Amino acid dipepetide frequency for Lachnospira multipara

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.51AlaAla: 5.51 ± 0.122	1.008AlaCys: 1.008 ± 0.033	4.133AlaAsp: 4.133 ± 0.082	3.964AlaGlu: 3.964 ± 0.119	2.869AlaPhe: 2.869 ± 0.069	4.715AlaGly: 4.715 ± 0.095	0.949AlaHis: 0.949 ± 0.038	5.933AlaIle: 5.933 ± 0.082	5.778AlaLys: 5.778 ± 0.094	6.169AlaLeu: 6.169 ± 0.094	1.913AlaMet: 1.913 ± 0.058	3.847AlaAsn: 3.847 ± 0.078	1.542AlaPro: 1.542 ± 0.056	1.583AlaGln: 1.583 ± 0.049	2.523AlaArg: 2.523 ± 0.054	4.662AlaSer: 4.662 ± 0.093	3.918AlaThr: 3.918 ± 0.09	4.698AlaVal: 4.698 ± 0.093	0.465AlaTrp: 0.465 ± 0.025	2.791AlaTyr: 2.791 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.845CysAla: 0.845 ± 0.035	0.212CysCys: 0.212 ± 0.015	0.779CysAsp: 0.779 ± 0.029	0.807CysGlu: 0.807 ± 0.031	0.523CysPhe: 0.523 ± 0.023	1.084CysGly: 1.084 ± 0.041	0.261CysHis: 0.261 ± 0.016	1.117CysIle: 1.117 ± 0.036	0.873CysLys: 0.873 ± 0.032	1.212CysLeu: 1.212 ± 0.04	0.351CysMet: 0.351 ± 0.018	0.666CysAsn: 0.666 ± 0.028	0.496CysPro: 0.496 ± 0.022	0.295CysGln: 0.295 ± 0.02	0.408CysArg: 0.408 ± 0.022	0.769CysSer: 0.769 ± 0.031	0.596CysThr: 0.596 ± 0.025	0.936CysVal: 0.936 ± 0.033	0.07CysTrp: 0.07 ± 0.011	0.56CysTyr: 0.56 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	3.911AspAla: 3.911 ± 0.076	0.839AspCys: 0.839 ± 0.034	3.638AspAsp: 3.638 ± 0.073	5.491AspGlu: 5.491 ± 0.091	3.286AspPhe: 3.286 ± 0.085	4.129AspGly: 4.129 ± 0.088	0.704AspHis: 0.704 ± 0.033	5.467AspIle: 5.467 ± 0.087	4.824AspLys: 4.824 ± 0.09	5.328AspLeu: 5.328 ± 0.081	1.817AspMet: 1.817 ± 0.047	3.52AspAsn: 3.52 ± 0.068	1.545AspPro: 1.545 ± 0.042	0.993AspGln: 0.993 ± 0.033	2.164AspArg: 2.164 ± 0.055	3.965AspSer: 3.965 ± 0.08	3.255AspThr: 3.255 ± 0.064	4.161AspVal: 4.161 ± 0.069	0.469AspTrp: 0.469 ± 0.024	3.523AspTyr: 3.523 ± 0.073	0.0AspXaa: 0.0 ± 0.0
Glu	5.413GluAla: 5.413 ± 0.093	0.809GluCys: 0.809 ± 0.032	4.971GluAsp: 4.971 ± 0.085	7.264GluGlu: 7.264 ± 0.141	2.925GluPhe: 2.925 ± 0.06	4.11GluGly: 4.11 ± 0.069	1.043GluHis: 1.043 ± 0.035	6.252GluIle: 6.252 ± 0.111	6.054GluLys: 6.054 ± 0.098	6.895GluLeu: 6.895 ± 0.105	2.118GluMet: 2.118 ± 0.07	4.771GluAsn: 4.771 ± 0.081	1.382GluPro: 1.382 ± 0.053	1.778GluGln: 1.778 ± 0.051	2.614GluArg: 2.614 ± 0.063	3.953GluSer: 3.953 ± 0.083	3.9GluThr: 3.9 ± 0.087	4.747GluVal: 4.747 ± 0.099	0.485GluTrp: 0.485 ± 0.025	3.258GluTyr: 3.258 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	2.843PheAla: 2.843 ± 0.062	0.566PheCys: 0.566 ± 0.026	2.926PheAsp: 2.926 ± 0.064	2.8PheGlu: 2.8 ± 0.063	1.838PhePhe: 1.838 ± 0.053	2.65PheGly: 2.65 ± 0.07	0.526PheHis: 0.526 ± 0.026	3.656PheIle: 3.656 ± 0.07	3.355PheLys: 3.355 ± 0.069	3.715PheLeu: 3.715 ± 0.072	1.115PheMet: 1.115 ± 0.038	2.484PheAsn: 2.484 ± 0.059	1.091PhePro: 1.091 ± 0.039	0.78PheGln: 0.78 ± 0.031	1.43PheArg: 1.43 ± 0.046	3.019PheSer: 3.019 ± 0.074	2.39PheThr: 2.39 ± 0.054	2.966PheVal: 2.966 ± 0.071	0.32PheTrp: 0.32 ± 0.022	1.907PheTyr: 1.907 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	4.156GlyAla: 4.156 ± 0.091	0.952GlyCys: 0.952 ± 0.036	3.587GlyAsp: 3.587 ± 0.068	4.052GlyGlu: 4.052 ± 0.075	3.054GlyPhe: 3.054 ± 0.061	3.843GlyGly: 3.843 ± 0.091	1.225GlyHis: 1.225 ± 0.039	5.588GlyIle: 5.588 ± 0.092	4.834GlyLys: 4.834 ± 0.075	5.609GlyLeu: 5.609 ± 0.091	1.832GlyMet: 1.832 ± 0.052	3.207GlyAsn: 3.207 ± 0.076	1.115GlyPro: 1.115 ± 0.041	1.655GlyGln: 1.655 ± 0.047	2.279GlyArg: 2.279 ± 0.051	3.884GlySer: 3.884 ± 0.089	3.534GlyThr: 3.534 ± 0.082	4.633GlyVal: 4.633 ± 0.087	0.511GlyTrp: 0.511 ± 0.027	3.233GlyTyr: 3.233 ± 0.072	0.0GlyXaa: 0.0 ± 0.0
His	0.788HisAla: 0.788 ± 0.032	0.237HisCys: 0.237 ± 0.017	0.801HisAsp: 0.801 ± 0.036	1.021HisGlu: 1.021 ± 0.035	0.75HisPhe: 0.75 ± 0.033	0.945HisGly: 0.945 ± 0.039	0.313HisHis: 0.313 ± 0.031	1.177HisIle: 1.177 ± 0.037	0.974HisLys: 0.974 ± 0.036	1.206HisLeu: 1.206 ± 0.038	0.403HisMet: 0.403 ± 0.023	0.776HisAsn: 0.776 ± 0.031	0.64HisPro: 0.64 ± 0.029	0.312HisGln: 0.312 ± 0.019	0.559HisArg: 0.559 ± 0.024	0.862HisSer: 0.862 ± 0.029	0.704HisThr: 0.704 ± 0.027	0.909HisVal: 0.909 ± 0.035	0.115HisTrp: 0.115 ± 0.011	0.64HisTyr: 0.64 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.807IleAla: 5.807 ± 0.089	1.213IleCys: 1.213 ± 0.038	5.471IleAsp: 5.471 ± 0.088	5.567IleGlu: 5.567 ± 0.093	3.386IlePhe: 3.386 ± 0.067	4.931IleGly: 4.931 ± 0.079	1.139IleHis: 1.139 ± 0.035	7.017IleIle: 7.017 ± 0.123	6.491IleLys: 6.491 ± 0.106	7.021IleLeu: 7.021 ± 0.115	2.022IleMet: 2.022 ± 0.052	4.924IleAsn: 4.924 ± 0.093	2.687IlePro: 2.687 ± 0.054	1.832IleGln: 1.832 ± 0.046	2.961IleArg: 2.961 ± 0.053	6.075IleSer: 6.075 ± 0.098	4.748IleThr: 4.748 ± 0.094	5.536IleVal: 5.536 ± 0.094	0.534IleTrp: 0.534 ± 0.028	3.48IleTyr: 3.48 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	5.688LysAla: 5.688 ± 0.084	0.757LysCys: 0.757 ± 0.033	5.291LysAsp: 5.291 ± 0.099	7.695LysGlu: 7.695 ± 0.112	2.65LysPhe: 2.65 ± 0.057	4.193LysGly: 4.193 ± 0.083	1.088LysHis: 1.088 ± 0.041	5.876LysIle: 5.876 ± 0.084	7.174LysLys: 7.174 ± 0.134	6.818LysLeu: 6.818 ± 0.1	2.131LysMet: 2.131 ± 0.05	4.799LysAsn: 4.799 ± 0.077	1.907LysPro: 1.907 ± 0.053	1.952LysGln: 1.952 ± 0.056	3.062LysArg: 3.062 ± 0.067	4.25LysSer: 4.25 ± 0.077	4.232LysThr: 4.232 ± 0.075	4.793LysVal: 4.793 ± 0.089	0.512LysTrp: 0.512 ± 0.027	3.667LysTyr: 3.667 ± 0.075	0.0LysXaa: 0.0 ± 0.0
Leu	6.324LeuAla: 6.324 ± 0.101	1.124LeuCys: 1.124 ± 0.043	5.814LeuAsp: 5.814 ± 0.094	6.66LeuGlu: 6.66 ± 0.104	3.457LeuPhe: 3.457 ± 0.072	5.432LeuGly: 5.432 ± 0.09	1.16LeuHis: 1.16 ± 0.041	6.985LeuIle: 6.985 ± 0.111	6.923LeuLys: 6.923 ± 0.099	7.227LeuLeu: 7.227 ± 0.129	2.399LeuMet: 2.399 ± 0.053	4.954LeuAsn: 4.954 ± 0.082	2.559LeuPro: 2.559 ± 0.064	1.884LeuGln: 1.884 ± 0.05	3.198LeuArg: 3.198 ± 0.066	6.641LeuSer: 6.641 ± 0.098	4.856LeuThr: 4.856 ± 0.085	6.282LeuVal: 6.282 ± 0.081	0.563LeuTrp: 0.563 ± 0.03	3.331LeuTyr: 3.331 ± 0.076	0.0LeuXaa: 0.0 ± 0.0
Met	2.122MetAla: 2.122 ± 0.062	0.318MetCys: 0.318 ± 0.017	1.679MetAsp: 1.679 ± 0.046	1.875MetGlu: 1.875 ± 0.054	0.962MetPhe: 0.962 ± 0.041	1.674MetGly: 1.674 ± 0.055	0.414MetHis: 0.414 ± 0.021	2.061MetIle: 2.061 ± 0.059	2.042MetLys: 2.042 ± 0.052	2.462MetLeu: 2.462 ± 0.055	0.705MetMet: 0.705 ± 0.031	1.532MetAsn: 1.532 ± 0.043	1.03MetPro: 1.03 ± 0.04	0.782MetGln: 0.782 ± 0.033	1.008MetArg: 1.008 ± 0.037	1.715MetSer: 1.715 ± 0.047	1.528MetThr: 1.528 ± 0.047	1.646MetVal: 1.646 ± 0.05	0.15MetTrp: 0.15 ± 0.012	0.947MetTyr: 0.947 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.635AsnAla: 3.635 ± 0.076	0.716AsnCys: 0.716 ± 0.034	3.114AsnAsp: 3.114 ± 0.065	4.054AsnGlu: 4.054 ± 0.072	2.256AsnPhe: 2.256 ± 0.051	3.83AsnGly: 3.83 ± 0.074	0.77AsnHis: 0.77 ± 0.028	4.813AsnIle: 4.813 ± 0.068	4.612AsnLys: 4.612 ± 0.088	5.095AsnLeu: 5.095 ± 0.088	1.548AsnMet: 1.548 ± 0.037	3.495AsnAsn: 3.495 ± 0.066	2.014AsnPro: 2.014 ± 0.057	1.49AsnGln: 1.49 ± 0.044	2.054AsnArg: 2.054 ± 0.063	3.645AsnSer: 3.645 ± 0.071	3.022AsnThr: 3.022 ± 0.069	4.014AsnVal: 4.014 ± 0.067	0.461AsnTrp: 0.461 ± 0.026	2.871AsnTyr: 2.871 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.681ProAla: 1.681 ± 0.055	0.349ProCys: 0.349 ± 0.021	1.844ProAsp: 1.844 ± 0.047	2.436ProGlu: 2.436 ± 0.057	1.243ProPhe: 1.243 ± 0.039	1.652ProGly: 1.652 ± 0.046	0.392ProHis: 0.392 ± 0.022	2.162ProIle: 2.162 ± 0.053	1.863ProLys: 1.863 ± 0.049	2.132ProLeu: 2.132 ± 0.054	0.678ProMet: 0.678 ± 0.031	1.328ProAsn: 1.328 ± 0.044	0.414ProPro: 0.414 ± 0.025	0.697ProGln: 0.697 ± 0.03	0.771ProArg: 0.771 ± 0.03	1.67ProSer: 1.67 ± 0.046	1.567ProThr: 1.567 ± 0.055	2.209ProVal: 2.209 ± 0.069	0.226ProTrp: 0.226 ± 0.016	1.211ProTyr: 1.211 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.763GlnAla: 1.763 ± 0.055	0.261GlnCys: 0.261 ± 0.018	1.252GlnAsp: 1.252 ± 0.042	1.746GlnGlu: 1.746 ± 0.042	1.001GlnPhe: 1.001 ± 0.033	1.372GlnGly: 1.372 ± 0.047	0.323GlnHis: 0.323 ± 0.022	2.079GlnIle: 2.079 ± 0.047	1.778GlnLys: 1.778 ± 0.049	2.145GlnLeu: 2.145 ± 0.053	0.744GlnMet: 0.744 ± 0.029	1.231GlnAsn: 1.231 ± 0.041	0.573GlnPro: 0.573 ± 0.029	0.696GlnGln: 0.696 ± 0.034	0.983GlnArg: 0.983 ± 0.038	1.337GlnSer: 1.337 ± 0.045	1.423GlnThr: 1.423 ± 0.046	1.509GlnVal: 1.509 ± 0.04	0.178GlnTrp: 0.178 ± 0.015	1.124GlnTyr: 1.124 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.33ArgAla: 2.33 ± 0.054	0.391ArgCys: 0.391 ± 0.022	2.188ArgAsp: 2.188 ± 0.068	2.882ArgGlu: 2.882 ± 0.055	1.655ArgPhe: 1.655 ± 0.043	1.993ArgGly: 1.993 ± 0.054	0.651ArgHis: 0.651 ± 0.031	3.084ArgIle: 3.084 ± 0.076	2.966ArgLys: 2.966 ± 0.063	3.27ArgLeu: 3.27 ± 0.066	1.037ArgMet: 1.037 ± 0.035	1.98ArgAsn: 1.98 ± 0.048	0.966ArgPro: 0.966 ± 0.037	1.14ArgGln: 1.14 ± 0.042	1.607ArgArg: 1.607 ± 0.051	1.726ArgSer: 1.726 ± 0.047	1.75ArgThr: 1.75 ± 0.045	2.47ArgVal: 2.47 ± 0.06	0.238ArgTrp: 0.238 ± 0.016	1.594ArgTyr: 1.594 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	4.035SerAla: 4.035 ± 0.07	0.73SerCys: 0.73 ± 0.03	4.038SerAsp: 4.038 ± 0.077	4.338SerGlu: 4.338 ± 0.075	3.158SerPhe: 3.158 ± 0.066	4.603SerGly: 4.603 ± 0.097	0.852SerHis: 0.852 ± 0.033	5.113SerIle: 5.113 ± 0.075	4.977SerLys: 4.977 ± 0.086	6.298SerLeu: 6.298 ± 0.092	1.664SerMet: 1.664 ± 0.049	3.734SerAsn: 3.734 ± 0.077	1.448SerPro: 1.448 ± 0.045	1.733SerGln: 1.733 ± 0.056	2.271SerArg: 2.271 ± 0.056	5.047SerSer: 5.047 ± 0.133	3.508SerThr: 3.508 ± 0.093	4.437SerVal: 4.437 ± 0.092	0.48SerTrp: 0.48 ± 0.028	3.215SerTyr: 3.215 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	3.904ThrAla: 3.904 ± 0.097	0.621ThrCys: 0.621 ± 0.025	3.464ThrAsp: 3.464 ± 0.074	3.486ThrGlu: 3.486 ± 0.09	2.272ThrPhe: 2.272 ± 0.055	4.139ThrGly: 4.139 ± 0.085	0.741ThrHis: 0.741 ± 0.031	4.652ThrIle: 4.652 ± 0.084	4.119ThrLys: 4.119 ± 0.071	4.533ThrLeu: 4.533 ± 0.085	1.194ThrMet: 1.194 ± 0.043	3.292ThrAsn: 3.292 ± 0.069	1.767ThrPro: 1.767 ± 0.053	1.24ThrGln: 1.24 ± 0.047	1.92ThrArg: 1.92 ± 0.056	4.01ThrSer: 4.01 ± 0.1	3.588ThrThr: 3.588 ± 0.104	4.135ThrVal: 4.135 ± 0.099	0.383ThrTrp: 0.383 ± 0.024	2.192ThrTyr: 2.192 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	5.084ValAla: 5.084 ± 0.109	1.042ValCys: 1.042 ± 0.039	4.519ValAsp: 4.519 ± 0.077	4.704ValGlu: 4.704 ± 0.089	2.83ValPhe: 2.83 ± 0.058	4.098ValGly: 4.098 ± 0.064	0.814ValHis: 0.814 ± 0.033	5.557ValIle: 5.557 ± 0.098	4.972ValLys: 4.972 ± 0.097	6.023ValLeu: 6.023 ± 0.098	1.687ValMet: 1.687 ± 0.055	3.831ValAsn: 3.831 ± 0.069	1.917ValPro: 1.917 ± 0.051	1.282ValGln: 1.282 ± 0.045	2.271ValArg: 2.271 ± 0.055	5.07ValSer: 5.07 ± 0.083	4.315ValThr: 4.315 ± 0.103	5.089ValVal: 5.089 ± 0.101	0.472ValTrp: 0.472 ± 0.023	2.916ValTyr: 2.916 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.459TrpAla: 0.459 ± 0.023	0.114TrpCys: 0.114 ± 0.013	0.459TrpAsp: 0.459 ± 0.023	0.473TrpGlu: 0.473 ± 0.024	0.314TrpPhe: 0.314 ± 0.021	0.543TrpGly: 0.543 ± 0.026	0.125TrpHis: 0.125 ± 0.011	0.579TrpIle: 0.579 ± 0.025	0.494TrpLys: 0.494 ± 0.024	0.683TrpLeu: 0.683 ± 0.03	0.19TrpMet: 0.19 ± 0.017	0.416TrpAsn: 0.416 ± 0.022	0.155TrpPro: 0.155 ± 0.016	0.271TrpGln: 0.271 ± 0.021	0.241TrpArg: 0.241 ± 0.016	0.389TrpSer: 0.389 ± 0.022	0.335TrpThr: 0.335 ± 0.022	0.403TrpVal: 0.403 ± 0.023	0.079TrpTrp: 0.079 ± 0.01	0.332TrpTyr: 0.332 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.672TyrAla: 2.672 ± 0.055	0.6TyrCys: 0.6 ± 0.031	3.065TyrAsp: 3.065 ± 0.068	3.427TyrGlu: 3.427 ± 0.07	1.951TyrPhe: 1.951 ± 0.048	2.845TyrGly: 2.845 ± 0.067	0.643TyrHis: 0.643 ± 0.029	3.673TyrIle: 3.673 ± 0.067	3.433TyrLys: 3.433 ± 0.068	3.93TyrLeu: 3.93 ± 0.087	1.104TyrMet: 1.104 ± 0.037	2.721TyrAsn: 2.721 ± 0.069	1.28TyrPro: 1.28 ± 0.048	1.121TyrGln: 1.121 ± 0.037	1.594TyrArg: 1.594 ± 0.048	2.986TyrSer: 2.986 ± 0.069	2.487TyrThr: 2.487 ± 0.062	2.92TyrVal: 2.92 ± 0.059	0.342TyrTrp: 0.342 ± 0.02	2.171TyrTyr: 2.171 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2518 proteins (824386 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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