Amino acid dipepetide frequency for Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.991AlaAla: 7.991 ± 0.132	0.931AlaCys: 0.931 ± 0.035	4.407AlaAsp: 4.407 ± 0.083	6.082AlaGlu: 6.082 ± 0.096	3.43AlaPhe: 3.43 ± 0.068	6.492AlaGly: 6.492 ± 0.104	1.596AlaHis: 1.596 ± 0.044	5.703AlaIle: 5.703 ± 0.089	4.213AlaLys: 4.213 ± 0.1	10.059AlaLeu: 10.059 ± 0.163	2.257AlaMet: 2.257 ± 0.054	2.533AlaAsn: 2.533 ± 0.073	2.853AlaPro: 2.853 ± 0.066	2.494AlaGln: 2.494 ± 0.066	4.243AlaArg: 4.243 ± 0.075	5.282AlaSer: 5.282 ± 0.112	4.277AlaThr: 4.277 ± 0.121	5.913AlaVal: 5.913 ± 0.099	0.854AlaTrp: 0.854 ± 0.033	2.257AlaTyr: 2.257 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.8CysAla: 0.8 ± 0.032	0.219CysCys: 0.219 ± 0.017	0.622CysAsp: 0.622 ± 0.026	0.556CysGlu: 0.556 ± 0.025	0.563CysPhe: 0.563 ± 0.025	1.02CysGly: 1.02 ± 0.038	0.338CysHis: 0.338 ± 0.025	0.691CysIle: 0.691 ± 0.032	0.529CysLys: 0.529 ± 0.028	0.918CysLeu: 0.918 ± 0.033	0.275CysMet: 0.275 ± 0.017	0.502CysAsn: 0.502 ± 0.028	0.561CysPro: 0.561 ± 0.031	0.353CysGln: 0.353 ± 0.02	0.743CysArg: 0.743 ± 0.032	0.938CysSer: 0.938 ± 0.047	0.531CysThr: 0.531 ± 0.025	0.597CysVal: 0.597 ± 0.033	0.124CysTrp: 0.124 ± 0.013	0.378CysTyr: 0.378 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.591AspAla: 4.591 ± 0.091	0.57AspCys: 0.57 ± 0.029	2.687AspAsp: 2.687 ± 0.084	3.809AspGlu: 3.809 ± 0.077	2.484AspPhe: 2.484 ± 0.068	3.542AspGly: 3.542 ± 0.087	1.095AspHis: 1.095 ± 0.047	3.91AspIle: 3.91 ± 0.067	2.657AspLys: 2.657 ± 0.066	5.263AspLeu: 5.263 ± 0.097	1.154AspMet: 1.154 ± 0.04	1.92AspAsn: 1.92 ± 0.055	2.274AspPro: 2.274 ± 0.049	1.541AspGln: 1.541 ± 0.048	2.927AspArg: 2.927 ± 0.074	2.778AspSer: 2.778 ± 0.064	2.676AspThr: 2.676 ± 0.116	3.228AspVal: 3.228 ± 0.077	0.662AspTrp: 0.662 ± 0.026	1.952AspTyr: 1.952 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	5.639GluAla: 5.639 ± 0.092	0.678GluCys: 0.678 ± 0.032	2.52GluAsp: 2.52 ± 0.08	5.317GluGlu: 5.317 ± 0.108	2.565GluPhe: 2.565 ± 0.062	4.218GluGly: 4.218 ± 0.074	1.661GluHis: 1.661 ± 0.048	4.677GluIle: 4.677 ± 0.073	5.022GluLys: 5.022 ± 0.09	7.706GluLeu: 7.706 ± 0.109	1.826GluMet: 1.826 ± 0.047	2.65GluAsn: 2.65 ± 0.055	2.391GluPro: 2.391 ± 0.055	2.845GluGln: 2.845 ± 0.065	4.471GluArg: 4.471 ± 0.098	4.152GluSer: 4.152 ± 0.068	3.261GluThr: 3.261 ± 0.06	4.098GluVal: 4.098 ± 0.076	0.839GluTrp: 0.839 ± 0.037	2.004GluTyr: 2.004 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.535PheAla: 3.535 ± 0.073	0.593PheCys: 0.593 ± 0.026	2.783PheAsp: 2.783 ± 0.057	2.617PheGlu: 2.617 ± 0.062	2.364PhePhe: 2.364 ± 0.063	3.267PheGly: 3.267 ± 0.072	0.967PheHis: 0.967 ± 0.036	2.764PheIle: 2.764 ± 0.067	1.818PheLys: 1.818 ± 0.053	4.362PheLeu: 4.362 ± 0.092	1.026PheMet: 1.026 ± 0.035	1.742PheAsn: 1.742 ± 0.045	1.783PhePro: 1.783 ± 0.048	1.266PheGln: 1.266 ± 0.044	2.578PheArg: 2.578 ± 0.065	3.674PheSer: 3.674 ± 0.069	2.499PheThr: 2.499 ± 0.078	2.812PheVal: 2.812 ± 0.06	0.505PheTrp: 0.505 ± 0.025	1.473PheTyr: 1.473 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.289GlyAla: 5.289 ± 0.111	0.941GlyCys: 0.941 ± 0.039	3.434GlyAsp: 3.434 ± 0.063	4.412GlyGlu: 4.412 ± 0.082	3.386GlyPhe: 3.386 ± 0.077	5.078GlyGly: 5.078 ± 0.099	1.484GlyHis: 1.484 ± 0.045	5.406GlyIle: 5.406 ± 0.082	4.814GlyLys: 4.814 ± 0.092	6.355GlyLeu: 6.355 ± 0.101	2.136GlyMet: 2.136 ± 0.063	2.877GlyAsn: 2.877 ± 0.096	1.568GlyPro: 1.568 ± 0.042	2.04GlyGln: 2.04 ± 0.046	3.778GlyArg: 3.778 ± 0.072	4.919GlySer: 4.919 ± 0.096	3.979GlyThr: 3.979 ± 0.081	4.931GlyVal: 4.931 ± 0.077	0.869GlyTrp: 0.869 ± 0.03	2.567GlyTyr: 2.567 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.739HisAla: 1.739 ± 0.05	0.3HisCys: 0.3 ± 0.018	1.264HisAsp: 1.264 ± 0.037	1.413HisGlu: 1.413 ± 0.041	1.028HisPhe: 1.028 ± 0.034	1.494HisGly: 1.494 ± 0.049	0.687HisHis: 0.687 ± 0.033	1.336HisIle: 1.336 ± 0.044	0.975HisLys: 0.975 ± 0.039	2.265HisLeu: 2.265 ± 0.053	0.394HisMet: 0.394 ± 0.022	0.87HisAsn: 0.87 ± 0.027	1.34HisPro: 1.34 ± 0.051	0.793HisGln: 0.793 ± 0.037	1.126HisArg: 1.126 ± 0.034	1.378HisSer: 1.378 ± 0.044	1.123HisThr: 1.123 ± 0.041	1.13HisVal: 1.13 ± 0.035	0.21HisTrp: 0.21 ± 0.017	0.88HisTyr: 0.88 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.473IleAla: 6.473 ± 0.087	0.79IleCys: 0.79 ± 0.028	4.049IleAsp: 4.049 ± 0.065	4.863IleGlu: 4.863 ± 0.062	2.661IlePhe: 2.661 ± 0.06	5.028IleGly: 5.028 ± 0.085	1.349IleHis: 1.349 ± 0.037	4.399IleIle: 4.399 ± 0.088	3.301IleLys: 3.301 ± 0.07	5.898IleLeu: 5.898 ± 0.097	1.473IleMet: 1.473 ± 0.045	2.715IleAsn: 2.715 ± 0.065	3.031IlePro: 3.031 ± 0.065	1.891IleGln: 1.891 ± 0.053	3.717IleArg: 3.717 ± 0.076	4.521IleSer: 4.521 ± 0.087	4.161IleThr: 4.161 ± 0.078	4.512IleVal: 4.512 ± 0.077	0.569IleTrp: 0.569 ± 0.026	1.87IleTyr: 1.87 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.578LysAla: 4.578 ± 0.082	0.425LysCys: 0.425 ± 0.025	2.134LysAsp: 2.134 ± 0.049	4.383LysGlu: 4.383 ± 0.078	1.616LysPhe: 1.616 ± 0.053	3.812LysGly: 3.812 ± 0.081	1.02LysHis: 1.02 ± 0.037	4.052LysIle: 4.052 ± 0.078	4.525LysLys: 4.525 ± 0.084	5.237LysLeu: 5.237 ± 0.072	1.381LysMet: 1.381 ± 0.044	2.649LysAsn: 2.649 ± 0.07	2.421LysPro: 2.421 ± 0.063	2.097LysGln: 2.097 ± 0.057	3.176LysArg: 3.176 ± 0.072	3.592LysSer: 3.592 ± 0.072	3.187LysThr: 3.187 ± 0.059	3.572LysVal: 3.572 ± 0.081	0.505LysTrp: 0.505 ± 0.027	1.593LysTyr: 1.593 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	8.879LeuAla: 8.879 ± 0.128	1.174LeuCys: 1.174 ± 0.041	5.838LeuAsp: 5.838 ± 0.113	6.466LeuGlu: 6.466 ± 0.105	5.457LeuPhe: 5.457 ± 0.098	6.356LeuGly: 6.356 ± 0.096	2.387LeuHis: 2.387 ± 0.055	5.945LeuIle: 5.945 ± 0.101	5.961LeuLys: 5.961 ± 0.093	11.759LeuLeu: 11.759 ± 0.149	2.377LeuMet: 2.377 ± 0.056	3.816LeuAsn: 3.816 ± 0.07	4.822LeuPro: 4.822 ± 0.092	4.276LeuGln: 4.276 ± 0.074	5.616LeuArg: 5.616 ± 0.092	7.523LeuSer: 7.523 ± 0.111	5.04LeuThr: 5.04 ± 0.09	6.688LeuVal: 6.688 ± 0.108	1.042LeuTrp: 1.042 ± 0.039	3.093LeuTyr: 3.093 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.221MetAla: 2.221 ± 0.059	0.155MetCys: 0.155 ± 0.013	1.041MetAsp: 1.041 ± 0.033	1.474MetGlu: 1.474 ± 0.044	0.793MetPhe: 0.793 ± 0.029	1.597MetGly: 1.597 ± 0.048	0.576MetHis: 0.576 ± 0.026	1.624MetIle: 1.624 ± 0.047	1.836MetLys: 1.836 ± 0.047	2.627MetLeu: 2.627 ± 0.063	0.731MetMet: 0.731 ± 0.029	1.133MetAsn: 1.133 ± 0.037	1.218MetPro: 1.218 ± 0.042	1.185MetGln: 1.185 ± 0.037	1.257MetArg: 1.257 ± 0.039	1.481MetSer: 1.481 ± 0.044	1.438MetThr: 1.438 ± 0.05	1.784MetVal: 1.784 ± 0.043	0.157MetTrp: 0.157 ± 0.014	0.467MetTyr: 0.467 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.02AsnAla: 3.02 ± 0.068	0.454AsnCys: 0.454 ± 0.026	1.828AsnAsp: 1.828 ± 0.054	2.157AsnGlu: 2.157 ± 0.058	1.606AsnPhe: 1.606 ± 0.05	2.689AsnGly: 2.689 ± 0.072	0.89AsnHis: 0.89 ± 0.033	2.849AsnIle: 2.849 ± 0.071	1.867AsnLys: 1.867 ± 0.06	3.894AsnLeu: 3.894 ± 0.08	0.824AsnMet: 0.824 ± 0.039	1.748AsnAsn: 1.748 ± 0.052	2.384AsnPro: 2.384 ± 0.06	1.227AsnGln: 1.227 ± 0.042	2.441AsnArg: 2.441 ± 0.059	2.455AsnSer: 2.455 ± 0.07	1.999AsnThr: 1.999 ± 0.071	2.284AsnVal: 2.284 ± 0.053	0.516AsnTrp: 0.516 ± 0.028	1.289AsnTyr: 1.289 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	3.471ProAla: 3.471 ± 0.062	0.425ProCys: 0.425 ± 0.022	3.008ProAsp: 3.008 ± 0.07	3.97ProGlu: 3.97 ± 0.074	2.076ProPhe: 2.076 ± 0.05	3.004ProGly: 3.004 ± 0.067	0.835ProHis: 0.835 ± 0.034	2.04ProIle: 2.04 ± 0.052	1.907ProLys: 1.907 ± 0.053	4.446ProLeu: 4.446 ± 0.063	0.937ProMet: 0.937 ± 0.034	1.23ProAsn: 1.23 ± 0.04	1.561ProPro: 1.561 ± 0.047	1.365ProGln: 1.365 ± 0.045	1.475ProArg: 1.475 ± 0.045	2.56ProSer: 2.56 ± 0.056	1.66ProThr: 1.66 ± 0.048	3.657ProVal: 3.657 ± 0.099	0.474ProTrp: 0.474 ± 0.023	1.264ProTyr: 1.264 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.988GlnAla: 2.988 ± 0.062	0.349GlnCys: 0.349 ± 0.02	1.378GlnAsp: 1.378 ± 0.042	2.587GlnGlu: 2.587 ± 0.055	1.32GlnPhe: 1.32 ± 0.039	2.197GlnGly: 2.197 ± 0.051	0.884GlnHis: 0.884 ± 0.033	2.291GlnIle: 2.291 ± 0.061	2.393GlnLys: 2.393 ± 0.057	3.703GlnLeu: 3.703 ± 0.069	0.835GlnMet: 0.835 ± 0.03	1.413GlnAsn: 1.413 ± 0.045	1.276GlnPro: 1.276 ± 0.039	1.863GlnGln: 1.863 ± 0.051	1.975GlnArg: 1.975 ± 0.058	2.173GlnSer: 2.173 ± 0.058	1.639GlnThr: 1.639 ± 0.064	2.026GlnVal: 2.026 ± 0.053	0.432GlnTrp: 0.432 ± 0.022	0.944GlnTyr: 0.944 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	3.782ArgAla: 3.782 ± 0.08	0.58ArgCys: 0.58 ± 0.029	2.656ArgAsp: 2.656 ± 0.068	4.391ArgGlu: 4.391 ± 0.085	2.731ArgPhe: 2.731 ± 0.052	2.906ArgGly: 2.906 ± 0.063	1.299ArgHis: 1.299 ± 0.045	3.879ArgIle: 3.879 ± 0.073	3.579ArgLys: 3.579 ± 0.066	5.623ArgLeu: 5.623 ± 0.094	1.516ArgMet: 1.516 ± 0.049	2.255ArgAsn: 2.255 ± 0.059	1.933ArgPro: 1.933 ± 0.063	2.403ArgGln: 2.403 ± 0.057	2.972ArgArg: 2.972 ± 0.066	3.534ArgSer: 3.534 ± 0.077	2.406ArgThr: 2.406 ± 0.052	3.515ArgVal: 3.515 ± 0.07	0.609ArgTrp: 0.609 ± 0.027	2.17ArgTyr: 2.17 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	5.568SerAla: 5.568 ± 0.106	0.84SerCys: 0.84 ± 0.032	3.417SerAsp: 3.417 ± 0.076	4.006SerGlu: 4.006 ± 0.068	3.163SerPhe: 3.163 ± 0.061	5.934SerGly: 5.934 ± 0.174	1.302SerHis: 1.302 ± 0.044	4.316SerIle: 4.316 ± 0.083	2.997SerLys: 2.997 ± 0.065	7.032SerLeu: 7.032 ± 0.117	1.71SerMet: 1.71 ± 0.044	2.393SerAsn: 2.393 ± 0.062	2.729SerPro: 2.729 ± 0.059	1.889SerGln: 1.889 ± 0.047	3.668SerArg: 3.668 ± 0.068	4.666SerSer: 4.666 ± 0.09	3.194SerThr: 3.194 ± 0.066	4.533SerVal: 4.533 ± 0.093	0.83SerTrp: 0.83 ± 0.03	1.92SerTyr: 1.92 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	4.54ThrAla: 4.54 ± 0.107	0.512ThrCys: 0.512 ± 0.024	2.661ThrAsp: 2.661 ± 0.084	3.085ThrGlu: 3.085 ± 0.062	2.229ThrPhe: 2.229 ± 0.066	4.663ThrGly: 4.663 ± 0.088	0.964ThrHis: 0.964 ± 0.036	4.134ThrIle: 4.134 ± 0.096	2.177ThrLys: 2.177 ± 0.06	6.21ThrLeu: 6.21 ± 0.124	1.237ThrMet: 1.237 ± 0.041	1.697ThrAsn: 1.697 ± 0.048	2.609ThrPro: 2.609 ± 0.058	1.255ThrGln: 1.255 ± 0.041	2.421ThrArg: 2.421 ± 0.057	3.014ThrSer: 3.014 ± 0.085	2.963ThrThr: 2.963 ± 0.088	3.978ThrVal: 3.978 ± 0.119	0.493ThrTrp: 0.493 ± 0.023	1.4ThrTyr: 1.4 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.632ValAla: 5.632 ± 0.097	0.742ValCys: 0.742 ± 0.031	3.601ValAsp: 3.601 ± 0.068	4.424ValGlu: 4.424 ± 0.078	2.927ValPhe: 2.927 ± 0.066	3.965ValGly: 3.965 ± 0.077	1.385ValHis: 1.385 ± 0.048	4.831ValIle: 4.831 ± 0.078	3.339ValLys: 3.339 ± 0.076	6.642ValLeu: 6.642 ± 0.103	1.792ValMet: 1.792 ± 0.043	2.514ValAsn: 2.514 ± 0.053	2.732ValPro: 2.732 ± 0.069	2.189ValGln: 2.189 ± 0.077	3.466ValArg: 3.466 ± 0.071	4.623ValSer: 4.623 ± 0.088	4.107ValThr: 4.107 ± 0.087	4.933ValVal: 4.933 ± 0.095	0.695ValTrp: 0.695 ± 0.028	1.866ValTyr: 1.866 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.754TrpAla: 0.754 ± 0.029	0.135TrpCys: 0.135 ± 0.013	0.547TrpAsp: 0.547 ± 0.029	0.677TrpGlu: 0.677 ± 0.032	0.563TrpPhe: 0.563 ± 0.027	0.619TrpGly: 0.619 ± 0.023	0.279TrpHis: 0.279 ± 0.018	0.722TrpIle: 0.722 ± 0.027	0.673TrpLys: 0.673 ± 0.033	1.293TrpLeu: 1.293 ± 0.042	0.357TrpMet: 0.357 ± 0.022	0.514TrpAsn: 0.514 ± 0.027	0.399TrpPro: 0.399 ± 0.023	0.545TrpGln: 0.545 ± 0.028	0.592TrpArg: 0.592 ± 0.032	0.72TrpSer: 0.72 ± 0.031	0.433TrpThr: 0.433 ± 0.027	0.582TrpVal: 0.582 ± 0.028	0.173TrpTrp: 0.173 ± 0.015	0.356TrpTyr: 0.356 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.379TyrAla: 2.379 ± 0.051	0.447TyrCys: 0.447 ± 0.022	1.844TyrAsp: 1.844 ± 0.065	1.85TyrGlu: 1.85 ± 0.05	1.464TyrPhe: 1.464 ± 0.044	2.38TyrGly: 2.38 ± 0.06	0.751TyrHis: 0.751 ± 0.031	1.701TyrIle: 1.701 ± 0.047	1.371TyrLys: 1.371 ± 0.043	3.222TyrLeu: 3.222 ± 0.069	0.558TyrMet: 0.558 ± 0.026	1.25TyrAsn: 1.25 ± 0.039	1.479TyrPro: 1.479 ± 0.045	1.148TyrGln: 1.148 ± 0.038	2.099TyrArg: 2.099 ± 0.05	2.124TyrSer: 2.124 ± 0.065	1.671TyrThr: 1.671 ± 0.051	1.633TyrVal: 1.633 ± 0.051	0.372TyrTrp: 0.372 ± 0.021	1.014TyrTyr: 1.014 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2685 proteins (851977 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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