207 ± 0.119
1.22ArgMet: 1.22 ± 0.067
2.679ArgAsn: 2.679 ± 0.105
1.266ArgPro: 1.266 ± 0.064
1.616ArgGln: 1.616 ± 0.081
2.111ArgArg: 2.111 ± 0.096
2.324ArgSer: 2.324 ± 0.084
2.037ArgThr: 2.037 ± 0.091
2.679ArgVal: 2.679 ± 0.107
0.372ArgTrp: 0.372 ± 0.036
1.82ArgTyr: 1.82 ± 0.09
0.0ArgXaa: 0.0 ± 0.0
Ser
3.397SerAla: 3.397 ± 0.114
0.845SerCys: 0.845 ± 0.063
3.197SerAsp: 3.197 ± 0.114
4.007SerGlu: 4.007 ± 0.11
3.422SerPhe: 3.422 ± 0.116
4.169SerGly: 4.169 ± 0.131
1.262SerHis: 1.262 ± 0.067
6.251SerIle: 6.251 ± 0.158
4.726SerLys: 4.726 ± 0.142
6.198SerLeu: 6.198 ± 0.162
1.462SerMet: 1.462 ± 0.07
3.394SerAsn: 3.394 ± 0.1
2.104SerPro: 2.104 ± 0.084
1.883SerGln: 1.883 ± 0.082
2.798SerArg: 2.798 ± 0.103
4.151SerSer: 4.151 ± 0.113
3.127SerThr: 3.127 ± 0.109
4.06SerVal: 4.06 ± 0.119
0.547SerTrp: 0.547 ± 0.039
2.577SerTyr: 2.577 ± 0.095
0.0SerXaa: 0.0 ± 0.0
Thr
3.043ThrAla: 3.043 ± 0.118
0.691ThrCys: 0.691 ± 0.053
2.444ThrAsp: 2.444 ± 0.091
2.735ThrGlu: 2.735 ± 0.116
2.402ThrPhe: 2.402 ± 0.088
3.338ThrGly: 3.338 ± 0.115
1.027ThrHis: 1.027 ± 0.057
5.143ThrIle: 5.143 ± 0.125
3.492ThrLys: 3.492 ± 0.139
4.751ThrLeu: 4.751 ± 0.124
0.94ThrMet: 0.94 ± 0.06
2.875ThrAsn: 2.875 ± 0.095
2.107ThrPro: 2.107 ± 0.08
1.451ThrGln: 1.451 ± 0.072
1.876ThrArg: 1.876 ± 0.078
3.054ThrSer: 3.054 ± 0.109
2.679ThrThr: 2.679 ± 0.107
3.117ThrVal: 3.117 ± 0.107
0.368ThrTrp: 0.368 ± 0.036
1.921ThrTyr: 1.921 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
3.432ValAla: 3.432 ± 0.119
0.954ValCys: 0.954 ± 0.055
3.148ValAsp: 3.148 ± 0.106
4.004ValGlu: 4.004 ± 0.114
3.113ValPhe: 3.113 ± 0.118
4.032ValGly: 4.032 ± 0.13
1.087ValHis: 1.087 ± 0.07
5.325ValIle: 5.325 ± 0.162
4.488ValLys: 4.488 ± 0.122
5.652ValLeu: 5.652 ± 0.142
1.406ValMet: 1.406 ± 0.077
2.927ValAsn: 2.927 ± 0.09
2.065ValPro: 2.065 ± 0.1
1.795ValGln: 1.795 ± 0.081
2.647ValArg: 2.647 ± 0.104
4.456ValSer: 4.456 ± 0.127
2.626ValThr: 2.626 ± 0.104
4.197ValVal: 4.197 ± 0.143
0.48ValTrp: 0.48 ± 0.047
2.342ValTyr: 2.342 ± 0.101
0.0ValXaa: 0.0 ± 0.0
Trp
0.498TrpAla: 0.498 ± 0.043
0.098TrpCys: 0.098 ± 0.019
0.578TrpAsp: 0.578 ± 0.051
0.596TrpGlu: 0.596 ± 0.049
0.47TrpPhe: 0.47 ± 0.043
0.589TrpGly: 0.589 ± 0.047
0.161TrpHis: 0.161 ± 0.023
0.915TrpIle: 0.915 ± 0.055
0.88TrpLys: 0.88 ± 0.073
0.869TrpLeu: 0.869 ± 0.054
0.298TrpMet: 0.298 ± 0.033
0.757TrpAsn: 0.757 ± 0.056
0.112TrpPro: 0.112 ± 0.016
0.403TrpGln: 0.403 ± 0.042
0.368TrpArg: 0.368 ± 0.035
0.428TrpSer: 0.428 ± 0.039
0.449TrpThr: 0.449 ± 0.044
0.466TrpVal: 0.466 ± 0.045
0.14TrpTrp: 0.14 ± 0.024
0.333TrpTyr: 0.333 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.303TyrAla: 2.303 ± 0.095
0.607TyrCys: 0.607 ± 0.044
2.083TyrAsp: 2.083 ± 0.096
2.517TyrGlu: 2.517 ± 0.104
2.09TyrPhe: 2.09 ± 0.088
2.605TyrGly: 2.605 ± 0.095
0.898TyrHis: 0.898 ± 0.062
3.215TyrIle: 3.215 ± 0.109
3.159TyrLys: 3.159 ± 0.111
3.846TyrLeu: 3.846 ± 0.119
0.817TyrMet: 0.817 ± 0.055
2.356TyrAsn: 2.356 ± 0.103
1.627TyrPro: 1.627 ± 0.071
1.409TyrGln: 1.409 ± 0.081
2.054TyrArg: 2.054 ± 0.093
2.822TyrSer: 2.822 ± 0.102
1.83TyrThr: 1.83 ± 0.071
2.079TyrVal: 2.079 ± 0.082
0.459TyrTrp: 0.459 ± 0.04
1.795TyrTyr: 1.795 ± 0.09
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 847 proteins (285234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski