Amino acid dipepetide frequency for Achromobacter phage 83-24

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.926AlaAla: 9.926 ± 1.181
0.714AlaCys: 0.714 ± 0.218
5.285AlaAsp: 5.285 ± 0.712
6.213AlaGlu: 6.213 ± 0.763
3.285AlaPhe: 3.285 ± 0.463
7.641AlaGly: 7.641 ± 1.166
1.785AlaHis: 1.785 ± 0.363
5.713AlaIle: 5.713 ± 0.63
4.142AlaLys: 4.142 ± 0.572
7.498AlaLeu: 7.498 ± 0.68
3.499AlaMet: 3.499 ± 0.593
3.571AlaAsn: 3.571 ± 0.611
4.642AlaPro: 4.642 ± 0.656
4.213AlaGln: 4.213 ± 0.523
6.07AlaArg: 6.07 ± 0.597
5.213AlaSer: 5.213 ± 0.511
5.856AlaThr: 5.856 ± 0.667
5.285AlaVal: 5.285 ± 0.693
1.714AlaTrp: 1.714 ± 0.276
2.714AlaTyr: 2.714 ± 0.416
0.0AlaXaa: 0.0 ± 0.0
Cys
0.928CysAla: 0.928 ± 0.304
0.214CysCys: 0.214 ± 0.121
0.643CysAsp: 0.643 ± 0.267
0.5CysGlu: 0.5 ± 0.196
0.428CysPhe: 0.428 ± 0.189
0.5CysGly: 0.5 ± 0.227
0.071CysHis: 0.071 ± 0.066
0.357CysIle: 0.357 ± 0.145
0.214CysLys: 0.214 ± 0.12
0.357CysLeu: 0.357 ± 0.143
0.214CysMet: 0.214 ± 0.121
0.428CysAsn: 0.428 ± 0.2
0.643CysPro: 0.643 ± 0.297
0.143CysGln: 0.143 ± 0.093
0.786CysArg: 0.786 ± 0.204
0.643CysSer: 0.643 ± 0.201
0.214CysThr: 0.214 ± 0.115
0.643CysVal: 0.643 ± 0.231
0.214CysTrp: 0.214 ± 0.134
0.357CysTyr: 0.357 ± 0.161
0.0CysXaa: 0.0 ± 0.0
Asp
6.07AspAla: 6.07 ± 0.779
0.286AspCys: 0.286 ± 0.134
3.999AspAsp: 3.999 ± 0.656
3.928AspGlu: 3.928 ± 0.627
3.285AspPhe: 3.285 ± 0.524
4.642AspGly: 4.642 ± 0.678
0.857AspHis: 0.857 ± 0.246
2.785AspIle: 2.785 ± 0.456
2.357AspLys: 2.357 ± 0.428
5.642AspLeu: 5.642 ± 0.524
1.285AspMet: 1.285 ± 0.283
2.0AspAsn: 2.0 ± 0.343
2.499AspPro: 2.499 ± 0.437
1.5AspGln: 1.5 ± 0.299
2.714AspArg: 2.714 ± 0.414
2.499AspSer: 2.499 ± 0.443
2.428AspThr: 2.428 ± 0.312
3.928AspVal: 3.928 ± 0.699
1.0AspTrp: 1.0 ± 0.283
2.499AspTyr: 2.499 ± 0.44
0.0AspXaa: 0.0 ± 0.0
Glu
7.641GluAla: 7.641 ± 0.935
0.571GluCys: 0.571 ± 0.201
3.071GluAsp: 3.071 ± 0.509
5.427GluGlu: 5.427 ± 0.742
2.571GluPhe: 2.571 ± 0.442
3.856GluGly: 3.856 ± 0.576
1.428GluHis: 1.428 ± 0.325
2.214GluIle: 2.214 ± 0.481
3.071GluLys: 3.071 ± 0.5
6.713GluLeu: 6.713 ± 0.603
2.071GluMet: 2.071 ± 0.362
2.142GluAsn: 2.142 ± 0.379
2.928GluPro: 2.928 ± 0.665
3.999GluGln: 3.999 ± 0.63
3.214GluArg: 3.214 ± 0.486
2.571GluSer: 2.571 ± 0.314
2.999GluThr: 2.999 ± 0.521
4.499GluVal: 4.499 ± 0.553
1.428GluTrp: 1.428 ± 0.299
2.142GluTyr: 2.142 ± 0.528
0.0GluXaa: 0.0 ± 0.0
Phe
2.999PheAla: 2.999 ± 0.384
0.5PheCys: 0.5 ± 0.16
2.571PheAsp: 2.571 ± 0.41
2.285PheGlu: 2.285 ± 0.513
1.214PhePhe: 1.214 ± 0.339
3.285PheGly: 3.285 ± 0.465
0.714PheHis: 0.714 ± 0.216
1.714PheIle: 1.714 ± 0.321
2.214PheLys: 2.214 ± 0.326
3.356PheLeu: 3.356 ± 0.527
1.0PheMet: 1.0 ± 0.214
1.428PheAsn: 1.428 ± 0.267
1.857PhePro: 1.857 ± 0.379
1.143PheGln: 1.143 ± 0.324
2.499PheArg: 2.499 ± 0.448
2.928PheSer: 2.928 ± 0.337
2.428PheThr: 2.428 ± 0.38
2.0PheVal: 2.0 ± 0.328
0.786PheTrp: 0.786 ± 0.247
0.857PheTyr: 0.857 ± 0.261
0.0PheXaa: 0.0 ± 0.0
Gly
6.57GlyAla: 6.57 ± 0.916
0.214GlyCys: 0.214 ± 0.111
3.571GlyAsp: 3.571 ± 0.443
4.57GlyGlu: 4.57 ± 0.487
2.999GlyPhe: 2.999 ± 0.423
7.498GlyGly: 7.498 ± 1.197
1.0GlyHis: 1.0 ± 0.305
4.142GlyIle: 4.142 ± 0.322
4.142GlyLys: 4.142 ± 0.624
6.284GlyLeu: 6.284 ± 0.828
2.214GlyMet: 2.214 ± 0.429
4.142GlyAsn: 4.142 ± 0.513
2.857GlyPro: 2.857 ± 0.559
3.356GlyGln: 3.356 ± 0.528
4.57GlyArg: 4.57 ± 0.71
6.356GlySer: 6.356 ± 0.951
5.356GlyThr: 5.356 ± 1.108
4.928GlyVal: 4.928 ± 0.682
2.142GlyTrp: 2.142 ± 0.456
2.357GlyTyr: 2.357 ± 0.313
0.0GlyXaa: 0.0 ± 0.0
His
1.714HisAla: 1.714 ± 0.289
0.357HisCys: 0.357 ± 0.169
0.5HisAsp: 0.5 ± 0.158
1.214HisGlu: 1.214 ± 0.338
0.786HisPhe: 0.786 ± 0.219
1.428HisGly: 1.428 ± 0.304
0.286HisHis: 0.286 ± 0.182
1.0HisIle: 1.0 ± 0.272
0.357HisLys: 0.357 ± 0.148
1.643HisLeu: 1.643 ± 0.395
0.286HisMet: 0.286 ± 0.127
0.643HisAsn: 0.643 ± 0.206
1.143HisPro: 1.143 ± 0.222
0.5HisGln: 0.5 ± 0.183
1.5HisArg: 1.5 ± 0.336
1.285HisSer: 1.285 ± 0.385
0.714HisThr: 0.714 ± 0.193
2.0HisVal: 2.0 ± 0.396
0.071HisTrp: 0.071 ± 0.062
0.571HisTyr: 0.571 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
4.785IleAla: 4.785 ± 0.669
0.5IleCys: 0.5 ± 0.265
2.999IleAsp: 2.999 ± 0.486
3.142IleGlu: 3.142 ± 0.466
1.214IlePhe: 1.214 ± 0.241
3.356IleGly: 3.356 ± 0.537
0.857IleHis: 0.857 ± 0.194
2.071IleIle: 2.071 ± 0.423
2.785IleLys: 2.785 ± 0.436
3.499IleLeu: 3.499 ± 0.424
1.643IleMet: 1.643 ± 0.361
2.571IleAsn: 2.571 ± 0.454
2.928IlePro: 2.928 ± 0.415
2.214IleGln: 2.214 ± 0.335
2.714IleArg: 2.714 ± 0.527
3.071IleSer: 3.071 ± 0.487
3.356IleThr: 3.356 ± 0.512
3.856IleVal: 3.856 ± 0.536
0.928IleTrp: 0.928 ± 0.285
1.357IleTyr: 1.357 ± 0.244
0.0IleXaa: 0.0 ± 0.0
Lys
4.928LysAla: 4.928 ± 0.739
0.214LysCys: 0.214 ± 0.103
2.928LysAsp: 2.928 ± 0.486
2.785LysGlu: 2.785 ± 0.611
2.285LysPhe: 2.285 ± 0.51
3.928LysGly: 3.928 ± 0.464
1.785LysHis: 1.785 ± 0.425
2.785LysIle: 2.785 ± 0.454
3.285LysLys: 3.285 ± 0.637
4.856LysLeu: 4.856 ± 0.722
1.5LysMet: 1.5 ± 0.272
1.928LysAsn: 1.928 ± 0.353
2.357LysPro: 2.357 ± 0.354
2.071LysGln: 2.071 ± 0.387
3.285LysArg: 3.285 ± 0.543
2.357LysSer: 2.357 ± 0.461
2.928LysThr: 2.928 ± 0.438
3.713LysVal: 3.713 ± 0.446
1.143LysTrp: 1.143 ± 0.437
1.785LysTyr: 1.785 ± 0.352
0.0LysXaa: 0.0 ± 0.0
Leu
8.998LeuAla: 8.998 ± 0.715
0.643LeuCys: 0.643 ± 0.256
4.856LeuAsp: 4.856 ± 0.564
6.927LeuGlu: 6.927 ± 0.776
2.714LeuPhe: 2.714 ± 0.386
5.927LeuGly: 5.927 ± 0.852
1.5LeuHis: 1.5 ± 0.355
3.071LeuIle: 3.071 ± 0.462
4.642LeuLys: 4.642 ± 0.648
6.641LeuLeu: 6.641 ± 0.67
1.357LeuMet: 1.357 ± 0.311
3.713LeuAsn: 3.713 ± 0.582
5.784LeuPro: 5.784 ± 0.817
3.856LeuGln: 3.856 ± 0.522
5.499LeuArg: 5.499 ± 0.571
5.427LeuSer: 5.427 ± 0.569
4.785LeuThr: 4.785 ± 0.678
4.999LeuVal: 4.999 ± 0.494
1.214LeuTrp: 1.214 ± 0.32
1.785LeuTyr: 1.785 ± 0.34
0.0LeuXaa: 0.0 ± 0.0
Met
3.142MetAla: 3.142 ± 0.431
0.071MetCys: 0.071 ± 0.066
1.214MetAsp: 1.214 ± 0.29
1.714MetGlu: 1.714 ± 0.378
1.214MetPhe: 1.214 ± 0.273
1.5MetGly: 1.5 ± 0.288
0.428MetHis: 0.428 ± 0.212
1.0MetIle: 1.0 ± 0.352
2.0MetLys: 2.0 ± 0.302
2.285MetLeu: 2.285 ± 0.326
0.714MetMet: 0.714 ± 0.269
1.285MetAsn: 1.285 ± 0.26
2.0MetPro: 2.0 ± 0.355
1.285MetGln: 1.285 ± 0.368
1.428MetArg: 1.428 ± 0.258
1.571MetSer: 1.571 ± 0.274
1.643MetThr: 1.643 ± 0.341
1.785MetVal: 1.785 ± 0.351
0.071MetTrp: 0.071 ± 0.073
0.5MetTyr: 0.5 ± 0.178
0.0MetXaa: 0.0 ± 0.0
Asn
4.57AsnAla: 4.57 ± 0.634
0.571AsnCys: 0.571 ± 0.191
1.714AsnAsp: 1.714 ± 0.39
2.428AsnGlu: 2.428 ± 0.42
1.285AsnPhe: 1.285 ± 0.281
4.285AsnGly: 4.285 ± 0.583
0.571AsnHis: 0.571 ± 0.181
2.785AsnIle: 2.785 ± 0.382
1.643AsnLys: 1.643 ± 0.36
3.428AsnLeu: 3.428 ± 0.449
0.928AsnMet: 0.928 ± 0.234
1.5AsnAsn: 1.5 ± 0.34
2.785AsnPro: 2.785 ± 0.383
1.143AsnGln: 1.143 ± 0.312
2.214AsnArg: 2.214 ± 0.345
2.285AsnSer: 2.285 ± 0.404
1.571AsnThr: 1.571 ± 0.283
2.499AsnVal: 2.499 ± 0.339
1.214AsnTrp: 1.214 ± 0.27
1.571AsnTyr: 1.571 ± 0.311
0.0AsnXaa: 0.0 ± 0.0
Pro
4.356ProAla: 4.356 ± 0.566
0.286ProCys: 0.286 ± 0.152
3.214ProAsp: 3.214 ± 0.421
3.999ProGlu: 3.999 ± 0.623
1.857ProPhe: 1.857 ± 0.367
5.427ProGly: 5.427 ± 0.803
0.857ProHis: 0.857 ± 0.239
2.428ProIle: 2.428 ± 0.395
3.713ProLys: 3.713 ± 0.609
3.999ProLeu: 3.999 ± 0.453
1.143ProMet: 1.143 ± 0.259
1.928ProAsn: 1.928 ± 0.426
2.285ProPro: 2.285 ± 0.326
1.643ProGln: 1.643 ± 0.357
2.357ProArg: 2.357 ± 0.589
2.785ProSer: 2.785 ± 0.46
3.356ProThr: 3.356 ± 0.477
3.571ProVal: 3.571 ± 0.462
0.571ProTrp: 0.571 ± 0.235
1.0ProTyr: 1.0 ± 0.195
0.0ProXaa: 0.0 ± 0.0
Gln
4.142GlnAla: 4.142 ± 0.597
0.428GlnCys: 0.428 ± 0.195
1.571GlnAsp: 1.571 ± 0.324
3.214GlnGlu: 3.214 ± 0.568
1.857GlnPhe: 1.857 ± 0.395
2.785GlnGly: 2.785 ± 0.346
0.571GlnHis: 0.571 ± 0.227
1.785GlnIle: 1.785 ± 0.372
2.142GlnLys: 2.142 ± 0.434
3.999GlnLeu: 3.999 ± 0.593
1.071GlnMet: 1.071 ± 0.288
1.5GlnAsn: 1.5 ± 0.335
1.857GlnPro: 1.857 ± 0.34
1.428GlnGln: 1.428 ± 0.384
2.642GlnArg: 2.642 ± 0.412
2.428GlnSer: 2.428 ± 0.472
1.928GlnThr: 1.928 ± 0.229
3.356GlnVal: 3.356 ± 0.326
0.643GlnTrp: 0.643 ± 0.141
1.285GlnTyr: 1.285 ± 0.415
0.0GlnXaa: 0.0 ± 0.0
Arg
5.427ArgAla: 5.427 ± 0.587
0.286ArgCys: 0.286 ± 0.145
2.999ArgAsp: 2.999 ± 0.49
3.214ArgGlu: 3.214 ± 0.546
2.071ArgPhe: 2.071 ± 0.376
5.213ArgGly: 5.213 ± 0.823
0.857ArgHis: 0.857 ± 0.232
2.714ArgIle: 2.714 ± 0.481
3.713ArgLys: 3.713 ± 0.57
4.856ArgLeu: 4.856 ± 0.57
2.428ArgMet: 2.428 ± 0.377
2.785ArgAsn: 2.785 ± 0.327
2.785ArgPro: 2.785 ± 0.45
2.285ArgGln: 2.285 ± 0.411
4.285ArgArg: 4.285 ± 0.542
3.356ArgSer: 3.356 ± 0.547
2.642ArgThr: 2.642 ± 0.507
4.713ArgVal: 4.713 ± 0.475
1.0ArgTrp: 1.0 ± 0.3
1.785ArgTyr: 1.785 ± 0.339
0.0ArgXaa: 0.0 ± 0.0
Ser
4.642SerAla: 4.642 ± 0.666
0.714SerCys: 0.714 ± 0.216
3.856SerAsp: 3.856 ± 0.4
2.571SerGlu: 2.571 ± 0.44
2.285SerPhe: 2.285 ± 0.331
4.713SerGly: 4.713 ± 0.588
0.857SerHis: 0.857 ± 0.245
3.642SerIle: 3.642 ± 0.551
2.642SerLys: 2.642 ± 0.481
5.07SerLeu: 5.07 ± 0.636
1.928SerMet: 1.928 ± 0.39
3.142SerAsn: 3.142 ± 0.507
2.0SerPro: 2.0 ± 0.342
2.285SerGln: 2.285 ± 0.434
3.571SerArg: 3.571 ± 0.347
3.713SerSer: 3.713 ± 0.487
4.356SerThr: 4.356 ± 0.691
4.213SerVal: 4.213 ± 0.395
0.928SerTrp: 0.928 ± 0.38
2.071SerTyr: 2.071 ± 0.415
0.0SerXaa: 0.0 ± 0.0
Thr
5.57ThrAla: 5.57 ± 0.737
0.357ThrCys: 0.357 ± 0.147
3.214ThrAsp: 3.214 ± 0.464
3.571ThrGlu: 3.571 ± 0.392
2.214ThrPhe: 2.214 ± 0.315
4.499ThrGly: 4.499 ± 0.722
0.714ThrHis: 0.714 ± 0.226
2.928ThrIle: 2.928 ± 0.489
2.571ThrLys: 2.571 ± 0.36
5.356ThrLeu: 5.356 ± 0.632
0.714ThrMet: 0.714 ± 0.193
1.785ThrAsn: 1.785 ± 0.427
3.071ThrPro: 3.071 ± 0.508
2.357ThrGln: 2.357 ± 0.421
2.571ThrArg: 2.571 ± 0.383
3.642ThrSer: 3.642 ± 0.513
3.071ThrThr: 3.071 ± 0.49
5.285ThrVal: 5.285 ± 0.634
1.071ThrTrp: 1.071 ± 0.262
2.285ThrTyr: 2.285 ± 0.398
0.0ThrXaa: 0.0 ± 0.0
Val
4.999ValAla: 4.999 ± 0.516
0.786ValCys: 0.786 ± 0.317
4.856ValAsp: 4.856 ± 0.563
3.713ValGlu: 3.713 ± 0.671
2.642ValPhe: 2.642 ± 0.41
4.928ValGly: 4.928 ± 0.706
1.857ValHis: 1.857 ± 0.369
3.785ValIle: 3.785 ± 0.458
4.142ValLys: 4.142 ± 0.633
5.285ValLeu: 5.285 ± 0.626
1.285ValMet: 1.285 ± 0.249
2.999ValAsn: 2.999 ± 0.571
3.785ValPro: 3.785 ± 0.572
3.356ValGln: 3.356 ± 0.464
3.856ValArg: 3.856 ± 0.529
3.999ValSer: 3.999 ± 0.488
4.428ValThr: 4.428 ± 0.572
5.356ValVal: 5.356 ± 0.895
1.357ValTrp: 1.357 ± 0.311
2.357ValTyr: 2.357 ± 0.441
0.0ValXaa: 0.0 ± 0.0
Trp
1.071TrpAla: 1.071 ± 0.291
0.357TrpCys: 0.357 ± 0.138
1.071TrpAsp: 1.071 ± 0.3
1.0TrpGlu: 1.0 ± 0.321
0.571TrpPhe: 0.571 ± 0.184
1.428TrpGly: 1.428 ± 0.295
0.357TrpHis: 0.357 ± 0.164
1.0TrpIle: 1.0 ± 0.298
1.5TrpLys: 1.5 ± 0.292
1.357TrpLeu: 1.357 ± 0.342
0.428TrpMet: 0.428 ± 0.183
0.571TrpAsn: 0.571 ± 0.187
1.143TrpPro: 1.143 ± 0.347
0.643TrpGln: 0.643 ± 0.255
1.0TrpArg: 1.0 ± 0.267
1.285TrpSer: 1.285 ± 0.386
1.0TrpThr: 1.0 ± 0.249
1.285TrpVal: 1.285 ± 0.244
0.357TrpTrp: 0.357 ± 0.145
0.928TrpTyr: 0.928 ± 0.214
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.499TyrAla: 2.499 ± 0.303
0.428TyrCys: 0.428 ± 0.185
2.071TyrAsp: 2.071 ± 0.289
2.142TyrGlu: 2.142 ± 0.433
1.0TyrPhe: 1.0 ± 0.248
2.428TyrGly: 2.428 ± 0.413
0.643TyrHis: 0.643 ± 0.226
1.928TyrIle: 1.928 ± 0.344
1.571TyrLys: 1.571 ± 0.339
2.214TyrLeu: 2.214 ± 0.406
1.071TyrMet: 1.071 ± 0.321
0.928TyrAsn: 0.928 ± 0.214
1.428TyrPro: 1.428 ± 0.372
1.214TyrGln: 1.214 ± 0.331
2.714TyrArg: 2.714 ± 0.443
1.785TyrSer: 1.785 ± 0.366
1.785TyrThr: 1.785 ± 0.323
1.857TyrVal: 1.857 ± 0.324
0.5TyrTrp: 0.5 ± 0.189
0.643TyrTyr: 0.643 ± 0.183
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (14004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski